Submitted to: International Plant Growth Promoting Rhizobacteria Workshop
Publication Type: Abstract Only
Publication Acceptance Date: 3/20/2006
Publication Date: 5/20/2006
Citation: Mavrodi, D., Bonsall, R.F., Blankenfelt, W., Weller, D.M., Thomashow, L.S. 2006. Diversity of phenazine biosynthetic pathways in plant-associated bacteria.. International Plant Growth Promoting Rhizobacteria Workshop. P42, page 60.
Technical Abstract: Phenazine compounds are heterocyclic nitrogen-containing secondary metabolites that are synthesized by a few bacterial genera and act as broadly active antibiotics and factors contributing to bacterial competitiveness and virulence. Using comparative analyses, we identified putative phenazine biosynthetic pathways in the recently sequenced genomes of members of Burkholderia and Erwinia genera that include bacterial species of agricultural and medical importance. Studies of these novel pathways are expected to provide a better understanding of how structural differences in key common phenazine biosynthetic enzymes influence the identity of the biosynthetic products, and reveal how the structure and physical properties of species-specific products are related to their biological activity.