Submitted to: Science
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 7/18/2006
Publication Date: 9/1/2006
Citation: Tyler, B.M., Tripathy, S., Xuemin, Z., Dehal, P., Jiang, R.H., Aerts, A., Arredondo, F., Baxter, L., Benasson, D., Beynon, J.L., Damasceno, C.M., Dickerman, A., Dorrance, A.E., Dou, D., Dubchak, I., Garbelotto, M., Gijzen, M., Gordon, S., Govers, F., Grunwald, N., Huang, W., Ivors, K., Jones, R.W., Kamoun, S., Konstantinos, K., Lamour, K., Lee, M., Mcdonald, W.H., Medina, M., Meijer, H.J., Nordberg, E., Maclean, D.J., Ospina-Giraldo, M.D., Morris, P., Phuntumart, V., Putnam, N., Rash, S., Rose, J.K., Sakihama, Y., Salamov, A., Savidor, A., Scheuring, C., Smith, B., Sobral, B.W., Terry, A., Torto-Alalibo, T., Win, J., Xu, Z., Zhang, H., Grigoriev, I., Rokhsar, D., Boore, J. 2006. Phytophthora genome sequences uncover evolutionary origins and mechanisms of pathogenesis. Science. 313:1261-1266. Interpretive Summary: DNA from two important plant pathogens have been assembled and put in sequence. This allows scientist to compare the two related pathogens with other organisms whose DNA sequence has been determined, and determine evolutionary origins. The two pathogens are responsible for billions of dollars in losses to soybeans, trees and shrubs. The DNA sequence provides a map for determining which genes may be important in causing the diseases that result in large economic and aesthetic losses. This information will be used initially by scientist involved in preventing plant disease.
Technical Abstract: Draft genome sequences of the soybean pathogen Phytophthora sojae and the sudden oak death pathogen Phytophthora ramorum have been determined. Oomycetes such as these Phytophthora species share the kingdom Stramenopiles with photosynthetic algae such as diatoms, and the Phytophthora sequences suggest that the kingdom’s ancestor harbored a photosynthetic endosymbiont. Comparison of the two species’ genomes reveals a rapid expansion and diversification of protein families associated with plant infection such as hydrolases, ABC transporters, protein toxins, proteinase inhibitors and in particular a superfamily of 700 proteins with similarity to known oomycete avirulence genes.