Submitted to: Germplasm Release
Publication Type: Germplasm Release
Publication Acceptance Date: 12/12/2005
Publication Date: 1/27/2006
Citation: Connor, E.E., Cates, E.A., Bannerman, D.D. 2006. Sequencing and mapping of bovine toll-like receptor signaling molecules. Germplasm Release. Accession Numbers DQ319070-DQ319076.
Technical Abstract: In cattle, approximately 40% of clinical mastitis is caused by gram-negative bacteria. Inflammation that accompanies gram-negative mastitis is mediated in part by lipopolysaccharide (LPS) shed from the bacterial cell surface. Toll-like receptor (TLR)-4 is the putative transmembrane receptor for LPS. To date, molecules of the TLR-4 signaling pathway have not been well-characterized in cattle The goal of this study was to clone and sequence the full-length coding regions of bovine genes involved in TLR-4 signaling including IRAK1, MD-2, TICAM2, TIRAP, TOLLIP, TRAF 6 and CASP8 to facilitate study of these molecules in cattle.