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ARS Home » Northeast Area » Boston, Massachusetts » Jean Mayer Human Nutrition Research Center On Aging » Research » Publications at this Location » Publication #180285
Title: ANTHOCYANINS CROSS THE BLOOD BRAIN BARRIER: EFFECTS ON OXIDATIVE STRESS-INDUCED APOPTOSIS

Author
item MILBURY, PAUL - TUFTS/HNRCA
item GRAF, BRIGITTE - TUFTS/HNRCA
item BLUMBERG, JEFFREY - TUFTS/HNRCA
item CURRAN-CELENTANO, JOANNE - UNIV OF NEW HAMPSHIRE
item MCDONALD, JANE - AGRICULTURE/AGRIFOOD,CANA
item VINQVIST, MELINDA - AGRICULTURE/AGRIFOOD,CANA
item KALT, WILHELMINA - AGRICULTURE/AGRIFOOD,CANA

Submitted to: The Cornucopia
Publication Type: Abstract Only
Publication Acceptance Date: 11/3/2004
Publication Date: 3/1/2005
Citation: Milbury, P.E., Graf, B.A., Blumberg, J.B., Curran-Celentano, J.M., Mcdonald, J., Vinqvist, M., Kalt, W. 2005. Anthocyanins cross the blood brain barrier: effects on oxidative stress-induced apoptosis [abstract]. In The Cornucopia. The 229th National Meeting of the American Chemical Society. March 3-17, 2005, San Diego, California. Paper No. 171.

Interpretive Summary:

Technical Abstract: Anthocyanins possess significant antioxidant activity in vitro, but it is not clear whether their intracellular concentrations are sufficient to quench radical species and mitigate oxidative stress in vivo. Using an in vitro human retinal pigment epithelial cell model of oxidative stress-induced apoptosis, we found an anthocyanin-enriched extract of Vaccinium myrtillus (bilberry) affects hemeoxygenase-1 expression and mitochondrial function. Other in vitro studies have shown differences between individual anthocyanidins (aglycones) and their corresponding anthocyanins (glycosides) with regard to other bioactivities, e.g., apoptosis induction and tyrosine kinase inhibition. Some, though not all, in vivo studies suggest anthocyanins, unlike most flavonoids, are absorbed and excreted unmetabolized, however, little data are available regarding their profile and concentrations in tissues. Using HPLC/ECD and/or HPLC/MS/MS, we have quantitatively identified unmetabolized glycosides of delphinidin, cyanidin, and malvidin in brains from pigs fed for 8 wk a diet enriched to 4% with lyophilized Vaccinium corymbosum (blueberry).