Submitted to: American Association of Swine Veterinarians Annual Meeting
Publication Type: Proceedings
Publication Acceptance Date: 12/21/2004
Publication Date: 2/2/2005
Citation: Lunney, J.K. 2005. General immunology acquired immunity [abstract]. American Association of Swine Veterinarians. p. 473-478.
Technical Abstract: This review, for the 2005 American Association of Swine Veterinarians (AASV) annual meeting, summarizes the swine acquired immune response. The swine immune system is comprised of both innate and acquired components. Whereas the innate immune system confers initial protection, the acquired, or adaptive, immune system provides a second, more specific and long lasting, line of defense against infectious organisms. The acquired immune system is activated once macrophages, dendritic cells, and other antigen presenting cells (APC) process foreign antigens, i.e., the products derived from infectious organisms, tumors, vaccines, etc. Many APC also transport the foreign antigen into regional immune lymph nodes where they help to amplify the immune response by interacting with different populations of T and B cells. It reviews the immune cell subsets involved in acquired immune responses and the immune proteins, the cytokines and chemokines, and their receptors, which regulate and modulate acquired immune responses. The review discusses the development of immune responses in the growing pig and the local regulation of immunity. By emphasizing the importance of understanding basic immunity this review sets the stage for other talks in this session that highlight swine disease and vaccine responses.