|YOUDIM, KURESH - KINGS COLLEGE LONDON
Submitted to: Book Chapter
Publication Type: Book / Chapter
Publication Acceptance Date: 7/1/2002
Publication Date: 7/1/2003
Citation: Youdim, K.A., Joseph, J.A. 2003. Phytochemicals and brain aging: a multiplicity of effects. Book Chapter.
Interpretive Summary: not needed
Technical Abstract: At the present time, for some neurodegenerative disorders there is very little in the form of treatment and what treatments are available are only effective for a short period and are often associated with debilitating side effects. Current drug therapy does not address the progressive nature of many of these diseases, and ultimately the patient becomes severely disabled and requires nursing/hospital care. In light of this it appears essential that novel strategies with potential to delay the onset or even prevent the manifestation of certain processes believed to contribute to neurological dysfunction be developed. As such renewed attention is being paid to the application of flavonoids commonly found in fruits, vegetables, and beverages such as tea and wine. The findings from these studies highlight their ability to afford neuroprotection, yet evidence of direct action within the brain is lacking. Only a few studies to date have reported that flavonoids localize within the brain. Although further studies are clearly required to support these findings, a more cautious approach must also be taken when attempting to elucidate potential mechanisms of action. Although use of the native flavonoid in in vitro studies has some relevance to the in vivo scenario, the application of the predominant in vivo physiological metabolites that enter the circulation will undoubtedly prove more fruitful in examining possible mechanisms of action.