Submitted to: Mechanisms of Aging and Development
Publication Type: Abstract Only
Publication Acceptance Date: 12/1/2006
Publication Date: 12/28/2006
Citation: Lai, C., Parnell, L.D., Lyman, R.F., Ordovas, J.M., Mackay, T.F. 2006. Candidate genes affecting Drosophila life span identified by integrating microarray gene expression analysis and QTL mapping. Mechanisms of Aging and Development 128:237-249.
Interpretive Summary: not needed
Technical Abstract: the current increase in life expectancy observed in industrialized societies underscores the need to achieve a better understanding of the aging process that could help the development of effective strategies to avhieve healthy aging. This will require not only identifying genes involved in the agingprocess, but also understanding how thier effects are modulated by environmental factors, such as dietary intake and life style. Although the human genome has been sequenced, it may be impractical to study humans or other long lived organisms to gain a mechanistic understanding about the aging process. Thus, short lived a animal models are essential to identifying the mechanisms and genes that affect the rate and quality of aging as a frist step towards identifying genetic variants in humans. In this study, we investigsted gene expression changes between two strains of Drosophila that vary genetically in lifespan and have been collected at young and old ages. By integrating the analysis of microarray gene expression data, bioinformatics, and the results of genetic mapping we reported previously, we identified candidate genes and pathways that could be potentially responsible for lifespan and involved in the process of aging in Drosophila and humans.