Submitted to: Expert Review of Anti-Infective Therapy
Publication Type: Review Article
Publication Acceptance Date: 6/1/2003
Publication Date: 12/1/2003
Citation: GRUBMAN, M.J. NEW APPROACHES TO RAPIDLY CONTROL FOOT-AND-MOUTH DISEASE OUTBREAKS. EXPERT REVIEW OF ANTI-INFECTIVE THERAPY.1(14):579-586, 2003
Technical Abstract: Foot-and-mouth disease (FMD) is economically the most important viral-induced livestock disease worldwide. The disease is highly contagious and FMDV replicates and spreads extremely rapidly. Recent outbreaks in previously FMD-free countries and the potential for intentional or unintentional introduction have demonstrated the vulnerability of countries and the need to develop control strategies that can rapidly inhibit or limit spread of the disease. The current vaccine, an inactivated whole virus preparation, has a number of limitations for use in outbreaks in disease-free countries. This review discusses the potential of the antiviral agent, type I interferon, to produce rapid protection and proposes a combination strategy of an antiviral agent and a FMD vaccine to induce both immediate and long-lasting protective responses.