Submitted to: International Congress on Anthrax, Brucellosis, CBPP, Mycobacterial Disease
Publication Type: Abstract Only
Publication Acceptance Date: 7/1/2003
Publication Date: 9/15/2003
Citation: Grushina, T.A., Tabatabai, L.B., Tserelson, L.E., Syzdykov, M.S., Rementsova, M.M., Daulbayeva, S.F., Beketov, B., Ospanov, K.S., Saidoullayeva, S.S., Koussainov, A.K. 2003. Diagnostics of human brucellosis caused by brucella melitensis. International Congress on Anthrax, Brucellosis, CBPP, Mycobacterial Disease. 56th Brucella Research Conference Proceedings, Navarra, Spain, Sept. 15-17, 2003, Abstract #35, p. 26.
Technical Abstract: About 2,200 new cases of human brucellosis are recorded annually in Kazakhstan; the morbidity rate has a growing trend and is in the range from 14.8 (average for the country) to 178 per 100,000 people in some districts. Clinical, epidemiological, and laboratory studies were undertaken covering 210 patients who were residents of two rural districts with the morbidity rate 3 times higher than the average for the country. We identified 114 patients (54.2%) having various clinical forms, such as latent brucellosis ¿ 30 cases (26. 3%), acute brucellosis -13 (11.4%), chronic brucellosis -62 (54.3%), and residual effects ¿ 9 (7.9%). Latent and chronic forms were prevailing. Disability rate was 25% for chronic brucellosis. Brucella melitensis biovar 1 (2 cases) and biovar 2 (4 cases) were isolated from the blood samples of 6 patients having acute (2), chronic (2) and latent (2) brucellosis. In 3 of the 6 cases, we identified sero-negative patients with chronic (1) and latent (2) brucellosis. In 3 patients with spondylitis, osteoarthritis Brucella were isolated 5, 8, and 9 months after the disease had begun. It was noted that 4 patients with Brucella melitensis ran a conventional livestock farming operation in Kazakhstan, with cows and sheep kept together. It suggests that B. melitensis pathogen could spread to cattle. These studies showed that human brucellosis remains a serious threat to the health of people living in rural districts. Brucellosis is difficult to diagnose, if possible at all, when using conventional diagnostic techniques.