Submitted to: Foot-and-Mouth Diseases: Control Strategies
Publication Type: Other
Publication Acceptance Date: 6/1/2002
Publication Date: 6/1/2002
Citation: GRUBMAN, M.J., MORAES, M.P., CHINSANGARAM, J., MAYR, G.A., MASON, P.W. NEW APPROACHES TO CONTROL FOOT-AND-MOUTH DISEASE. FOOT-AND-MOUTH DISEASES: CONTROL STRATEGIES. p337-343, 2003
Technical Abstract: The recent outbreaks of foot-and-mouth disease (FMD) in previously disease-free countries have demonstrated that FMD-free countries are vulnerable to disease incursion. Over the past 50 years inactivated FMD vaccines have been successfully used to dramatically reduce the number of outbreaks in enzootic areas, but there are a number of drawbacks with their use during outbreaks into disease-free countries. We have developed a combination control strategy to address the concerns of disease-free countries. New generation vaccines utilizing an FMD virus (FMDV) empty viral capsid subunit delivered to animals by a live virus vector have been developed. Inoculation of a replication-defective recombinant human adenovirus containing the capsid and 3C proteinase coding regions of FMDV induces an FMDV-specific neutralizing antibody response in inoculated animals. Swine vaccinated with one dose of this recombinant adenovirus and challenged one, two, or six weeks later with virulent animal-passaged homologous virus are protected from clinical signs of FMD as well as from replication of the challenge virus. Administration of a recombinant replication-defective adenovirus containing a porcine type I interferon gene induces protection in swine challenged one day later with virulent FMDV. Thus, a combination of this antiviral treatment and the empty capsid subunit approach should induce immediate as well as long-term protection against FMD.