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ARS Home » Northeast Area » Beltsville, Maryland (BHNRC) » Beltsville Human Nutrition Research Center » Diet, Genomics and Immunology Laboratory » Research » Publications at this Location » Publication #143007
Title: ANIMAL MODEL OF NIPPOSTRONGYLUS BRASILIENSIS AND HELIGMOSOMOIDES POLYGYRUS

Author
item CAMBERIS, MALI - MALAGHAN INST.,NEW ZLND
item LE GROS, GRAHAM - MALAGHAN INST.,NEW ZLND
item Urban, Joseph

Submitted to: Current Protocols in Immunology
Publication Type: Book / Chapter
Publication Acceptance Date: 5/10/2003
Publication Date: 8/10/2003
Citation: Camberis, M., Le Gros, G., Urban Jr, J.F. 2003. Animal model of nippostrongylus brasiliensis and heligmosomoides polygyrus. In: Coico, R., editor. Current Protocols in Immunology. John Wiley and Sons, Incorporated. 19.12:1-27 (2003).

Interpretive Summary:

Technical Abstract: Animal models of Nippostrongylus brasiliensis and Heligmosomoides polygyrus infection are powerful tools for the investigation of the basic biology of immune responses and protective immunity. In particular they model the induction and maintenance of Th2 type immune responses and exhibiting all the requisite hallmarks of CD4 T cell dependent IgE production, eosinophilia, mastocytosis and mucus production. This chapter describes simple cost effective techniques for using and maintaining these easy to work with parasites in the context of a modern laboratory.