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item Bayles, Darrell

Submitted to: American Society for Microbiology
Publication Type: Other
Publication Acceptance Date: 9/14/2002
Publication Date: 4/1/2003
Citation: Bayles, D.O. 2003. Dna microarrays: gene expression applications. American Society for Microbiology. ASM News. 69(4):204.

Interpretive Summary:

Technical Abstract: The advent of whole genome sequencing and the application of bioinformatics tools have heralded a new era in biology. The coming of age of these tools and techniques has engendered a shift from deductive question-specific research to an inductive large-scale analysis research approach. This shift has been fueled initially by the availability of DNA microarrays for studying whole genome gene expression in a variety of organisms. Within the community of microbiologists, there is an understandably large interest in the techniques used to perform and evaluate these gene expression analyses. The goal of the editor to provide functional perspectives and a range of actual laboratory methods relating to DNA microarrays is well met within the pages of this slim volume. The book is straightforward and very approachable. Researchers actively using DNA array technologies author the chapters and these scientists provide their protocols and method insights, which cover a wide variety of gene expression methodologies. Research scientists actively using or contemplating using DNA array technologies in bench research will benefit most from this book. Readers primarily interested in a theoretical overview of DNA array techniques might want to look elsewhere. The methods presented are concisely written and should provide the reader with the basic starting points for embarking on a program in gene expression analysis.