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Title: Genetic diversity of vesicular stomatitus virus throughout the Americas

item Rodriguez, Luis

Submitted to: Proceedings of the Noble Foundation Workshop in Virus Evolution
Publication Type: Proceedings
Publication Acceptance Date: 9/28/2002
Publication Date: 10/3/2002
Citation: Rodriguez, L.L. 2002. Genetic diversity of vesicular stomatitis virus throughout the Americas. Proceedings of the Noble Foundation Workshop in Virus Evolution.

Interpretive Summary:

Technical Abstract: Vesicular stomatitis viruses (VSV) are rhabdoviruses that cause vesicular disease in domestic livestock throughout the Americas. Two main virus serotypes: New Jersey (NJ) and Indiana (IN) occur from northern South America to southern US. In addition, two subtypes of VSV-IN; Cocal virus (VSV-IN2) and Alagoas virus (VSV-IN3) cause disease in Brazil and Argentina. Phylogenetic analyses of VSV-NJ and VSV-IN1 from Central and North America suggested that ecological factors rather than immune selection are the main selective forces influencing VSV evolution in enzootic areas. In this study we describe the phylogenetic as well as the serological relationships of VSV NJ and VSV-IN1 to VSV-IN2 and VSV-IN3 strains from South America. Together with epidemiological data and geographical distribution of these viruses, the data confirm the distribution of VSV serotypes and subtypes causing disease outbreaks in domestic animals throughout the Americas.