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Title: REPEATED INTRAVENOUS DOSES OF ALL-TRANS-RETINOYL BETA-D-GLUCURONIDE IS NOT EFFECTIVE IN THE TREATMENT OF BACTERIAL BRONCHOPNEUMONIA IN LAMBS BUT IS DEVOID OF GROSS AND ACUTE TOXICITY

Author
item GALLUP, JACK - IA STATE UNIV., AMES, IA
item GRUBOR, BRANKA - IA STATE UNIV., AMES, IA
item BARUA, ARUN - IA STATE UNIV., AMES, IA
item MOHAMMADI, GHOLAMREZA - UNIV. FERDOUSI, IRAN
item Brogden, Kim
item OLSON, JAMES - IA STATE UNIV., AMES, IA
item ACKERMANN, MARK - IA STATE UNIV., AMES, IA

Submitted to: Medical Science Monitor
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 7/7/2002
Publication Date: N/A
Citation: N/A

Interpretive Summary: Vitamin A and its derivatives are used in the therapy of respiratory diseases, dermatology, and oncology. One derivative, a water-soluble Vitamin A, has low toxicity yet high reparative effects on epithelium in many in vitro and in vivo models. In this study, we assessed the effect(s) of intravenously administered water-soluble Vitamin A in lambs with chronic bacterial bronchopneumonia. In noninfected lambs, repeated IV administration of high amounts of water-soluble Vitamin A did not elicit signs of toxicity. It did not cause changes in appetite, activity, or other behaviors nor did it cause lesions in liver and lung. In infected lambs, IV administration of high amounts of water-soluble Vitamin A did not improve gross or microscopic lesion scores, suggesting it was not effective in the treatment of bacterial bronchopneumonia.

Technical Abstract: All-trans-retinoyl beta-D-glucuronide is a water-soluble conjugate of all-trans-retinoic acid. It has low toxicity yet high reparative effects on epithelium in many in vitro and in vivo models. In this study we assessed the effect(s) of intravenously-administered all-trans-retinoyl beta-D-glucuronide in lambs with chronic Mannheimia haemolytica bronchopneumonia. In noninfected lambs, repeated IV administration of high amounts of all-trans-retinoyl beta-D-glucuronide did not elicit signs of gross or microscopic toxicity. It did not cause changes in appetite, activity or other behaviors nor did it cause histologic lesions in liver and lung. In M. haemolytica infected lambs, IV administration of high amounts of all-trans-retinoyl beta-D-glucuronide did not improve gross or microscopic lesion scores suggesting it was not effective in the treatment of bacterial bronchopneumonia.