Submitted to: American Association of Veterinary Laboratory Diagnosticians
Publication Type: Abstract Only
Publication Acceptance Date: 8/18/2000
Publication Date: N/A
Technical Abstract: Ten serotypes of bovine adenovirus (BAV), designated BAV-1 through BAV-10, are recognized worldwide. Of these, BAV-1, -2, -3, -4, -7 and 10 have been isolated from cattle in the United States. Isolates have been obtained from apparently healthy animals as well from clinically ill animals, most often associated with pneumonia and enteritis. This report concerns the isolation of BAV-7 from clinically ill animals from four states (NM, NY, OK and TX). The BAV-7 isolates in this report were obtained when peripheral blood leukocytes (PBLs) were inoculated onto bovine turbinate (BT) cells for bovine viral diarrhea virus (BVDV) isolation. The virus caused extensive cytopathic effects characterized by cell rounding, increased refractiveness, clumping and rapid destruction of the cell monolayer. Virus identification was done by electron microscopy and serotyping with the serum neutralization test using a panel of control BAV antisera representing the 10 recognized serotypes. The common clinica sign in the four cases described in this report was respiratory disease. BAV-7 has been associated with both respiratory disease and enteric diseases in calves and experimental inoculation has reproduced mild respiratory disease. However, the virus has also been isolated from apparently healthy calves. Therefore, it is difficult to establish a cause-effect relationship between the virus and the syndromes observed in this report. The possible role of these isolates of BAV-7 in cattle disease, especially respiratory disease, will be investigated in a future study.