Submitted to: Journal of Natural Products
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 12/29/2000
Publication Date: N/A
Interpretive Summary: The fungus Verticillium lecanii is known to parasitize nematodes, aphids, insects, and other fungi identified as crop pests. There is an urgent need for new sources of environmentally friendly pesticides and fungi displaying a 'broad spectrum' of parasitic abilities such as V. lecanii which are potential sources of new biologically active chemicals useful to agriculture and medicine. A known compound that kills nematodes and five new fungal metabolites, the vertilecanins, were isolated from a culture extract of V. lecanii. While these compounds did not account for observed antiinsectan or antifungal activity, vertilecanin A strongly inhibited bacterial growth. This compound may prove useful in controlling bacterial disease of plants, animals, or people.
Technical Abstract: Five new phenopicolinic acid analogs have been isolated from the EtOAc extract of Verticillium lecanii. These compound were obtained by chromatographic fractionation of the EtOAc extract of V. lecanii solid-substrate fermentation cultures. The structures of these metabolites were determined on the basis of NMR and MS data. The known fungal metabolites 2-decenedioic acid and 10- hydroxy-8-decenoic acid were also isolated from this organism.