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Title: KINETIC DIFFERENCES IN INTESTINAL AND SYSTEMIC INTERFON-GAMMA AND ANTIGEN- SPECIFIC ANTIBODIES IN CHICKENS EXPERIMENTALLY INFECTED WITH EIMERIA MAXIMA

Author
item YUN, CHEOL - NIH BETHESDA MD
item Lillehoj, Hyun
item Zhu, James
item MIN, WONGI - USDA, ARS, LPSI, IDRL

Submitted to: American Association of Veterinary Parasitologists Proceedings
Publication Type: Abstract Only
Publication Acceptance Date: 4/3/2000
Publication Date: N/A
Citation: N/A

Interpretive Summary:

Technical Abstract: Recombinant chicken interleukin-2 (IL-2) promotes the growth of T cells in vitro and enhances NK-cell activity in chickens. Stimulation of IL-2- dependent T-cells with Con A induced interferon-gamma (IFNg) and IL-2 mRNA transcripts whereas stimulation with rIL-2 induced only IFN-mRNA. Subcutaneous injection of rIL-2 RNA to day-old chickens increased the percentage of cells which express the CD8 and TCR antigens in the spleen. Chickens which were orally infected with Eimeria acervulina showed a significant enhancement of IL-2 mRNA transcripts in the spleen and intestine and increased percentage of T-cells in the duodenum following both primary and secondary infections. These results indicate that host immune responses to E. acervulina involve an up-regulation of IL-2 secretion and an increased duodenum T-cells. 1