Research Project: Nutrient Metabolism and Musculoskeletal Health in Older Adults

Location: Jean Mayer Human Nutrition Research Center On Aging

Publications (Clicking on the reprint icon will take you to the publication reprint.)

Association between multimorbidity and rate of falls: a 3-year 5-country prospective study in generally healthy and active community-dwelling adults aged 70+ - (Peer Reviewed Journal)
Huberty, S., Freystatter, G., Wieczorek, M., Dawson-Hughes, B., Kanis, J.A., Rizzoli, R., Kressig, R., Vellas, B., Da Silva, J., Armbrecht, G., Theiler, R., Egli, A.L., Orav, E., Bischoff-Ferrari, H.A. 2023. Association between multimorbidity and rate of falls: a 3-year 5-country prospective study in generally healthy and active community-dwelling adults aged 70+. Journal of the American Medical Directors Association - Post-Acute and Long Term Care Medicine. https://doi.org/10.1016/j.jamda.2022.12.011.

The need to distinguish intervention thresholds and diagnostic thresholds in the management of osteoporosis - (Review Article)
Kanis, J.A., McCloskey, E.V., Harvey, N.C., Cooper, C., Rizzoli, R., Dawson-Hughes, B., Maggi, S., Reginster, J. 2022. The need to distinguish intervention thresholds and diagnostic thresholds in the management of osteoporosis. Osteoporosis International. https://doi.org/10.1007/s00198-022-06567-9.

Nutritional aspects of healthy aging - (Review Article)
Panda, A., Booth, S.L. 2022. Nutritional aspects of healthy aging. Medical Clinics of North America. 106(5): 853-864. https://doi.org/10.1016/j.mcna.2022.04.008.

Extracellular nicotinamide phosphoribosyltransferase is a component of the senescence-associated secretory phenotype - (Peer Reviewed Journal)
Kuehnemann, C., Hu, K., Butera, K., Patel, S.K., Bons, J., Schilling, B., Aguayo-Mazzucato, C., Wiley, C. 2022. Extracellular nicotinamide phosphoribosyltransferase is a component of the senescence-associated secretory phenotype. Frontiers in Endocrinology. 13:Article 935106. https://doi.org/10.3389/fendo.2022.935106.

Leveraging observational cohorts to study diet and nutrition in older adults: Opportunities and obstacles - (Review Article)
Shea, K., Ardisson Korat, A., Jacques, P., Sebastiani, P., Cohen, R., Lavertu, A., Booth, S.L. 2022. Leveraging observational cohorts to study diet and nutrition in older adults: Opportunities and obstacles. Advances in Nutrition. https://doi.org/10.1093/advances/nmac031.

Feeding practice and delivery mode are determinants of vitamin K in the infant gut: An exploratory analysis - (Peer Reviewed Journal)
Ellis, J.L., Wang, M., Fu, X., Fields, C.J., Donovan, S.M., Booth, S.L. 2022. Feeding practice and delivery mode are determinants of vitamin K in the infant gut: An exploratory analysis. Current Developments in Nutrition. 6(3):nzac019. https://doi.org/10.1093/cdn/nzac019.

Intra-trial mean 25(OH)D and PTH levels and risk of falling in older men and women in the Boston STOP IT trial - (Peer Reviewed Journal)
Dawson-Hughes, B., Wang, J., Barger, K., Bischoff-Ferrari, H.A., Sempos, C.T., Durazo-Arvizu, R.A., Ceglia, L. 2022. Intra-trial mean 25(OH)D and PTH levels and risk of falling in older men and women in the Boston STOP IT trial. Journal of Clinical Endocrinology and Metabolism. https://doi.org/10.1210/clinem/dgac012.

Association of vitamin k with cognitive decline and neuropathology in community-dwelling older persons - (Peer Reviewed Journal)
Booth, S., Shea, K., Barger, K., Leurgans, S.E., James, B.D., Holland, T.M., Agarwal, P., Fu, X., Wang, J., Matuszek, G., Schneider, J. 2022. Association of vitamin k with cognitive decline and neuropathology in community-dwelling older persons. Alzheimer's & Dementia. https://doi.org/10.1002/trc2.12255.

Vitamin K status, all-cause mortality, and cardiovascular disease in adults with chronic kidney disease: the chronic renal insufficiency cohort - (Peer Reviewed Journal)
Shea, K., Barger, K., Booth, S.L., Wang, J., Feldman, H.I., Townsend, R.R., Chen, J., Flack, J., He, J., Jaar, B.G., Kansal, M., Rosas, S.E., Weiner, D.E. 2022. Vitamin K status, all-cause mortality, and cardiovascular disease in adults with chronic kidney disease: the chronic renal insufficiency cohort. American Journal of Clinical Nutrition. https://doi.org/10.1093/ajcn/nqab375.

Vitamin K - (Review Article)
Shea, K., Booth, S.L. 2021. Vitamin K. Advances in Nutrition. https://doi.org/10.1093/advances/nmab133.

Vitamin D: bolus is bogus--a narrative review - (Review Article)
Mazess, R., Bischoff-Ferrari, H., Dawson-Hughes, B. 2021. Vitamin D: bolus is bogus--a narrative review. JBMR Plus. 5(12): e10567. https://doi.org/10.1002/jbm4.10567.

The metabolic roots of senescence: mechanisms and opportunities for intervention - (Review Article)
Wiley, C., Campisi, J. 2021. The metabolic roots of senescence: mechanisms and opportunities for intervention. Nature Metabolism. 3:1290-1301. https://doi.org/10.1038/s42255-021-00483-8.

Multiple dietary vitamin K forms are converted to tissue menaquinone-4 in mice - (Peer Reviewed Journal)
Ellis, J.L., Fu, X., Karl, P.J., Hernandez, C.J., Mason, J.B., Debose-Boyd, R.A., Booth, S. 2021. Multiple dietary vitamin K forms are converted to tissue menaquinone-4 in mice. Journal of Nutrition. https://doi.org/10.1093/jn/nxab332.

Sufficient plasma vitamin C is related to greater bone mineral density among postmenopausal women from the Boston Puerto Rican health study - (Peer Reviewed Journal)
Mangano, K.M., Noel, S.E., Dawson-Hughes, B., Tucker, K.L. 2021. Sufficient plasma vitamin C is related to greater bone mineral density among postmenopausal women from the Boston Puerto Rican health study. Journal of Nutrition. https://doi.org/10.1093/jn/nxab291.

Assessment of the performance of the SarQol questionnaire in screening for sarcopenia in older people - (Peer Reviewed Journal)
Geerinck, A., Dawson-Hughes, B., Beaudart, C., Locquet, M., Reginster, J., Bruyer, O. 2021. Assessment of the performance of the SarQol questionnaire in screening for sarcopenia in older people. Aging Clinical Experimental Research. https://doi.org/10.1007/s40520-021-01913-z.

Components of the gut microbiome that influence bone tissue-level strength - (Peer Reviewed Journal)
Luna, M., Guss, J., Vasquez-Bolanos, L., Castaneda, M., Vargas Rojas, M., Strong, J.M., Alabi, D.A., Dornevil, S., Nixon, J.C., Taylor, E.A., Donnelly, E., Fu, X., Shea, K., Booth, S.L., Bicalho, R.C., Hernandez, C.J. 2021. Components of the gut microbiome that influence bone tissue-level strength. Journal of Bone and Mineral Research. https://doi.org/10.1002/jbmr.4341.

Issues related to the research on vitamin K supplementation and bone mineral density - (Review Article)
Zhang, Y., Shea, K., Judd, S., D'Alton, M., Kahe, K. 2021. Issues related to the research on vitamin K supplementation and bone mineral density. European Journal of Clinical Nutrition. 76:335-339. https://doi.org/10.1038/s41430-021-00941-2.

Cross-calibration of prodigy and horizon a densitometers and precision of the horizon a densitometer - (Peer Reviewed Journal)
Reitshamer, E., Viera, K.B., Shea, K., Dawson-Hughes, B. 2021. Cross-calibration of prodigy and horizon a densitometers and precision of the horizon a densitometer. Journal of Clinical Densitometry. https://doi.org/10.1016/j.jocd.2021.02.003.

Dietary vitamin K is remodeled by gut microbiota and influences community composition - (Peer Reviewed Journal)
Ellis, J.L., Karl, J., Oliverio, A.M., Fu, X., Soares, J.W., Wolfe, B.E., Hernandez, C.J., Mason, J.L., Booth, S.L. 2021. Dietary vitamin K is remodeled by gut microbiota and influences community composition. Gut Microbes. 13(1):1-16. https://doi.org/10.1080/19490976.2021.1887721.

Evidence before enthusiasm: A critical review of the potential cardiovascular benefits of vitamin K - (Review Article)
Shea, K., Berkner, K., Ferland, G., Fu, X., Holden, R., Booth, S.L. 2021. Evidence before enthusiasm: A critical review of the potential cardiovascular benefits of vitamin K. Advances in Nutrition. https://doi.org/10.1093/advances/nmab004.

Vitamin D and Vitamin K concentrations in human brain tissue are influenced by freezer storage time: the memory and aging project - (Peer Reviewed Journal)
Fu, X., Shea, K., Dolnikowski, G.G., Patterson, W.B., Dawson-Hughes, B., Holland, T.M., Schneider, J.A., Booth, S.L. 2020. Vitamin D and Vitamin K concentrations in human brain tissue are influenced by freezer storage time: the memory and aging project. Journal of Nutrition. https://doi.org/10.1093/jn/nxaa336.

Controversies in Vitamin D: a statement from the third international conference - (Proceedings)
Giustina, A., Bouillon, R., Binkley, N., Sempos, C.T., Adler, R.A., Bollerslev, J., Dawson-Hughes, B., Ebeling, P.R., Feldman, D., Heijboer, A.C., Jones, G., Kovacs, C.S., Lazaretti-Castro, M., Lips, P., Marcocci, C., Minisola, S., Napoli, N., Rizzoli, R., Scragg, R., White, J.H., Formenti, A., Bilezikian, J. 2020. Controversies in Vitamin D: a statement from the third international conference. JBMR Plus. https://doi.org/10.1002/jbm4.10417.

Intratrial exposure to vitamin D and new-onset diabetes among adults with prediabetes: a secondary analysis from the vitamin D and type 2 diabetes (D2d) study - (Peer Reviewed Journal)
Dawson-Hughes, B., Staten, M.A., Knowler, W.C., Nelson, J., Vickery, E.M., LeBlanc, E.S., Neff, L.M., Park, J., Pittas, A.G. 2020. Intratrial exposure to vitamin D and new-onset diabetes among adults with prediabetes: a secondary analysis from the vitamin D and type 2 diabetes (D2d) study. Diabetes Care. https://doi.org/10.2337/dc20-1765.

Effect of vitamin D supplementation, omega-3 fatty acid supplementation, or a strength-training exercise program on clinical outcomes in older adults: the DO-HEALTH randomized clinical trial - (Peer Reviewed Journal)
Bischoff-Ferrari, H.A., Vellas, B., Rizzoli, R., Kressig, R.W., da Silva, J., Blauth, M., Felson, D.T., McCloskey, E., Watzl, B., Hofbauer, L., Felsenberg, D., Willett, W.C., Dawson-Hughes, B., Manson, J.E., Siebert, U., Theiler, R., Stahelin, H.B., de Godoi Rezende Costa, C., Chocano-Bedoya, P.O., Abderhalden, L.A., Egli, A., Kanis, J.A., Orav, J. 2020. Effect of vitamin D supplementation, omega-3 fatty acid supplementation, or a strength-training exercise program on clinical outcomes in older adults: the DO-HEALTH randomized clinical trial. Journal of the American Medical Association. 324(18):1855-1868. https://doi.org/10.1001/jama.2020.16909.

DO-HEALTH: vitamin D3 - omega3 - home exercise - healthy aging and longevity trial - design of a multinational clinical trial on healthy aging among european seniors - (Peer Reviewed Journal)
Bischoff-Ferrara, H.A., De Godoi Rezende Costa Caroline, Rival, S., Vellas, B., Rizzoli, R., Kressig, R.W., Kanis, J.A., Manson, J.E., Dawson-Hughes, B., Orav, E.J., Da Silva, J.A., Blauth, M., Felsenberg, D., Ferrari, S.M., Theiler, R., Egli, A. 2020. DO-HEALTH: vitamin D3 - omega3 - home exercise - healthy aging and longevity trial - design of a multinational clinical trial on healthy aging among european seniors. Contemporary Clinical Trials. 100(2021):106124. https://doi.org/10.1016/j.cct.2020.106124.

Vitamin D supplementation for prevention of type 2 diabetes mellitus. To D or not to D? - (Review Article)
Pittas, A.G., Jorde, R., Kawahara, T., Dawson-Hughes, B. 2020. Vitamin D supplementation for prevention of type 2 diabetes mellitus. To D or not to D? Journal of Clinical Endocrinology and Metabolism. 105(12):3721-3733. https://doi.org/10.1210/clinem/dgaa594.

Acid-base balance of the diet-implications for bone and muscle - (Review Article)
Dawson-Hughes, B. 2020. Acid-base balance of the diet-implications for bone and muscle. European Journal of Clinical Nutrition. 74:7-13. https://doi.org/10.1038/s41430-020-0691-7.

Effect of daily 2000 IU versus 800 IU vitamin D on blood pressure among adults age 60 years and older: a randomized clinical trial - (Peer Reviewed Journal)
Abderhalden, L.A., Meyer, S., Dawson-Hughes, B., Orav, E.J., Meyer, U., De Godoi Rezenda, C.C., Theiler, R., Stahelin, H.B., Ruschitzka, F., Egli, A., Forman, J.P., Willett, W.C., Bischoff-Ferrari, H.A. 2020. Effect of daily 2000 IU versus 800 IU vitamin D on blood pressure among adults age 60 years and older: a randomized clinical trial. American Journal of Clinical Nutrition. https://doi.org/10.1093/ajcn/nqaa145.

Relationship between chronic kidney disease, glucose homeostasis, and plasma osteocalcin carboxylation and fragmentation - (Peer Reviewed Journal)
Kratz, M., Zelnick, L.R., Trenchevska, O., Jeffs, J.W., Borges, C.R., Tseng, H., Booth, S.L., Kestenbaum, B.R., Utzschneider, K.M., De Boer, I.H. 2020. Relationship between chronic kidney disease, glucose homeostasis, and plasma osteocalcin carboxylation and fragmentation. Journal of Renal Nutrition. 31(3):248-256. https://doi.org/10.1053/j.jrn.2020.05.013.

Associations between circulating lipids and fat-soluble vitamins and carotenoids in healthy overweight and obese men - (Peer Reviewed Journal)
Kelly, J.M., Matuszek, G., Van Den Broek, T.J., Huggins, G.S., Smith, C.E., Ordovas, J.M., Wopereis, S., Booth, S.L. 2020. Associations between circulating lipids and fat-soluble vitamins and carotenoids in healthy overweight and obese men. Current Developments in Nutrition. 4(6). https://doi.org/10.1093/cdn/nzaa089.

DASH, mediterranean and alternative healthy eating indices are associated with bone health among Puerto Rican adults from the Boston Puerto Rican osteoporosis study - (Peer Reviewed Journal)
Sabrina, N.E., Mangano, K.M., Mattei, J., Griffith, J.L., Dawson-Hughes, B., Bigornia, S., Tucker, K.L. 2020. DASH, mediterranean and alternative healthy eating indices are associated with bone health among Puerto Rican adults from the Boston Puerto Rican osteoporosis study. American Journal of Clinical Nutrition. https://doi.org/10.1093/ajcn/nqaa090.

Vitamin K status, cardiovascular disease and all-cause mortality: a participant-level meta-analysis of 3 US cohorts - (Peer Reviewed Journal)
Shea, M., Barger, K., Booth, S.L., Matuszek, G., Cushman, M., Benjamin, E.J., Kritchevsky, S.B., Weiner, D.E. 2020. Vitamin K status, cardiovascular disease and all-cause mortality: a participant-level meta-analysis of 3 US cohorts. American Journal of Clinical Nutrition. 111(6):1170-1177. https://doi.org/10.1093/ajcn/nqaa082.

Algorithm for the management of patients at low, high and very high risk of osteoporotic fractures - (Review Article)
Kanis, J.A., Harvey, N.C., Mccloskey, E., Bruyere, O., Veronese, N., Lorentzon, M., Cooper, C., Rizzoli, R., Adib, G., Al-Daghri, N., Campusano, C., Chandran, M., Dawson-Hughes, B., Javaid, K., Jiwa, F., Johansson, H., Lee, J.K., Liu, E., Messina, O.D., Mkinsi, O., Pinto, D., Prieto-Alhambra, D., Saag, K., Xia, W., Zakraoui, L., Reginster, J. 2019. Algorithm for the management of patients at low, high and very high risk of osteoporotic fractures. Osteoporosis International. https://doi.org/10.1007/s00198-019-05176-3.

The contribution of lipids to the inter-individual response of vitamin K biomarkers to vitamin K supplementation - (Peer Reviewed Journal)
Kelly, J.M., Ordovas, J.M., Matuszek, G.H., Smith, C.E., Huggins, G.S., Dashti, H.S., Ichikawa, R., Booth, S.L. 2019. The contribution of lipids to the inter-individual response of vitamin K biomarkers to vitamin K supplementation. Molecular Nutrition and Food Research. https://doi.org/10.1002/mnfr.201900399.

Effects of a simple home exercise program and vitamin D supplementation on health-related quality of life after a hip fracture: a randomized controlled trial - (Peer Reviewed Journal)
Renerts, K., Fischer, K., Dawson-Hughes, B., Orav, E.J., Freystaetter, G., Simmen, H., Pape, H., Egli, A., Theiler, R., Bischoff-Ferrari, H. 2019. Effects of a simple home exercise program and vitamin D supplementation on health-related quality of life after a hip fracture: a randomized controlled trial. Quality of Life Research. 28(5):1377-1386. https://doi.org/10.1007/s11136-019-02100-4.

Effect of monthly high-dose vitamin D on mental health in older adults: secondary analysis of a RCT - (Peer Reviewed Journal)
Gugger, A., Marzel, A., Orav, E.J., Willett, W.C., Dawson-Hughes, B., Theiler, R., Freystatter, G., Egli, A., Bischoff-Ferrari, H.A. 2019. Effect of monthly high-dose vitamin D on mental health in older adults: Secondary analysis of a RCT. Journal of the American Geriatrics Society. 67(6):1211-1217. https://doi.org/10.1111/jgs.15808.

Effect of monthly vitamin D on chronic pain among community-dwelling seniors: a randomized, double-blind controlled trial - (Peer Reviewed Journal)
Schlogl, M., Chocano-Bedoya, P., Dawson-Hughes, B., Orav, E.J., Freystaetter, G., Theiler, R., Kressig, R.W., Egli, A., Bischoff-Ferrari, H. 2019. Effect of monthly vitamin D on chronic pain among community-dwelling seniors: a randomized, double-blind controlled trial. Journal of the American Medical Directors Association - Post-Acute and Long Term Care Medicine. 20(3):356-361. https://doi.org/10.1016/j.jamda.2018.09.004.