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Research Project: Metabolic and Epigenetic Regulation of Nutritional Metabolism

Location: Children's Nutrition Research Center

Publications (Clicking on the reprint icon Reprint Icon will take you to the publication reprint.)

Dietary folate and cofactors accelerate age-dependent p16 epimutation to promote intestinal tumorigenesis Reprint Icon - (Peer Reviewed Journal)
Yang, L., Peery, R.C., Farmer, L.M., Gao, X., Zhang, Y., Creighton, C.J., Zhang, L., Shen, L. 2024. Dietary folate and cofactors accelerate age-dependent p16 epimutation to promote intestinal tumorigenesis. Cancer Research Communications. 4(1):164-169. https://doi.org/10.1158/2767-9764.CRC-23-0356.

The field of population epigenetics is failing on rigor and reproducibility - (Other)
Waterland, R. 2023. The field of population epigenetics is failing on rigor and reproducibility. Cancer Letters. 49(45):27-28. Available at: https://cancerletter.com/letter-to-the-editor/20231208_5/.

Glycemia and gluconeogenesis with metformin and liraglutide: A randomized trial in youth-onset type 2 diabetes Reprint Icon - (Peer Reviewed Journal)
Dietsche, K.B., Magge, S.N., Dixon, S.A., Davis, F.S., Krenek, A., Chowdhury, A., Mabundo, L., Stagliano, M., Courville, A.B., Yang, S., Turner, S., Cai, H., Kasturi, K., Sherman, A.S., Ha, J., Shouppe, E., Walter, M., Walter, P.J., Chen, K.Y., Brychta, R.J., Peer, C., Zeng, Y., Figg, W., Cogen, F., Estrada, D., Chacko, S., Chung, S.T. 2023. Glycemia and gluconeogenesis with metformin and liraglutide: A randomized trial in youth-onset type 2 diabetes. Journal of Clinical Endocrinology and Metabolism. https://doi.org/10.1210/clinem/dgad669.

Nutrition and the brain- exploring pathways for optimal brain health through nutrition: A call for papers Reprint Icon - (Other)
Barbey, A.K., Davis, T.A. 2023. Nutrition and the brain- exploring pathways for optimal brain health through nutrition: A call for papers. Journal of Nutrition. 153(12): 3349–3351. https://doi.org/10.1016/j.tjnut.2023.10.026.

Leptin decreases gluconeogenesis and gluconeogenic substrate availability in patients with lipodystrophy Reprint Icon - (Peer Reviewed Journal)
Quaye, E., Chacko, S., Startzell, M., Brown, R.J. 2023. Leptin decreases gluconeogenesis and gluconeogenic substrate availability in patients with lipodystrophy. Journal of Clinical Endocrinology and Metabolism. 109(1):e209-e215. https://doi.org/10.1210/clinem/dgad445.

Baseline leptin predicts response to metformin in adolescents with type 1 diabetes and increased body mass index Reprint Icon - (Peer Reviewed Journal)
Ismail, H.M., Barua, S., Wang, J., Sabharwal, A., Libman, I., Bacha, F., Nadeau, K.J., Tosur, M., Redondo, M.J. 2023. Baseline leptin predicts response to metformin in adolescents with type 1 diabetes and increased body mass index. Diabetes Obesity and Metabolism. https://doi.org/10.1111/dom.15218.

NUDT21 alters glioma migration through differential alternative polyadenylation of LAMC1 Reprint Icon - (Peer Reviewed Journal)
Jonnakuti, V.S., Ji, P., Gao, Y., Lin, A., Chu, Y., Elrod, N., Huang, K., Li, W., Yalamanchili, H.K., Wagner, E.J. 2023. NUDT21 alters glioma migration through differential alternative polyadenylation of LAMC1. Journal of Neuro-Oncology. https://doi.org/10.1007/s11060-023-04370-y.

Probiotics and human milk differentially influence the gut microbiome and NEC incidence in preterm pigs Reprint Icon - (Peer Reviewed Journal)
Melendez Hebib, V., Taft, D., Stoll, B., Liu, J., Call, L., Guthrie, G., Jensen, N., Hair, A.B., Mills, D.A., Burrin, D.G. 2023. Probiotics and human milk differentially influence the gut microbiome and NEC incidence in preterm pigs. Gut Microbes. 15(11):2585. https://doi.org/10.3390/nu15112585.

Hyperglycemia: A determinant of cardiac autonomic dysfunction in youth with obesity across the spectrum of glycemic regulation Reprint Icon - (Peer Reviewed Journal)
El-Ayash, H., Puyau, M., Bacha, F. 2023. Hyperglycemia: A determinant of cardiac autonomic dysfunction in youth with obesity across the spectrum of glycemic regulation. Pediatric Obesity. Article e13063. https://doi.org/10.1111/ijpo.13063.

Insulin-like growth factor 1 supplementation supports motor coordination and affects myelination in preterm pigs Reprint Icon - (Peer Reviewed Journal)
Christiansen, L.I., Ventura, G.C., Holmqvist, B., Aasmul-Olsen, K., Lindholm, S.H., Lycas, M.D., Mori, Y., Bojsen-Møller Secher, J., Burrin, D.G., Thymann, T., Sangild, P., Pankratova, S. 2023. Insulin-like growth factor 1 supplementation supports motor coordination and affects myelination in preterm pigs. Frontiers in Neuroscience. 17. Article 1205819. https://doi.org/10.3389/fnins.2023.1205819.

Towards a model of biliary atresia - pilot feasibility study in newborn piglets Reprint Icon - (Peer Reviewed Journal)
Wesenberg Helt, T., Buelund, L., Borgewardt, L., Eriksen, T., Johansen, L., De Nijs, R., Holm, S., Burrin, D.G., Thymann, T., Brix Christensen, V. 2023. Towards a model of biliary atresia - pilot feasibility study in newborn piglets. Biochemistry and Biophysics Reports. 34. Article 101487. https://doi.org/10.1016/j.bbrep.2023.101487.

Effect of early glycemic control in youth-onset type 2 diabetes on longer-term glycemic control and b-cell function: Results from the TODAY Study Reprint Icon - (Peer Reviewed Journal)
Nadeau, K.J., El Ghormli, L., Arslanian, S., Bacha, F., Caprio, S., Chan, C., Chao, L.C., Rayas, M., Siska, M.K., Zeitler, P. 2023. Effect of early glycemic control in youth-onset type 2 diabetes on longer-term glycemic control and b-cell function: Results from the TODAY Study. Diabetes Care. 46(8):1507-1514. https://doi.org/10.2337/dc23-0560.

Functional characterization of age-dependent p16 epimutation reveals biological drivers and therapeutic targets for colorectal cancer Reprint Icon - (Peer Reviewed Journal)
Yang, L., Chen, X., Lee, C., Shi, J., Lawrence, E.B., Zhang, L., Li, Y., Gao, N., Jung, S., Creighton, C.J., Li, J., Cui, Y., Arimura, S., Lei, Y., Li, W., Shen, L. 2023. Functional characterization of age-dependent p16 epimutation reveals biological drivers and therapeutic targets for colorectal cancer. Journal of Experimental and Clinical Cancer Research. 42. Article 113. https://doi.org/10.1186/s13046-023-02689-y.

Candidate biomarkers as predictors of future kidney disease and cardiovascular dysfunction in adolescents with type 2 diabetes Reprint Icon - (Peer Reviewed Journal)
Bacha, F., El Ghormli, L., Braffett, B.H., Shah, A.S., Marcovina, S.M., Levitt Katz, L.E., Willi, S.M., Caprio, S., Dhaliwal, R., Gidding, S.S., for the Today Study Group. 2023. Candidate biomarkers as predictors of future kidney disease and cardiovascular dysfunction in adolescents with type 2 diabetes. Diabetes Research and Clinical Practice. 199. Article 110671. https://doi.org/10.1016/j.diabres.2023.110671.

Insulin-like growth factor-1 supplementation promotes brain maturation in preterm pigs Reprint Icon - (Peer Reviewed Journal)
Christiansen, L.I., Holmqvist, B., Pan, X., Holgersen, K., Lindholm, S.E., Henriksen, N.L., Burrin, D.G., Ley, D., Thymann, T., Sangild, P., Pankratova, S. 2023. Insulin-like growth factor-1 supplementation promotes brain maturation in preterm pigs. eNeuro. 10(4):1-15. https://doi.org/10.1523/ENEURO.0430-22.2023.

Characteristics of type 2 diabetes in female and male youth Reprint Icon - (Peer Reviewed Journal)
Castillo Rodriguez, B., Astudillo, M., Tosur, M., Rafaey, A., McKay, S., Bacha, F., Balasubramanyam, A., Redondo, M.J. 2023. Characteristics of type 2 diabetes in female and male youth. Clinical Diabetes. 41(2):239–243. https://doi.org/10.2337/cd22-0057.

Dimeric p53 mutant elicits unique tumor-suppressive activities through an altered metabolic program Reprint Icon - (Peer Reviewed Journal)
Gencel-Augusto, J., Su, X., Qi, Y., Whitley, E.M., Pant, V., Xiong, S., Shah, V., Lin, J., Perez, E., Fiorotto, M.L., Jain, A.K., Lorenzi, P.L., Navin, N.E., Richie, E.R., Lozano, G. 2023. Dimeric p53 mutant elicits unique tumor-suppressive activities through an altered metabolic program. Cancer Discovery. 13(5):1230-1249. https://doi.org/10.1158/2159-8290.cd-22-0872.

A comprehensive and integrative approach to MeCP2 disease transcriptomics Reprint Icon - (Peer Reviewed Journal)
Trostle, A., Li, L., Kim, S., Wang, J., Al-Ouran, R., Yalamanchili, H.K., Liu, Z., Wan, Y. 2023. A comprehensive and integrative approach to MeCP2 disease transcriptomics. International Journal of Molecular Sciences. 24(6). Article 5122. https://doi.org/10.3390/ijms24065122.

Alternative polyadenylation alters protein dosage by switching between intronic and 3'UTR sites Reprint Icon - (Peer Reviewed Journal)
De Prisco, N., Ford, C., Elrod, N.D., Lee, W., Tang, L.C., Huang, K., Lin, A., Ji, P., Jonnakuti, V.S., Boyle, L., Cabaj, M., Botta, S., Yalamanchili, H.K. 2023. Alternative polyadenylation alters protein dosage by switching between intronic and 3'UTR sites. Science Advances. 9(7). Article eade4814. https://doi.org/10.1126/sciadv.ade4814.

Fibroblast growth factor 19 secretion and function in perinatal development Reprint Icon - (Review Article)
Vonderohe, C., Guthrie, G., Burrin, D.G. 2023. Fibroblast growth factor 19 secretion and function in perinatal development. American Journal of Physiology - Gastrointestinal and Liver Physiology. 324(3):G190-G195. https://doi.org/10.1152/ajpgi.00208.2022.

Bile acids and their receptors in regulation of gut health and diseases Reprint Icon - (Review Article)
Lin, S., Wang, S., Wang, P., Tang, C., Wang, Z., Chen, L., Luo, G., Chen, H., Liu, Y., Feng, B., Wu, D., Burrin, D.G., Fang, Z. 2022. Bile acids and their receptors in regulation of gut health and diseases. Progress in Lipid Research. 89. Article 101210. https://doi.org/10.1016/j.plipres.2022.101210.

Prematurity blunts protein synthesis in skeletal muscle independently of body weight in neonatal pigs Reprint Icon - (Peer Reviewed Journal)
Rudar, M., Naberhuis, J.K., Suryawan, A., Nguyen, H.V., Fiorotto, M.L., Davis, T.A. 2023. Prematurity blunts protein synthesis in skeletal muscle independently of body weight in neonatal pigs. Pediatric Research. 94(1):143-152. https://www.nature.com/articles/s41390-022-02456-3.

PGC-1alpha senses the CBC of pre-mRNA to dictate the fate of promoter-proximally paused RNAPII Reprint Icon - (Peer Reviewed Journal)
Rambout, X., Cho, H., Blanc, R., Lyu, Q., Miano, J.M., Chakkalakal, J.V., Nelson, G.M., Yalamanchili, H.K., Adelman, K., Maquat, L.E. 2023. PGC-1alpha senses the CBC of pre-mRNA to dictate the fate of promoter-proximally paused RNAPII. Molecular Cell. 83(2):186-202. https://doi.org/10.1016/j.molcel.2022.12.022.

Systemic interindividual epigenetic variation in humans is associated with transposable elements and under strong genetic control Reprint Icon - (Peer Reviewed Journal)
Gunasekara, C., MacKay, H., Scott, C., Li, S., Laritsky, E., Baker, M., Grimm, S.L., Jun, G., Li, Y., Chen, R., Wiemels, J.L., Coarfa, C., Waterland, R.A. 2023. Systemic interindividual epigenetic variation in humans is associated with transposable elements and under strong genetic control. Genome Biology. 24. Article 2. https://doi.org/10.1186/s13059-022-02827-3.

Increased circulating cortisol after vaginal birth is associated with increased FGF19 secretion in neonatal pigs Reprint Icon - (Peer Reviewed Journal)
Vonderohe, C., Guthrie, G., Stoll, B., Melendez Hebib, V., Dawson, H.D., Burrin, D.G. 2022. Increased circulating cortisol after vaginal birth is associated with increased FGF19 secretion in neonatal pigs. Endocrinology. 164(1). https://doi.org/10.1210/endocr/bqac188.

Advancement of enteral feeding in very-low-birth-weight infants: Global issues and challenges Reprint Icon - (Review Article)
Perez, K., Valentine, G.C., Nangia, S., Burrin, D.G., Maheshwari, A., Abayneh, M., Workneh, R., Jerome, M., Dinerstein, A., Salas, A. 2022. Advancement of enteral feeding in very-low-birth-weight infants: Global issues and challenges. Newborn. https://doi.org/10.5005/jp-journals-11002-0038.

Regulation of skeletal muscle protein synthesis in the preterm pig by intermittent leucine pulses during continuous parenteral feeding Reprint Icon - (Peer Reviewed Journal)
Rudar, M., Suryawan, A., Nguyen, H.V., Chacko, S.K., Vonderohe, C., Stoll, B., Burrin, D.G., Fiorotto, M.L., Davis, T.A. 2023. Regulation of skeletal muscle protein synthesis in the preterm pig by intermittent leucine pulses during continuous parenteral feeding. American Society for Parenteral and Enteral Nutrition. https://doi.org/10.1002/jpen.2450.

Haploinsufficiency of CYP8B1 associates with increased insulin sensitivity in humans Reprint Icon - (Peer Reviewed Journal)
Zhong, S., Chevre, R., Castano Mayan, D., Corliano, M., Cochran, B.J., Ping Sem, K., Van Dijik, T.H., Peng, J., Juin Tan, L., Hartimath, S.V., Ramasamy, B., Cheng, P., Groen, A.K., Kuipers, F., Goggi, J.L., Drum, C., Van Dam, R.M., San Tan, R., Rye, K., Hayden, M.R., Cheng, C., Chacko, S., Flannick, J., Sim, X., Chang Tan, H., Singaraja, R.R. 2022. Haploinsufficiency of CYP8B1 associates with increased insulin sensitivity in humans. Journal of Clinical Investigation. 132(21). Article e152961. https://doi.org/10.1172/JCI152961.

Sex-specific epigenetic development in the mouse hypothalamic arcuate nucleus pinpoints human genomic regions associated with body mass index Reprint Icon - (Peer Reviewed Journal)
MacKay, H., Gunasekara, C.J., Yam, K., Srisai, D., Yalamanchili, H.K., Li, Y., Chen, R., Coarfa, C., Waterland, R.A. 2022. Sex-specific epigenetic development in the mouse hypothalamic arcuate nucleus pinpoints human genomic regions associated with body mass index. Science Advances. 8(39). https://doi.org/10.1126%2Fsciadv.abo3991.

Use of nuclear techniques in human nutrition research: A call for papers Reprint Icon - (Other)
Hoffman, D.J., Loechl, C.U., Davis, T.A. 2022. Use of nuclear techniques in human nutrition research: A call for papers. Journal of Nutrition. 152(2):371-372. https://doi.org/10.1093/jn/nxab394.

The role of sleep and eating patterns in adiposity gain among preschool-aged children Reprint Icon - (Peer Reviewed Journal)
Goetz, A.R., Jindal, I., Moreno, J.P., Puyau, M.R., Adolph, A.L., Musaad, S., Butte, N.F., Bacha, F. 2022. The role of sleep and eating patterns in adiposity gain among preschool-aged children. American Journal of Clinical Nutrition. https://doi.org/10.1093/ajcn/nqac197.

Dietary fat composition shapes bile acid metabolism and severity of liver injury in a pig model of pediatric NAFLD Reprint Icon - (Peer Reviewed Journal)
Manjarin, R., Dillard, K., Coffin, M., Hernandez, G.V., Smith, V.A., Noland-Lidell, T., Gehani, T.R., Smart, H.J., Wheeler, K., Sprayberry, K.A., Edwards, M.S., Fanter, R.K., Glanz, H., Immoos, C., Santiago-Rodriguez, T.M., Blank, J.M., Burrin, D.G., Piccolo, B., Abo-Ismail, M., La Frano, M.R., Maj, M. 2022. Dietary fat composition shapes bile acid metabolism and severity of liver injury in a pig model of pediatric NAFLD. American Journal of Physiology - Endocrinology and Metabolism. 323:E187-E206. https://doi.org/10.1152/ajpendo.00052.2022.

Maternal and fetal bile acid homeostasis regulated by sulfated progesterone metabolites through FXR signaling pathway in a pregnant sow model Reprint Icon - (Peer Reviewed Journal)
Wang, P., Yuan, P., Lin, S., Zhong, H., Zhang, X., Zhuo, Y., Li, J., Che, L., Feng, B., Lin, Y., Xu, S., Wu, D., Burrin, D.G., Fang, Z. 2022. Maternal and fetal bile acid homeostasis regulated by sulfated progesterone metabolites through FXR signaling pathway in a pregnant sow model. International Journal of Molecular Sciences. 23. Article 6496. https://doi.org/10.3390/ijms23126496.

Cholestasis alters brain lipid and bile acid composition and compromises motor function in neonatal piglets Reprint Icon - (Peer Reviewed Journal)
Henriksen, N.L., Hansen, S.H., Lycas, M.D., Pan, X., Eriksen, T., Johansen, L.S., Sprenger, R.R., Ejsing, C.S., Burrin, D.G., Skovgaard, K., Christensen, V.B., Thymann, T., Pankratova, S. 2022. Cholestasis alters brain lipid and bile acid composition and compromises motor function in neonatal piglets. Physiological Reports. 10(13). Article e15368. https://doi.org/10.14814/phy2.15368.

Adiposity, insulin resistance, cardiorespiratory fitness and bone health in Hispanic children Reprint Icon - (Peer Reviewed Journal)
Shawar, R.S., Puyau, M., Shypailo, R., Musaad, S., Butte, N.F., Bacha, F. 2022. Adiposity, insulin resistance, cardiorespiratory fitness and bone health in Hispanic children. Journal of Clinical Endocrinology and Metabolism. https://doi.org/10.1210/clinem/dgac344.

Development of food pattern recommendations for infants and toddlers 6–24 months of age to support the Dietary Guidelines for Americans, 2020–2025 Reprint Icon - (Peer Reviewed Journal)
Dewey, K.G., Pannucci, T., Kellie, C.O., Davis, T.A., Donovan, S.M., Kleinman, R.E., Taveras, E.M., Bailey, R.L., Novotny, R., Schneeman, B.O., Stang, J., De Jesus, J., Stoody, E.E. 2021. Development of food pattern recommendations for infants and toddlers 6–24 months of age to support the Dietary Guidelines for Americans, 2020–2025. Journal of Nutrition. 151(10):3113-3124. https://doi.org/10.1093/jn/nxab201.

Acanthosis nigricans is a strong predictor of low blood calcidiol levels in children and adolescents Reprint Icon - (Peer Reviewed Journal)
Isart, F.A., Isart-Infante, F.J., Heidel, E.R., Sisley, S. 2022. Acanthosis nigricans is a strong predictor of low blood calcidiol levels in children and adolescents. Metabolic Syndrome and Related Disorders. https://doi.org/10.1089/met.2022.0005.

De novo glycine synthesis is reduced in adults with morbid obesity and increases following bariatric surgery Reprint Icon - (Peer Reviewed Journal)
Tan, H.C., Hsu, J.W., Tai, E., Chacko, S., Wu, V., Lee, C.F., Kovalik, J., Jahoor, F. 2022. De novo glycine synthesis is reduced in adults with morbid obesity and increases following bariatric surgery. Frontiers in Endocrinology. 9(13). Article 900343. https://doi.org/10.3389/fendo.2022.900343.

Relationships between food-related behaviors, obesity, and medication use in individuals with Smith-Magenis syndrome Reprint Icon - (Peer Reviewed Journal)
Gandhi, A.A., Wilson, T.A., Sisley, S., Elsea, S., Foster, R.H. 2022. Relationships between food-related behaviors, obesity, and medication use in individuals with Smith-Magenis syndrome. Research in Developmental Disabilities. 127. Article 104257. https://doi.org/10.1016/j.ridd.2022.104257.

Paraventricular vitamin D receptors are required for glucose tolerance in males but not females Reprint Icon - (Peer Reviewed Journal)
Beck, J., Da Silva Teixeira, S., Harrison, K., Phillips, G., He, Y., Sisley, S. 2022. Paraventricular vitamin D receptors are required for glucose tolerance in males but not females. Frontiers in Endocrinology. 13. Article 869678. https://doi.org/10.3389/fendo.2022.869678.

The role of palmitoleic acid in regulating hepatic gluconeogenesis through SIRT3 in obese mice Reprint Icon - (Peer Reviewed Journal)
Guo, X., Jiang, X., Chen, K., Liang, Q., Zhang, S., Zheng, J., Ma, X., Jiang, H., Wu, H., Tong, Q. 2022. The role of palmitoleic acid in regulating hepatic gluconeogenesis through SIRT3 in obese mice. Nutrients. 14(7). Article 1482. https://doi.org/10.3390/nu14071482.

Exposure to per-and polyfluoroalkyl substances and markers of liver injury: A systematic review and meta-analysis Reprint Icon - (Review Article)
Costello, E., Rock, S., Stratakis, N., Eckel, S.P., Walker, D.I., Valvi, D., Cserbik, D., Jenkins, T., Xanthakos, S.A., Kohli, R., Sisley, S., Vasiliou, V., LaMerrill, M.A., Rosen, H., Conti, D.V., McConnell, R., Chatzi, L. 2022. Exposure to per-and polyfluoroalkyl substances and markers of liver injury: A systematic review and meta-analysis. Environmental Health Perspectives. 130(4). Article 46001. https://doi.org/10.1289/EHP10092.

Mitochondrial sirtuin-3 (SIRT3) prevents doxorubicin-induced dilated cardiomyopathy by modulating protein acetylation and oxidative stress Reprint Icon - (Peer Reviewed Journal)
Tomczyk, M.M., Cheung, K.G., Xiang, B., Tamanna, N., Fonseca Teixeira, A.L., Argawal, P., Kereliuk, S.M., Spicer, V., Lin, L., Treberg, J., Tong, Q., Dolinsky, V.W. 2022. Mitochondrial sirtuin-3 (SIRT3) prevents doxorubicin-induced dilated cardiomyopathy by modulating protein acetylation and oxidative stress. Circulation: Heart Failure. 15(5). Article e008547. https://doi.org/10.1161/CIRCHEARTFAILURE.121.008547.

Relationship between arterial stiffness and subsequent cardiac structure and function in young adults with youth-onset type 2 diabetes: Results from the TODAY study Reprint Icon - (Peer Reviewed Journal)
Shah, A.S., Gidding, S.S., El Ghormli, L., Tryggestad, J.B., Nadeau, K.J., Bacha, F., Levitt Katz, L.E., Willi, S.M., Lima, J., Urbina, E.M., TODAY Study Group. 2022. Relationship between arterial stiffness and subsequent cardiac structure and function in young adults with youth-onset type 2 diabetes: Results from the TODAY study. Journal of the American Society of Echocardiography. 35(6):620-628. https://doi.org/10.1016/J.ECHO.2022.02.001.

Cleavage stimulating factor 64 depletion mitigates cardiac fibrosis through alternative polyadenylation Reprint Icon - (Peer Reviewed Journal)
Neupane, R., Youker, K., Yalamanchili, H.K., Cieslik, K.A., Karmouty-Quintana, H., Guha, A., Thandavarayan, R.A. 2022. Cleavage stimulating factor 64 depletion mitigates cardiac fibrosis through alternative polyadenylation. Biochemical and Biophysical Research Communications. 597:109-114. https://doi.org/10.1016/j.bbrc.2022.01.093.

Fibroblast growth factor 15/19 expression, regulation, and function: An overview Reprint Icon - (Review Article)
Guthrie, G., Vonderohe, C., Burrin, D.G. 2022. Fibroblast growth factor 15/19 expression, regulation, and function: An overview. Molecular and Cellular Endocrinology. 548. Article 111617. https://doi.org/10.1016/j.mce.2022.111617.

The role of epigenetics in the developmental origins of health and disease Reprint Icon - (Book / Chapter)
Michels, K.B., Gunasekara, C., Waterland, R.A. 2022. The role of epigenetics in the developmental origins of health and disease. In: Michels, K.B., editors. Epigenetic Epidemiology. 2nd Edition. Cham, Switzerland: Springer Cham. p. 123-124.

Disruption of MeCP2-TCF20 complex underlies distinct neurodevelopmental disorders Reprint Icon - (Peer Reviewed Journal)
Zhou, J., Hamdan, H., Yalamanchili, H.K., Pang, K., Pohodich, A.E., Lopez, J., Shao, Y., Oses-Prieto, J.A., Li, L., Kim, W., Durham, M.A., Bajikar, S.S., Palmer, D.J., Ng, P., Thompson, M.L., Bebin, E.M., Muller, A.J., Kuechler, A., Kampmeier, A., Haak, T.B., Burlingame, A.L., Liu, Z., Rasband, M.N., Zoghbi, H.Y. 2022. Disruption of MeCP2-TCF20 complex underlies distinct neurodevelopmental disorders. Proceedings of the National Academy of Sciences (PNAS). 119(4). Article e2119078119. https://doi.org/10.1073/pnas.2119078119.

Tissue-specific mechanisms of bile acid homeostasis and activation of FXR-FGF19 signaling in preterm and term neonatal pigs Reprint Icon - (Peer Reviewed Journal)
Vonderohe, C., Guthrie, G., Stoll, B., Chacko, S., Dawson, H.D., Burrin, D.G. 2021. Tissue-specific mechanisms of bile acid homeostasis and activation of FXR-FGF19 signaling in preterm and term neonatal pigs. American Journal of Physiology. https://doi.org/10.1152/ajpgi.00274.2021.

High-fructose, high-fat diet alters muscle composition and fuel utilization in a juvenile iberian pig model of non-alcoholic fatty liver disease Reprint Icon - (Peer Reviewed Journal)
Spooner, H., Derrick, S., Maj, M., Manjarin, R., Hernandez, G., Tailor, D., Bastani, P., Fanter, R., Fiorotto, M., Burrin, D.G., LaFrano, M., Sikalidis, A., Blank, J. 2021. High-fructose, high-fat diet alters muscle composition and fuel utilization in a juvenile Iberian pig model of non-alcoholic fatty liver disease. Nutrients. 13(12). Article 4195. https://doi.org/10.3390/nu13124195.

Trends in body mass index and association with outcomes in pediatric patients on continuous flow ventricular assist device support Reprint Icon - (Peer Reviewed Journal)
Puri, K., Adachi, I., Bocchini, C., Spinner, J., Denfield, S., Sisley, S., Elias, B., Jimenez-Gomez, A., Price, J., Dreyer, W., Choudhry, S., Tunuguntla, H. 2021. Trends in body mass index and association with outcomes in pediatric patients on continuous flow ventricular assist device support. ASAIO Journal. https://doi.org/10.1097/MAT.0000000000001633.

Metabolic inflexibility in youth with obesity: Is it a feature of obesity or distinctive of youth who are metabolically unhealthy? Reprint Icon - (Peer Reviewed Journal)
Gebara, N.Y., Kim, J.Y., Bacha, F., Lee, S., Arslanian, S. 2022. Metabolic inflexibility in youth with obesity: Is it a feature of obesity or distinctive of youth who are metabolically unhealthy? Clinical Obesity. 12(2). Article e12501. https://doi.org/10.1111/cob.12501.

Energy expenditure due to gluconeogenesis in pathological conditions of insulin resistance Reprint Icon - (Peer Reviewed Journal)
Quaye, E., Chacko, S., Chung, S.T., Brychta, R.J., Chen, K.Y., Brown, R.J. 2021. Energy expenditure due to gluconeogenesis in pathological conditions of insulin resistance. American Journal of Physiology - Endocrinology and Metabolism. 321:E795-E801. https://doi.org/10.1152/ajpendo.00281.2021.

DNA methylation at a nutritionally sensitive region of the PAX8 gene is associated with thyroid volume and function in Gambian children Reprint Icon - (Peer Reviewed Journal)
Candler, T., Kessler, N., Gunasekara, C., Ward, K., James, P., Laritsky, E., Baker, M., Dyer, R., Elango, R., Jeffries, D., Waterland, R., Moore, S., Ludgate, M., Prentice, A., Silver, M. 2021. DNA methylation at a nutritionally sensitive region of the PAX8 gene is associated with thyroid volume and function in Gambian children. Science Advances. 7(45). Article eabj1561. https://doi.org/10.1126/sciadv.abj1561.

Epigenome - A mediator for host-microbiome crosstalk Reprint Icon - (Review Article)
Peery, R.C., Pammi, M., Claud, E., Shen, L. 2021. Epigenome - A mediator for host-microbiome crosstalk. Seminars in Perinatology. 45(6). Article 151455. https://doi.org/10.1016/j.semperi.2021.151455.

Longitudinal changes in vascular stiffness and heart rate variability among young adults with youth-onset type 2 diabetes: Results from the follow-up observational treatment options for type 2 diabetes in adolescents and yout Reprint Icon - (Peer Reviewed Journal)
The TODAY Study Group, Shah, A.S., El Ghormi, L., Gidding, S.S., Hughan, K.S., Levitt Katz, L.E., Koren, D., Tryggestad, J.B., Bacha, F., Braffett, B.H., Arslanian, S., Urbina, E.M. 2021. Longitudinal changes in vascular stiffness and heart rate variability among young adults with youth-onset type 2 diabetes: Results from the follow-up observational treatment options for type 2 diabetes in adolescents and youth (TODAY) study. Acta Diabetologia. 59(2):197-205. https://doi.org/10.1007/s00592-021-01796-6.

Type 2 diabetes in prepubertal children Reprint Icon - (Peer Reviewed Journal)
Astudillo, M., Tosur, M., Castillo, B., Refaey, A., Siller, A., Nieto, J., Sisley, S., McKay, S., Nella, A.A., Balasubramanyam, A., Bacha, F., Redondo, M.J. 2021. Type 2 diabetes in prepubertal children. Pediatric Diabetes. 22(7):946-950. https://doi.org/10.1111/pedi.13254.

Type 2 diabetes in prepubertal children Reprint Icon - (Peer Reviewed Journal)
Astudillo, M., Tosur, M., Castillo, B., Rafaey, A., Siller, A., Nieto, J., Sisley, S., McKay, S., Nella, A., Balasubramanyam, A., Bacha, F., Redondo, M. 2021. Type 2 diabetes in prepubertal children. Pediatric Diabetes. https://doi.org/10.1111/pedi.13254 .

Variation in AIN-93G/M diets across different commercial manufacturers: Not all AIN-93 diets are created equal Reprint Icon - (Peer Reviewed Journal)
Joshi, T.P., Fiorotto, M.L. 2021. Variation in AIN-93G/M diets across different commercial manufacturers: Not all AIN-93 diets are created equal. Journal of Nutrition. 151(11):3271-3275. https://doi.org/10.1093/jn/nxab274.

Potential benefits of bovine colostrum in pediatric nutrition and health Reprint Icon - (Review Article)
Sangild, P., Vonderohe, C., Melendez Hebib, V., Burrin, D.G. 2021. Potential benefits of bovine colostrum in pediatric nutrition and health. Nutrients. 13(8). Article 2551. https://doi.org/10.3390/nu13082551.

Monogenic diabetes in youth with presumed type 2 diabetes: Results from the Progress in Diabetes Genetics in Youth (ProDiGY) collaboration Reprint Icon - (Peer Reviewed Journal)
Todd, J.N., Kleinberger, J.W., Zhang, H., Srinivasan, S., Tollefsen, S.E., Levitsky, L.L., Levitt Katz, L.E., Tryggestad, J.B., Bacha, F., Imperatore, G., Lawrence, J.M., Pihoker, C., Divers, J., Flannick, J., Dabelea, D., Florez, J.C., Pollin, T.I. 2021. Monogenic diabetes in youth with presumed type 2 diabetes: Results from the Progress in Diabetes Genetics in Youth (ProDiGY) collaboration. Diabetes Care. 44(10):2312-2319. https://doi.org/10.2337/dc21-0491.

Berberine remodels adipose tissue to attenuate metabolic disorders by activating sirtuin 3 Reprint Icon - (Peer Reviewed Journal)
Li, D., Yang, C., Zhu, J., Lopez, E., Zhang, T., Tong, Q., Peng, C., Lin, L. 2021. Berberine remodels adipose tissue to attenuate metabolic disorders by activating sirtuin 3. Acta Pharmacologica Sinica. 43:1285-1298. https://doi.org/10.1038/s41401-021-00736-y.

Racial and ethnic disparities in comorbidities in youth with type 2 Diabetes in the Pediatric Diabetes Consortium (PDC) Reprint Icon - (Peer Reviewed Journal)
Bacha, F., Cheng, P., Gal, R.L., Beaulieu, L.C., Kollman, C., Adolph, A., Shoemaker, A.H., Wolf, R., Klingensmith, G.J., Tamborlane, W.V. 2021. Racial and ethnic disparities in comorbidities in youth with type 2 Diabetes in the Pediatric Diabetes Consortium (PDC). Diabetes Care. 44:2245-2251. https://doi.org/10.2337/dc21-0143.

A machine learning case-control classifier for schizophrenia based on DNA methylation in blood Reprint Icon - (Peer Reviewed Journal)
Gunasekara, C., Hannon, E., MacKay, H., Coarfa, C., McQuillin, A., St. Clair, D., Mill, J., Waterland, R.A. 2021. A machine learning case-control classifier for schizophrenia based on DNA methylation in blood. Translational Psychiatry. 11(1). Article 412. https://doi.org/10.1038/s41398-021-01496-3.

Emerging roles of alternative cleavage and polyadenylation (APA) in human disease Reprint Icon - (Review Article)
Dharmalingam, P., Mahalingam, R., Yalamanchili, H.K., Weng, T., Karmouty-Quintana, H., Guha, A., Thandavarayan, R.A. 2021. Emerging roles of alternative cleavage and polyadenylation (APA) in human disease. Journal of Cellular Physiology. 237:149-160. https://doi.org/10.1002/jcp.30549.

TCF7L2 genetic variants do not influence insulin sensitivity or secretion indices in autoantibody-positive individuals at risk for type 1 diabetes Reprint Icon - (Peer Reviewed Journal)
Redondo, M.J., Warnock, M.V., Libman, I.M., Bocchino, L.E., Cuthbertson, D., Geyer, S., Pugliese, A., Steck, A.K., Evans-Molina, C., Becker, D., Sosenko, J.M., Bacha, F., and the Type 1 Diabetes TrialNet Study Group. 2021. TCF7L2 genetic variants do not influence insulin sensitivity or secretion indices in autoantibody-positive individuals at risk for type 1 diabetes. Diabetes Care. 44(9):2039-2044. https://doi.org/10.2337/dc21-0531.

Breastfeeding and risk of overweight in childhood and beyond: A systematic review with emphasis on sibling-pair and intervention studies Reprint Icon - (Review Article)
Dewey, K.G., Gungor, D., Donovan, S.M., Madan, E.M., Venkatramanan, S., Davis, T.A., Kleinman, R.E., Taveras, E.M., Bailey, R.L., Novotny, R., Terry, N., Butera, G., Obbagy, J., De Jesus, J., Stoody, E. 2021. Breastfeeding and risk of overweight in childhood and beyond: A systematic review with emphasis on sibling-pair and intervention studies. American Journal of Clinical Nutrition. 114(5):1774-1790. https://doi.org/10.1093/ajcn/nqab206.

Intermittent bolus compared with continuous feeding enhances insulin and amino acid signaling to translation initiation in skeletal muscle of neonatal pigs Reprint Icon - (Peer Reviewed Journal)
Suryawan, A., El-Kadi, S.W., Nguyen, H.V., Fiorotto, M.L., Davis, T.A. 2021. Intermittent bolus compared with continuous feeding enhances insulin and amino acid signaling to translation initiation in skeletal muscle of neonatal pigs. Journal of Nutrition. https://doi.org/10.1093/jn/nxab190.

Application and design considerations for 3'-end sequencing using click-chemistry Reprint Icon - (Book / Chapter)
Jensen, M.K., Elrod, N.D., Yalamanchili, H.K., Ji, P., Lin, A., Liu, Z., Wagner, E.J. 2021. Application and design considerations for 3'-end sequencing using click-chemistry. In: Tian, B. editor. Methods in Enzymology. 1st edition. Cambridge, MA: Academic Press. p. 1-23. https://doi.org/10.1016/bs.mie.2021.03.012.

The shape of the oral glucose tolerance test-glucose response curve in islet cell antibody-positive vs. -negative obese youth clinically diagnosed with type 2 diabetes Reprint Icon - (Peer Reviewed Journal)
Kim, J.Y., Tfayli, H., Bacha, F., Arslanian, S. 2021. The shape of the oral glucose tolerance test-glucose response curve in islet cell antibody-positive vs. -negative obese youth clinically diagnosed with type 2 diabetes. Journal of Obesity. https://doi.org/10.7570/jomes20088.

Sirtuin-3 mediates sex differences in kidney ischemia-reperfusion injury Reprint Icon - (Peer Reviewed Journal)
Shen, H., Holliday, M., Sheikh-Hamad, D., Li, Q., Tong, Q., David Hamad, C., Pan, J.S. 2021. Sirtuin-3 mediates sex differences in kidney ischemia-reperfusion injury. Translational Research. https://doi.org/10.1016/j.trsl.2021.03.015.

A computational pipeline to infer alternative poly-adenylation from 3' sequencing data Reprint Icon - (Book / Chapter)
Yalamanchili, H.K., Elrod, N.D., Jensen, M.K., Ji, P., Lin, A., Wagner, E.J., Liu, Z. 2021. A computational pipeline to infer alternative poly-adenylation from 3' sequencing data. In: Tian, B. editor. Methods in Enzymology. 1st edition. Cambridge, MA: Academic Press. p. 185-204. https://doi.org/10.1016/bs.mie.2021.04.001.

Case-based curriculum for pediatric residents in diabetes fundamentals Reprint Icon - (Peer Reviewed Journal)
Al-Gadi, I., Sisley, S. 2021. Case-based curriculum for pediatric residents in diabetes fundamentals. MedEdPORTAL. 17:11157. https://doi.org/10.15766/mep_2374-8265.11157.

SIRT3 is required for liver regeneration but not for the beneficial effect of nicotinamide riboside Reprint Icon - (Peer Reviewed Journal)
Mukherjee, S., Mo, J., Paolella, L.M., Perry, C.E., Toth, J., Hugo, M.M., Chu, Q., Tong, Q., Chellappa, K., Baur, J.A. 2021. SIRT3 is required for liver regeneration but not for the beneficial effect of nicotinamide riboside. Journal of Clinical Immunology Insights (JCI Insights). 6(7):E147193. https://doi.org/10.1172/jci.insight.147193.

Depletion and enrichment of phytosterols in soybean oil lipid emulsions directly associate with serum markers of cholestasis in preterm PN-fed pigs Reprint Icon - (Peer Reviewed Journal)
Guthrie, G., Stoll, B., Chacko, S., Mohammad, M., Style, C., Verla, M., Olutoye, O., Schady, D., Lauridsen, C., Tataryn, N., Burrin, D.G. 2021. Depletion and enrichment of phytosterols in soybean oil lipid emulsions directly associate with serum markers of cholestasis in preterm PN-fed pigs. Journal of Parenteral and Enteral Nutrition. https://doi.org/10.1002/jpen.2088.

Impact of parenteral lipid emulsion components on cholestatic liver disease in neonates Reprint Icon - (Review Article)
Guthrie, G., Burrin, D.G. 2021. Impact of parenteral lipid emulsion components on cholestatic liver disease in neonates. Nutrients. 13(2):508. https://doi.org/10.3390/nu13020508.

Should the AIN-93 rodent diet formulas be revised? Reprint Icon - (Other)
Klurfeld, D.M., Gregory, J.F., Fiorotto, M.L. 2021. Should the AIN-93 rodent diet formulas be revised?. Journal of Nutrition. 151(6):1380-1382. https://doi.org/10.1093/jn/nxab041.

Metabolic flexibility across the spectrum of glycemic regulation in youth Reprint Icon - (Peer Reviewed Journal)
Bacha, F., Bartz, S.K., Puyau, M., Adolph, A., Sharma, S. 2021. Metabolic flexibility across the spectrum of glycemic regulation in youth. Journal of Clinical Investigation. 6(4):e146000. https://doi.org/10.1172/jci.insight.146000.

Prematurity blunts the insulin- and amino acid-induced stimulation of translation initiation and protein synthesis in skeletal muscle of neonatal pigs Reprint Icon - (Peer Reviewed Journal)
Rudar, M., Naberhuis, J.K., Suryawan, A., Nguyen, H.V., Stoll, B., Style, C.C., Verla, M.A., Olutoye, O.O., Burrin, D.G., Fiorotto, M.L. 2021. Prematurity blunts the insulin- and amino acid-induced stimulation of translation initiation and protein synthesis in skeletal muscle of neonatal pigs. American Journal of Physiology - Endocrinology and Metabolism. 320(3):E551–E565. https://doi.org/10.1152/ajpendo.00203.2020.

Parenteral fish-oil containing lipid emulsions limit initial lipopolysaccharide-induced host immune responses in preterm pigs Reprint Icon - (Peer Reviewed Journal)
Yakah, W., Ramiro-Cortijo, D., Singh, P., Brown, J., Stoll, B., Kulkarni, M., Oosterloo, B., Burrin, D.G., Maddipati, K., Fichorova, R., Freedman, S., Martin, C. 2021. Parenteral fish-oil containing lipid emulsions limit initial lipopolysaccharide-induced host immune responses in preterm pigs . Nutrients. 13(1):25. https://doi.org/10.3390/nu13010205.

New insights and enhanced human norovirus cultivation in human intestinal enteroids Reprint Icon - (Peer Reviewed Journal)
Ettayebi, K., Tenge, V., Cortes-Penfield, N., Crawford, S., Neill, F., Zeng, X., Yo, X., Ayyar, V., Burrin, D.G., Ramani, S., Atmar, R., Estes, M. 2021. New insights and enhanced human norovirus cultivation in human intestinal enteroids . American Society for Microbiology. 6(1):e01136-20. https://doi.org/10.1128/mSphere.01136-20.

Pegylated arginine deiminase depletes plasma arginine but maintains tissue arginine availability in young pigs Reprint Icon - (Peer Reviewed Journal)
Mohammad, M., Didelija, I., Stoll, B., Nguyen, T., Marini, J. 2021. Pegylated arginine deiminase depletes plasma arginine but maintains tissue arginine availability in young pigs. American Journal of Physiology. 320(3):E641-E652. https://doi.org/10.1152/ajpendo.00472.2020.

Advancements in research on necrotizing enterocolitis pathogenesis and prevention using pigs Reprint Icon - (Book / Chapter)
Burrin, D.G., Marini, J., Premkumar, M., Stoll, B., Sangild, P. 2021. Advancements in research on necrotizing enterocolitis pathogenesis and prevention using pigs. In: Hackam, D.J. editor. Necrotizing Enterocolitis: Pathogenesis, Diagnosis and Treatment. 1st edition. Boca Raton, FL: CRC Press. p.220-232. https://doi.org/10.1201/9780429288302.

Perfluorooctanoic acid (PFOA) or perfluorooctane sulfonate (PFOS) and DNA methylation in newborn dried blood spots in the upstate KIDS cohort Reprint Icon - (Peer Reviewed Journal)
Robinson, S.L., Zeng, X., Guan, W., Sundaram, R., Mendola, P., Putkick, D.L., Waterland, R.A., Ganasekara, C., Kannan, K., Gao, C., Bell, E., Yeung, E.H. 2021. Perfluorooctanoic acid (PFOA) or perfluorooctane sulfonate (PFOS) and DNA methylation in newborn dried blood spots in the upstate KIDS cohort. Environmental Research. 194:110668. https://doi.org/10.1016/j.envres.2020.110668.

Consumption of high-fructose corn syrup compared with sucrose promotes adiposity and increased triglyceridemia but comparable NAFLD severity in juvenile Iberian pigs Reprint Icon - (Peer Reviewed Journal)
Maj, M., Harbottle, B., Thomas, P., Hernandez, G., Smith, V., Edwards, M., Fanter, R., Glanz, H., Immoos, C., Burrin, D.G., Santiago-Rodriguez, T., La Franco, M., Manjarin, R. 2021. Consumption of high-fructose corn syrup compared with sucrose promotes adiposity and increased triglyceridemia but comparable NAFLD severity in juvenile Iberian pigs . Journal of Nutrition. 151(5):1139-1149. https://doi.org/10.1093/jn/nxaa441.

Defining vitamin D receptor expression in the brain using a novel VDRCre mouse Reprint Icon - (Peer Reviewed Journal)
Liu, H., He, Y., Beck, J., Da Silva Teixeira, S., Harrison, K., Xu, Y., Sisley, S. 2020. Defining vitamin D receptor expression in the brain using a novel VDRCre mouse. Journal of Comparative Neurology. https://doi.org/10.1002/cne.25100.

Predict multicategory causes of death in lung cancer patients using clinicopathologic factors Reprint Icon - (Peer Reviewed Journal)
Deng, F., Zhou, H., Lin, Y., Heim, J.A., Shen, L., Li, Y., Zhang, L. 2021. Predict multicategory causes of death in lung cancer patients using clinicopathologic factors. Computers in Biology and Medicine. 129:104161. https://doi.org/10.1016/j.compbiomed.2020.104161.

Classify multicategory outcome in patients with lung adenocarcinoma using clinical, transcriptomic and clinico-transcriptomic data: Machine learning versus multinomial models - (Peer Reviewed Journal)
Deng, F., Shen, L., Wang, H., Zhang, L. 2020. Classify multicategory outcome in patients with lung adenocarcinoma using clinical, transcriptomic and clinico-transcriptomic data: Machine learning versus multinomial models. American Journal of Cancer Research. 10(12):4624-4639.

Intermittent bolus feeding enhances organ growth more than continuous feeding in a neonatal piglet model Reprint Icon - (Peer Reviewed Journal)
El-Kadi, S.W., Boutry-Regard, C., Suryawan, A., Nguyen, H.V., Kimball, S.R., Fiorotto, M.L., Davis, T.A. 2020. Intermittent bolus feeding enhances organ growth more than continuous feeding in a neonatal piglet model. Current Developments in Nutrition. 4(12):nzaa170. https://doi.org/10.1093/cdn/nzaa170.

Arginine kinetics are altered in a pilot sample of adolescents and young adults with Barth syndrome Reprint Icon - (Peer Reviewed Journal)
Cade, T.W., Bohnert, K.L., Bittel, A.J., Chacko, S.J., Patterson, B.W., Pacak, C.A., Byrne, B.J., Vernon, H.J., Reeds, D.N. 2020. Arginine kinetics are altered in a pilot sample of adolescents and young adults with Barth syndrome. Molecular Genetics and Metabolism. 25:100675. https://doi.org/10.1016/j.ymgmr.2020.100675.

The 2020 FASEB virtual science research conference on nutrient sensing and metabolic signaling Reprint Icon - (Proceedings)
Kimball, S.R., Davis, T.A. 2020. The 2020 FASEB virtual science research conference on nutrient sensing and metabolic signaling. Journal of Federation of American Societies for Experimental Biology. 34(12):5627-15629. https://doi.org/10.1096/fj.202002259.

Arginase II plays a central role in the sexual dimorphism of arginine metabolism in C57BL/6 mice Reprint Icon - (Peer Reviewed Journal)
Mohammad, M.A., Didelija, I.C., Marini, J.C. 2020. Arginase II plays a central role in the sexual dimorphism of arginine metabolism in C57BL/6 mice. Journal of Nutrition. 150(12):3133-3140. https://doi.org/10.1093/jn/nxaa318.

Sex differences in circulating leptin as a marker of adiposity in obese or overweight adolescents with type 1 diabetes Reprint Icon - (Peer Reviewed Journal)
Redondo, M., Siller, A., Gu, X., Tosur, M., Bondy, M., Devaraj, S., Sisley, S. 2020. Sex differences in circulating leptin as a marker of adiposity in obese or overweight adolescents with type 1 diabetes. BMJ Open Diabetes Research & Care. https://doi.org/10.1136/bmjdrc-2020-001683.

Parenteral lipid emulsions induce unique ileal fatty acid and metabolomic profiles but do not increase the risk of necrotizing enterocolitis in preterm pigs Reprint Icon - (Peer Reviewed Journal)
Yakah, W., Singh, P., Brown, J., Stoll, B., Burrin, D.G., Premkumar, M., Otu, H., Gu, X., Dillon, S., Liberman, T., Freedman, S., Martin, C. 2020. Parenteral lipid emulsions induce unique ileal fatty acid and metabolomic profiles but do not increase the risk of necrotizing enterocolitis in preterm pigs. American Journal of Physiology - Gastrointestinal and Liver Physiology. https://doi.org/10.1152/ajpgi.00311.2020.

Modeling age-dependent developmental changes in the expression of genes involved in citrulline synthesis using pig enteroids Reprint Icon - (Peer Reviewed Journal)
Mohammad, M., Didelija, I., Stoll, B., Burrin, D.G., Marini, J. 2020. Modeling age-dependent developmental changes in the expression of genes involved in citrulline synthesis using pig enteroids. Physiological Reports. 8(21):e14565. https://doi.org/10.14814/phy2.14565.

Neurodegeneration in juvenile Iberian pigs with diet-induced nonalcoholic fatty liver disease Reprint Icon - (Peer Reviewed Journal)
Zeltser, N., Meyer, I., Hernandez, G., Trahan, M., Fanter, R., Abo-Ismail, M., Glanz, H., Strand, C., Burrin, D.G., La Frano, M., Manjarin, R., Maj, M. 2020. Neurodegeneration in juvenile Iberian pigs with diet-induced nonalcoholic fatty liver disease. American Journal of Physiology - Endocrinology and Metabolism. 319(3):E592-E606. https://doi.org/10.1152/ajpendo.00120.2020.

The duration, frequency, and volume of exclusive human milk and/or infant formula consumption and nutrient status: A systematic review Reprint Icon - (Review Article)
Dewey, K., Bazzano, L., Davis, T., Donovan, S., Taveras, E., Kleinman, R. 2020. The duration, frequency, and volume of exclusive human milk and/or infant formula consumption and nutrient status: A systematic review. Dietary Guidelines Advisory Committee Project. https://doi.org/10.52570/NESR.DGAC2020.SR0302.

Iron from supplements consumed during infancy and toddlerhood and growth, size, and body composition: A systematic review Reprint Icon - (Review Article)
Dewey, K., Bazzano, L., Davis, T., Donovan, S., Taveras, E., Kleinman, R. 2020. Iron from supplements consumed during infancy and toddlerhood and growth, size, and body composition: A systematic review. Dietary Guidelines Advisory Committee Project. https://doi.org/10.52570/NESR.DGAC2020.SR0303.

The duration, frequency, and volume of exclusive human milk and/or infant formula consumption and overweight and obesity: A systematic review Reprint Icon - (Review Article)
Dewey, K., Bazzano, L., Davis, T., Donovan, S., Taveras, E., Kleinman, R. 2020. The duration, frequency, and volume of exclusive human milk and/or infant formula consumption and overweight and obesity: A systematic review. Dietary Guidelines Advisory Committee Project. https://doi.org/10.52570/NESR.DGAC2020.SR0301.

Vitamin D from supplements consumed during infancy and toddlerhood and bone health: A systematic review Reprint Icon - (Review Article)
Dewey, K., Bazzano, L., Davis, T., Donovan, S., Taveras, E., Kleinman, R. 2020. Vitamin D from supplements consumed during infancy and toddlerhood and bone health: A systematic review. 2020 Dietary Guidelines Advisory Committee Project. https://doi.org/10.52570/NESR.DGAC2020.SR0304.

The relationship of sleep duration and quality to energy expenditure and physical activity in children Reprint Icon - (Peer Reviewed Journal)
Jindal, I., Puyau, M., Adolph, A., Butte, N., Musaad, S., Bacha, F. 2020. The relationship of sleep duration and quality to energy expenditure and physical activity in children. Pediatric Obesity. e12751. https://doi.org/10.1111/ijpo.12751.

Leptin decreases de novo lipogenesis in patients with lipodystrophy Reprint Icon - (Peer Reviewed Journal)
Baykal, A.P., Parks, E.J., Shamburek, R., Syed-Abdul, M.M., Chacko, S., Cochran, E., Startzell, M., Gharib, A.M., Ouwerkerk, R., Abd-Elmoniem, K.Z., Walter, P.J., Muniyappa, R., Chung, S.T., Brown, R.J. 2020. Leptin decreases de novo lipogenesis in patients with lipodystrophy. Journal of Clinical Investigation. 5(14):e137180. https://doi.org/10.1172/jci.insight.137180.

Decline pattern of beta cell function in LADA: Relationship to GAD autoantibodies Reprint Icon - (Other)
Bacha, F., Redondo, M.J. 2020. Decline pattern of beta cell function in LADA: Relationship to GAD autoantibodies. Journal of Clinical Endocrinology and Metabolism. 105(8):e3008-e3009. https://doi.org/10.1210/clinem/dgaa374.

Identification of cell type-specific methylation signals in bulk whole genome bisulfite sequencing data Reprint Icon - (Peer Reviewed Journal)
Scott, A.C., Duryea, J.D., MacKay, H., Baker, M.S., Laritsky, E., Gunasekara, C.J., Coarfa, C., Waterland, R.A. 2020. Identification of cell type-specific methylation signals in bulk whole genome bisulfite sequencing data. Genome Biology. 21(1):156. https://doi.org/10.1186/s13059-020-02065-5.

Saturated fats and health: A reassessment and proposal for food-based recommendations: JACC state-of-the-art review Reprint Icon - (Review Article)
Astrup, A., Magkos, F., Bier, D.M., Brenna, J., De Oliveira Otto, M.C., Hill, J.O., King, J.C., Mente, A., Ordovas, J.M., Volek, J.S., Dphil, S., Krauss, R.M. 2020. Saturated fats and health: A reassessment and proposal for food-based recommendations: JACC state-of-the-art review. Journal of the American College of Cardiology. https://doi.org/10.1016/j.jacc.2020.05.077.

Vitamin D actions in neurons require the PI3K pathway for both enhancing insulin signaling and rapid depolarizing effects Reprint Icon - (Peer Reviewed Journal)
Teixeira, S., Harrison, K., Uzodike, M., Rajapakshe, K., Coarfa, C., He, Y., Xu, Y., Sisley, S. 2020. Vitamin D actions in neurons require the PI3K pathway for both enhancing insulin signaling and rapid depolarizing effects. The Journal of Steroid Biochemistry and Molecular Biology. 200:105690. https://doi.org/10.1016/j.jsbmb.2020.105690.

Myeloma cells shift osteoblastogenesis to adipogenesis by inhibiting the ubiquitin ligase MURF1 in mesenchymal stem cells Reprint Icon - (Peer Reviewed Journal)
Liu, Z., Liu, H., He, J., Lin, P., Tong, Q., Yang, J. 2020. Myeloma cells shift osteoblastogenesis to adipogenesis by inhibiting the ubiquitin ligase MURF1 in mesenchymal stem cells. Science Signaling. 13(633):eaay8203. https://doi.org/10.1126/scisignal.aay8203.

Methylphenidate improves weight control in childhood brain tumor survivors with hypothalamic obesity Reprint Icon - (Peer Reviewed Journal)
Horne, V., Bielamowicz, K., Nguyen, J., Hilsenbeck, S., Holly, L., Sonabend, R., Wood, A., Okcu, F., Sisley, S. 2020. Methylphenidate improves weight control in childhood brain tumor survivors with hypothalamic obesity. Pediatric Blood and Cancer. e28379. https://doi.org/10.1002/pbc.28379.

Novel role of dynamin-related-protein 1 in dynamics of ER-lipid droplets in adipose tissue Reprint Icon - (Peer Reviewed Journal)
Xin, L., Yang, L., Mao, Z., Pan, X., Zhao, Y., Gu, X., Eckel-Mahan, K., Zuo, Z., Tong, Q., Hartig, S.M., Cheng, X., Du, G., Moore, D.D., Bellen, H.J., Sesaki, H., Sun, K. 2020. Novel role of dynamin-related-protein 1 in dynamics of ER-lipid droplets in adipose tissue. Federation of American Societies for Experimental Biology Conference. https://doi.org/10.1096/fj.201903100RR.

The pediatric obesity encounter: Literature and resources to help with 4 common issues Reprint Icon - (Review Article)
Zachery, M., Sisley, S. 2020. The pediatric obesity encounter: Literature and resources to help with 4 common issues. Current Nutrition Reports. 9:94–100. https://doi.org/10.1007/s13668-020-00308-2.

Free fatty acid processing diverges in human pathologic insulin resistance conditions Reprint Icon - (Peer Reviewed Journal)
Sekizkardes, H., Chung, S.T., Chacko, S., Haymond, M.W., Startzell, M., Walter, M., Walter, P.J., Lightbourne, M., Brown, R.J. 2020. Free fatty acid processing diverges in human pathologic insulin resistance conditions. Journal of Clinical Investigation. 130(7):3592-3602. https://doi.org/10.1172/JCI135431.

The Healthy Cooking Index does not predict the carotenoid content of home-cooked meals Reprint Icon - (Peer Reviewed Journal)
Raber, M., Basen-Engquist, K., Moran, N.E., Chandra, J. 2020. The Healthy Cooking Index does not predict the carotenoid content of home-cooked meals. Nutrients. 12(2): 524. https://doi.org/10.3390/nu12020524.

Can children catch up from the consequences of undernourishment? Evidence from child linear growth, developmental epigenetics, and brain and neurocognitive development Reprint Icon - (Review Article)
Leroy, J.L., Frongillo, E.A., Dewan, P., Black, M.M., Waterland, R.A. 2020. Can children catch up from the consequences of undernourishment? Evidence from child linear growth, developmental epigenetics, and brain and neurocognitive development. Advances in Nutrition. 11(4):1032-1041. https://doi.org/10.1093/advances/nmaa020.

Nutrient restriction has limited short-term effects on gut, immunity, and brain development in preterm pigs Reprint Icon - (Peer Reviewed Journal)
Ahnfeldt, A., Baek, O., Hui, Y., Nielsen, C., Obelitz-Ryom, K., Busk-Anderson, T., Ruge, A., Holst, J., Rudloff, S., Burrin, D.G., Nguyen, D., Nielsen, D., Zachariassen, G., Bering, S., Thymann, T., Sangild, P. 2020. Nutrient restriction has limited short-term effects on gut, immunity, and brain development in preterm pigs. Journal of Nutrition. https://doi.org/10.1093/jn/nxaa030.

Differential regulation of mTORC1 activation by leucine and beta-hydroxy-beta-methylbutyrate in skeletal muscle of neonatal pigs Reprint Icon - (Peer Reviewed Journal)
Suryawan, A.A., Rudar, M., Fiorotto, M.L., Davis, T.A. 2020. Differential regulation of mTORC1 activation by leucine and beta-hydroxy-beta-methylbutyrate in skeletal muscle of neonatal pigs. Journal of Applied Physiology. 128(2):286-295. https://doi.org/10.1152/japplphysiol.00332.2019.

SIRT3 acts as a positive autophagy regulator to promote lipid mobilization in adipocytes via activating AMPK Reprint Icon - (Peer Reviewed Journal)
Zang, T., Liu, J., Tong, Q., Lin, L. 2020. SIRT3 acts as a positive autophagy regulator to promote lipid mobilization in adipocytes via activating AMPK. International Journal of Molecular Sciences. 21(2):372. https://doi.org/10.3390/ijms21020372.

Channeling of citrulline for the renal synthesis of guanidino acetate Reprint Icon - (Other)
Marini, J. 2019. Channeling of citrulline for the renal synthesis of guanidino acetate. Journal of Nutrition. 150(3):423-424. https://doi.org/10.1093/jn/nxz310.

DNA methylation in AgRP neurons regulates voluntary exercise behavior in mice Reprint Icon - (Peer Reviewed Journal)
MacKay, H., Scott, C., Duryea, J.D., Baker, M.S., Laritsky, E., Elson, A.E., Garland, T., Fiorotto, M.L., Chen, R., Li, Y., Coarfa, C., Simerly, R.B., Waterland, R.A. 2019. DNA methylation in AgRP neurons regulates voluntary exercise behavior in mice. Nature Communications. 10:5364. https://doi.org/10.1038/s41467-019-13339-3.

A new era for epigenetic epidemiology Reprint Icon - (Other)
Gunasekara, C.J., Waterland, R.A. 2019. A new era for epigenetic epidemiology. Epigenomics. 11(15):1647-1649. https://doi.org/10.2217/epi-2019-0282.

Early postnatal overnutrition accelerates aging-associated epigenetic drift in pancreatic islets Reprint Icon - (Peer Reviewed Journal)
Li, G., Petkova, T.D., Laritsky, E., Kessler, N., Baker, M.S., Zhu, S., Waterland, R.A. 2019. Early postnatal overnutrition accelerates aging-associated epigenetic drift in pancreatic islets. Environmental Epigenetics. 5(3):dvz015. https://doi.org/10.1093/eep/dvz015.

Current opportunities to catalyze research in nutrition and cancer prevention - An interdisciplinary perspective Reprint Icon - (Review Article)
The Cancer Research UK - Ludwig Cancer Research Nutrition and Cancer Prevention Collaborative Group. 2019. Current opportunities to catalyze research in nutrition and cancer prevention - An interdisciplinary perspective. BioMed Central (BMC) Medicine. 17:148. https://doi.org/10.1186/s12916-019-1383-9.

Study of environmental enteropathy and malnutrition (SEEM) in Pakistan: Protocols for biopsy based biomarker discovery and validation Reprint Icon - (Peer Reviewed Journal)
Iqbal, N.T., Syed, S., Sadiq, K., Khan, M.N., Iqbal, J., Ma, J.Z., Umrani, F., Ahmed, S., Maier, E.A., Denson, L.A., Haberman, Y., McNeal, M.M., Setchell, K.D., Zhao, X., Qureshi, S., Shen, L., Moskaluk, C.A., Liu, T., Yilmaz, O., Brown, D.E., Barratt, M.J., Kung, V.L., Gordon, J.I., Moore, S.R., Ali, S.A. 2019. Study of environmental enteropathy and malnutrition (SEEM) in Pakistan: Protocols for biopsy based biomarker discovery and validation. BMC Pediatrics. 19:247. https://doi.org/10.1186/s12887-019-1564-x

SIRT3 promotes lipophagy and chaperon-mediated autophagy to protect hepatocytes against lipotoxicity Reprint Icon - (Peer Reviewed Journal)
Zhang, T., Liu, J., Shen, S., Tong, Q., Ma, X., Lin, L. 2020. SIRT3 promotes lipophagy and chaperon-mediated autophagy to protect hepatocytes against lipotoxicity. Cell Death and Differentiation. 27:329-344. https://doi.org/10.1038/s41418-019-0356-z.

Diabetes curriculum for pediatric endocrine fellowship utilizing modified team-based learning Reprint Icon - (Peer Reviewed Journal)
Athanassaki, I., Lyons, S., Desalvo, D., Hendrix, K., Ebenezer, S., McCann-Crosby, B., Redondo, M., Chen, M., Uysal, S., Sisley, S. 2020. Diabetes curriculum for pediatric endocrine fellowship utilizing modified team-based learning. MedEdPORTAL. 16:10948. https://doi.org/10.15766/mep_2374-8265.10948.