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ARS Home » Plains Area » Houston, Texas » Children's Nutrition Research Center » Research » Publications at this Location » Publication #391906

Research Project: Metabolic and Epigenetic Regulation of Nutritional Metabolism

Location: Children's Nutrition Research Center

Title: Fibroblast growth factor 15/19 expression, regulation, and function: An overview

item GUTHRIE, GREG - Children'S Nutrition Research Center (CNRC)
item VONDEROHE, CAITLIN - Children'S Nutrition Research Center (CNRC)
item Burrin, Douglas - Doug

Submitted to: Molecular and Cellular Endocrinology
Publication Type: Review Article
Publication Acceptance Date: 1/18/2022
Publication Date: 3/15/2022
Citation: Guthrie, G., Vonderohe, C., Burrin, D.G. 2022. Fibroblast growth factor 15/19 expression, regulation, and function: An overview. Molecular and Cellular Endocrinology. 548. Article 111617.

Interpretive Summary:

Technical Abstract: Since the discovery of fibroblast growth factor (FGF)-19 over 20 years ago, our understanding of the peptide and its role in human biology has moved forward significantly. A member of a superfamily of paracrine growth factors regulating embryonic development, FGF19 is unique in that it is a dietary-responsive endocrine hormone linked with bile acid homeostasis, glucose and lipid metabolism, energy expenditure, and protein synthesis during the fed to fasted state. FGF19 achieves this through targeting multiple tissues and signaling pathways within those tissues. The diverse functional capabilities of FGF19 is due to the unique structural characteristics of the protein and its receptor binding in various cell types. This review will cover the current literature on the protein FGF19, its target receptors, and the biological pathways they target through unique signaling cascades.