Bile acids and their receptors in regulation of gut health and diseases

Authors: LIN, SEN - Sichuan Agricultural University; WANG, SUTIAN - Guangdong Academy Of Agricultural Sciences; WANG, PENG - Henan University Of Technology; TANG, CUIMING - Guangdong Academy Of Agricultural Sciences; WANG, ZHENJIANG - Guangdong Academy Of Agricultural Sciences; CHEN, LIAN - Guangdong Academy Of Agricultural Sciences; LUO, GUOQING - Guangdong Academy Of Agricultural Sciences; CHEN, HONG - Sichuan Agricultural University; LIU, YUNTAO - Sichuan Agricultural University; FENG, BIN - Sichuan Agricultural University; WU, DE - Sichuan Agricultural University; Burrin, Douglas - Doug; FANG, ZHENGFENG - Sichuan Agricultural University

Submitted to: Progress in Lipid Research
Publication Type: Review Article
Publication Acceptance Date: 12/22/2022
Publication Date: 12/25/2022
Citation: Lin, S., Wang, S., Wang, P., Tang, C., Wang, Z., Chen, L., Luo, G., Chen, H., Liu, Y., Feng, B., Wu, D., Burrin, D.G., Fang, Z. 2022. Bile acids and their receptors in regulation of gut health and diseases. Progress in Lipid Research. 89. Article 101210. https://doi.org/10.1016/j.plipres.2022.101210.
DOI: https://doi.org/10.1016/j.plipres.2022.101210

Interpretive Summary:

Technical Abstract: It is well established that bile acids play important roles in lipid metabolism. In recent decades, bile acids have also been shown to function as signaling molecules via interacting with various receptors. Bile acids circulate continuously through the enterohepatic circulation and go through microbial transformation by gut microbes, and thus bile acids metabolism has profound effects on the liver and intestinal tissues as well as the gut microbiota. Farnesoid X receptor and G protein-coupled bile acid receptor 1 are two pivotal bile acid receptors that highly expressed in the intestinal tissues, and they have emerged as pivotal regulators in bile acids metabolism,innate immunity and inflammatory responses. There is considerable interest in manipulating the metabolism of bile acids and the expression of bile acid receptors as this may be a promising strategy to regulate intestinal health and disease. This review aims to summarize the roles of bile acids and their receptors in regulation of gut health and diseases.