Research Project: Energy Regulation and Obesity

Location: Jean Mayer Human Nutrition Research Center On Aging

Publications (Clicking on the reprint icon will take you to the publication reprint.)

Akkermansia muciniphila abundance is lower in severe obesity but its increased level after bariatric surgery is not associated with metabolic health improvement - (Peer Reviewed Journal)
Dao, C., Belda, E., Prifti, E., Everard, A., Kayser, B., Bouillot, J., Chevallier, J., Pons, N., Le Chatelier, E., Ehrlich, D., Dore, J., Aron-Wisnewsky, J., Zucker, J., Cani, P.D., Clement, K. 2019. Akkermansia muciniphila abundance is lower in severe obesity but its increased level after bariatric surgery is not associated with metabolic health improvement. American Journal of Clinical Nutrition. https://doi.org/10.1152/ajpendo.00140.2019.

Different and unequal: a qualitative evaluation of salient factors influencing energy intake in adults with overweight and obesity - (Peer Reviewed Journal)
Dao, M.C., Messer, E., Conigliaro, T., Sakaida, K., Ouellette, A.F., Himaras, V., Thiron, S., Roberts, S.B. 2019. Different and unequal: a qualitative evaluation of salient factors influencing energy intake in adults with overweight and obesity. Nutrients. 11(6). https://doi.org/10.3390/nu11061365.

2 years of calorie restriction and cardiometabolic risk (CALERIE): exploratory outcomes of a multicentre, phase 2, randomised controlled trial - (Peer Reviewed Journal)
Kraus, W.E., Bhapkar, M., Huffman, K.M., Pieper, C.F., Das, S., Redman, L.M., Villareal, D.T., Rochon, J., Roberts, S., Ravussin, E., Holloszy, J.O., Fontana, L. 2019. 2 years of calorie restriction and cardiometabolic risk (CALERIE): exploratory outcomes of a multicentre, phase 2, randomised controlled trial. Lancet Diabetes Endocrinology. https://doi.org/10.1016/S2213-8587(19)30151-2.

Development of a videoconference-adapted version of the community Diabetes Prevention Program, and comparison of weight loss with in-person program delivery - (Peer Reviewed Journal)
Taetzsch, A.G., Gilhooly, C., Bukhari, A., Das, S., Martin, E., Hatch, A.M., Silver, R., Montain, S.J., Roberts, S. 2019. Development of a videoconference-adapted version of the community Diabetes Prevention Program, and comparison of weight loss with in-person program delivery. Military Medicine. https://doi.org/10.1093/milmed/usz069.

A data integration multi-omics approach to study calorie restriction-induced changes in insulin sensitivity - (Peer Reviewed Journal)
Dao, C.M., Sokolovska, N., Brazeilles, R., Affeldt, S., Pelloux, V., Prifti, E., Chilloux, J., Verger, E.O., Kayser, B., Aron-Wisnewsky, J., Ichou, F., Pujos-Guillot, E., Hoyles, L., Juste, C., Dore, J., Dumas, M., Rizkalla, S.W., Holmes, B.A., Zucker, J., Clement, K. 2019. A data integration multi-omics approach to study calorie restriction-induced changes in insulin sensitivity. Frontiers in Physiology. 9:1958. https://doi.org/10.3389/fphys.2018.01958.

Fast-food offerings in the United States in 1986, 1991, and 2016 show large increases in food variety, portion size, dietary energy, and selected micronutrients - (Review Article)
McCrory, M.A., Harbaugh, A.G., Appeadu, S., Roberts, S.B. 2019. Fast-food offerings in the United States in 1986, 1991, and 2016 show large increases in food variety, portion size, dietary energy, and selected micronutrients. Journal of the Academy of Nutrition and Dietetics. 119(6):923-933. https://doi.org/10.1016/j.jand.2018.12.004.

Are gluten-free diets more nutritious? An evaluation of self-selected and recommended gluten-free and gluten-containing dietary patterns - (Review Article)
Taetzsch, A.G., Das Sai, K., Brown, C., Krauss, A., Silver, R.E., Roberts, S. 2018. Are gluten-free diets more nutritious? An evaluation of self-selected and recommended gluten-free and gluten-containing dietary patterns. Nutrients. 10(12). https://doi.org/10.3390/nu10121881.

Measured energy content of frequently purchased restaurant meals: multi-country cross sectional study - (Peer Reviewed Journal)
Roberts, S., Das, S., Suen, V.M., Pihlajamaki, J., Kuriyan, R., Steiner-Asiedu, M., Taetzsch, A.G., Anderson, A.K., Silver, R.E., Barger, K., Krauss, A.J., Karhunen, L., Zhang, X., Hambly, C., Schwab, U., Melo, A.T., Fassini, P.G., Taylor, S.F., Economos, C., Kurpad, A.V., Speakman, J.R. 2018. Measured energy content of frequently purchased restaurant meals: multi-country cross sectional study. British Medical Journal. 363:k4864. https://doi.org/10.1136/bmj.k4864.

Dietary assessment toolkits: an overview - (Review Article)
Dao, M.C., Subar, A.F., Warthon-Medina, M., Cade, J.E., Burrows, T., Golley, R.K., Forouhi, N.G., Pearce, M., Homes, B.A. 2018. Dietary assessment toolkits: an overview. Public Health Nutrition. https://doi.org/10.1017/S1368980018002951.

Dietary intake and physical activity assessment: current tools, techniques, and technologies for use in adult population - (Review Article)
McClung, H.L., Ptomey, L.T., Shook, R.P., Aggarwal, A., Gorczyca, A.M., Sazonov, E.S., Becofsky, K., Weiss, R., Das, S. 2018. Dietary intake and physical activity assessment: current tools, techniques, and technologies for use in adult population. American Journal of Preventive Medicine. 55(4):e93-e104. https://doi.org/10.1016/j.amepre.2018.06.011.

Diet and activity assessments and interventions using technology in older adults - (Review Article)
Takemoto, M., Manini, T.M., Rosenberg, D.E., Lazar, A., Zlatar, Z.Z., Das, S., Kerr, J. 2018. Diet and activity assessments and interventions using technology in older adults. American Journal of Preventive Medicine. 55(4):e105-e115. https://doi.org/10.1016/j.amepre.2018.06.005.

Making progress on the global crisis of obesity and weight management - (Review Article)
Lean, M.E., Astrup, A., Roberts, S. 2018. Making progress on the global crisis of obesity and weight management. British Medical Journal. 361:k2538. https://doi.org/10.1136/bmj.k2538.

Effectiveness of an energy management training course on employee well-being: a randomized controlled trial - (Peer Reviewed Journal)
Das, S., Mason, S.T., Vail, T.A., Rogers, G.T., Livingston, K.A., Whelan, J.G., Chin, M.K., Blanchard, C.M., Turgiss, J.L., Roberts, S.B. 2018. Effectiveness of an energy management training course on employee well-being: a randomized controlled trial. American Journal of Health Promotion. https://doi.org/10.1177/0890117118776875.

CDK6 inhibits white to beige fat transition by suppressing RUNX1 - (Peer Reviewed Journal)
Hou, X., Zhang, Y., Li, W., Hu, A.J., Luo, C., Zhou, W., Hu, J.K., Daniele, S.G., Wang, J., Sheng, J., Fan, Y., Greenberg, A., Farmer, S.R., Hu, M.G. 2018. CDK6 inhibits white to beige fat transition by suppressing RUNX1. Nature Communications. 9:1023. https://doi.org/10.1038/s41467-018-03451-1.

Accumulating Data to Optimally Predict Obesity Treatment (ADOPT) core measures: behavioral domain - (Peer Reviewed Journal)
Lytle, L.A., Nicastro, H.L., Roberts, S., Evans, M.R., Jakicic, J.M., Laposky, A.D., Loria, C.M. 2018. Accumulating Data to Optimally Predict Obesity Treatment (ADOPT) core measures: behavioral domain. Obesity. 26(2):S16-S23. https://doi.org/10.1002/oby.22157.

A role for long-chain acyl-CoA synthetase-4 (ACSL4) in diet-induced phospholipid remodeling and obesity-associated adipocyte dysfunction - (Peer Reviewed Journal)
Killion, E.A., Reeves, A.R., El Azzouny, M.A., Yan, Q., Surujon, D., Griffin, J.D., Bowman, T.A., Wang, C., Matthan, N.R., Klett, E.L., Kong, D., Newman, J.W., Han, X., Lee, M., Coleman, R.A., Greenberg, A.S. 2018. A role for long-chain acyl-CoA synthetase-4 (ACSL4) in diet-induced phospholipid remodeling and obesity-associated adipocyte dysfunction. Molecular Metabolism. 9:43-56. https://doi.org/10.1016/j.molmet.2018.01.012.

Vegan diets - (Book / Chapter)
Das, S., Karlsen, M.C., Blanchard, C., Roberts, S. 2018. Vegan diets. In: Apovian, C., Brouillard, L., Young, L., editors. Vegan Diet. Philadelphia, PA: Taylor & Francis Group. p. 99-112.

Effects of 2 years of caloric restriction on oxidative status assessed by urinary F2-isoprostanes: the CALERIE 2 randomized clinical trial - (Peer Reviewed Journal)
Il'yasova, D., Fontana, L., Bhapkar, M., Pieper, C.F., Spasojevic, I., Redman, L.M., Das, S., Huffman, K.M., Kraus, W.E. 2018. Effects of 2 years of caloric restriction on oxidative status assessed by urinary F2-isoprostanes: the CALERIE 2 randomized clinical trial. Aging Cell. 17(2):e12719. https://doi.org/10.1111/acel.12719.

Gut microbiota and obesity: concepts relevant to clinical care - (Review Article)
Dao, C.M., Clement, K. 2017. Gut microbiota and obesity: concepts relevant to clinical care. European Journal of Internal Medicine. 48:18-24. https://doi.org/10.1016/j.ejim.2017.10.005.

Effects of two years of calorie restriction on aerobic capacity and muscle strength - (Peer Reviewed Journal)
Racette, S.B., Rochon, J., Uhrich, M.L., Villareal, D.T., Das, S.K., Fontana, L., Bhapkar, M., Martin, C.K., Redman, L.M., Fuss, P.J., Roberts, S.B., Kraus, W.E. 2017. Effects of two years of calorie restriction on aerobic capacity and muscle strength. Medicine and Science in Sports and Exercise. 49(11):2240-2249. https://doi.org/10.1249/MSS.0000000000001353.

Nutrition modulation of human aging: the calorie restriction paradigm - (Review Article)
Das, S., Balasubramanian, P., Weerasekera, Y.K. 2017. Nutrition modulation of human aging: the calorie restriction paradigm. Molecular and Cellular Endocrinology. 455:148-157. https://doi.org/10.1016/j.mce.2017.04.011.

Substituting whole grains for refined grains in a 6-week randomized trial favorably affects energy balance parameters in healthy men and post-menopausal women - (Peer Reviewed Journal)
Karl, J.P., Meydani, M., Barnett, J.B., Vanegas, S.M., Goldin, B., Rasmussen, H., Saltzman, E., Chen, C., Das, S., Jonnalagadda, S.S., Meydani, S.N., Roberts, S.B. 2017. Substituting whole grains for refined grains in a 6-week randomized trial favorably affects energy balance parameters in healthy men and post-menopausal women. American Journal of Clinical Nutrition. 105:589-599. doi: 10.3945/ajcn.116.139683.

Dietary substitution of whole grains for refined grains favorably effects fiber intake and energy metabolism in adults - (Abstract Only)
Karl, J., Meydani, M., Barnett, J., Vanegas, S., Goldin, B., Rasmussen, H., Saltzman, E., Jonnalagadda, S.S., Meydani, S.N., Roberts, S. 2016. Dietary substitution of whole grains for refined grains favorably effects fiber intake and energy metabolism in adult [abstract]. Journal of Federation of American Societies for Experimental Biology. 30:1 Supplement 405.3.

Effectiveness of workplace weight management interventions: a systematic review - (Review Article)
Kumari, Y.P., Roberts, S., Kahn, M.A., LaVertu, A.E., Das, S. 2016. Effectiveness of workplace weight management interventions: a systematic review. Current Obesity Reports. 5:298-306. https://doi.org/10.1007/s13679-016-0205-z.

Effect of calorie restriction on mood, quality of life, sleep, and sexual function in healthy nonobese adults: the CALERIE 2 randomized clinical trial - (Peer Reviewed Journal)
Martin, C.K., Bhapkar, M., Pittas, A.G., Pieper, C.F., Das, S., Williamson, D.A., Scott, T., Redman, L.M., Stein, R., Gilhooly, C.H., Stewart, T., Robinson, L., Roberts, S.B. 2016. Effect of calorie restriction on mood, quality of life, sleep, and sexual function in healthy nonobese adults: the CALERIE 2 randomized clinical trial. Internal Medicine. 176(6):743-752. https://doi.org/10.1001/jamainternmed.2016.1189.

Energy contents of frequently ordered restaurant meals and comparison with human energy requirements and US Department of Agriculture database information: a multisite randomized study - (Peer Reviewed Journal)
Urban, L.E., Weber, J.L., Heyman, M.B., Schichtl, R.L., Verstraete, S., Lowery, N.S., Das, S., Schleicher, M.M., Rogers, G., Economos, C., Masters, W.A., Roberts, S. 2016. Energy contents of frequently ordered restaurant meals and comparison with human energy requirements and US Department of Agriculture database information: a multisite randomized study. Journal of the Academy of Nutrition and Dietetics. 116(4):590-598. https://doi.org/10.1016/j.jand.2015.11.009.

Effects of carbohydrate quantity and glycemic index on resting metabolic rate and body composition during weight loss - (Peer Reviewed Journal)
Karl, J.P., Roberts, S.B., Schaefer, E.J., Gleason, J.A., Fuss, P., Rasmussen, H., Saltzman, E., Das, S. 2015. Effects of carbohydrate quantity and glycemic index on resting metabolic rate and body composition during weight loss. Obesity. 23(11):2190-2198.

One strike against low-carbohydrate diets - (Other)
Roberts, S.B., Das, S. 2015. One strike against low-carbohydrate diets. Cell Metabolism. 22(3):357-358.

Characterization of the proteome of cytoplasmic lipid droplets in mouse enterocytes after a dietary fat challenge - (Peer Reviewed Journal)
D'Aguila, T., Sirohi, D., Grabowski, J.M., Hedrick, V.E., Paul, L.N., Greenberg, A., Kuhn, R.J., Buhman, K.K. 2015. Characterization of the proteome of cytoplasmic lipid droplets in mouse enterocytes after a dietary fat challenge. PLoS One. 10(5):e0126823. https://doi.org/10.1371/journal.pone.0126823.

Pilot randomized trial demonstrating reversal of obesity-related abnormalities in reward system responsivity to food cues with a behavioral intervention - (Peer Reviewed Journal)
Deckersbach, T., Das, S., Urgan, L.E., Salindardi, T., Batra, P., Rodman, A.M., Arulpragasam, A.R., Dougherty, D., Roberts, S. 2014. Pilot randomized trial demonstrating reversal of obesity-related abnormalities in reward system responsivity to food cues with a behavioral intervention. Nutrition and Diabetes. 4:e129. https://doi.org/10.1038/nutd.2014.26.