Location: Jean Mayer Human Nutrition Research Center On Aging
2017 Annual Report
Accomplishments
1. Drinking sugar-sweetened beverages increases risk of diabetes. Evidence suggests that consumption of sugar-sweetened beverages (SSB), such as soda and fruit-flavored drinks, is associated with increased risk of type 2 diabetes and may contribute to weight gain. Using a meta-analysis of 22 large cohorts within the CHARGE (Cohorts for Heart and Aging Research in Genomic Epidemiology) consortium, ARS-funded researchers in Boston, Massachusetts found a significant association between long-term sugar-sweetened beverage consumption and higher fasting glucose and insulin levels related to increased risk for type 2 diabetes and heart disease. These findings may lead to greater awareness of the dangers of SSBs and new dietary recommendations which may reduce diabetes and other cardiovascular disease.
2. Dairy foods are differentially associated with incidence of prediabetes and progression to type 2 diabetes. Dairy intake in relation to chronic diseases, such as type 2 diabetes, has been a topic of interest for nutrition researchers for many years, but the evidence about dairy's relationship with health and disease remains inconsistent. With this mixed evidence in mind, ARS-funded researchers in Boston, Massachusetts, undertook a study to see whether consumption of different dairy (from cows’ milk only) foods was related to risk of developing type 2 diabetes, a chronic disease that affects an estimated 1 in 3 Americans. In both participants with and without prediabetes, intake of dairy products was associated with a decreased risk of developing diabetes or prediabetes, respectively. Researchers also found that the type of dairy most beneficial in lowering risk of prediabetes or diabetes may depend on an individual's metabolic health status. These findings could inform diet recommendations for individuals at high risk for developing prediabetes.
Review Publications
Ma, J., Jacques, P.F., Meigs, J.B., Fox, C.S., Rogers, G., Smith, C.E., Hurby, A., Saltzman, E., Mckeown, N. 2016. Sugar-sweetened beverage but not diet soda consumption is positively associated with progression of insulin resistance and prediabetes. Journal of Nutrition. doi: 10.3945/jn.116.234047.
Costello, R.B., Elin, R.J., Rosanoff, A., Wallace, T.C., Guerrero-Romero, F., Hruby, A., Lutsey, P.L., Nielsen, F.H., Rodgriguez-Moran, M., Song, Y., Van Horn, L.V. 2016. The case for an evidence based reference interval for serum magnesium - The time has come. Advances in Nutrition. doi: 10.3945/an.116.012765.
Karakis, I., Pase, M.P., Beiser, A., Booth, S.L., Jacques, P.F., Rogers, G., Decarli, C., Vasan, R.S., Wang, T.J., Himali, J., Annweiler, C., Seshadri, S. 2016. Association of serum vitamin D with the risk of incident dementia and subclinical indices of brain aging the framingham heart study. Journal of Alzheimer's Disease. doi: 10.3233/JAD-150991.
Perry III, C.S., Thomas, A.K., Taylor, H.A., Jacques, P.F., Kanarek, R.B. 2016. The impact of caffeine use across the lifespan on cognitive performance in elderly women. Appetite. doi: 10.1016/j.appet.2016.07.028.
Staffier, K.L., Chung, M., Sawicki, C., Lyle, B.J., Wang, D., Roberts, S., McKeown, N.M. 2016. Development of a publicly available, comprehensive database of fiber and health outcomes: rationale and methods. PLoS One. doi: 10.1371/journal.pone.0156961.
Ma, J., Jacques, P.F., Hwang, S., Troy, L.M., McKeown, N.M., Chu, A.Y., Fox, C.S. 2016. Dietary guideline adherence index and kidney measures in the framingham heart study. American Journal of Kidney Diseases. doi: 10.1053/j.ajkd.2016.04.015.
Makarem, N., Lin, Y., Bandera, E.V., Jacques, P.F., Parekh, N. 2015. Concordance with World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) guidelines for cancer prevention and obesity-related cancer risk in the Framingham Offspring cohort (1991-2008). Cancer Causes and Control. 26(2):277-286.
Jarolim, P., Claggett, B., Conrad, M.J., Carpenter, M.A., Invanova, A., Bostom, A.G., Kusek, J.W., Hunsicker, H.G., Jacques, P.F., Gravens-Mueller, L., Finn, P., Solomon, S.D., Weiner, D.E., Levey, A.S., Pfeffer, M.A. 2016. B-type natriuretic peptide and cardiac troponin I are associated with adverse outcomes in stable kidney transplant recipients. Transplantation. doi: 10.1097/TP.0000000000001080.
Dai, Z., Niu, J., Zhang, Y., Jacques, P.F., Felson, D.T. 2017. Dietary intake of fiber and risk of knee osteoarthritis in two U.S. prospective cohorts. Annals of the Rheumatic Diseases. doi: 10.1136/annrheumdis-2016-210810.
McRorie, J.W., McKeown, N.M. 2017. Understanding the physics of functional fibers in the gastrointestinal tract: an evidence-based approach to resolving enduring misconceptions about insoluble and soluble fiber. Journal of the Academy of Nutrition and Dietetics. doi: 10.1016/j.jand.2016.09.021.
