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United States Department of Agriculture

Agricultural Research Service

Related Topics

Research Project: Impact of Early Dietary Factors on Child Development and Health

Location: Arkansas Children's Nutrition Center

Publications (Clicking on the reprint icon Reprint Icon will take you to the publication reprint.)

High fat, high fructose, high cholesterol feeding causes severe NASH and cecal microbiota dysbiosis in juvenile Ossabaw swine - (Peer Reviewed Journal)

Anesthesia and bariatric surgery gut preparation alter plasma acylcarnitines reflective of mitochondrial fat and branched-chain amino acid oxidation - (Peer Reviewed Journal)
Bhattacharyya, S., Ali, M., Smith, W.H., Minkler, P.E., Stoll, M.S., Hoppel, C.L., Adams, S.H. 2017. Anesthesia and bariatric surgery gut preparation alter plasma acylcarnitines reflective of mitochondrial fat and branched-chain amino acid oxidation. American Journal of Physiology - Endocrinology and Metabolism. doi:10.1152/ajpendo.00222.2017.

Gestational age at birth and brain white matter development in term-born infants and children - (Peer Reviewed Journal)

Maternal obesity and gestational weight gain are modestly associated with umbilical cord DNA methylation - (Peer Reviewed Journal)
Thakali, K.M., Jennifer B Faske, J.B., Ishwar, A., Alfaro, M.P., Cleves, M.A., Badger, T.M., Andres, A., Shankar, K. 2017. Maternal obesity and gestational weight gain are modestly associated with umbilical cord DNA methylation. Placenta. Available: https://doi.org/10.1016/j.placenta.2017.07.009.

Formula diet driven microbiota shifts tryptophan metabolism from serotonin to tryptamine in neonatal porcine colon - (Peer Reviewed Journal)
Saraf, M.K., Piccolo, B.D., Bowlin, A.K., Mercer, K.E., Leroith, T., Chintapalli, S.V., Shankar, K., Badger, T.M., Yeruva, L. 2017. Formula diet driven microbiota shifts tryptophan metabolism from serotonin to tryptamine in neonatal porcine colon. BMC Microbiome. 5:77. doi:10.1186/s40168-017-0297-z.

Early postnatal diets affect the bioregional small intestine microbiome and ileal metabolome in neonatal piglets - (Peer Reviewed Journal)
Piccolo, B.D., Mercer, K.E., Bhattacharya, S., Bowlin, A.K., Saraf, M.K., Pack, L., Chintapalli, S.V., Shankar, K., Adams, S.H., Badger, T.M., Yeruva, L. 2017. Early postnatal diets affect the bioregional small intestine microbiome and ileal metabolome in neonatal piglets. Journal of Nutrition. doi:10.3945/jn.117.252767.

Soy compared with milk protein in a western diet changes fecal microbiota and decreases hepatic steatosis in obese OLETF rats - (Peer Reviewed Journal)
Panasevich, M.R., Schuster, C.M., Phillips, K.E., Meers, G., Chintapalli, S.V., Wankhade, U.D., Shankar, K., Butteiger, D.N., Krul, E., Thyfault, J.P., Rector, R.S. 2017. Soy compared with milk protein in a western diet changes fecal microbiota and decreases hepatic steatosis in obese OLETF rats. Journal of Nutritional Biochemistry. 46:125-136. doi:10.1016/j.jnutbio.2017.05.004.

Dynamic assessment of microbial ecology (DAME): A shiny app for analysis and visualization of microbial sequencing data - (Abstract Only)

Neonatal diet composition modulates ileum mitochondrial function in a neonatal pig model Eugenia Carvalho1 - (Abstract Only)
Carvalho, E., Moreira, A.R., Bowlin, A.K., Saraf, M.K., Adams, S.H., Borsheim, E., Yeruva, L. 2017. Neonatal diet composition modulates ileum mitochondrial function in a neonatal pig model Eugenia Carvalho1. Journal of Federation of American Societies for Experimental Biology. 31:654.1.

Early diet has differential effects on the small intestine microbiome by region in neonatal piglets - (Abstract Only)
Piccolo, B., Bowlin, A., Saraf, M., Mercer, K., Bhattacharya, S., Chintapalli, S., Adams, S.H., Shankar, K., Badger, T.M., Yeruva, L. 2017. Early diet has differential effects on the small intestine microbiome by region in neonatal piglets. Journal of Federation of American Societies for Experimental Biology. 31:444.1.

Transcriptome analysis reveals persistent effects of neonatal diet on small intestine gene expression profile in a porcine model - (Abstract Only)
Saraf, M.K., Bowlin, A.K., Chen, C.T., Dawson, H.D., Badger, T.M., Yeruva, L. 2017. Transcriptome analysis reveals persistent effects of neonatal diet on small intestine gene expression profile in a porcine model. Journal of Federation of American Societies for Experimental Biology. 31:434.5.

Human breast milk feeding induces stronger humoral immune response than formula feeding in neonatal porcine model - (Abstract Only)
Yeruva, L., Saraf, M.K., Bowlin, A.K., Badger, T.M. 2017. Human breast milk feeding induces stronger humoral immune response than formula feeding in neonatal porcine model. Journal of Federation of American Societies for Experimental Biology. 31:434.6.

Enhanced offspring predisposition to steatohepatitis with maternal high-fat diet is associated with epigenetic and microbiome alterations - (Peer Reviewed Journal)
Wankhade, U.D., Zhong, Y., Kang, P., Alfaro, M., Chintapalli, S.V., Thakali, K.M., Shankar, K. 2017. Enhanced offspring predisposition to steatohepatitis with maternal high-fat diet is associated with epigenetic and microbiome alterations. PLoS One. 12(4):e0175675. doi:10.1371/journal.pone.0175675.

Obesity modulates inflammation and lipid metabolism oocyte gene expression: A single cell transcriptome perspective - (Peer Reviewed Journal)
Ruebel, M.L., Cotter, M., Sims, C.R., Moutos, D.M., Badger, T.M., Cleves, M.A., Kartik, S., Andres, A. 2017. Obesity modulates inflammation and lipid metabolism oocyte gene expression: A single cell transcriptome perspective. Journal of Clinical Endocrinology and Metabolism. doi:10.1210/jc.2016-3524.

Associations among the cecal microbiome and bacterially-derived cecal xeno-metabolites during diabetes progression in the UC Davis-Type 2 diabetes rat model - (Abstract Only)

Increased physical activity ameliorates high fat diet-induced bone resorption in mice - (Abstract Only)
Chen, J., Lazarenko, O.P., Blackburn, M.L., Carvalho, E., Shankar, K., Borsheim, E. 2017. Increased physical activity ameliorates high fat diet-induced bone resorption in mice. Journal of Federation of American Societies for Experimental Biology. 31(1):799.2.

First trimester maternal adiposity is associated with infant body fat at age 2 weeks: A longitudinal follow-up study - (Abstract Only)
Andres, A., Ruebel, M., Krukoswski, R., Badger, T.M., Shankar, K., Cleves, M. 2017. First trimester maternal adiposity is associated with infant body fat at age 2 weeks: A longitudinal follow-up study. Journal of Federation of American Societies for Experimental Biology. 31:958.24.

Developmental changes in resting gamma power from age three months to five years are modulated by infant diet - (Abstract Only)
Pivik, R.T., Andres, A., Cleves, M.A., Tennal, K.B., Gu, Y., Badger, T.M. 2017. Developmental changes in resting gamma power from age three months to five years are modulated by infant diet. Journal of Federation of American Societies for Experimental Biology. 31:958.9.

Infant formula feeding alters the proliferative status of neonatal mammary glands independent of estrogen signaling - (Abstract Only)
Bhattacharyya, S., Mercer, K.E., Hennings, L., Sharma, N., Chaudhury, M., Yeruva, L., Ronis, M., Badger, T.M. 2017. Infant formula feeding alters the proliferative status of neonatal mammary glands independent of estrogen signaling. Journal of Federation of American Societies for Experimental Biology. 31:792.11.

Male testicular development is affected by estrogens but not altered in neonatal piglets receiving soy infant formula - (Abstract Only)
Mercer, K.E., Chen, C.T., Hennings, L., Sharma, N., Dawson, H.D., Yeruva, L., Ronis, M., Badger, T.M. 2017. Male testicular development is affected by estrogens but not altered in neonatal piglets receiving soy infant formula. Federation of American Societies for Experimental Biology Conference. 31:792.5.

Native whey induces higher and faster leucinemia than other whey protein supplements and milk: A randomized controlled trial - (Peer Reviewed Journal)
Hamarsland, H., Larsen Laahne, J., Paulsen, G., Cotter, M., Borsheim, E., Raastad, T. 2017. Native whey induces higher and faster leucinemia than other whey protein supplements and milk: A randomized controlled trial. Biomed Central (BMC) Nutrition. 3:10. doi:10.1186/s40795-017-0131-9.

Effects of early cholesterol intake on cholesterol 7 alpha hydroxylase (Cyp7a1) expression in piglets receiving sow's breast milk or infant formula until weaning - (Abstract Only)

Application of an in vivo hepatic triacylglycerol production method in the setting of a high fat diet in mice - (Peer Reviewed Journal)
Ono-Moore, K.D., Ferguson, M., Blackburn, M.L., Issafras, H., Adams, S.H. 2016. Application of an in vivo hepatic triacylglycerol production method in the setting of a high fat diet in mice. Nutrients. 9(1):16. doi:10.3390/nu9010016.

Placental transcriptome co-expression analysis reveals conserved regulatory program across gestation - (Peer Reviewed Journal)
Buckberry, S., Bianco-Miotto, T., Bent, S.J., Clifton, V., Shoubridge, C., Shankar, K., Roberts, C.T. 2017. Placental transcriptome co-expression analysis reveals conserved regulatory program across gestation. BMC Genomics. 18(1):10. doi:10.1186/s12864-016-3384-9.

Obesity and pregnancy: Mechanisms of short term and long term adverse consequences for mother and child - (Review Article)
Catalano, P.M., Shankar, K. 2017. Obesity and pregnancy: Mechanisms of short term and long term adverse consequences for mother and child. British Medical Journal. doi:10.1136/bmj.j1.

Soy protein isolate inhibits hepatic tumor promotion in mice fed a high-fat liquid diet - (Peer Reviewed Journal)
Mercer, K., Pulliam, C.F., Brint, K., Hennings, L., Ronis, M.J. 2017. Soy protein isolate inhibits hepatic tumor promotion in mice fed a high-fat liquid diet. Experimental Biology and Medicine. 242(6):635-644. doi:10.1177/1535370216685436.

Novel browning agents, mechanisms and therapeutic potentials of brown adipose tissue - (Review Article)
Wankhade, U.D., Shen, M., Yadav, H., Thakali, K.M. 2016. Novel browning agents, mechanisms and therapeutic potentials of brown adipose tissue. BioMed Research International. 2016:Article ID 2365609. Available: doi.10.1155/2016/2365609.

Are early first trimester weights valid proxies for preconception weight? - (Peer Reviewed Journal)
Krukowski, R.A., West, D.S., DiCarlo, M., Shankar, K., Cleves, M.A., Saylors, M.E., Andres, A. 2016. Are early first trimester weights valid proxies for preconception weight? BMC Pregnancy & Childbirth. 16:357. doi:10.1186/s12884-016-1159-6.

A novel amino acid and metabolomics signature in mice overexpressing muscle uncoupling protein 3 - (Peer Reviewed Journal)
Aguer, C., Piccolo, B., Fiehn, O., Adams, S.H., Harper, M. 2016. A novel amino acid and metabolomics signature in mice overexpressing muscle uncoupling protein 3. Journal of Federation of American Societies for Experimental Biology. doi:10.1096/fj.201600914R.

Global deletion of glutathione S-Transferase A4 exacerbates developmental nonalcoholic steatohepatitis - (Peer Reviewed Journal)
Ronis, M.J., Mercer, K.E., Engi, B., Pulliam, C., Zimniak, P., Hennings, L., Shearn, C.T., Badger, T.M., Petersen, D.R. 2017. Global deletion of glutathione S-Transferase A4 exacerbates developmental nonalcoholic steatohepatitis. American Journal of Pathology. 187(2):418-430.

Acylcarnitines as markers of exercise-associated fuel partitioning, xenometabolism, and potential signals to muscle afferent neurons - (Peer Reviewed Journal)
Zhang, J., Light, A.R., Hoppel, C.L., Campbell, C., Chandler, C.J., Burnett, D.J., Souza, E.C., Casazza, G.A., Hughen, R.W., Keim, N.L., Newman, J.W., Hunter, G.R., Fernandez, J.R., Garvey, W.T., Harper, M., Fiehn, O., Adams, S.H. 2017. Acylcarnitines as markers of exercise-associated fuel partitioning, xenometabolism, and potential signals to muscle afferent neurons. Experimental Physiology. 102(1):48-69. doi:10.1113/EP086019..

Novel molecular interactions of acylcarnitines and fatty acids with myoglobin - (Peer Reviewed Journal)
Chintapalli, S.V., Jayanthi, S., Mallipeddi, P.L., Gundampati, R.K., Suresh Kumar, T.K., Van Rossum, D.B., Anishkin, A., Adams, S.H. 2016. Novel molecular interactions of acylcarnitines and fatty acids with myoglobin. Journal of Biological Chemistry. 291(48):25133-25143. doi:10.1074/jbc.M116.754978.

Association of gestational weight gain expectations with advice on actual weight gain - (Peer Reviewed Journal)
Krukowski, R.A., West, D.S., Dicarlo, M., Cleves, M.A., Saylors, M.E., Andres, A. 2017. Association of gestational weight gain expectations with advice on actual weight gain. Obstetrics & Gynecology. 129(1):76-82. doi:10.1097/AOG.0000000000001780.

Mice fed a high-fat diet supplemented with resistant starch display marked shifts in the liver metabolome concurrent with altered gut bacteria - (Peer Reviewed Journal)
Kieffer, D.A., Piccolo, B.D., Marco, M.L., Kim, E., Goodson, M.L., Keenan, M.J., Dunn, T.N., Knudsen, K., Martin, R.J., Adams, S.H. 2016. Mice fed a high-fat diet supplemented with resistant starch display marked shifts in the liver metabolome concurrent with altered gut bacteria. Journal of Nutrition. doi:10.3945/jn.116.238931.

Obese mice fed a diet supplemented with enzyme-treated wheat bran display marked shifts in the liver metabolome concurrent with altered gut bacteria - (Peer Reviewed Journal)
Kieffer, D.A., Piccolo, B.D., Marco, M.L., Kim, E., Goodson, M.L., Keenan, M.J., Dunn, T.N., Knudsen, K.E., Adams, S.H., Martin, R.J. 2016. Obese mice fed a diet supplemented with enzyme-treated wheat bran display marked shifts in the liver metabolome concurrent with altered gut bacteria. Journal of Nutrition. doi:10.3945/jn.116.238923.

Maternal obesity programs senescence signaling and glucose metabolism in osteo-progenitors from rat and human - (Peer Reviewed Journal)
Chen, J., Lazarenko, O.P., Blackburn, M.L., Rose, S., Frye, R.E., Badger, T.M., Andres, A., Shankar, K. 2016. Maternal obesity programs senescence signaling and glucose metabolism in osteo-progenitors from rat and human. Endocrinology. 157(11):4172-4183. doi:10.1210/en.2016-1408.

Dietary factors during early life program bone formation in female rats - (Peer Reviewed Journal)
Chen, J., Lazarenko, O.P., Blackburn, M.L., Shankar, K. 2017. Dietary factors during early life program bone formation in female rats. Federation of American Societies for Experimental Biology Conference. 31(1):376-387. doi:10.1096/fj.201600703R.

Differences in brain functional connectivity at resting state in neonates born to healthy obese or normal-weight mothers - (Peer Reviewed Journal)
Ou, X., Li, X., Zhang, Y., Andres, A., Pivik, R.T., Glasier, C., Ramakrishnaiah, R., Badger, T., Shankar, K. 2016. Differences in brain functional connectivity at resting state in neonates born to healthy obese or normal-weight mothers. International Journal of Obesity. doi:10.1038/ijo.2016.166.

Profiling of urinary bile acids in piglets by a combination of enzymatic deconjugation and targeted LC-MRM-MS - (Peer Reviewed Journal)
Fang, N., Yu, S., Adams, S.H., Ronis, M.J., Badger, T.M. 2016. Profiling of urinary bile acids in piglets by a combination of enzymatic deconjugation and targeted LC-MRM-MS. Journal of Lipid Research. doi:10.1194/jlr.D069831.

Impact of dietary fibers on nutrient management and detoxification organs: Gut, liver, and kidneys - (Review Article)
Kieffer, D., Martin, R.J., Adams, S.H. 2016. Impact of dietary fibers on nutrient management and detoxification organs: Gut, liver, and kidneys. Advances in Nutrition. 7(6):1111-1121. doi:10.3945/an.116.013219.

A behavioral intervention to reduce excessive gestational weight gain - (Peer Reviewed Journal)
Krukowski, R.A., West, D., Dicarlo, M., Shankar, K., Cleves, M.A., Tedford, E., Andres, A. 2016. A behavioral intervention to reduce excessive gestational weight gain. Maternal and Child Health Journal. DOI 10.1007/s10995-016-2127-5.

Persistent influence of maternal obesity on offspring health: Mechanisms from animal models and clinical studies - (Review Article)
Wankhade, U.D., Thakali, K.M., Shankar, K. 2016. Persistent influence of maternal obesity on offspring health: Mechanisms from animal models and clinical studies. Molecular and Cellular Endocrinology. doi: 10.1016/j.mce.2016.07.001.

Gut microbiota are linked to increased susceptibility to hepatic steatosis in low aerobic capacity rats fed an acute high fat diet - (Peer Reviewed Journal)
Panasevich, M.R., Morris, E.M., Chintapalli, S.V., Wankhade, U.D., Shankar, K., Britton, S.L., Koch, L.G., Thyfault, J.P., Rector, R.S. 2016. Gut microbiota are linked to increased susceptibility to hepatic steatosis in low aerobic capacity rats fed an acute high fat diet. American Journal of Physiology - Gastrointestinal and Liver Physiology. 311(1):G166-G179. doi: 10.1152/ajpgi.00065.2016.

Maternal obesity is associated with ovarian inflammation and up-regulation of early growth response factor 1 - (Peer Reviewed Journal)
Ruebel, M., Shankar, K., Gaddy, D., Lindsey, F., Badger, T.M., Andres, A. 2016. Maternal obesity is associated with ovarian inflammation and up-regulation of early growth response factor 1. American Journal of Physiology - Endocrinology and Metabolism. 311(1):E269-E277. doi: 10.1152/ajpendo.00524.2015.

Infant diet-related changes in syllable processing between 4 and 5 months: Implications for developing native language sensitivity - (Peer Reviewed Journal)
Pivik, T.R., Andres, A., Bai, S., Cleves, M.A., Tennal, K.B., Gu, Y., Badger, T.M. 2016. Infant diet-related changes in syllable processing between 4 and 5 months: Implications for developing native language sensitivity. Developmental Neuropsychology. 41(4):215-230. doi:10.1080/87565641.2016.1236109.

Plasma amino acid and metabolite signatures tracking diabetes progression in the UCD-T2DM rat model - (Peer Reviewed Journal)
Piccolo, B., Graham, J., Stanhope, K., Fiehn, O., Havel, P., Adams, S.H. 2016. Plasma amino acid and metabolite signatures tracking diabetes progression in the UCD-T2DM rat model. American Journal of Physiology - Endocrinology and Metabolism. 310(11):958-969. doi: 10.1152/ajpendo.00052.2016.

RNA-sequencing data analysis of uterus in ovariectomized rats fed with soy protein isolate,17B-estradiol and casein - (Peer Reviewed Journal)
Ronis, M.J., Gomez-Acevedo, H., Blackburn, M.L., Cleves, M.A., Singhal, R., Badger, T.M. 2016. RNA-sequencing data analysis of uterus in ovariectomized rats fed with soy protein isolate,17B-estradiol and casein. Data in Brief. 7:1491-1496. http://dx.doi.org/10.1016/j.dib.2016.04.033

Uterine responses to feeding soy protein isolate and treatment with 17B-estradiol differ in ovariectomized female rats - (Peer Reviewed Journal)
Ronis, M.J., Gomez-Acevedo, H., Blackburn, M.L., Cleves, M.A., Singhal, R., Badger, T.M. 2016. Uterine responses to feeding soy protein isolate and treatment with 17B-estradiol differ in ovariectomized female rats. Toxicology and Applied Pharmacology. 297:68-80. doi.org/10.1016/j.taap.2016.02.019.

Soy protein isolate protects against ethanol mediated tumor progression in diethylnitrosamine treated male mice - (Peer Reviewed Journal)
Mercer, K.E., Pulliam, C., Hennings, L., Lai, K., Cleves, M., Jones, E., Drake, R.R., Ronis, M.J. 2016. Soy protein isolate protects against ethanol mediated tumor progression in diethylnitrosamine treated male mice. Cancer Prevention Research. 9(6):466-475. doi: 10.1158/1940-6207.CAPR-15-0417.

Resistant starch alters gut microbiome and metabolomics profiles concurrent with amelioration of chronic kidney disease in rats - (Peer Reviewed Journal)
Kieffer, D., Piccolo, B., Vaziri, N., Liu, S., Lau, W., Khazaeli, M., Nazertehrani, S., Moore, M., Marco, M., Martin, R. 2016. Resistant starch alters gut microbiome and metabolomics profiles concurrent with amelioration of chronic kidney disease in rats. American Journal of Physiology - Renal Physiology. 310(9):857-871. doi: 10.1152/ajprenal.00513.2015.

Unique plasma metabolomic signatures of individuals with inherited disorders of long-chain fatty acid oxidation - (Peer Reviewed Journal)
Mccoin, C.S., Piccolo, B.D., Knotts, T.A., Matern, D., Vockley, J., Gillingham, M.B. 2016. Unique plasma metabolomic signatures of individuals with inherited disorders of long-chain fatty acid oxidation. Journal of Inherited Metabolic Disease. 39(3):399-408.

Effect of diet-induced maternal obesity on fetal skeletal development - (Book / Chapter)
Chen, J. 2016. Effect of diet-induced maternal obesity on fetal skeletal development. In: Watson, R.R., Mahadevan, D., editors. Handbook of Nutrition and Diet in Therapy of Bone Diseases. The Netherlands: Wageningen Academic. p. 67-79.

Blueberry diet derived 3-(3-hydroxyphenyl) propionic acid (PPA) suppresses osteoblastic cell senescence to promote bone accretion in mice - (Abstract Only)

Transcriptomic and epigenomic landscapes during cell fusion in BeWo trophoblast cells - (Peer Reviewed Journal)
Shankar, K., Kang, P., Zhong, Y., Borengasser, S.J., Wingfield, C., Saben, J., Gomez-Acevedo, H., Thakali, K.M. 2015. Transcriptomic and epigenomic landscapes during cell fusion in BeWo trophoblast cells. Placenta. 36(12):1342-1351.

Long-term skeletal muscle mitochondrial dysfunction is associated with hypermetabolism in severely burned children - (Peer Reviewed Journal)
Porter, C., Herndon, D., Borsheim, E., Bhattarai, N., Chao, T., Reidy, P.T., Rasmussen, B.B., Andersen, C.R., Suman, O.E., Sidossis, L.S. 2016. Long-term skeletal muscle mitochondrial dysfunction is associated with hypermetabolism in severely burned children. Journal of Burn Care and Rehabilitation. 37(1):53-63. doi: 10.1097/BCR.0000000000000308.

Voxel-based morphometry and fMRI revealed differences in brain gray matter in breastfed and milk formula–fed children - (Peer Reviewed Journal)
Ou, X., Andres, A., Pivik, R.T., Cleves, M.A., Snow, J.H., Ding, Z., Badger, T.M. 2015. Voxel-based morphometry and fMRI revealed differences in brain gray matter in breastfed and milk formula–fed children. American Journal of Neuroradiology. 37:713-719. doi: 10.3174/ajnr.A4593.

Revisiting separation properties of convex fuzzy sets - (Peer Reviewed Journal)
Gomez-Acevedo, H. 2015. Revisiting separation properties of convex fuzzy sets. Journal of Intelligent & Fuzzy Systems. 29(2):845-849. doi: 10.3233/IFS-151613.

Metabolic, anabolic, and mitogenic insulin responses: A tissue-specific perspective for insulin receptor activators - (Review Article)
Bedinger, D.H., Adams, S.H. 2015. Metabolic, anabolic, and mitogenic insulin responses: A tissue-specific perspective for insulin receptor activators. Molecular and Cellular Endocrinology. 415:143-156. doi: 10.1016/j.mce.2015.08.013.

Acylcarnitines: old actors auditioning for new roles in metabolic physiology - (Review Article)
Mccoin, C.S., Knotts, T.A., Adams, S.H. 2015. Acylcarnitines: Old actors auditioning for new roles in metabolic physiology. Nature Reviews Endocrinology. doi:10.1038/2015.129.

Reversing gestational undernutrition via kick-starting early growth - (Review Article)
Shankar, K. 2015. Reversing gestational undernutrition via kick-starting early growth. Endocrinology. 156(9):3059-3062. doi: 10.1210/en.2015-1625.

p47phox-Nox2-dependent ROS signaling inhibits early bone development in mice but protects against skeletal aging - (Peer Reviewed Journal)
Chen, J., Lazarenko, O.P., Blackburn, M.L., Mercer, K.E., Badger, T.M., Ronis, M.J. 2015. p47phox-Nox2-dependent ROS signaling inhibits early bone development in mice but protects against skeletal aging. Journal of Biological Chemistry. 290(23):14692-14704.

Obesity-related changes in bone structural and material properties in hyperphagic OLETF rats and protection by voluntary wheel running - (Peer Reviewed Journal)
Hinton, P.S., Shankar, K., Eaton, L.M., Rector, R.S. 2015. Obesity-related changes in bone structural and material properties in hyperphagic OLETF rats and protection by voluntary wheel running. Metabolism. 64(8):905-916. doi: 10.1016/j.metabol.2015.04.004.

Brain gray and white matter differences in healthy normal weight and obese children - (Peer Reviewed Journal)
Ou, X., Andres, A., Pivik, R.T., Cleves, M.A., Badger, T.M. 2015. Brain gray and white matter differences in healthy normal weight and obese children. Journal of Magnetic Resonance Imaging. 42(5):1205-1213.

Compared with feeding infants breast milk or cow-milk formula, soy formula feeding does not affect subsequent reproductive organ size at 5 years of age - (Peer Reviewed Journal)
Andres, A., Moore, M.B., Linam, L., Casey, P.H., Cleves, M., Badger, T.M. 2015. Compared with Feeding Infants Breast Milk or Cow-milk formula, soy formula feeding does not affect subsequent reproductive organ size at 5 years of age. Journal of Nutrition. 145(5):871-875.

Longitudinal body composition of children born to normal weight, overweight and obese mothers - (Peer Reviewed Journal)
Andres, A., Hull, H., Cleves, M., Casey, P., Badger, T., Shankar, K. 2015. Longitudinal body composition of children born to normal weight, overweight and obese mothers. Obesity. 23(6):1252-1258.

Enzyme-treated wheat bran alters gut microbiota and liver metabolome in mice fed a high fat diet - (Abstract Only)
Kieffer, D.A., Martin, R.J., Piccolo, B.D., Marco, M.L., Kim, E.B., Keenan, K.E., Knudsten, T.N., Dunn, T.N., Adams, S.H. 2015. Enzyme-treated wheat bran alters gut microbiota and liver metabolome in mice fed a high fat diet. Federation of American Societies for Experimental Biology Conference. 29(1):258.6.

Resistant starch alters gut microbiota and reduces uremic retention solutes in rats with adenine-induced chronic kidney disease - (Abstract Only)
Kieffer, D.A., Piccolo, B.D., Liu, S., Khazaeli, M., Nazertherranni, S.D., Vaziri, N.D., Martin, R.J., Adams, S.H. 2015. Resistant starch alters gut microbiota and reduces uremic retention solutes in rats with adenine-induced chronic kidney disease. Federation of American Societies for Experimental Biology Conference. 29(1):274.4.

Differential pathway coupling efficiency of the activated insulin receptor drives signaling selectivity by xmeta, an allosteric partial agonist antibody - (Peer Reviewed Journal)
Bedinger, D.H., Goldfine, I.D., Corbin, J.A., Roell, M.K., Adams, S.H. 2015. Differential pathway coupling efficiency of the activated insulin receptor drives signaling selectivity by xmeta, an allosteric partial agonist antibody. Journal of Pharmacology and Experimental Therapeutics. 353(1):35-43.

Maternal adiposity negatively influences infant brain white matter development - (Peer Reviewed Journal)
Ou, X., Thakali, K.M., Shankar, K., Andres, A., Badger, T.M. 2015. Maternal adiposity negatively influences infant brain white matter development. Obesity. 23(5):1047-1054.

Predictors of muscle protein synthesis after severe pediatric burns - (Peer Reviewed Journal)
Diaz, E.C., Herndon, D.N., Lee, J., Porter, C., Cotter, M., Suman, O.E., Sidossis, L.S., Borsheim, E. 2015. Predictors of muscle protein synthesis after severe pediatric burns. Journal of Trauma and Acute Care Surgery. 78(4):816-822.

Whey protein supplementation does not alter plasma branched-chained amino acid profiles but results in unique metabolomics patterns in obese women enrolled in an 8-week weight loss trial - (Peer Reviewed Journal)
Piccolo, B.D., Comerford, K.B., Karakas, S.E., Knotts, T.A., Fiehn, O., Adams, S.H. 2015. Whey protein supplementation does not alter plasma branched-chained amino acid profiles but results in unique metabolomics patterns in obese women enrolled in an 8-week weight loss trial. Journal of Nutrition. 145(4):691-700, R1-R134.

High amylose resistant starch diet ameliorates oxidative stress, inflammation, and progression of chronic kidney disease - (Peer Reviewed Journal)
Vaziri, N.D., Oiu, S., Lau, W., Nazertehrani, S., Farzaneh, S.H., Kieffer, D.A., Adams, S.H., Martin, R.J. 2014. High amylose resistant starch diet ameliorates oxidative stress, inflammation, and progression of chronic kidney disease. PLoS One. 9(12) doi:http://dx.doi.org/10.1371/journal.pone.0114881.

RNA-seq analysis of the rat placentation site reveals maternal obesity-associated changes in placental and offspring thyroid hormone signaling - (Peer Reviewed Journal)
Saben, J., Kang, P., Zhong, Y., Thakali, K., Gomez-Acevedo, H., Borengasser, S.J., Andres, A., Badger, T.M., Shankar, K. 2014. RNA-seq analysis of the rat placentation site reveals maternal obesity-associated changes in placental and offspring thyroid hormone signaling. Placenta. 35(12):1013-1020.

Temporal metabolomic responses of cultured HepG2 liver cells to high fructose and high glucose exposures - (Peer Reviewed Journal)
Meissen, J.K., Hirahatake, K.M., Adams, S.H., Fiehn, O. 2015. Temporal metabolomic responses of cultured HepG2 liver cells to high fructose and high glucose exposures. Metabolomics. 11(3):707-721.

N-acetylcysteine inhibits the up-regulation of mitochondrial biogenesis genes in livers from rats fed ethanol chronically - (Peer Reviewed Journal)
Caro, A.A., Bell, M., Ejiofor, S., Zurcher, G., Petersen, D.R., Ronis, M.J. 2014. N-acetylcysteine inhibits the up-regulation of mitochondrial biogenesis genes in livers from rats fed ethanol chronically. Alcoholism: Clinical and Experimental. 38(12):2896-2906.

Body composition from age 3 months to 6 years of children born to lean, overweight and obese mothers Reprint Icon - (Abstract Only)
Andres, A., Hull, H.R., Shankar, K., Cleves, M., Casey, P.H., Badger, T.M. 2014. [Poster#T-2323-P] Body composition from age 3 months to 6 years of children born to lean, overweight and obese mothers. Annual Scientific Meeting NAASO, The Obesity Society. http://obesityweek.com/app/uploads/2015/03/2014-TOS-Abstracts.pdf.

Habitual physical activity and plasma metabolomic patterns distinguish individuals with low vs. high weight loss during controlled energy restriction - (Peer Reviewed Journal)
Piccolo, B.D., Keim, N.L., Fiehn, O., Adams, S.H., Van Loan, M.D., Newman, J.W. 2014. Habitual physical activity and plasma metabolomic patterns distinguish individuals with low vs. high weight loss during controlled energy restriction. Journal of Nutrition. 145(4):681-690.

Matrix effects break the LC behavior rule for analytes in LC-MS/MS analysis of biological samples - (Peer Reviewed Journal)
Fang, N., Yu, S., Ronis, M.J., Badger, T.M. 2015. Matrix effects break the LC behavior rule for analytes in LC-MS/MS analysis of biological samples.Experimental Biology and Medicine. 240(4):488-497.

Trace element status and zinc homeostasis differ in breast and formula-fed piglets - (Peer Reviewed Journal)
Ronis, M.J., Miousse, I.R., Mason, A.Z., Sharma, N., Blackburn, M.L., Badger, T.M. 2015. Trace element status and zinc homeostasis differ in breast and formula-fed piglets. Experimental Biology and Medicine. 240(1):58-66.

Distinct adipogenic differentiation phenotypes of human umbilical cord mesenchymal cells dependent on adipogenic conditions - (Peer Reviewed Journal)
Saben, J., Thakali, K.M., Lindsey, F.E., Zhong, Y., Badger, T.M., Andres, A., Shankar, K. 2015. Distinct adipogenic differentiation phenotypes of human umbilical cord mesenchymal cells dependent on adipogenic conditions. Experimental Biology and Medicine. 239(10):1340-1351.

Sex-specific association between infant diet and white matter integrity in 8-y-old children - (Peer Reviewed Journal)
Ou, X., Andres, A., Cleves, M.A., Pivik, R.T., Snow, J.H., Ding, Z., Badger, T.M. 2014. Sex-specific association between infant diet and white matter integrity in 8-y-old children. Pediatric Research. 76(6):535-543. doi: 10.1038/pr.2014.129.

Sex-specific association between infant diet and white matter integrity in 8-y-old children - (Peer Reviewed Journal)
Ou, X., Andres, A., Cleves, M.A., Pivik, R.T., Snow, J.H., Ding, Z., Badger, T.M. 2014. Sex-specific association between infant diet and white matter integrity in 8-y-old children. Pediatric Research. 76(6):535-543.

Alcohol consumption, Wnt/ß-catenin cignaling, and hepatocarcinogenesis - (Book / Chapter)
Mercer, K.E., Hennings, L., Ronis, M.J. 2014. Alcohol consumption, Wnt/ß-catenin cignaling, and hepatocarcinogenesis. Advances in Experimental Medicine and Biology. 815:185-195.

Nox2-dependent ROS signaling protects against skeletal ageing - (Abstract Only)
Chen, J., Lazarenko, O.P., Mercer, K., Blackburn, M.L., Badger, T.M., Ronis, M.J. 2015. Nox2-dependent ROS signaling protects against skeletal ageing. Journal of Bone and Mineral Research. 29(S1):Presentation Number: SA0463. Available at http://www.asbmr.org/education/2014-abstracts.

Soy protein isolate inhibits high fat diet-induced senescence pathways in osteoblasts to maintain bone acquisition in rats - (Abstract Only)
Chen, J., Lazarenko, O.P., Blackburn, M.L., Badger, T.M., Ronis, M.J. 2015. Soy protein isolate inhibits high fat diet-induced senescence pathways in osteoblasts to maintain bone acquisition in rats. Journal of Bone and Mineral Research. 29(S1):Presentation Number:SU0185. Available at http://www.asbmr.org/education/2014-abstracts.

Alcohol consumption promotes diethylnitrosamine-induced hepatocarcinogenesis in male mice through the activation of the Wnt/Beta-catenin signaling pathway - (Peer Reviewed Journal)
Mercer, K.E., Hennings, L., Sharma, N., Lai, K.K., Cleves, M.A., Wynne, R.A., Badger, T.M., Ronis, M.J. 2014. Alcohol consumption promotes diethylnitrosamine-induced hepatocarcinogenesis in male mice through the activation of the Wnt/Beta-catenin signaling pathway. Cancer Prevention Research. 7(7):675-685.

Short term feeding of a high fat diet exerts an additive effect on hepatocellular damage and steatosis in liver-specific PTEN knockout mice - (Peer Reviewed Journal)
Shearn, C.T., Mercer, K.E., Orlicky, D., Hennings, L., Smathers-Mccullough, R.L., Stiles, B.L., Petersen, D.R. 2014. Short term feeding of a high fat diet exerts an additive effect on hepatocellular damage and steatosis in liver-specific PTEN knockout mice. PLoS One. 9(5):e96553.

Soy protein isolate inhibits high-Ffat diet-induced senescence pathways in osteoblasts to maintain bone acquisition in male rats - (Peer Reviewed Journal)
Chen, J., Lazarendo, O.P., Blackburn, M.L., Badger, T.M., Ronis, M.J. 2015. Soy protein isolate inhibits high-Ffat diet-induced senescence pathways in osteoblasts to maintain bone acquisition in male rats. Endocrinology. 156(2):475-487.

Soy protein isolate down-regulates caveolin-1 expression to suppress osteoblastic cell senescence pathways - (Peer Reviewed Journal)
Zhang, J., Lazarenko, O.P., Vlxkvuen, M.L., Badger, T.M., Ronis, M.J., Chen, J. 2014. Soy protein isolate down-regulates caveolin-1 expression to suppress osteoblastic cell senescence pathways. FASEB Journal. 28(7):3134-3145.

Genistein supplementation increases bone turnover but does not prevent alcohol-induced bone loss in male mice - (Peer Reviewed Journal)
Yang, C.S., Mercer, K.E., Alund, A.W., Suva, L.J., Badger, T.M., Ronis, M.J. 2014. Genistein supplementation increases bone turnover but does not prevent alcohol-induced bone loss in male mice. Experimental Biology and Medicine. 239(10):1380-1389.

A comprehensive analysis of the human placenta transcriptome - (Peer Reviewed Journal)
Saben, J., Zhong, Y., McKelvey, S., Dajani, N., Andres, A., Badger, T., Gomez-Acevedo, H., Shankar, K. 2014. A comprehensive analysis of the human placenta transcriptome. Placenta. 35(2):125-131.

Differential susceptibilities to azithromycin treatment of chlamydial infection in the gastrointestinal tract and cervix - (Peer Reviewed Journal)
Yeruva, L., Melnyk, S., Spencer, N., Bowlin, A., Rank, R.G. 2014. Differential susceptibilities to azithromycin treatment of chlamydial infection in the gastrointestinal tract and cervix. Antimicrobial Agents and Chemotherapy. 57(12):6290-6294.

Health effects of protein intake in healthy adults: A systematic literature review - (Review Article)
Pedersen, A.N., Kondrup, J., Borsheim, E. 2013. Health effects of protein intake in healthy adults: A systematic literature review. Food and Nutrition Research. 57:21245. Available at http://dx.doi.org/10.3402/fnr.v57i0.21245.

Soy protein inhibits inflammation-induced VCAM-1 and inflammatory cytokine induction by inhibiting the NF-kappaB and AKT signaling pathway in apolipoprotein E-deficient mice - (Peer Reviewed Journal)
Burris, R.L., Ng, H., Nagarajan, S. 2014. Soy protein inhibits inflammation-induced VCAM-1 and inflammatory cytokine induction by inhibiting the NF-kappaB and AKT signaling pathway in apolipoprotein E-deficient mice. European Journal of Nutrition. 53(1):135-148.

Untargeted metabolomics reveal disparate metabolite profile in follicular fluid between obese and normal weight women - (Abstract Only)
Ruebel, M., Piccolo, B., Moutos, D., Shankar, K., Andres, A. 2017. Untargeted metabolomics reveal disparate metabolite profile in follicular fluid between obese and normal weight women. Journal of Federation of American Societies for Experimental Biology. 31:457.2.

Last Modified: 10/18/2017
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