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ARS Home » Southeast Area » Little Rock, Arkansas » Microbiome and Metabolism Research Unit » Research » Research Project #426492

Research Project: Impact of Early Dietary Factors on Child Development and Health

Location: Microbiome and Metabolism Research Unit

Publications (Clicking on the reprint icon Reprint Icon will take you to the publication reprint.)

Brain cortical structure and executive function in children may be influenced by parental choices of infant diets Reprint Icon - (Peer Reviewed Journal)
Li, T., Badger, T.M., Bellando, B.J., Sorensen, S.T., Lou, X., Ou, X. 2020. Brain cortical structure and executive function in children may be influenced by parental choices of infant diets. American Journal of Neuroradiology. 41(7):1302-1308. https://doi.org/10.3174/ajnr.A6601.

Developmental assessments during the first 5 years of life in infants fed breast milk, cow's milk formula or soy formula Reprint Icon - (Peer Reviewed Journal)
Bellando, J., Mccorkle, G., Spray, B., Sims, C.R., Badger, T.M., Casey, P.H., Scott, H., Beall, S.R., Sorensen, S.T., Andres, A. 2020. Developmental assessments during the first 5 years of life in infants fed breast milk, cow's milk formula or soy formula. Food Science and Nutrition. https://doi.org/10.1002/fsn3.1630.

Neonatal diet alters fecal microbiota and metabolome profiles at different ages in infants fed breast milk or formula Reprint Icon - (Peer Reviewed Journal)
Brink, L.R., Mercer, K.E., Piccolo, B.D., Chintapalli, S.V., Elolimy, A., Bowlin, A.K., Matazel, K.S., Pack, L., Adams, S.H., Shankar, K., Badger, T.M., Andres, A., Yeruva, L. 2020. Neonatal diet alters fecal microbiota and metabolome profiles at different ages in infants fed breast milk or formula. American Journal of Clinical Nutrition. https://doi.org/10.1093/ajcn/nqaa076.

Eating behavior and weight gain during pregnancy Reprint Icon - (Peer Reviewed Journal)
Tang, X., Andres, A., West, D., Lou, X., Krukowski, R. 2020. Eating behavior and weight gain during pregnancy. Eating Behaviors. 36: 101364. https://doi.org/10.1016/j.eatbeh.2020.101364.

Risk of being overweight at 5 years of age is associated with weight gain and energy intake during infancy in formula-fed children - (Peer Reviewed Journal)
Andres, A., Fawcett, K., Casey, P., Badger, T.M., Cleves, M. 2020. Risk of being overweight at 5 years of age is associated with weight gain and energy intake during infancy in formula-fed children. Annals of Pediatric Research. 4(1):1029.

Maternal regulation of SATB2 in osteo-progeniters impairs skeletal development in offspring Reprint Icon - (Peer Reviewed Journal)
Chen, J., Zhao, H., Lazarenko, O.P., Blackburn, M.L., Shankar, K. 2019. Maternal regulation of SATB2 in osteo-progeniters impairs skeletal development in offspring. Journal of Federation of American Societies for Experimental Biology. https://doi.org/10.1096/fj.201901901R.

Maternal adiposity is associated with fat mass accretion in female but not male offspring during the first two years of life Reprint Icon - (Peer Reviewed Journal)
Heard-Lipsmeyer, M.E., Diaz, E.C., Sims, C.R., Sobik, S.R., Ruebel, M.L., Thakali, K.M., Kruowski, R.A., Cleves, M., Borsheim, E., Shankar, K., Andres, A. 2020. Maternal adiposity is associated with fat mass accretion in female but not male offspring during the first two years of life. Obesity. https://doi.org/10.1002/oby.22735.

Parental adiposity differentially associates with newborn body composition Reprint Icon - (Peer Reviewed Journal)
Diaz Fuentes, E.C., Cleves, M.A., Dicarlo, M., Sobik, S.R., Ruebel, M.L., Thakali, K.M., Sims, C.R., Dajani, N.K., Krukowski, R.A., Borsheim, E., Badger, T.M., Shankar, K., Andres, A. 2019. Parental adiposity differentially associates with newborn body composition. Pediatric Obesity. https://doi.org/10.1111/ijpo.12596.

Infant formula feeding changes the proliferative status in piglet neonatal mammary glands independently of estrogen signaling Reprint Icon - (Peer Reviewed Journal)
Mercer, K.E., Bhattacharyya, S., Sharma, N., Chaudhury, M., Lin, H., Yeruva, L., Ronis, M.J. 2019. Infant formula feeding changes the proliferative status in piglet neonatal mammary glands independently of estrogen signaling. Journal of Nutrition. https://doi.org/10.1093/jn/nxz273.

Exercise plasma metabolomics and xenometabolomics in obese, sedentary, insulin-resistant women: Impact of a fitness and weight loss intervention Reprint Icon - (Peer Reviewed Journal)
Grapov, D., Fiehn, O., Campbell, C., Chandler, C.J., Burnett, D.J., Souza, E.C., Casazza, G.A., Keim, N.L., Newman, J.W., Hunter, G.R., Fernandez, J.R., Garvey, W., Hoppel, C.L., Harper, M., Adams, S.H. 2019. Exercise plasma metabolomics and xenometabolomics in obese, sedentary, insulin-resistant women: Impact of a fitness and weight loss intervention. American Journal of Physiology - Endocrinology and Metabolism. 317(6):E999-E1014. https://doi.org/10.1152/ajpendo.00091.2019.

Oxylipin profiling of alzheimer's disease in nondiabetic and type 2 diabetic elderly Reprint Icon - (Peer Reviewed Journal)
Morris, J.K., Piccolo, B.D., John, C.S., Green, Z.D., Thyfault, J.P., Adams, S.H. 2019. Oxylipin profiling of alzheimer's disease in nondiabetic and type 2 diabetic elderly. Metabolites. 9(9): 177. https://doi.org/10.3390/metabo9090177.

Dairy foods and dairy fats: New perspectives on pathways implicated in cardiometabolic health Reprint Icon - (Review Article)
Hirahatake, K.M., Bruno, R.S., Bolling, B.W., Blesso, C., Alexander, L.M., Adams, S.H. 2019. Dairy foods and dairy fats: New perspectives on pathways implicated in cardiometabolic health. Advances in Nutrition. https://doi.org/10.1093/advances/nmz105.

Obesity Is associated with changes in breastmilk metabolites at 0.5, 2 and 6 months partum - (Abstract Only)

Changes in plasma branched chain amino acids during pregnancy: Relationship to insulin sensitivity - (Abstract Only)

Perspective: Guiding principles for the implementation of personalized nutrition approaches that benefit health and function Reprint Icon - (Review Article)
Adams, S.H., Anthony, J.C., Carvajal, R., Chae, L., Khoo, C., Latulippe, M.E., Matusheski, N.V., Mcclung, H.L., Rozga, M., Schmid, C.H., Wopereis, S., Yan, W. 2019. Perspective: Guiding principles for the implementation of personalized nutrition approaches that benefit health and function. Advances in Nutrition. https://doi.org/10.1093/advances/nmz086.

Offspring sex differences in metabolic consequences of maternal high fat diet-induced obesity - (Abstract Only)

Probiotic supplementation influences placental mitochondrial respiration in obese pregnant women - (Abstract Only)

Postnatal diet impact on microrna expression - (Abstract Only)

Bioregional shifts in the microbiome of piglets fed either human milk or infant formula during the postnatal period - (Abstract Only)

Activation of Nox4 is not required for OVX-induced osteoblast senescence and bone loss in mice - (Abstract Only)

GPR109A regulates osteoclastogenesis and bone resorption in mice - (Abstract Only)

Neonatal diet impacts bioregional microbiota composition in piglets fed human breast milk or infant formula Reprint Icon - (Peer Reviewed Journal)
Brink, L.R., Matazel, K., Piccolo, B.D., Bowlin, A.K., Chintapalli, S.V., Shankar, K., Yeruva, L. 2019. Neonatal diet impacts bioregional microbiota composition in piglets fed human breast milk or infant formula. Journal of Nutrition. https://doi.org/10.1093/jn/nxz170.

A comparative study of mitochondrial respiration in circulating blood cells and skeletal muscle fibers in women Reprint Icon - (Peer Reviewed Journal)
Rose, S., Carvalho, E., Diaz, E.C., Cotter, M., Bennuri, S.C., Azhar, G., Frye, R.E., Adams, S.H., Borsheim, E. 2019. A comparative study of mitochondrial respiration in circulating blood cells and skeletal muscle fibers in women. American Journal of Physiology - Endocrinology and Metabolism. 317(3):E503-E512. https://doi.org/10.1152/ajpendo.00084.2019.

Hippuric acid and 3-(3-hydroxyphenyl) propionic acid inhibit murine osteoclastogenesis through RANKL-RANK independent pathway Reprint Icon - (Peer Reviewed Journal)
Zhao, H., Lazarenko, O.P., Chen, J. 2019. Hippuric acid and 3-(3-hydroxyphenyl) propionic acid inhibit murine osteoclastogenesis through RANKL-RANK independent pathway. Journal of Cellular Physiology. https://doi.org/10.1002/jcp.28998.

Estradiol and NADPH oxidase crosstalk regulates responses to high fat feeding in female mice Reprint Icon - (Peer Reviewed Journal)
Ronis, M.J., Blackburn, M.L., Shankar, K., Ferguson, M., Cleves, M.A., Badger, T.M. 2019. Estradiol and NADPH oxidase crosstalk regulates responses to high fat feeding in female mice. Experimental Biology and Medicine. https://doi.org/10.1177/1535370219853563.

Sex modulates hepatic mitochondrial adaptations to high fat diet and physical activity Reprint Icon - (Peer Reviewed Journal)
McCoin, C.S., Schulze, A., Allen, J., Fuller, K., Xia, Q., Koestler, D., Houchen, C., Maurer, A., Dorn II, G., Shankar, K., Morris E., M., Thyfault, J. 2019. Sex modulates hepatic mitochondrial adaptations to high fat diet and physical activity. American Journal of Physiology - Endocrinology and Metabolism. https://doi.org/10.1152/ajpendo.00098.2019.

The influence of maternal body composition and carbohydrate intake on inflammation - (Abstract Only)

3-(3-hydroxyphenyl)-Propionic Acid (PPA) suppresses osteoblastic cell senescence to promote bone accretion in mice Reprint Icon - (Peer Reviewed Journal)
Chen, J., Wankhade, U.D., Alund, A.W., Blackburn, M.L., Shankar, K., Lazarenko, O.P. 2019. 3-(3-hydroxyphenyl)-Propionic Acid (PPA) suppresses osteoblastic cell senescence to promote bone accretion in mice. JBMR Plus. https://doi.org/10.1002/jbm4.10201.

The association of maternal protein intake during pregnancy in humans with maternal and offspring insulin sensitivity measures Reprint Icon - (Review Article)
Allman, B.R., Andres, A., Borsheim, E. 2019. The association of maternal protein intake during pregnancy in humans with maternal and offspring insulin sensitivity measures. Current Developments in Nutrition. 3(6). https://doi.org/10.1093/cdn/nzz055.

Diffusion tensor MRI of white matter of healthy full-term newborns: Relationship to neurodevelopmental outcomes Reprint Icon - (Peer Reviewed Journal)
Feng, K., Rowell, A.C., Andres, A., Bellando, B., Lou, X., Glasier, C.M., Ramakrishnaiah, R.H., Badger, T.M., Ou, X. 2019. Diffusion tensor MRI of white matter of healthy full-term newborns: Relationship to neurodevelopmental outcomes. Radiology. https://doi.org/10.1148/radiol.2019182564.

Intrinsic high aerobic capacity in male rats protects against diet-induced insulin resistance Reprint Icon - (Peer Reviewed Journal)
Morris E., M., Meers, G., Ruegsegger, G.N., Wankhade, U.D., Robinson, T., Koch, L.G., Britton, S.L., R., S., Shankar, K., Thyfault, J.P. 2019. Intrinsic high aerobic capacity in male rats protects against diet-induced insulin resistance. Endocrinology. 160(5):1179-1192. https://doi.org/10.1210/en.2019-00118.

Blood cytokine patterns suggest a modest inflammation phenotype in subjects with long-chain fatty acid acid oxidation disorders Reprint Icon - (Peer Reviewed Journal)
McCoin, C.S., Gillingham, M.B., Knotts, T.A., Vockley, J., Ono-Moore, K.D., Blackburn, M.L., Norman, J.E., Adams, S.H. 2019. Blood cytokine patterns suggest a modest inflammation phenotype in subjects with long-chain fatty acid acid oxidation disorders. Physiological Reports. https://doi.org/10.14814/phy2.14037.

Maternal BMI modulates placental expression of lipid transport, metabolism and innate immune response genes at term - (Abstract Only)

Weight loss and fitness intervention increases markers of hepatic bile acid (BA) synthesis, while reducing serum total BA concentrations in sedentary, obese insulin resistant women - (Abstract Only)

Sex-specific changes in gut microbiome composition following blueberry consumption in C57BL/6J mice Reprint Icon - (Peer Reviewed Journal)
Wankhade, U.D., Zhong, Y., Lazarenko, O.P., Chintapalli, S.V., Piccolo, B.D., Chen, J., Shankar, K. 2019. Sex-specific changes in gut microbiome composition following blueberry consumption in C57BL/6J mice. Nutrients. 11(2):313. https://doi.org/10.3390/nu11020313.

Dietary supplementation with strawberry induces marked changes in the composition and functional potential of the gut microbiome in diabetic mice Reprint Icon - (Peer Reviewed Journal)
Petersen, C., Wankhade, U.D., Bharat, D., Wong, K., Mueller, J., Chintapalli, S.V., Piccolo, B.D., Jalili, T., Zhenquan, J., Symons, J., Shankar, K., Anandh Babu, P. 2019. Dietary supplementation with strawberry induces marked changes in the composition and functional potential of the gut microbiome in diabetic mice. Journal of Nutritional Biochemistry. https://doi.org/10.1016/j.jnutbio.2019.01.004.

Obesity leads to distinct metabolomic signatures in the follicular fluid of women undergoing in vitro fertilization Reprint Icon - (Peer Reviewed Journal)
Ruebel, M.L., Piccolo, B.D., Mercer, K.E., Pack, L., Moutos, D., Shankar, K., Andres, A. 2019. Obesity leads to distinct metabolomic signatures in the follicular fluid of women undergoing in vitro fertilization. American Journal of Physiology - Endocrinology and Metabolism. https://doi.org/10.1152/ajpendo.00401.2018.

Metaproteomics reveals potential mechanisms by which dietary resistant starch supplementation attenuates chronic kidney disease progression in rats Reprint Icon - (Peer Reviewed Journal)
Zybaylov, B.L., Glazko, G.V., Rahmatallah, Y., Andreyev, D.S., McElroy, T., Karaduta, O., Byrum, S.D., Orr, L., Tackett, A.J., Mackintosh, S.G., Edmondson, R.D., Kieffer, D.A., Martin, R.J., Adams, S.H., Vaziri, N.D., Arthur, J.M. 2019. Metaproteomics reveals potential mechanisms by which dietary resistant starch supplementation attenuates chronic kidney disease progression in rats. PLoS One. 14(1):e0199274. https://doi.org/10.1371/journal.pone.0199274.

Maternal adiposity influences neonatal brain functional connectivity Reprint Icon - (Peer Reviewed Journal)
Salzwedel, A., Gao, W., Andres, A., Badger, T.M., Glasier, C., Ramakrishnaiah, R., Rowell, A., Ou, X. 2019. Maternal adiposity influences neonatal brain functional connectivity. Frontiers in Human Neuroscience. 12:514. https://doi.org/10.3389/fnhum.2018.00514.

Effects of infant formula feeding on neonatal mammary gland development - (Abstract Only)

Pre-pregnancy fat free mass and associations to glucose metabolism before and during pregnancy Reprint Icon - (Peer Reviewed Journal)
Diaz Fuentes, E.C., Borsheim, E., Shankar, K., Cleves, M.A., Andres, A. 2018. Pre-pregnancy fat free mass and associations to glucose metabolism before and during pregnancy. Journal of Clinical Endocrinology and Metabolism. https://doi.org/10.1210/jc.2018-01381.

Modulating sterol concentrations in infant formula influences cholesterol absorption and synthesis in the neonatal piglet Reprint Icon - (Peer Reviewed Journal)
Babawale, E.A., Jones, P., Mercer, K.E., Lin, H., Yeruva, L., Bar Yoseph, F., Rutherford, S.M. 2018. Modulating sterol concentrations in infant formula influences cholesterol absorption and synthesis in the neonatal piglet. Nutrients. 10(12):1848. https://doi.org/10.3390/nu10121848.

Resting gamma power during the postnatal critical period for GABAergic system development is modulated by infant diet and sex Reprint Icon - (Peer Reviewed Journal)
Pivik, R., Andres, A., Tennal, K.B., Gu, Y., Downs, H., Bellando, B.J., Jarratt, K., Cleves, M.A., Badger, T.M. 2018. Resting gamma power during the postnatal critical period for GABAergic system development is modulated by infant diet and sex. International Journal of Psychophysiology. 135:73-94. https://doi.org/10.1016/j.ijpsycho.2018.11.004.

Skeletal muscle interstitial fluid metabolomics at rest and associated with an exercise bout: Application in rats and humans Reprint Icon - (Peer Reviewed Journal)
Zhang, J., Bhattacharyya, S., Hickner, R.C., Light, A.R., Lambert, C.J., Gale, B.K., Fiehn, O., Adams, S.H. 2018. Skeletal muscle interstitial fluid metabolomics at rest and associated with an exercise bout: Application in rats and humans. American Journal of Physiology - Endocrinology and Metabolism. https://doi.org/10.1152/ajpendo.00156.2018.

White matter microstructure correlates with memory performance in healthy children: A diffusion tensor imaging study Reprint Icon - (Peer Reviewed Journal)
Samara, A., Feng, K., Pivik, R., Jarrett, K.P., Badger, T.M., Ou, X. 2018. White matter microstructure correlates with memory performance in healthy children: A diffusion tensor imaging study. Journal of Neuroimaging. https://doi.org/10.1111/jon.12580.

Binding energies and the entry route of palmitic acid and palmitoylcarnitine into myoglobin Reprint Icon - (Review Article)
Chintapalli, S.V., Anishkin, A., Adams, S.H. 2018. Binding energies and the entry route of palmitic acid and palmitoylcarnitine into myoglobin. Data in Brief. 21:1106-1110. http://doi.org/10.1016/j.dib.2018.10.118.

Diet supplementation with soy protein isolate, but not the isoflavone genistein, protects against alcohol-induced tumor progression in DEN-treated male mice Reprint Icon - (Book / Chapter)
Mercer, K.E., Pulliam, C.F., Hennings, L., Cleves, M.A., Jones, E.E., Drake, R.R., Ronis, M.J.J. 2018. Diet supplementation with soy protein isolate, but not the isoflavone genistein, protects against alcohol-induced tumor progression in DEN-treated male mice. In: Vasiliou, V., Zakhari, S., Mishra, L., Seitz, H., editors. Alcohol and Cancer. Advances Experimental Medicine and Biology. Vol 1032. Switzerland. Springer Nature. 115-126. https://doi.org/10.1007/978-3-319-98788-0_9.

Maternal high-fat diet programs offspring liver steatosis in a sexually dimorphic manner in association with changes in gut microbial ecology in mice Reprint Icon - (Peer Reviewed Journal)
Wankhade, U.D., Zhong, Y., Kang, P., Alfaro, M., Chintapalli, S.V., Piccolo, B.D., Mercer, K.E., Andres, A., Thakali, K., Shankar, K. 2018. Maternal high-fat diet programs offspring liver steatosis in a sexually dimorphic manner in association with changes in gut microbial ecology in mice. Scientific Reports. 8:16502. https://doi.org/10.1038/s41598-018-34453-0.

Caesarean section delivery impacts infant brain development Reprint Icon - (Peer Reviewed Journal)
Deoni, S.C., Adams, S.H., Li, X., Badger, T.M., Pivik, T., Glasier, C.M., Ramakrishnaiah, R.H., Rowell, A.C., Ou, X. 2018. Caesarean section delivery impacts infant brain development. American Journal of Neuroradiology. https://doi.org/10.3174/ajnr.A5887.

Liver tumorigenesis is promoted by a high saturated fat diet specifically in male mice and is associated with hepatic expression of the proto-oncogene Agap2 and enrichment of the intestinal microbiome with Coprococcus Reprint Icon - (Peer Reviewed Journal)
Pedersen, K., Pulliam, C., Patel, A., Del Piero, F., Watanabe, T., Wankhade, U., Shankar, K., Hicks, C., Ronis, M. 2018. Liver tumorigenesis is promoted by a high saturated fat diet specifically in male mice and is associated with hepatic expression of the proto-oncogene Agap2 and enrichment of the intestinal microbiome with Coprococcus. Carcinogenesis. https://doi.org/10.1093/carcin/bgy141.

Generalized multifactor dimensionality reduction approaches to identification of genetic interactions underlying ordinal traits Reprint Icon - (Peer Reviewed Journal)
Hou, T., Lin, F., Bai, S., Cleves, M.A., Xu, H., Lou, X. 2018. Generalized multifactor dimensionality reduction approaches to identification of genetic interactions underlying ordinal traits. Genetic Epidemiology. https://doi.org/10.1002/gepi.22169.

Brain activation to high-calorie food images in healthy normal weight and obese children: A fMRI study Reprint Icon - (Peer Reviewed Journal)
Samara, A., Li, X., Pivik, R., Badger, T.M., Ou, X. 2018. Brain activation to high-calorie food images in healthy normal weight and obese children: A fMRI study. BMC Obesity. 5:31. https://doi.org/10.1186/s40608-018-0209-1.

Concentrations of purine metabolites are elevated in human fluids from adults and infants and in livers from mice fed diets depleted of bovine milk exosomes and their RNA cargos Reprint Icon - (Peer Reviewed Journal)
Aguilar-Lozano, A., Baier, S., Grove, R., Shu, J., Leiferman, A., Mercer, K., Cui, J., Badger, T.M., Adamec, J., Andres, A., Zempleni, J. 2018. Concentrations of purine metabolites are elevated in human fluids from adults and infants and in livers from mice fed diets depleted of bovine milk exosomes and their RNA cargos. Journal of Nutrition. 148(12):1886-1894. https://doi.org/10.1093/jn/nxy223.

Exploring the entry route of palmitic acid and palmitoylcarnitine into myoglobin Reprint Icon - (Peer Reviewed Journal)
Chintapalli, S.V., Anishkin, A., Adams, S.H. 2018. Exploring the entry route of palmitic acid and palmitoylcarnitine into myoglobin. Archives Of Biochemistry and Biophysics. https://doi.org/10.1016/j.abb.2018.07.024.

Maternal obesity impairs skeletal development in adult offspring Reprint Icon - (Peer Reviewed Journal)
Chen, J., Lazarenkolazarenko, O.P., Zhao, H., Alund, A.W., Shankar, K. 2018. Maternal obesity impairs skeletal development in adult offspring. Journal of Endocrinology. https://doi.org/10.1530/JOE-18-0244.

TGF-B receptor 1 regulates progenitors that promote browning of white fat Reprint Icon - (Peer Reviewed Journal)
Wankhade, U.D., Lee, J., Dagur, P.K., Yadav, H., Shen, M., Chen, W., Kulkarni, A.B., McCoy, J., Finkel, T., Cypess, A.M., Rane, S.G. 2018. TGF-B receptor 1 regulates progenitors that promote browning of white fat. Molecular Metabolism. https://doi.org/10.1016/j.molmet.2018.07.008.

Functional differences in platelet mitochondrial respiration in children with excess weight - (Abstract Only)

Diabetes-associated alterations in the cecal microbiome and metabolome are independent of diet or environment in the UC Davis type 2-diabetes mellitus rat model Reprint Icon - (Peer Reviewed Journal)
Piccolo, B.D., Graham, J.L., Stanhope, K.L., Nookaew, I., Mercer, K.E., Chintapalli, S.V., Wankhade, U.D., Shankar, K., Havel, P.J., Adams, S.H. 2018. Diabetes-associated alterations in the cecal microbiome and metabolome are independent of diet or environment in the UC Davis type 2-diabetes mellitus rat model. American Journal of Physiology - Endocrinology and Metabolism. https://doi.org/10.1152/ajpendo.00203.2018.

Is palmitate truly pro-inflammatory? Experimental confounders and context-specificity Reprint Icon - (Peer Reviewed Journal)
Ono-Moore, K.D., Blackburn, M.L., Adams, S.H. 2018. Is palmitate truly pro-inflammatory? Experimental confounders and context-specificity. American Journal of Physiology - Endocrinology and Metabolism. http://doi.org/10.1152/ajpendo.00187.2018.

Human breast-milk feeding enhances the humoral and cell-mediated immune response in neonatal piglets Reprint Icon - (Peer Reviewed Journal)
Miklavcic, J.J., Badger, T.M., Bowlin, A.K., Matazel, K.S., Cleves, M.A., Leroith, T., Saraf, M.K., Chintapalli, S.V., Piccolo, B.D., Shankar, K., Yeruva, L. 2018. Human breast-milk feeding enhances the humoral and cell-mediated immune response in neonatal piglets. Journal of Nutrition. 148:1-11. https://doi.org/10.1093/jn/nxy170.

Maternal obesity-mediated epigenetic regulation of osteoblast differentiation through SATB2 - (Abstract Only)

A cautionary response to SMFM statement: Pharmacological treatment of gestational diabetes Reprint Icon - (Other)
Barbour, L., Scifres, C., Valent, A., Freidman, J., Buchanan, T., Coustan, D., Aaagard, K., Thornburg, K., Catalano, P., Galan, H., Hay, W., Frias, A., Shankar, K., Simmons, R., Moses, R., Sacks, D.A., Loeken, M. 2018. A cautionary response to SMFM statement: Pharmacological treatment of gestational diabetes. American Journal of Obstetrics and Gynecology. 9378(18): 30529-30535. http://doi.org/10.1016/j.ajog.2018.06.013.

Soy protein isolate feeding does not result in reproductive toxicity in the pre-pubertal rat testis Reprint Icon - (Peer Reviewed Journal)
Ronis, M.J., Gomez-Acebedo, H., Shankar, K., Sharma, N., Blackburn, M., Singhal, R., Mercer, K.E., Badger, T.M. 2018. Soy protein isolate feeding does not result in reproductive toxicity in the pre-pubertal rat testis. Experimental Biology and Medicine. 243:695-707. https://doi.org/10.1177/1535370218771333.

Cecal versus fecal microbiota in ossabaw swine and implications for obesity - (Peer Reviewed Journal)
Panasevich, M., Wankhade, U.D., Chintapalli, S.V., Shankar, K., Rector, R. 2018. Cecal versus fecal microbiota in ossabaw swine and implications for obesity. Physiological Genomics. https://doi.org/10.1152/physiolgenomics.00110.2017.

Infant formula feeding increases hepatic cholesterol 7 alpha hydroxylase (CYP7A1) expression and fecal bile acid loss in neonatal piglets Reprint Icon - (Peer Reviewed Journal)
Mercer, K.E., Bhattacharyya, S., Diaz-Rubio, M.E., Piccolo, B.D., Pack, L.M., Sharma, N., Chaudhury, M., Cleves, M.A., Chintapalli, S.V., Shankar, K., Ronis, M.J., Yeruva, L. 2018. Infant formula feeding increases hepatic cholesterol 7 alpha hydroxylase (CYP7A1) expression and fecal bile acid loss in neonatal piglets. Journal of Nutrition. 148(5):702-711. https://doi.org/10.1093/jn/nxy038.

Association between household food environment and excessive gestational weight gain Reprint Icon - (Peer Reviewed Journal)
Porter, H., West, D.S., Celeves, M.A., Saylors, M.E., Andres, A., Krukowski, R.A. 2018. Association between household food environment and excessive gestational weight gain. Journal of Women's Health. 27(8):1064-1070. http://doi.org/10.1089/jwh.2017.6552.

A novel human breast milk-fed piglet model to examine persistent effects of neonatal diet on duodenal microbiota composition - (Abstract Only)

Dehydroabietic Acid (DHAA) distinguishes early vs late stages of diabetes and is associated with bacterial species and bacterial metabolic pathways in the UC Davis-Type 2 Diabetes (UCD-T2DM) rat model - (Abstract Only)

Persistent effects of pre-weaning in piglets on composition of fecal microbiota are diet-, genus-, and time-specific - (Abstract Only)

Environmental forces that shape early development: What we know and still need to know - (Peer Reviewed Journal)
Shankar, K., Pivik, R.T., Johnson, S.L., Van Ommen, B., Demmer, E., Murray, R. 2017. Environmental forces that shape early development: What we know and still need to know. Current Developments in Nutrition. 1(11):S17081. https://doi.org/10.3945/cdn.117.001826.

Putative inflammatory effects of saturated fatty acids: Experimental confounders and context-specificity - (Abstract Only)

Dynamic Assessment of Microbial Ecology (DAME): A web app for interactive analysis and visualization of microbial sequencing data Reprint Icon - (Peer Reviewed Journal)
Piccolo, B.D., Wankhade, U.D., Chintapalli, S.V., Bhattacharyya, S., Luo, C., Shankar, K. 2018. Dynamic Assessment of Microbial Ecology (DAME): A web app for interactive analysis and visualization of microbial sequencing data. Bioinformatics. 34(6):1050-1052. https://doi.org/10.1093/bioinformatics/btx686.

Fuel trafficking in muscle—potential role of myoglobin/lipid binding - (Abstract Only)

High-fat diet and maternal obesity-associated epigenetic regulation of bone development Reprint Icon - (Book / Chapter)
Chen, J. 2017. High-fat diet and maternal obesity-associated epigenetic regulation of bone development. In: Patel, V., Preedy, V., editors. Handbook of Nutrition, Diet, and Epigenetics. Cham, Swizterland: Springer International Publishing. p. 1-17. https://doi.org/10.1007/978-3-319-31143-2_113-1.

High-fat, high-fructose, high-cholesterol feeding causes severe NASH and cecal microbiota dysbiosis in juvenile Ossabaw swine Reprint Icon - (Peer Reviewed Journal)
Panasevich, M.R., Meers, G.M., Linden, M.A., Booth, F.W., Perfield II, J.W., Fritsche, K., Wankhade, U.D., Chintapalli, S.V., Shankar, K.L., Ibdah, J.A., Rector, R. 2018. High-fat, high-fructose, high-cholesterol feeding causes severe NASH and cecal microbiota dysbiosis in juvenile Ossabaw swine. American Journal of Physiology - Endocrinology and Metabolism. 314:E78-E92. https://doi.org/10.1152/ajpendo.00015.2017.

Prenatal phthalate metabolite concentrations and infant fat mass across the first year of life: A pilot study - (Abstract Only)

Associations between maternal early pregnancy body mass index (BMI) and placental DNA methylation at term - (Abstract Only)

Postpartum maternal fat distribution and its association with offspring body fat through the first year of life - (Abstract Only)

Maternal high-fat diet modulates brown adipose tissue response to B-adrenergic agonist - (Abstract Only)

Anesthesia and bariatric surgery gut preparation alter plasma acylcarnitines reflective of mitochondrial fat and branched-chain amino acid oxidation - (Peer Reviewed Journal)
Bhattacharyya, S., Ali, M., Smith, W.H., Minkler, P.E., Stoll, M.S., Hoppel, C.L., Adams, S.H. 2017. Anesthesia and bariatric surgery gut preparation alter plasma acylcarnitines reflective of mitochondrial fat and branched-chain amino acid oxidation. American Journal of Physiology - Endocrinology and Metabolism. doi:10.1152/ajpendo.00222.2017.

17B-estradiol reduces Cav1.2 channel abundance and attenuates Ca2+-dependent contractions in coronary arteries Reprint Icon - (Peer Reviewed Journal)
Hill, B., Dalton, R.J., Joseph, B.K., Thakali, K.M., Rusch, N.J. 2017. 17B-estradiol reduces Cav1.2 channel abundance and attenuates Ca2+-dependent contractions in coronary arteries. Pharmacology Research and Perspectives. 5(5): e00358. https://doi.org/10.1002/prp2.358.

Gestational age at birth and brain white matter development in term-born infants and children Reprint Icon - (Peer Reviewed Journal)
Ou, X., Glasier, C.M., Ramakrishnaiah, R.H., Kanif, A., Rowell, A.C., Pivik, R.T., Andres, A., Cleves, M.A., Badger, T.M. 2017. Gestational age at birth and brain white matter development in term-born infants and children. American Journal of Neuroradiology. 38(12):2373-2379. http://doi.org/10.3174/ajnr.A5408.

Maternal obesity and gestational weight gain are modestly associated with umbilical cord DNA methylation - (Peer Reviewed Journal)
Thakali, K.M., Jennifer B Faske, J.B., Ishwar, A., Alfaro, M.P., Cleves, M.A., Badger, T.M., Andres, A., Shankar, K. 2017. Maternal obesity and gestational weight gain are modestly associated with umbilical cord DNA methylation. Placenta. Available: https://doi.org/10.1016/j.placenta.2017.07.009.

Formula diet driven microbiota shifts tryptophan metabolism from serotonin to tryptamine in neonatal porcine colon - (Peer Reviewed Journal)
Saraf, M.K., Piccolo, B.D., Bowlin, A.K., Mercer, K.E., Leroith, T., Chintapalli, S.V., Shankar, K., Badger, T.M., Yeruva, L. 2017. Formula diet driven microbiota shifts tryptophan metabolism from serotonin to tryptamine in neonatal porcine colon. BMC Microbiome. 5:77. doi:10.1186/s40168-017-0297-z.

Early postnatal diets affect the bioregional small intestine microbiome and ileal metabolome in neonatal piglets - (Peer Reviewed Journal)
Piccolo, B.D., Mercer, K.E., Bhattacharya, S., Bowlin, A.K., Saraf, M.K., Pack, L., Chintapalli, S.V., Shankar, K., Adams, S.H., Badger, T.M., Yeruva, L. 2017. Early postnatal diets affect the bioregional small intestine microbiome and ileal metabolome in neonatal piglets. Journal of Nutrition. doi:10.3945/jn.117.252767.

Soy compared with milk protein in a western diet changes fecal microbiota and decreases hepatic steatosis in obese OLETF rats - (Peer Reviewed Journal)
Panasevich, M.R., Schuster, C.M., Phillips, K.E., Meers, G., Chintapalli, S.V., Wankhade, U.D., Shankar, K., Butteiger, D.N., Krul, E., Thyfault, J.P., Rector, R.S. 2017. Soy compared with milk protein in a western diet changes fecal microbiota and decreases hepatic steatosis in obese OLETF rats. Journal of Nutritional Biochemistry. 46:125-136. doi:10.1016/j.jnutbio.2017.05.004.

Dynamic assessment of microbial ecology (DAME): A shiny app for analysis and visualization of microbial sequencing data - (Abstract Only)

Neonatal diet composition modulates ileum mitochondrial function in a neonatal pig model Eugenia Carvalho1 - (Abstract Only)
Carvalho, E., Moreira, A.R., Bowlin, A.K., Saraf, M.K., Adams, S.H., Borsheim, E., Yeruva, L. 2017. Neonatal diet composition modulates ileum mitochondrial function in a neonatal pig model Eugenia Carvalho1. Journal of Federation of American Societies for Experimental Biology. 31:654.1.

Early diet has differential effects on the small intestine microbiome by region in neonatal piglets - (Abstract Only)
Piccolo, B., Bowlin, A., Saraf, M., Mercer, K., Bhattacharya, S., Chintapalli, S., Adams, S.H., Shankar, K., Badger, T.M., Yeruva, L. 2017. Early diet has differential effects on the small intestine microbiome by region in neonatal piglets. Journal of Federation of American Societies for Experimental Biology. 31:444.1.

Transcriptome analysis reveals persistent effects of neonatal diet on small intestine gene expression profile in a porcine model - (Abstract Only)
Saraf, M.K., Bowlin, A.K., Chen, C.T., Dawson, H.D., Badger, T.M., Yeruva, L. 2017. Transcriptome analysis reveals persistent effects of neonatal diet on small intestine gene expression profile in a porcine model. Journal of Federation of American Societies for Experimental Biology. 31:434.5.

Human breast milk feeding induces stronger humoral immune response than formula feeding in neonatal porcine model - (Abstract Only)
Yeruva, L., Saraf, M.K., Bowlin, A.K., Badger, T.M. 2017. Human breast milk feeding induces stronger humoral immune response than formula feeding in neonatal porcine model. Journal of Federation of American Societies for Experimental Biology. 31:434.6.

Enhanced offspring predisposition to steatohepatitis with maternal high-fat diet is associated with epigenetic and microbiome alterations - (Peer Reviewed Journal)
Wankhade, U.D., Zhong, Y., Kang, P., Alfaro, M., Chintapalli, S.V., Thakali, K.M., Shankar, K. 2017. Enhanced offspring predisposition to steatohepatitis with maternal high-fat diet is associated with epigenetic and microbiome alterations. PLoS One. 12(4):e0175675. doi:10.1371/journal.pone.0175675.

Obesity modulates inflammation and lipid metabolism oocyte gene expression: A single cell transcriptome perspective - (Peer Reviewed Journal)
Ruebel, M.L., Cotter, M., Sims, C.R., Moutos, D.M., Badger, T.M., Cleves, M.A., Kartik, S., Andres, A. 2017. Obesity modulates inflammation and lipid metabolism oocyte gene expression: A single cell transcriptome perspective. Journal of Clinical Endocrinology and Metabolism. doi:10.1210/jc.2016-3524.

Associations among the cecal microbiome and bacterially-derived cecal xeno-metabolites during diabetes progression in the UC Davis-Type 2 diabetes rat model - (Abstract Only)

Increased physical activity ameliorates high fat diet-induced bone resorption in mice - (Abstract Only)
Chen, J., Lazarenko, O.P., Blackburn, M.L., Carvalho, E., Shankar, K., Borsheim, E. 2017. Increased physical activity ameliorates high fat diet-induced bone resorption in mice. Journal of Federation of American Societies for Experimental Biology. 31(1):799.2.

First trimester maternal adiposity is associated with infant body fat at age 2 weeks: A longitudinal follow-up study - (Abstract Only)
Andres, A., Ruebel, M., Krukoswski, R., Badger, T.M., Shankar, K., Cleves, M. 2017. First trimester maternal adiposity is associated with infant body fat at age 2 weeks: A longitudinal follow-up study. Journal of Federation of American Societies for Experimental Biology. 31:958.24.

Developmental changes in resting gamma power from age three months to five years are modulated by infant diet - (Abstract Only)
Pivik, R.T., Andres, A., Cleves, M.A., Tennal, K.B., Gu, Y., Badger, T.M. 2017. Developmental changes in resting gamma power from age three months to five years are modulated by infant diet. Journal of Federation of American Societies for Experimental Biology. 31:958.9.

Infant formula feeding alters the proliferative status of neonatal mammary glands independent of estrogen signaling - (Abstract Only)
Bhattacharyya, S., Mercer, K.E., Hennings, L., Sharma, N., Chaudhury, M., Yeruva, L., Ronis, M., Badger, T.M. 2017. Infant formula feeding alters the proliferative status of neonatal mammary glands independent of estrogen signaling. Journal of Federation of American Societies for Experimental Biology. 31:792.11.

Male testicular development is affected by estrogens but not altered in neonatal piglets receiving soy infant formula - (Abstract Only)
Mercer, K.E., Chen, C.T., Hennings, L., Sharma, N., Dawson, H.D., Yeruva, L., Ronis, M., Badger, T.M. 2017. Male testicular development is affected by estrogens but not altered in neonatal piglets receiving soy infant formula. Federation of American Societies for Experimental Biology Conference. 31:792.5.

Native whey induces higher and faster leucinemia than other whey protein supplements and milk: A randomized controlled trial - (Peer Reviewed Journal)
Hamarsland, H., Larsen Laahne, J., Paulsen, G., Cotter, M., Borsheim, E., Raastad, T. 2017. Native whey induces higher and faster leucinemia than other whey protein supplements and milk: A randomized controlled trial. Biomed Central (BMC) Nutrition. 3:10. doi:10.1186/s40795-017-0131-9.

Effects of early cholesterol intake on cholesterol 7 alpha hydroxylase (Cyp7a1) expression in piglets receiving sow's breast milk or infant formula until weaning - (Abstract Only)

Application of an in vivo hepatic triacylglycerol production method in the setting of a high fat diet in mice - (Peer Reviewed Journal)
Ono-Moore, K.D., Ferguson, M., Blackburn, M.L., Issafras, H., Adams, S.H. 2016. Application of an in vivo hepatic triacylglycerol production method in the setting of a high fat diet in mice. Nutrients. 9(1):16. doi:10.3390/nu9010016.

Placental transcriptome co-expression analysis reveals conserved regulatory program across gestation - (Peer Reviewed Journal)
Buckberry, S., Bianco-Miotto, T., Bent, S.J., Clifton, V., Shoubridge, C., Shankar, K., Roberts, C.T. 2017. Placental transcriptome co-expression analysis reveals conserved regulatory program across gestation. BMC Genomics. 18(1):10. doi:10.1186/s12864-016-3384-9.

Soy protein isolate inhibits hepatic tumor promotion in mice fed a high-fat liquid diet - (Peer Reviewed Journal)
Mercer, K., Pulliam, C.F., Brint, K., Hennings, L., Ronis, M.J. 2017. Soy protein isolate inhibits hepatic tumor promotion in mice fed a high-fat liquid diet. Experimental Biology and Medicine. 242(6):635-644. doi:10.1177/1535370216685436.

Obesity and pregnancy: Mechanisms of short term and long term adverse consequences for mother and child - (Review Article)
Catalano, P.M., Shankar, K. 2017. Obesity and pregnancy: Mechanisms of short term and long term adverse consequences for mother and child. British Medical Journal. doi:10.1136/bmj.j1.

Novel browning agents, mechanisms and therapeutic potentials of brown adipose tissue - (Review Article)
Wankhade, U.D., Shen, M., Yadav, H., Thakali, K.M. 2016. Novel browning agents, mechanisms and therapeutic potentials of brown adipose tissue. BioMed Research International. 2016:Article ID 2365609. Available: doi.10.1155/2016/2365609.

Are early first trimester weights valid proxies for preconception weight? - (Peer Reviewed Journal)
Krukowski, R.A., West, D.S., DiCarlo, M., Shankar, K., Cleves, M.A., Saylors, M.E., Andres, A. 2016. Are early first trimester weights valid proxies for preconception weight? BMC Pregnancy & Childbirth. 16:357. doi:10.1186/s12884-016-1159-6.

A novel amino acid and metabolomics signature in mice overexpressing muscle uncoupling protein 3 - (Peer Reviewed Journal)
Aguer, C., Piccolo, B., Fiehn, O., Adams, S.H., Harper, M. 2016. A novel amino acid and metabolomics signature in mice overexpressing muscle uncoupling protein 3. Journal of Federation of American Societies for Experimental Biology. doi:10.1096/fj.201600914R.

Global deletion of glutathione S-Transferase A4 exacerbates developmental nonalcoholic steatohepatitis - (Peer Reviewed Journal)
Ronis, M.J., Mercer, K.E., Engi, B., Pulliam, C., Zimniak, P., Hennings, L., Shearn, C.T., Badger, T.M., Petersen, D.R. 2017. Global deletion of glutathione S-Transferase A4 exacerbates developmental nonalcoholic steatohepatitis. American Journal of Pathology. 187(2):418-430.

Acylcarnitines as markers of exercise-associated fuel partitioning, xenometabolism, and potential signals to muscle afferent neurons - (Peer Reviewed Journal)
Zhang, J., Light, A.R., Hoppel, C.L., Campbell, C., Chandler, C.J., Burnett, D.J., Souza, E.C., Casazza, G.A., Hughen, R.W., Keim, N.L., Newman, J.W., Hunter, G.R., Fernandez, J.R., Garvey, W.T., Harper, M., Fiehn, O., Adams, S.H. 2017. Acylcarnitines as markers of exercise-associated fuel partitioning, xenometabolism, and potential signals to muscle afferent neurons. Experimental Physiology. 102(1):48-69. doi:10.1113/EP086019.

Novel molecular interactions of acylcarnitines and fatty acids with myoglobin - (Peer Reviewed Journal)
Chintapalli, S.V., Jayanthi, S., Mallipeddi, P.L., Gundampati, R.K., Suresh Kumar, T.K., Van Rossum, D.B., Anishkin, A., Adams, S.H. 2016. Novel molecular interactions of acylcarnitines and fatty acids with myoglobin. Journal of Biological Chemistry. 291(48):25133-25143. doi:10.1074/jbc.M116.754978.

Association of gestational weight gain expectations with advice on actual weight gain - (Peer Reviewed Journal)
Krukowski, R.A., West, D.S., Dicarlo, M., Cleves, M.A., Saylors, M.E., Andres, A. 2017. Association of gestational weight gain expectations with advice on actual weight gain. Obstetrics & Gynecology. 129(1):76-82. doi:10.1097/AOG.0000000000001780.

Mice fed a high-fat diet supplemented with resistant starch display marked shifts in the liver metabolome concurrent with altered gut bacteria - (Peer Reviewed Journal)
Kieffer, D.A., Piccolo, B.D., Marco, M.L., Kim, E., Goodson, M.L., Keenan, M.J., Dunn, T.N., Knudsen, K., Martin, R.J., Adams, S.H. 2016. Mice fed a high-fat diet supplemented with resistant starch display marked shifts in the liver metabolome concurrent with altered gut bacteria. Journal of Nutrition. doi:10.3945/jn.116.238931.

Obese mice fed a diet supplemented with enzyme-treated wheat bran display marked shifts in the liver metabolome concurrent with altered gut bacteria - (Peer Reviewed Journal)
Kieffer, D.A., Piccolo, B.D., Marco, M.L., Kim, E., Goodson, M.L., Keenan, M.J., Dunn, T.N., Knudsen, K.E., Adams, S.H., Martin, R.J. 2016. Obese mice fed a diet supplemented with enzyme-treated wheat bran display marked shifts in the liver metabolome concurrent with altered gut bacteria. Journal of Nutrition. doi:10.3945/jn.116.238923.

Maternal obesity programs senescence signaling and glucose metabolism in osteo-progenitors from rat and human - (Peer Reviewed Journal)
Chen, J., Lazarenko, O.P., Blackburn, M.L., Rose, S., Frye, R.E., Badger, T.M., Andres, A., Shankar, K. 2016. Maternal obesity programs senescence signaling and glucose metabolism in osteo-progenitors from rat and human. Endocrinology. 157(11):4172-4183. doi:10.1210/en.2016-1408.

Dietary factors during early life program bone formation in female rats - (Peer Reviewed Journal)
Chen, J., Lazarenko, O.P., Blackburn, M.L., Shankar, K. 2017. Dietary factors during early life program bone formation in female rats. Federation of American Societies for Experimental Biology Conference. 31(1):376-387. doi:10.1096/fj.201600703R.

Differences in brain functional connectivity at resting state in neonates born to healthy obese or normal-weight mothers - (Peer Reviewed Journal)
Ou, X., Li, X., Zhang, Y., Andres, A., Pivik, R.T., Glasier, C., Ramakrishnaiah, R., Badger, T., Shankar, K. 2016. Differences in brain functional connectivity at resting state in neonates born to healthy obese or normal-weight mothers. International Journal of Obesity. doi:10.1038/ijo.2016.166.

Profiling of urinary bile acids in piglets by a combination of enzymatic deconjugation and targeted LC-MRM-MS - (Peer Reviewed Journal)
Fang, N., Yu, S., Adams, S.H., Ronis, M.J., Badger, T.M. 2016. Profiling of urinary bile acids in piglets by a combination of enzymatic deconjugation and targeted LC-MRM-MS. Journal of Lipid Research. doi:10.1194/jlr.D069831.

Impact of dietary fibers on nutrient management and detoxification organs: Gut, liver, and kidneys - (Review Article)
Kieffer, D., Martin, R.J., Adams, S.H. 2016. Impact of dietary fibers on nutrient management and detoxification organs: Gut, liver, and kidneys. Advances in Nutrition. 7(6):1111-1121. doi:10.3945/an.116.013219.

A behavioral intervention to reduce excessive gestational weight gain - (Peer Reviewed Journal)
Krukowski, R.A., West, D., Dicarlo, M., Shankar, K., Cleves, M.A., Tedford, E., Andres, A. 2016. A behavioral intervention to reduce excessive gestational weight gain. Maternal and Child Health Journal. DOI 10.1007/s10995-016-2127-5.

Persistent influence of maternal obesity on offspring health: Mechanisms from animal models and clinical studies - (Review Article)
Wankhade, U.D., Thakali, K.M., Shankar, K. 2016. Persistent influence of maternal obesity on offspring health: Mechanisms from animal models and clinical studies. Molecular and Cellular Endocrinology. doi: 10.1016/j.mce.2016.07.001.

Gut microbiota are linked to increased susceptibility to hepatic steatosis in low aerobic capacity rats fed an acute high fat diet - (Peer Reviewed Journal)
Panasevich, M.R., Morris, E.M., Chintapalli, S.V., Wankhade, U.D., Shankar, K., Britton, S.L., Koch, L.G., Thyfault, J.P., Rector, R.S. 2016. Gut microbiota are linked to increased susceptibility to hepatic steatosis in low aerobic capacity rats fed an acute high fat diet. American Journal of Physiology - Gastrointestinal and Liver Physiology. 311(1):G166-G179. doi: 10.1152/ajpgi.00065.2016.

Maternal obesity is associated with ovarian inflammation and up-regulation of early growth response factor 1 - (Peer Reviewed Journal)
Ruebel, M., Shankar, K., Gaddy, D., Lindsey, F., Badger, T.M., Andres, A. 2016. Maternal obesity is associated with ovarian inflammation and up-regulation of early growth response factor 1. American Journal of Physiology - Endocrinology and Metabolism. 311(1):E269-E277. doi: 10.1152/ajpendo.00524.2015.

Infant diet-related changes in syllable processing between 4 and 5 months: Implications for developing native language sensitivity - (Peer Reviewed Journal)
Pivik, T.R., Andres, A., Bai, S., Cleves, M.A., Tennal, K.B., Gu, Y., Badger, T.M. 2016. Infant diet-related changes in syllable processing between 4 and 5 months: Implications for developing native language sensitivity. Developmental Neuropsychology. 41(4):215-230. doi:10.1080/87565641.2016.1236109.

Brown adipose tissue activation is linked to distinct systemic effects on lipid metabolism in humans - (Peer Reviewed Journal)
Chondronikola, M., Volpi, E., Borsheim, E., Porter, C., Saraf, M.K., Annamalai, P., Yfanti, C., Chao, T., Wong, D., Shinoda, K., Labbe, S.M., Hurren, N.M., Cesani, F., Kajimura, S., Sidossis, L.S. 2016. Brown adipose tissue activation is linked to distinct systemic effects on lipid metabolism in humans. Cell Metabolism. 23:1200-1206.

Plasma amino acid and metabolite signatures tracking diabetes progression in the UCD-T2DM rat model - (Peer Reviewed Journal)
Piccolo, B., Graham, J., Stanhope, K., Fiehn, O., Havel, P., Adams, S.H. 2016. Plasma amino acid and metabolite signatures tracking diabetes progression in the UCD-T2DM rat model. American Journal of Physiology - Endocrinology and Metabolism. 310(11):958-969. doi: 10.1152/ajpendo.00052.2016.

RNA-sequencing data analysis of uterus in ovariectomized rats fed with soy protein isolate,17B-estradiol and casein - (Peer Reviewed Journal)
Ronis, M.J., Gomez-Acevedo, H., Blackburn, M.L., Cleves, M.A., Singhal, R., Badger, T.M. 2016. RNA-sequencing data analysis of uterus in ovariectomized rats fed with soy protein isolate,17B-estradiol and casein. Data in Brief. 7:1491-1496. http://dx.doi.org/10.1016/j.dib.2016.04.033

Brown adipose tissue is linked to a distinct thermoregulatory response to mild cold in people - (Peer Reviewed Journal)
Chondronikola, M., Volpi, E., Borsheim, E., Chao, T., Porter, C., Annamalai, P., Yfanti, C., Labbe, S.M., Hurren, N.M., Malagaris, I., Cesani, F., Sidossis, L.S. 2016. Brown adipose tissue is linked to a distinct thermoregulatory response to mild cold in people. Frontiers in Physiology. 7:129. https://doi.org/10.3389/fphys.2016.00129.

Formula diet alters small intestine morphology, microbial abundance and reduces VE-cadherin and IL-10 expression in neonatal porcine model - (Peer Reviewed Journal)
Yeruva, L., Spencer, N.E., Saraf, M.K., Hennings, L., Bowlin, A.K., Cleves, M., Mercer, K., Chintappalli, S.V., Shankar, K., Rank, R., Badger, T.M., Ronis, M.J. 2016. Formula diet alters small intestine morphology, microbial abundance and reduces VE-cadherin and IL-10 expression in neonatal porcine model. BioMed Central (BMC) Gastroenterology. 16:40. doi: 10.1186/s12876-016-0456-x.

Uterine responses to feeding soy protein isolate and treatment with 17B-estradiol differ in ovariectomized female rats - (Peer Reviewed Journal)
Ronis, M.J., Gomez-Acevedo, H., Blackburn, M.L., Cleves, M.A., Singhal, R., Badger, T.M. 2016. Uterine responses to feeding soy protein isolate and treatment with 17B-estradiol differ in ovariectomized female rats. Toxicology and Applied Pharmacology. 297:68-80. doi.org/10.1016/j.taap.2016.02.019.

Soy protein isolate protects against ethanol mediated tumor progression in diethylnitrosamine treated male mice - (Peer Reviewed Journal)
Mercer, K.E., Pulliam, C., Hennings, L., Lai, K., Cleves, M., Jones, E., Drake, R.R., Ronis, M.J. 2016. Soy protein isolate protects against ethanol mediated tumor progression in diethylnitrosamine treated male mice. Cancer Prevention Research. 9(6):466-475. doi: 10.1158/1940-6207.CAPR-15-0417.

Resistant starch alters gut microbiome and metabolomics profiles concurrent with amelioration of chronic kidney disease in rats - (Peer Reviewed Journal)
Kieffer, D., Piccolo, B., Vaziri, N., Liu, S., Lau, W., Khazaeli, M., Nazertehrani, S., Moore, M., Marco, M., Martin, R. 2016. Resistant starch alters gut microbiome and metabolomics profiles concurrent with amelioration of chronic kidney disease in rats. American Journal of Physiology - Renal Physiology. 310(9):857-871. doi: 10.1152/ajprenal.00513.2015.

Unique plasma metabolomic signatures of individuals with inherited disorders of long-chain fatty acid oxidation - (Peer Reviewed Journal)
Mccoin, C.S., Piccolo, B.D., Knotts, T.A., Matern, D., Vockley, J., Gillingham, M.B. 2016. Unique plasma metabolomic signatures of individuals with inherited disorders of long-chain fatty acid oxidation. Journal of Inherited Metabolic Disease. 39(3):399-408.

Effect of diet-induced maternal obesity on fetal skeletal development - (Book / Chapter)
Chen, J. 2016. Effect of diet-induced maternal obesity on fetal skeletal development. In: Watson, R.R., Mahadevan, D., editors. Handbook of Nutrition and Diet in Therapy of Bone Diseases. The Netherlands: Wageningen Academic. p. 67-79.

Blueberry diet derived 3-(3-hydroxyphenyl) propionic acid (PPA) suppresses osteoblastic cell senescence to promote bone accretion in mice - (Abstract Only)

Transcriptomic and epigenomic landscapes during cell fusion in BeWo trophoblast cells - (Peer Reviewed Journal)
Shankar, K., Kang, P., Zhong, Y., Borengasser, S.J., Wingfield, C., Saben, J., Gomez-Acevedo, H., Thakali, K.M. 2015. Transcriptomic and epigenomic landscapes during cell fusion in BeWo trophoblast cells. Placenta. 36(12):1342-1351.

Long-term skeletal muscle mitochondrial dysfunction is associated with hypermetabolism in severely burned children - (Peer Reviewed Journal)
Porter, C., Herndon, D., Borsheim, E., Bhattarai, N., Chao, T., Reidy, P.T., Rasmussen, B.B., Andersen, C.R., Suman, O.E., Sidossis, L.S. 2016. Long-term skeletal muscle mitochondrial dysfunction is associated with hypermetabolism in severely burned children. Journal of Burn Care and Rehabilitation. 37(1):53-63. doi: 10.1097/BCR.0000000000000308.

Voxel-based morphometry and fMRI revealed differences in brain gray matter in breastfed and milk formula–fed children - (Peer Reviewed Journal)
Ou, X., Andres, A., Pivik, R.T., Cleves, M.A., Snow, J.H., Ding, Z., Badger, T.M. 2015. Voxel-based morphometry and fMRI revealed differences in brain gray matter in breastfed and milk formula–fed children. American Journal of Neuroradiology. 37:713-719. doi: 10.3174/ajnr.A4593.

Revisiting separation properties of convex fuzzy sets - (Peer Reviewed Journal)
Gomez-Acevedo, H. 2015. Revisiting separation properties of convex fuzzy sets. Journal of Intelligent & Fuzzy Systems. 29(2):845-849. doi: 10.3233/IFS-151613.

Metabolic, anabolic, and mitogenic insulin responses: A tissue-specific perspective for insulin receptor activators - (Review Article)
Bedinger, D.H., Adams, S.H. 2015. Metabolic, anabolic, and mitogenic insulin responses: A tissue-specific perspective for insulin receptor activators. Molecular and Cellular Endocrinology. 415:143-156. doi: 10.1016/j.mce.2015.08.013.

Acylcarnitines: old actors auditioning for new roles in metabolic physiology - (Review Article)
Mccoin, C.S., Knotts, T.A., Adams, S.H. 2015. Acylcarnitines: Old actors auditioning for new roles in metabolic physiology. Nature Reviews Endocrinology. doi:10.1038/2015.129.

Reversing gestational undernutrition via kick-starting early growth - (Review Article)
Shankar, K. 2015. Reversing gestational undernutrition via kick-starting early growth. Endocrinology. 156(9):3059-3062. doi: 10.1210/en.2015-1625.

Amino acid availability regulates the effect of hyperinsulinemia on skin protein metabolism in pigs - (Peer Reviewed Journal)
Tuvdendorj, D., Borsheim, E., Sharp, C.P., Zhang, X., Barone, C.M., Chinkes, D.L., Wolfe, R.R. 2015. Amino acid availability regulates the effect of hyperinsulinemia on skin protein metabolism in pigs. Journal of Biological Chemistry. 290(29):17776-17783.

p47phox-Nox2-dependent ROS signaling inhibits early bone development in mice but protects against skeletal aging - (Peer Reviewed Journal)
Chen, J., Lazarenko, O.P., Blackburn, M.L., Mercer, K.E., Badger, T.M., Ronis, M.J. 2015. p47phox-Nox2-dependent ROS signaling inhibits early bone development in mice but protects against skeletal aging. Journal of Biological Chemistry. 290(23):14692-14704.

Obesity-related changes in bone structural and material properties in hyperphagic OLETF rats and protection by voluntary wheel running - (Peer Reviewed Journal)
Hinton, P.S., Shankar, K., Eaton, L.M., Rector, R.S. 2015. Obesity-related changes in bone structural and material properties in hyperphagic OLETF rats and protection by voluntary wheel running. Metabolism. 64(8):905-916. doi: 10.1016/j.metabol.2015.04.004.

Brain gray and white matter differences in healthy normal weight and obese children - (Peer Reviewed Journal)
Ou, X., Andres, A., Pivik, R.T., Cleves, M.A., Badger, T.M. 2015. Brain gray and white matter differences in healthy normal weight and obese children. Journal of Magnetic Resonance Imaging. 42(5):1205-1213.

Compared with feeding infants breast milk or cow-milk formula, soy formula feeding does not affect subsequent reproductive organ size at 5 years of age - (Peer Reviewed Journal)
Andres, A., Moore, M.B., Linam, L., Casey, P.H., Cleves, M., Badger, T.M. 2015. Compared with Feeding Infants Breast Milk or Cow-milk formula, soy formula feeding does not affect subsequent reproductive organ size at 5 years of age. Journal of Nutrition. 145(5):871-875.

Longitudinal body composition of children born to normal weight, overweight and obese mothers - (Peer Reviewed Journal)
Andres, A., Hull, H., Cleves, M., Casey, P., Badger, T., Shankar, K. 2015. Longitudinal body composition of children born to normal weight, overweight and obese mothers. Obesity. 23(6):1252-1258.

Enzyme-treated wheat bran alters gut microbiota and liver metabolome in mice fed a high fat diet - (Abstract Only)
Kieffer, D.A., Martin, R.J., Piccolo, B.D., Marco, M.L., Kim, E.B., Keenan, K.E., Knudsten, T.N., Dunn, T.N., Adams, S.H. 2015. Enzyme-treated wheat bran alters gut microbiota and liver metabolome in mice fed a high fat diet. Federation of American Societies for Experimental Biology Conference. 29(1):258.6.

Resistant starch alters gut microbiota and reduces uremic retention solutes in rats with adenine-induced chronic kidney disease - (Abstract Only)
Kieffer, D.A., Piccolo, B.D., Liu, S., Khazaeli, M., Nazertherranni, S.D., Vaziri, N.D., Martin, R.J., Adams, S.H. 2015. Resistant starch alters gut microbiota and reduces uremic retention solutes in rats with adenine-induced chronic kidney disease. Federation of American Societies for Experimental Biology Conference. 29(1):274.4.

Differential pathway coupling efficiency of the activated insulin receptor drives signaling selectivity by xmeta, an allosteric partial agonist antibody - (Peer Reviewed Journal)
Bedinger, D.H., Goldfine, I.D., Corbin, J.A., Roell, M.K., Adams, S.H. 2015. Differential pathway coupling efficiency of the activated insulin receptor drives signaling selectivity by xmeta, an allosteric partial agonist antibody. Journal of Pharmacology and Experimental Therapeutics. 353(1):35-43.

Maternal adiposity negatively influences infant brain white matter development - (Peer Reviewed Journal)
Ou, X., Thakali, K.M., Shankar, K., Andres, A., Badger, T.M. 2015. Maternal adiposity negatively influences infant brain white matter development. Obesity. 23(5):1047-1054.

Predictors of muscle protein synthesis after severe pediatric burns - (Peer Reviewed Journal)
Diaz, E.C., Herndon, D.N., Lee, J., Porter, C., Cotter, M., Suman, O.E., Sidossis, L.S., Borsheim, E. 2015. Predictors of muscle protein synthesis after severe pediatric burns. Journal of Trauma and Acute Care Surgery. 78(4):816-822.

Whey protein supplementation does not alter plasma branched-chained amino acid profiles but results in unique metabolomics patterns in obese women enrolled in an 8-week weight loss trial - (Peer Reviewed Journal)
Piccolo, B.D., Comerford, K.B., Karakas, S.E., Knotts, T.A., Fiehn, O., Adams, S.H. 2015. Whey protein supplementation does not alter plasma branched-chained amino acid profiles but results in unique metabolomics patterns in obese women enrolled in an 8-week weight loss trial. Journal of Nutrition. 145(4):691-700, R1-R134.

High amylose resistant starch diet ameliorates oxidative stress, inflammation, and progression of chronic kidney disease - (Peer Reviewed Journal)
Vaziri, N.D., Oiu, S., Lau, W., Nazertehrani, S., Farzaneh, S.H., Kieffer, D.A., Adams, S.H., Martin, R.J. 2014. High amylose resistant starch diet ameliorates oxidative stress, inflammation, and progression of chronic kidney disease. PLoS One. 9(12) doi:http://dx.doi.org/10.1371/journal.pone.0114881.

RNA-seq analysis of the rat placentation site reveals maternal obesity-associated changes in placental and offspring thyroid hormone signaling - (Peer Reviewed Journal)
Saben, J., Kang, P., Zhong, Y., Thakali, K., Gomez-Acevedo, H., Borengasser, S.J., Andres, A., Badger, T.M., Shankar, K. 2014. RNA-seq analysis of the rat placentation site reveals maternal obesity-associated changes in placental and offspring thyroid hormone signaling. Placenta. 35(12):1013-1020.

Temporal metabolomic responses of cultured HepG2 liver cells to high fructose and high glucose exposures - (Peer Reviewed Journal)
Meissen, J.K., Hirahatake, K.M., Adams, S.H., Fiehn, O. 2015. Temporal metabolomic responses of cultured HepG2 liver cells to high fructose and high glucose exposures. Metabolomics. 11(3):707-721.

N-acetylcysteine inhibits the up-regulation of mitochondrial biogenesis genes in livers from rats fed ethanol chronically - (Peer Reviewed Journal)
Caro, A.A., Bell, M., Ejiofor, S., Zurcher, G., Petersen, D.R., Ronis, M.J. 2014. N-acetylcysteine inhibits the up-regulation of mitochondrial biogenesis genes in livers from rats fed ethanol chronically. Alcoholism: Clinical and Experimental. 38(12):2896-2906.

Body composition from age 3 months to 6 years of children born to lean, overweight and obese mothers Reprint Icon - (Abstract Only)
Andres, A., Hull, H.R., Shankar, K., Cleves, M., Casey, P.H., Badger, T.M. 2014. [Poster#T-2323-P] Body composition from age 3 months to 6 years of children born to lean, overweight and obese mothers. Annual Scientific Meeting NAASO, The Obesity Society. http://obesityweek.com/app/uploads/2015/03/2014-TOS-Abstracts.pdf.

Habitual physical activity and plasma metabolomic patterns distinguish individuals with low vs. high weight loss during controlled energy restriction - (Peer Reviewed Journal)
Piccolo, B.D., Keim, N.L., Fiehn, O., Adams, S.H., Van Loan, M.D., Newman, J.W. 2014. Habitual physical activity and plasma metabolomic patterns distinguish individuals with low vs. high weight loss during controlled energy restriction. Journal of Nutrition. 145(4):681-690.

Matrix effects break the LC behavior rule for analytes in LC-MS/MS analysis of biological samples - (Peer Reviewed Journal)
Fang, N., Yu, S., Ronis, M.J., Badger, T.M. 2015. Matrix effects break the LC behavior rule for analytes in LC-MS/MS analysis of biological samples.Experimental Biology and Medicine. 240(4):488-497.

Trace element status and zinc homeostasis differ in breast and formula-fed piglets - (Peer Reviewed Journal)
Ronis, M.J., Miousse, I.R., Mason, A.Z., Sharma, N., Blackburn, M.L., Badger, T.M. 2015. Trace element status and zinc homeostasis differ in breast and formula-fed piglets. Experimental Biology and Medicine. 240(1):58-66.

Brown adipose tissue improves whole-body glucose homeostasis and insulin sensitivity in humans - (Peer Reviewed Journal)
Chondronikola, M., Volpi, E., Borsheim, E., Porter, C., Annamalai, P., Enerback, S., Lidell, M.E., Saraf, M.K., Labbe, S.M., Hurren, N.M., Yfanti, C., Chao, T., Andersen, C.R., Cesani, F., Hawkins, H., Sidossis, L.S. 2014. Brown adipose tissue improves whole-body glucose homeostasis and insulin sensitivity in humans. Diabetes. 63:4089-4099.

Distinct adipogenic differentiation phenotypes of human umbilical cord mesenchymal cells dependent on adipogenic conditions - (Peer Reviewed Journal)
Saben, J., Thakali, K.M., Lindsey, F.E., Zhong, Y., Badger, T.M., Andres, A., Shankar, K. 2015. Distinct adipogenic differentiation phenotypes of human umbilical cord mesenchymal cells dependent on adipogenic conditions. Experimental Biology and Medicine. 239(10):1340-1351.

Sex-specific association between infant diet and white matter integrity in 8-y-old children - (Peer Reviewed Journal)
Ou, X., Andres, A., Cleves, M.A., Pivik, R.T., Snow, J.H., Ding, Z., Badger, T.M. 2014. Sex-specific association between infant diet and white matter integrity in 8-y-old children. Pediatric Research. 76(6):535-543. doi: 10.1038/pr.2014.129.

Sex-specific association between infant diet and white matter integrity in 8-y-old children - (Peer Reviewed Journal)
Ou, X., Andres, A., Cleves, M.A., Pivik, R.T., Snow, J.H., Ding, Z., Badger, T.M. 2014. Sex-specific association between infant diet and white matter integrity in 8-y-old children. Pediatric Research. 76(6):535-543.

Alcohol consumption, Wnt/ß-catenin cignaling, and hepatocarcinogenesis - (Book / Chapter)
Mercer, K.E., Hennings, L., Ronis, M.J. 2014. Alcohol consumption, Wnt/ß-catenin cignaling, and hepatocarcinogenesis. Advances in Experimental Medicine and Biology. 815:185-195.

Nox2-dependent ROS signaling protects against skeletal ageing - (Abstract Only)
Chen, J., Lazarenko, O.P., Mercer, K., Blackburn, M.L., Badger, T.M., Ronis, M.J. 2015. Nox2-dependent ROS signaling protects against skeletal ageing. Journal of Bone and Mineral Research. 29(S1):Presentation Number: SA0463. Available at http://www.asbmr.org/education/2014-abstracts.

Soy protein isolate inhibits high fat diet-induced senescence pathways in osteoblasts to maintain bone acquisition in rats - (Abstract Only)
Chen, J., Lazarenko, O.P., Blackburn, M.L., Badger, T.M., Ronis, M.J. 2015. Soy protein isolate inhibits high fat diet-induced senescence pathways in osteoblasts to maintain bone acquisition in rats. Journal of Bone and Mineral Research. 29(S1):Presentation Number:SU0185. Available at http://www.asbmr.org/education/2014-abstracts.

Alcohol consumption promotes diethylnitrosamine-induced hepatocarcinogenesis in male mice through the activation of the Wnt/Beta-catenin signaling pathway - (Peer Reviewed Journal)
Mercer, K.E., Hennings, L., Sharma, N., Lai, K.K., Cleves, M.A., Wynne, R.A., Badger, T.M., Ronis, M.J. 2014. Alcohol consumption promotes diethylnitrosamine-induced hepatocarcinogenesis in male mice through the activation of the Wnt/Beta-catenin signaling pathway. Cancer Prevention Research. 7(7):675-685.

Short term feeding of a high fat diet exerts an additive effect on hepatocellular damage and steatosis in liver-specific PTEN knockout mice - (Peer Reviewed Journal)
Shearn, C.T., Mercer, K.E., Orlicky, D., Hennings, L., Smathers-Mccullough, R.L., Stiles, B.L., Petersen, D.R. 2014. Short term feeding of a high fat diet exerts an additive effect on hepatocellular damage and steatosis in liver-specific PTEN knockout mice. PLoS One. 9(5):e96553.

Soy protein isolate inhibits high-Ffat diet-induced senescence pathways in osteoblasts to maintain bone acquisition in male rats - (Peer Reviewed Journal)
Chen, J., Lazarendo, O.P., Blackburn, M.L., Badger, T.M., Ronis, M.J. 2015. Soy protein isolate inhibits high-Ffat diet-induced senescence pathways in osteoblasts to maintain bone acquisition in male rats. Endocrinology. 156(2):475-487.

Soy protein isolate down-regulates caveolin-1 expression to suppress osteoblastic cell senescence pathways - (Peer Reviewed Journal)
Zhang, J., Lazarenko, O.P., Vlxkvuen, M.L., Badger, T.M., Ronis, M.J., Chen, J. 2014. Soy protein isolate down-regulates caveolin-1 expression to suppress osteoblastic cell senescence pathways. FASEB Journal. 28(7):3134-3145.

Genistein supplementation increases bone turnover but does not prevent alcohol-induced bone loss in male mice - (Peer Reviewed Journal)
Yang, C.S., Mercer, K.E., Alund, A.W., Suva, L.J., Badger, T.M., Ronis, M.J. 2014. Genistein supplementation increases bone turnover but does not prevent alcohol-induced bone loss in male mice. Experimental Biology and Medicine. 239(10):1380-1389.

A comprehensive analysis of the human placenta transcriptome - (Peer Reviewed Journal)
Saben, J., Zhong, Y., McKelvey, S., Dajani, N., Andres, A., Badger, T., Gomez-Acevedo, H., Shankar, K. 2014. A comprehensive analysis of the human placenta transcriptome. Placenta. 35(2):125-131.

Differential susceptibilities to azithromycin treatment of chlamydial infection in the gastrointestinal tract and cervix - (Peer Reviewed Journal)
Yeruva, L., Melnyk, S., Spencer, N., Bowlin, A., Rank, R.G. 2014. Differential susceptibilities to azithromycin treatment of chlamydial infection in the gastrointestinal tract and cervix. Antimicrobial Agents and Chemotherapy. 57(12):6290-6294.

Health effects of protein intake in healthy adults: A systematic literature review - (Review Article)
Pedersen, A.N., Kondrup, J., Borsheim, E. 2013. Health effects of protein intake in healthy adults: A systematic literature review. Food and Nutrition Research. 57:21245. Available at http://dx.doi.org/10.3402/fnr.v57i0.21245.

Soy protein inhibits inflammation-induced VCAM-1 and inflammatory cytokine induction by inhibiting the NF-kappaB and AKT signaling pathway in apolipoprotein E-deficient mice - (Peer Reviewed Journal)
Burris, R.L., Ng, H., Nagarajan, S. 2014. Soy protein inhibits inflammation-induced VCAM-1 and inflammatory cytokine induction by inhibiting the NF-kappaB and AKT signaling pathway in apolipoprotein E-deficient mice. European Journal of Nutrition. 53(1):135-148.

Untargeted metabolomics reveal disparate metabolite profile in follicular fluid between obese and normal weight women - (Abstract Only)
Ruebel, M., Piccolo, B., Moutos, D., Shankar, K., Andres, A. 2017. Untargeted metabolomics reveal disparate metabolite profile in follicular fluid between obese and normal weight women. Journal of Federation of American Societies for Experimental Biology. 31:457.2.