Research Project: Immunity, Inflammation, and Nutrition in Aging

Location: Jean Mayer Human Nutrition Research Center On Aging

Publications (Clicking on the reprint icon will take you to the publication reprint.)

Lack of differences in inflammation and T cell-mediated function between young and older women with obesity - (Peer Reviewed Journal)
Dao, M.C., Saltzman, E., Page, M., Reece, J., Mojtahed, T., Wu, D., Meydani, S.N. 2020. Lack of differences in inflammation and T cell-mediated function between young and older women with obesity. Nutrients. 12(1):237. https://doi.org/10.3390/nu12010237.

Dietary fruit and vegetable supplementation suppresses diet-induced atherosclerosis in LDL receptor knockout mice - (Abstract Only)
Guo, W., Kim, S., Wu, D., Li, L., Thomas, M., Meydani, S.N., Meydani, M. 2019. Dietary fruit and vegetable supplementation suppresses diet-induced atherosclerosis in LDL receptor knockout mice [abstract]. American Society for Nutrition. Abstract No. OR24-07-19.

Edible mushrooms reduce atherosclerotic risk in Ldlr-/- mice fed high-fat diet - (Peer Reviewed Journal)
Kim, S.H., Thomas, M.J., Wu, D., Carman, C.V., Ordovas, J.M., Meydani, M. 2019. Edible mushrooms reduce atherosclerotic risk in Ldlr-/- mice fed high-fat diet. Journal of Nutrition. https://doi.org/10.1093/jn/nxz075.

Regulatory role of vitamin E in the immune system and inflammation - (Review Article)
Lewis, E.D., Meydani, S.N., Wu, D. 2018. Regulatory role of vitamin E in the immune system and inflammation. International Union of Biochemistry and Molecular Biology Life. 71(4). https://doi.org/10.1002/iub.1976.

Vitamin E, immune function, and protection against infection - (Book / Chapter)
Wu, D., Meydani, S.N. 2019. Vitamin E, immune function, and protection against infection. In: Weber P, Birringer M, Blumberg JB, Eggersdorfer M., Frank J., editors. Vitamin E in Human Health. Springer Nature, New York, NY. p. 371-384. https://doi.org/10.1007/978-3-030-05315-4_26.

Perspective: should vitamin E recommendations for older adults be increased? - (Review Article)
Meydani, S.N., Lewis, E.D., Wu, D. 2018. Perspective: should vitamin E recommendations for older adults be increased? Advances in Nutrition. 9(5):533-543. https://doi.org/10.1093/advances/nmy035.

Naringenin is an inhibitor of T cell effector functions - (Peer Reviewed Journal)
Niu, X., Wu, C., Li, M., Zhao, Q., Meydani, S.N., Wang, J., Wu, D. 2018. Naringenin is an inhibitor of T cell effector functions. Journal of Nutritional Biochemistry. 58:71-79. https://doi.org/10.1016/j.jnutbio.2018.04.008.

Dietary supplementation with blueberry partially restores T cell-mediated function in high fat diet-induced obese mice - (Peer Reviewed Journal)
Lewis, E.D., Ren, Z., DeFuria, J., Obin, M.S., Meydani, S.N., Wu, D. 2018. Dietary supplementation with blueberry partially restores T cell-mediated function in high fat diet-induced obese mice. British Journal of Nutrition. 119(12):1393-1399. https://doi.org/10.1017/S0007114518001034.

Dysregulated 1,25-dihydroxyvitamin D levels in high fat diet-induced obesity can be restored by changing to a lower fat diet in mice - (Peer Reviewed Journal)
Jung, Y., Wu, D., Smith, D.E., Meydani, S.N., Han, S. 2018. Dysregulated 1,25-dihydroxyvitamin D levels in high fat diet-induced obesity can be restored by changing to a lower fat diet in mice. Nutrition Research. 53:51-60.

Loss of ovarian function in association with a high-fat diet promotes insulin resistance and disturbs adipose tissue immune homeostasis - (Peer Reviewed Journal)
Pae, M., Baek, Y., Lee, S., Wu, D. 2018. Loss of ovarian function in association with a high-fat diet promotes insulin resistance and disturbs adipose tissue immune homeostasis. Journal of Nutritional Biochemistry. 57:93-102. https://doi.org/10.1016/j.jnutbio.2018.03.0110955-2863.

Curcumin and piperine supplementation of obese mice under caloric restriction modulates body fat and interleukin-1beta - (Peer Reviewed Journal)
Miyazawa, T., Nakagawa, K., Kim, S.H., Thomas, M.J., Paul, L., Zingg, J., Dolnikowski, G.G., Roberts, S.B., Kimura, F., Miyazawa, T., Azzi, A., Meydani, M. 2018. Curcumin and piperine supplementation of obese mice under caloric restriction modulates body fat and interleukin-1beta. Nutrition and Metabolism. 15:12. https://doi.org/10.1186/s12986-018-0250-6.

High levels of avenanthramides in oat-based diet further suppress high fat diet-induced atherosclerosis in Ldlr-/- mice - (Peer Reviewed Journal)
Thomas, M., Kim, S., Collins, F., Wise, M.L., Meydani, M. 2018. High levels of avenanthramides in oat-based diet further suppress high fat diet-induced atherosclerosis in Ldlr-/- mice. Journal of Nutrition. https:/doi.org/10.1021/acs.jafc.7b04860.

Dietary naringenin supplementation attenuates experimental autoimmune encephalomyelitis by modulating autoimmune inflammatory responses in mice - (Peer Reviewed Journal)
Wang, J., Qi, Y., Niu, X., Tang, H., Meydani, S.N., Wu, D. 2018. Dietary naringenin supplementation attenuates experimental autoimmune encephalomyelitis by modulating autoimmune inflammatory responses in mice. Journal of Nutritional Biochemistry. 54:130-139. https://doi.org/10.1016/j.jnutbio.2017.12.004.

The alpha-tocopherol form of vitamin E boosts elastase activity of human PMNs and their ability to kill Streptococcus pneumoniae - (Peer Reviewed Journal)
Bou Ghanem, E.N., Lee, J.N., Joma, B.H., Meydani, S.N., Leong, J.M., Panda, A. 2017. The alpha-tocopherol form of vitamin E boosts elastase activity of human PMNs and their ability to kill Streptococcus pneumoniae. Frontiers in Cellular and Infection Microbiology. doi: 10.3389/fcimb.2017.00161.

Nutrition across the lifespan for healthy aging: proceedings of a workshop--in brief - (Proceedings)
Pray, L., Meydani, S.N. 2017. Nutrition across the lifespan for healthy aging: proceedings of a workshop--in brief. In: Nutrition across the lifespan for healthy aging, September 13-14, 2016, Washington, DC. doi: 10.17226/030709.

Nutritional modulation of age-related changes in the immune system and risk of infection - (Review Article)
Pae, M., Wu, D. 2017. Nutritional modulation of age-related changes in the immune system and risk of infection. Nutrition Research Reviews. 41:14-35. doi: 10.1016/j.nutres.2017.02.001.

Alpha-Tocopheryl phosphate induces VEGF expression via CD36/PI3Kgamma in THP-1 monocytes - (Peer Reviewed Journal)
Zingg, J., Azzi, A., Meydani, M. 2017. Alpha-Tocopheryl phosphate induces VEGF expression via CD36/PI3Kgamma in THP-1 monocytes. Journal of Cellular Biochemistry. 118:1855-1867.

Substituting whole grains for refined grains in a 6-wk randomized trial has a modest effect on gut microbiota and immune and inflammatory markers of healthy adults - (Peer Reviewed Journal)
Vanegas, S.M., Meydani, M., Barnett, J.B., Goldin, B., Kane, A., Rasmussen, H., Brown, C., Vangay, P., Knights, D., Jonnalagadda, S., Koecher, K., Karl, J., Thomas, M.J., Dolnikowski, G.G., Li, L., Saltzman, E., Wu, D., Meydani, S.N. 2017. Substituting whole grains for refined grains in a 6-wk randomized trial has a modest effect on gut microbiota and immune and inflammatory markers of healthy adults. American Journal of Clinical Nutrition. 105:635-650. doi: 10.3945/ajcn.116.146928.

Consensus statement: immunonutrition and exercise - (Review Article)
Bermon, S., Castell, L.M., Calder, P.C., Bishop, N.C., Blomstrand, E., Mooren, F.C., Krugeer, K., Kavazis, A.N., Quindry, J.C., Senchina, D.S., Nieman, D., Gleeson, M., Pyne, D.B., Kitic, C.M., Close, G.L., Larson-Meyer, D., Marcos, A., Meydani, S.N., Wu, D., Walsh, N.P., Nagatomi, R. 2017. Consensus statement: immunonutrition and exercise. Exercise Immunology Review. 23:8-50.

Nutritional considerations for healthy aging and reduction in age-related chronic disease - (Review Article)
Shilsky, J., Bloom, D.E., Beaudreault, A.R., Tucker, K.L., Keller, H.H., Freund-Levi, Y., Fielding, R.A., Cheng, F.W., Jensen, G.L., Wu, D., Meydani, S.N. 2017. Nutritional considerations for healthy aging and reduction in age-related chronic disease. Advances in Nutrition. 8:17-26. https://doi.org/10.3945/an.116.013474.

Medical foods: guidelines for development and usage - (Other)
Johnson, E.J., Barnett, J., Meydani, S.N. 2016. Medical foods: guidelines for development and usage. Electronic Publication. http://www.raps.org/Regulatory-Focus/Features/2016/09/01/25760/Medical-Foods-Guidlines-for-development-and-usage/.

Green tea EGCG, T-cell function, and T-cell-mediated autoimmune encephalomyelitis - (Review Article)
Wu, D. 2016. Green tea EGCG, T-cell function, and T-cell-mediated autoimmune encephalomyelitis. Journal of Investigative Medicine. 4(8):1213-1219. https://doi.org/10.1136/jim-2016-000158.

Modulation of cAMP levels by high fat diet and curcumin and regulatory effects on CD36/FAT scavenger receptor/fatty acids transporter gene expression - (Peer Reviewed Journal)
Zingg, J-M., Hasan, S.T., Nakagawa, K., Canepa, E., Ricciarelli, R., Villacorta, L., Azzi, A., Meydani, M. 2016. Modulation of cAMP levels by high fat diet and curcumin and regulatory effects on CD36/FAT scavenger receptor/fatty acids transporter gene expression. Biofactors. doi: 10.1002/biof.1307.

Lower hepatic iron storage associated with obesity in mice can be restored by decreasing body fat mass through feeding a low-fat diet - (Peer Reviewed Journal)
Chung, H., Wu, D., Smith, D.E., Meydani, S.N., Han, S. 2016. Lower hepatic iron storage associated with obesity in mice can be restored by decreasing body fat mass through feeding a low-fat diet. Nutrition Research. 36(9):955-963. https://doi.org/10.1016/j.nutres.2016.06.003.

Validation of a dietary questionnaire assessed with multiple weighed dietary records or 24-hour recalls - (Peer Reviewed Journal)
Yuan, C., Spiegelman, D., Rimm, E.B., Rosner, B.A., Stampfer, M.J., Barnett, J.B., Chavarro, J.E., Subar, A.F., Sampson, L.K., Willett, W.C. 2017. Validation of a dietary questionnaire assessed with multiple weighed dietary records or 24-hour recalls. American Journal of Epidemiology. doi: 1093/aje/kww104.

Potential effects of curcumin on peroxisome proliferator-activated receptor-gamma in vitro and in vivo - (Review Article)
Mazidi, M., Karimi, E., Meydani, M., Ghayour-Mobarhan, M., Ferns, G.A. 2016. Potential effects of curcumin on peroxisome proliferator-activated receptor-gamma in vitro and in vivo. Review Article. 6(1):112-117.

Dietary antioxidants and bioflavonoids in atherosclerosis and angiogenesis - (Book / Chapter)
Meydani, M., Azzi, A. 2017. Dietary antioxidants and bioflavonoids in atherosclerosis and angiogenesis. In: Kussman, M., Stover, P.J., editors. Nutrigenomics and Proteomics in Health and Disease: Towards A Systems-Level Understanding of Gene-Diet Interactions. 2nd edition. Hoboken, NJ: John Wiley & Sons, Inc. p. 125-142.

Vitamin E, immunity, and infection - (Book / Chapter)
Wu, D., Meydani, S. 2017. Vitamin E, immunity, and infection. In: Calder, P.C., Kulkarni, A.D., editors. Nutrition, Immunity and Infection. Boca Raton, FL: Taylor & Francis Group. p. 197-212.

Cardio metabolic and immunological impacts of extra virgin olive oil consumption in overweight and obese older adults: a randomized controlled trial - (Peer Reviewed Journal)
Rozati, M., Barnett, J., Wu, D., Handelman, G., Saltzman, E., Wilson, T., Li, L., Wang, J., Marcos, A., Ordovas, J.M., Lee, Y., Meydani, M., Meydani, S.N. 2015. Cardio metabolic and immunological impacts of extra virgin olive oil consumption in overweight and obese older adults: a randomized controlled trial. Journal of Nutrition. 12:28. doi: 10.1186/s12986-015-0022-5.

The alpha-tocopherol form of vitamin E reverses age-associated susceptibility to Streptococcus pneumoniae lung infection by modulating pulmonary neutrophil recruitment - (Peer Reviewed Journal)
Bou Ghanem, E.N., Clark, S., Du, X., Wu, D., Camilli, A., Leong, J.M., Meydani, S.N. 2015. The alpha-tocopherol form of vitamin E reverses age-associated susceptibility to Streptococcus pneumoniae lung infection by modulating pulmonary neutrophil recruitment. Journal of Immunology. 194:1090-1099. https://doi.org/10.4049/jimmunol.1402401.

Inflammation and Nutritional Science for Programs/Policies and Interpretation of Research Evidence (INSPIRE) - (Proceedings)
Raiten, D.J., Ashour, F.A., Ross, A.C., Meydani, S.N., Dawson, H.D., Stephensen, C.B., Brabin, B.J., Suchdev, P.S., Van Ommen, B. 2015. Inflammation and Nutritional Science for Programs/Policies and Interpretation of Research Evidence (INSPIRE). Journal of Nutrition. 145(5):1039S-1108S. https://doi.org/10.3945/jn.114.194571.

Induction of VEGF expression by alpha-tocopherol and alpha-tocopheryl phosphate via PI3Kgamma/PKB and hTAP1/SEC14L2-mediated lipid exchange - (Peer Reviewed Journal)
Zingg, J., Azzi, A., Meydani, M. 2014. Induction of VEGF expression by alpha-tocopherol and alpha-tocopheryl phosphate via PI3Kgamma/PKB and hTAP1/SEC14L2-mediated lipid exchange. Journal of Cellular Biochemistry. 116:398-407. https://doi.org/10.1002/jcb.24988.