Research Project: Molecular, Cellular, and Regulatory Aspects of Nutrition During Development

Location: Children's Nutrition Research Center

Publications (Clicking on the reprint icon will take you to the publication reprint.)

Clinical outcome and gut development after insulin-like growth factor-1 supplementation to preterm pigs - (Peer Reviewed Journal)
Holgersen, K., Rasmussen, M.B., Carey, G., Burrin, D.G., Thymann, T., Sangild, P. 2022. Clinical outcome and gut development after insulin-like growth factor-1 supplementation to preterm pigs. Frontiers in Pediatrics. https://doi.org/10.3389/fped.2022.868911.

Intermittent leucine pulses during continuous feeding alters novel components involved in skeletal muscle growth of neonatal pigs - (Peer Reviewed Journal)
Manjarin, R., Boutry-Regard, C., Suryawan, A., Canovas, A., Piccolo, B.D., Maj, M., Abo-Ismail, M., Nguyen, H.V., Fiorotto, M.L., Davis, T.A. 2020. Intermittent leucine pulses during continuous feeding alters novel components involved in skeletal muscle growth of neonatal pigs. Amino Acids. 52:1319–1335. https://doi.org/10.1007/s00726-020-02894-5.

Parenteral lipids shape gut bile acid pools and microbiota profiles in the prevention of cholestasis in preterm pigs - (Peer Reviewed Journal)
Call, L., Molina, T., Stoll, B., Guthrie, G., Chacko, S., Plat, J., Robinson, J., Lin, S., Vonderohe, C., Mohammad, M., Kunichoff, D., Cruz, S., Lau, P., Premkumar, M., Nielsen, J., Fang, Z., Olutoye, O., Thymann, T., Britton, R., Sanglid, P., Burrin, D.G. 2020. Parenteral lipids shape gut bile acid pools and microbiota profiles in the prevention of cholestasis in preterm pigs. Journal of Lipid Research. https://doi.org/10.1194/jlr.RA120000652.

Dysregulated FXR-FGF19 signaling and choline metabolism is associated with gut dysbiosis and hyperplasia in a novel pig model of pediatric NASH - (Peer Reviewed Journal)
Hernandez, G.V., Smith, V.A., Melynk, M., Burd, M.A., Sprayberry, K.A., Edwards, M.S., Peterson, D.G., Bennet, D.C., Fanter, R.K., Columbus, D.A., Steibel, J., Glanz, H., Immoos, C., Rice, M.S., Santiago-Rodriguez, T.M., Blank, J.M., Vanderkelen, J.J., Kitts, C.L., Piccolo, B.D., La Frano, M.R., Burrin, D.G., Maj, M., Manjarin, R. 2020. Dysregulated FXR-FGF19 signaling and choline metabolism is associated with gut dysbiosis and hyperplasia in a novel pig model of pediatric NASH. American Journal of Physiology - Gastrointestinal and Liver Physiology. 318(3):G582-G609. https://doi.org/10.1152/ajpgi.00344.2019.

Alpha-lactalbumin enriched whey protein concentrate to improve gut, immunity and brain development in preterm pigs - (Peer Reviewed Journal)
Nielsen, C., Hui, Y., Nguyen, D., Ahnfeldt, A., Burrin, D.G., Hartmann, B., Heckmann, A., Sangild, P., Thymann, T., Berinf, S. 2020. Alpha-lactalbumin enriched whey protein concentrate to improve gut, immunity and brain development in preterm pigs. Nutrients. 12(1):245. https://doi.org/10.3390/nu12010245.

Rapid postnatal upregulation of intestinal FXR-FGF19 signalling in premature pigs - (Peer Reviewed Journal)
Smith, V., Jiang, Y., Thymann, T., Sangild, P., Maj, M., Manjarin, R., Burrin, D.G. 2020. Rapid postnatal upregulation of intestinal FXR-FGF19 signalling in premature pigs. Journal of Pediatric Gastroenterology and Nutrition. https://doi.org/10.1097/MPG.0000000000002645.

Translational advances in pediatric nutrition and gastroenterology: New insights from pig models - (Review Article)
Burrin, D.G., Sangild, P., Stoll, B., Thymann, T., Buddington, R., Marini, J., Olutoye, O., Shulman, R. 2020. Translational advances in pediatric nutrition and gastroenterology: New insights from pig models. Annual Review of Animal Biosciences. 8(321):354. https://doi.org/10.1146/annurev-animal-020518-115142.

Developmental changes in the utilization of citrulline by neonatal pigs - (Peer Reviewed Journal)
Mohammad, M., Didelija, I., Wang, X., Stoll, B., Burrin, D.G., Marini, J. 2019. Developmental changes in the utilization of citrulline by neonatal pigs. American Journal of Physiology - Renal Physiology. https://doi.org/doi:10.1152/ajprenal.00469.2019.

Rifampicin, not vitamin E, suppresses parenteral nutrition-associated liver disease development through pregnane X receptor pathway in piglets - (Peer Reviewed Journal)
Guthrie, G.J., Stoll, B., Chako, S., Lauridsen, C., Plat, J., Burrin, D.G. 2019. Rifampicin, not vitamin E, suppresses parenteral nutrition-associated liver disease development through pregnane X receptor pathway in piglets. American Journal of Physiology - Gastrointestinal and Liver Physiology. 318:G41-G52. https://doi.org/10.1152/ajpgi.00193.2019.

Prematurity blunts the feeding-induced stimulation of translation initiation signaling and protein synthesis in muscle of neonatal piglets - (Peer Reviewed Journal)
Naberhuis, J.K., Suryawan, A., Nguyen, H.V., Hernandez-Garcia, A., Cruz, S.M., Lau, P.E., Olutoye, O.O., Stoll, B., Burrin, D.G., Fiorotto, M.L., Davis, T.A. 2019. Prematurity blunts the feeding-induced stimulation of translation initiation signaling and protein synthesis in muscle of neonatal piglets. American Journal of Physiology. https://doi.org/10.1152/ajpendo.00151.2019.

Gut-derived GIP activates central Rap1 to impair neural leptin sensitivity during overnutrition - (Peer Reviewed Journal)
Kaneko, K., Fu, Y., Lin, H.Y., Cordonier, E.L., Mo, Q., Gao, Y., Yan, T., Naylor, J., Howard, V., Saito, K., Xu, P., Chen, S.S., Xu, Y., Williams, K.W., Ravn, P., Fukuda, M. 2019. Gut-derived GIP activates central Rap1 to impair neural leptin sensitivity during overnutrition. Journal of Clinical Investigation. https://doi.org/10.1172/JCI126107.

New generation lipid emulsions increase brain DHA and improve body composition, but not short-term neurodevelopment in parenterally-fed preterm piglets - (Peer Reviewed Journal)
Molina, T.L., Stoll, B., Mohammad, M., Mohila, C.A., Call, L., Cui, L., Guthrie, G., Kunichoff, D., Lin, S., Welch-Jernigan, R., Nielsen, J., Premkumar, M., Robinson, J., Smith, V., Teets, H., Obelitz-Ryom, K., Hagan, J., Cruz, S., Lau, P., Puyau, M., Fang, Z., Shypailo, R., Manjarin, R., Butte, N., Burrin, D.G., Olutoye, O., Thymann, T., Sangild, P. 2019. New generation lipid emulsions increase brain DHA and improve body composition, but not short-term neurodevelopment in parenterally-fed preterm piglets. Brain Behavior and Immunity. https://doi.org/10.1016/j.bbi.2019.04.031.

Luciferase reporter mice for in vivo monitoring and ex vivo assessment of hypothalamic signaling of Socs3 expression - (Peer Reviewed Journal)
Cordonier, E.L., Liu, T., Saito, K., Chen, S.S., Xu, Y., Fukuda, M. 2019. Luciferase reporter mice for in vivo monitoring and ex vivo assessment of hypothalamic signaling of Socs3 expression. Journal of the Endocrine Society. 3(7):1246-1260. https://doi.org/10.1210/js.2019-00077.

Targeted metabolomics analysis of maternal-placental-fetal metabolism in pregnant swine reveals links in fetal bile acid homeostasis and sulfation capacity - (Peer Reviewed Journal)
Wang, P., Zhong, H., Song, Y., Yuan, P., Li, Y., Lin, S., Zhang, X., Li, J., Che, L., Feng, B., Lin, Y., Xu, S., Zhuo, Y., Tian, G., Chen, D., We, D., Burrin, D.G., Fang, Z. 2019. Targeted metabolomics analysis of maternal-placental-fetal metabolism in pregnant swine reveals links in fetal bile acid homeostasis and sulfation capacity. American Journal of Physiology - Gastrointestinal and Liver Physiology. 317:G8-G16. https://doi.org/10.1152/ajpgi.00056.2019.

Differential action of TGR5 agonists on GLP-2 secretion and promotion of intestinal adaptation in piglet short bowel model - (Peer Reviewed Journal)
Lin, S., Stoll, B., Robinson, J., Pastor, J.J., Marini, J.C., Ipharraguerre, I.R., Hartmann, B., Holst, J.J., Cruz, S., Lau, P., Olutoye, O., Fang, Z., Burrin, D.G. 2019. Differential action of TGR5 agonists on GLP-2 secretion and promotion of intestinal adaptation in piglet short bowel model. American Journal of Physiology. https://doi.org/10.1152/ajpgi.00360.2018.

Reduced plasma amino acid levels during allogeneic haematopoietic stem cell transplantation are associated with systemic inflammation and treatment-related complications - (Peer Reviewed Journal)
Weischendorff, S., Kielsen, K., Nederby, M., Svendsen, L., Burrin, D.G., Heilmann, C., Ifversen, M., Sengelov, H., Molgaard, C., Muller, K. 2019. Reduced plasma amino acid levels during allogeneic haematopoietic stem cell transplantation are associated with systemic inflammation and treatment-related complications. Biology of Blood and Marrow Transplantation. https://doi.org/10.1016/j.bbmt.2019.03.018.

Undernutrition shapes the gut microbiota and bile acid profile in association with altered gut-liver FXR signaling in weaning pigs - (Review Article)
Lin, S., Yang, X., Yuan, P., Yang, J., Wang, P., Zhong, H., Zhang, X., Che, L., Feng, B., Li, J., Zhuo, Y., Lin, Y., Xu, S., Wu, D.E., Burrin, D.G., Fang, Z. 2019. Undernutrition shapes the gut microbiota and bile acid profile in association with altered gut-liver FXR signaling in weaning pigs. Progress in Lipid Research. 67(13):3691-3701. https://doi.org/10.1016/j.plipres.2019.02.003.

Plant-based sterols and stanols in health & disease: Consequences of human development in a plant-based environment? - (Review Article)
Plat, J., Baumgartner, S., Vanmierlo, T., Lutjohann, D., Calkins, K.L., Burrin, D.G., Guthrie, G., Thijs, C., Te Velde, A.A., Vreudenhil, A.C.E., Sverdlov, R., Garssen, J., Wouters, K., Trautwein, E.A., Wolfs, T.G., van Gorp, C., Mulder, M.T., Riksen, N.P., Groen, A.K., Mensink, R.P. 2019. Plant-based sterols and stanols in health & disease: Consequences of human development in a plant-based environment? Progress in Lipid Research. 74:87-102. https://doi.org/10.1016/j.plipres.2019.02.003.

Postprandial amino acid kinetics of milk protein mixtures are affected by composition, but not denaturation, in neonatal piglets - (Peer Reviewed Journal)
Welch-Jernigan, R.J., Abrahamse, E., Stoll, B., Smith, O., Wierenga, P.A., Van De Heijning, B., Renes, I., Burrin, D.G. 2018. Postprandial amino acid kinetics of milk protein mixtures are affected by composition, but not denaturation, in neonatal piglets. Current Developments in Nutrition. 3(4):1-11. https://doi.org/10.1093/cdn/nzy102.

Regulation of muscle growth in early postnatal life in a swine model - (Review Article)
Rudar, M., Fiorotto, M.L., Davis, T.A. 2018. Regulation of muscle growth in early postnatal life in a swine model. Annual Review of Animal Biosciences. 7:309-335. https://doi.org/10.1146/annurev-animal-020518-115130.

Citrulline generation test: What does it measure? - (Peer Reviewed Journal)
Mohammad, M.A., Didelija, I.C., Stoll, B., Marini, J.C. 2018. Citrulline generation test: What does it measure? Journal of Parenteral and Enteral Nutrition. https://doi.org/10.1002/jpen.1462.

Incompatibility of the circadian protein BMAL1 and HNF 4a in hepatocellular carcinoma - (Peer Reviewed Journal)
Fekry, B., Ribas-Latre, A., Baumgartner, C., Deans, J.R., Kwok, C., Patel, P., Fu, L., Berdeaux, R., Sun, K., Kolonin, M.G., Wang, S.H., Yoo, S., Sladek, F.M., Eckel-Mahan, K. 2018. Incompatibility of the circadian protein BMAL1 and HNF 4a in hepatocellular carcinoma. Nature Communications. https://doi.org/10.1038/s41467-018-06648-6.

Intermittent bolus feeding promotes greater lean growth than continuous feeding in a neonatal piglet model - (Peer Reviewed Journal)
El-Kadi, S.W., Boutry, C., Suryawan, A., Gazzaneo, M.C., Orellana, R.A., Srivastava, N., Nguyen, H.V., Kimball, S.R., Fiorotto, M.L., Davis, T.A. 2018. Intermittent bolus feeding promotes greater lean growth than continuous feeding in a neonatal piglet model. American Journal of Clinical Nutrition. 108(4):830-841. https://doi.org/10.1093/ajcn/nqy133.

Prematurity reduces citrulline-arginine-nitric oxide production and precedes the onset of necrotizing enterocolitis in piglets - (Peer Reviewed Journal)
Robinson, J.L., Smith, V.A., Stoll, B., Agarwal, U., Premkumar, M.H., Lau, P., Cruz, S.M., Manjarin, R., Olutoye, O., Burrin, D.G., Marini, J.C. 2018. Prematurity reduces citrulline-arginine-nitric oxide production and precedes the onset of necrotizing enterocolitis in piglets. American Journal of Physiology - Gastrointestinal and Liver Physiology. 5:9. https://doi.org/10.1152/ajpgi.00198.2018.

Human milk fortification with bovine colostrum is superior to formula-based fortifier to prevent gut dysfunction, necrotizing enterocolitis, and systemic infection in preterm pigs - (Peer Reviewed Journal)
Sun, J., Li, Y., Pan, X., Nguyen, D., Brunse, A., Bojesen, A., Rudloff, S., Mortensen, M., Burrin, D., Sangild, P. 2018. Human milk fortification with bovine colostrum is superior to formula-based fortifier to prevent gut dysfunction, necrotizing enterocolitis, and systemic infection in preterm pigs. Journal of Parenteral and Enteral Nutrition. http://doi.org/10.1002/jpen.1422

Metabolic signatures distinguish the impact of formula carbohydrates on disease outcome in a pretern piglet model of NEC - (Peer Reviewed Journal)
Call, L., Stoll, B., Oosterloo, B., Ajami, N., Sheikh, F., Wittke, A., Waworuntu, R., Berg, B., Petrosino, J., Olutoye, O., Burrin, D.G. 2018. Metabolic signatures distinguish the impact of formula carbohydrates on disease outcome in a pretern piglet model of NEC. BMC Microbiome. 6:111. https://doi.org/10.1186/s40168-018-0498-0

Ex vivo enteroids recapitulate in vivo citrulline production in mice - (Peer Reviewed Journal)
Wang, X., Yuan, Y., Didelija, I.C., Mohammad, M.A., Marini, J.C. 2018. Ex vivo enteroids recapitulate in vivo citrulline production in mice. Journal of Nutrition. 148(9):1415-1420. https://doi.org/10.1093/jn/nxy126.

The citrulline recycling pathway sustains cardiovascular function in arginine-depleted healthy mice, but cannot sustain nitric oxide production during endotoxin challenge - (Peer Reviewed Journal)
Yuan, Y., Mohammad, M., Betancourt, A., Didelija, I.C., Yallampalli, C., Marini, J.C. 2018. The citrulline recycling pathway sustains cardiovascular function in arginine-depleted healthy mice, but cannot sustain nitric oxide production during endotoxin challenge. Journal of Nutrition. 148(6):844–850. https://dx.doi.org/10.1093/jn/nxy065.

Growth and clinical variables in nitrogen-restricted piglets fed an adjusted essential amino acid mix: Effects using free amino acid-based diets - (Peer Reviewed Journal)
Lykke, M., Sangild, P.T., Van Goudoever, J.B., Van Harskamp, D., Schierbeek, H., Koletzko, B., Van Der Beek, E.M., Abrahamse-Berkeveld, M., Van De Heijning, B., Stoll, B., Burrin, D.G., Thymann, T. 2018. Growth and clinical variables in nitrogen-restricted piglets fed an adjusted essential amino acid mix: Effects using free amino acid-based diets. Journal of Nutrition. 148(7):1109-1117. http://doi.org/10.1093/jn/nxy072

Growth and clinical variables in nitrogen-restricted piglets fed an adjusted essential amino acid mix: Effects using partially intact protein-based diets - (Peer Reviewed Journal)
Worsoe, P.S., Sangild, P.T., Van Goudoever, J.B., Koletzko, B., Van Der Beek, E.M., Abrahamse-Berkeveld, M., Burrin, D.G., Van De Heijning, B., Thymann, T. 2018. Growth and clinical variables in nitrogen-restricted piglets fed an adjusted essential amino acid mix: Effects using partially intact protein-based diets. Journal of Nutrition. 148(7):1118-1125. http://doi.org/10.1093/jn/nxy073

Nutrient fortification of human donor milk affects intestinal function and protein metabolism in preterm pigs - (Peer Reviewed Journal)
Sun, J., Li, Y., Nguyen, D., Mortensen, M.S., Van Den Akker, C., Skeath, T., Pors, S.E., Pankratova, S., Rudloff, S., Sorensen, S.J., Burrin, D.G., Thymann, T., Sangild, P.T. 2018. Nutrient fortification of human donor milk affects intestinal function and protein metabolism in preterm pigs. Journal of Nutrition. 148(3):336-347. https://doi.org/10.1093/jn/nxx033.

A randomized trial to study the comparative efficacy of phenylbutyrate and benzoate on nitrogen excretion and ureagenesis in healthy volunteers - (Peer Reviewed Journal)
Nagamani, S.C., Agarwal, U., Tam, A., Azamian, M., McMeans, A., Didelija, I.C., Mohammad, M.A., Marini, J.C. 2017. A randomized trial to study the comparative efficacy of phenylbutyrate and benzoate on nitrogen excretion and ureagenesis in healthy volunteers. Genetics in Medicine. https://dx.doi.org/10.1038/gim.2017.167.

Phytosterols synergize with endotoxin to augment inflammation in Kupffer cells but alone have limited direct effect on hepatocytes - (Peer Reviewed Journal)
Guthrie, G., Tackett, B., Stoll, B., Martin, C., Olutoye, O., Burrin, D.G. 2017. Phytosterols synergize with endotoxin to augment inflammation in Kupffer cells but alone have limited direct effect on hepatocytes. Journal of Parenteral and Enteral Nutrition. doi:10.1177/0148607117722752.

Ablation of arginase II spares arginine and abolishes the arginine requirement for growth in male mice - (Peer Reviewed Journal)
Didelija, I.C., Mohammad, M.A., Marini, J.C. 2017. Ablation of arginase II spares arginine and abolishes the arginine requirement for growth in male mice. Journal of Nutrition. 147(8):1510-1516.

The intestinal-renal axis for arginine synthesis is present and functional in the neonatal pig - (Peer Reviewed Journal)
Marini, J.C., Agarwal, U., Robinson, J.L., Yuan, Y., Didelija, I.C., Stoll, B., Burrin, D.G. 2017. The intestinal-renal axis for arginine synthesis is present and functional in the neonatal pig. American Journal of Physiology - Endocrinology and Metabolism. doi:10.1152/ajpendo.00055.2017.

Phytosterols have limited direct effect on hepatocyte transporter expression but synergize with endotoxin to enhance Kupffer cell inflammatory response - (Abstract Only)
Buthrie, G., Tackett, B., Stoll, B., Martin, C., Burrin, D.G. 2017. Phytosterols have limited direct effect on hepatocyte transporter expression but synergize with endotoxin to enhance kupffer cell inflammatory response [abstract]. Federation of American Societies for Experimental Biology Conference. 31(1 Suppl):315.8. April 22-26, 2017, Chicago, Illinois. Available: http://www.fasebj.org/

Diminished citrulline-arginine-nitric oxide production rates are associated with necrotizing enterocolitis incidence in premature pigs - (Abstract Only)
Robinson, J.L., Smith, V., Cruz, S.M., Lau, P.E., Manjarin, R., Olutoye, O.O., Stoll, B., Marini, J.C., Burrin, D.G. 2017. Diminished citrulline-arginine-nitric oxide production rates are associated with necrotizing enterocolitis incidence in premature pigs [abstract]. Federation of American Societies for Experimental Biology Conference. 31(1 Suppl):164.1. April 22-26, 2017, Chicago, Illinois. Available: http://www.fasebj.org/

Gastrointestinal toxicity, systemic inflammation, and liver biochemistry in allogeneic hematopoietic stem cell transplantation - (Peer Reviewed Journal)
Jordan, K., Pontoppidan, P., Uhlving, H.H., Kielsen, K., Burrin, D.G., Weischendorff, S., Christensen, I.J., Jorgensen, M.H., Heilmann, C., Sengelov, H., Muller, K. 2017. Gastrointestinal toxicity, systemic inflammation, and liver biochemistry in allogeneic hematopoietic stem cell transplantation. Biology of Blood and Marrow Transplantation. 23(7):1170-1176.

Preserving Mother Nature's best food for preterm infants - (Other)
Burrin, D.G. 2017. Preserving Mother Nature's best food for preterm infants. Journal of Nutrition, Commentary. 147(6):1023-1024.

Plasma glutamine is a minor precursor for the synthesis of citrulline: A multispecies study - (Peer Reviewed Journal)
Marini, J.C., Agarwal, U., Didelija, I.C., Azamian, M., Stoll, B., Nagamani, S.C. 2017. Plasma glutamine is a minor precursor for the synthesis of citrulline: A multispecies study. Journal of Nutrition. 147(4):549–555.

Use of a novel docosahexaenoic acid formulation vs control in a neonatal porcine model of short bowel syndrome leads to greater intestinal absorption and higher systemic levels of DHA - (Peer Reviewed Journal)
Martin, C.R., Stoll, B., Cluette-Brown, J., Akinkuotu, A.C., Olutoye, O.O., Gura, K., Singh, P., Zaman, M.M., Perillo, M.C., Puder, M., Freedman, S.D., Burrin, D.G. 2017. Use of a novel docosahexaenoic acid formulation vs control in a neonatal porcine model of short bowel syndrome leads to greater intestinal absorption and higher systemic levels of DHA. Nutrition Research. 39:51-60.

Emerging clinical benefits of new generation fat emulsions in preterm neonates - (Review Article)
Guthrie, G., Premkumar, M., Burrin, D.G. 2017. Emerging clinical benefits of new generation fat emulsions in preterm neonates. Nutrition in Clinical Practice. 32(3):326-336.

Supplemental citrulline is more efficient than arginine to increase systemic arginine availability in mice - (Peer Reviewed Journal)
Agarwal, U., Didelija, I.C., Yuan, Y., Wang, X., Marini, J.C. 2017. Supplemental citrulline is more efficient than arginine to increase systemic arginine availability in mice. Journal of Nutrition. 147(4):596-602.

Minimal enteral nutrition to improve adaptation after intestinal resection in piglets and infants - (Peer Reviewed Journal)
Aunsholt, L., Qvist, N., Sanglid, P.T., Vegge, A., Stoll, B., Burrin, D.G., Jeppesen, P.B., Ericksen, T., Husby, S., Thymann, T. 2017. Minimal enteral nutrition to improve adaptation after intestinal resection in piglets and infants. Journal of Parenteral and Enteral Nutrition. doi:10.1177/0148607117690527.

IL-20 promotes epithelial healing of the injured mouse cornea - (Peer Reviewed Journal)
Zhang, W., Magadi, S., Li, Z., Smith, C., Burns, A.R. 2016. IL-20 promotes epithelial ealing of the injured mouse cornea. Experimental Eye Research. 154:22-29.

Targeting stromal glutamine synthetase in tumors disrupts tumor microenvironment-regulated cancer cell growth - (Peer Reviewed Journal)
Yang, L., Achreja, A., Yeung, T., Mangala, L.S., Jiang, D., Han, C., Baddour, J., Marini, J.C. 2016. Targeting stromal glutamine synthetase in tumors disrupts tumor microenvironment-regulated cancer cell growth. Cell Metabolism. 24(5):685-700.

Circadian homeostatis of liver metabolism suppresses hepatocarcinogenesis - (Peer Reviewed Journal)
Kettner, N.M., Volcu, H., Finegold, M.J., Coarfa, C., Sreekumar, A., Putluri, N., Katchy, C.A., Lee, C., Moore, D.D., Fu, L. 2016. Circadian homeostatis of liver metabolism suppresses hepatocarcinogenesis. Cancer Cell International. 30:909-924.

Leucine supplementation stimulates protein synthesis and reduces degradation signal activation in muscle of newborn pigs during acute endotoxemia - (Peer Reviewed Journal)
Hernandez-Garcia, A.D., Columbus, D.A., Manjarin, R., Nguyen, H.V., Suryawan, A., Orellana, R.A., Davis, T.A. 2016. Leucine supplementation stimulates protein synthesis and reduces degradation signal activation in muscle of newborn pigs during acute endotoxemia. American Journal of Physiology - Endocrinology and Metabolism. 311(4):E791-E801.

Replication of human noroviruses in stem cell-derived human enteroids - (Peer Reviewed Journal)
Ettayebi, K., Crawford, S.E., Murakami, K., Broughman, J.R., Karandikar, U., Tenge, V.R., Neill, F.H., Blutt, S.E., Zeng, X., Qu, L., Kou, B., Opekun, A.R., Burrin, D.G., Graham, D.Y., Ramani, S., Atmar, R.L., Estes, M.K. 2016. Replication of human noroviruses in stem cell-derived human enteroids. Science. doi: 10.1126/science.aaf5211.

Neuronal Rap1 regulates energy balance, glucose homeostasis, and leptin actions - (Peer Reviewed Journal)
Kaneko, K., Xu, P., Cordonier, E.L., Chen, S.S., Ng, A., Xu, Y., Morozov, A., Fukuda, M. 2016. Neuronal Rap1 regulates energy balance, glucose homeostasis, and leptin actions. Cell Reports. 16:3003-3015.

Multi-omic profiles of hepatic metabolism in TPN-fed preterm pigs - (Peer Reviewed Journal)
Guthrie, G., Kulkarni, M., Vlaardingerbroek, H., Stoll, B., Ng, K., Martin, C., Belmont, J., Hadsell, D.L., Heird, W., Newgard, C., Olutoye, O., Van Goudoever, J., Lauridsen, C., Schuchman, E., Burrin, D.G. 2016. Multi-omic profiles of hepatic metabolism in TPN-fed preterm pigs. Journal of Lipid Research. 57(8):1-18. doi:10.1194/jlr.M069526.

Genetic and environmental models of circadian disruption link SRC-2 function to hepatic pathology - (Peer Reviewed Journal)
Fleet, T., Stashi, E., Zhu, B., Rajapakshe, K., Marcelo, K.L., Kettner, N.M., Gorman, B.K., Coarfa, C., Fu, L., O'Malley, B.W., York, B. 2016. Genetic and environmental models of circadian disruption link SRC-2 function to hepatic pathology. Journal of Biological Rhythms. 31(5):443-460.

Enteral B-hydroxy-B-methylbutyrate supplementation increases protein synthesis in skeletal muscle of neonatal pigs - (Peer Reviewed Journal)
Kao, M., Columbus, D.A., Suryawan, A., Steinhoff-Wagner, J., Hernandez-Garcia, A.D., Nguyen, H.V., Fiorotto, M., Davis, T. 2016. Enteral B-hydroxy-B-methylbutyrate supplementation increases protein synthesis in skeletal muscle of neonatal pigs. American Journal of Physiology - Endocrinology and Metabolism. 310(11):1072-1084.

Determination of 7alpha-OH cholesterol by LC-MS/MS: Application in assessing the activity of CYP7A1 in cholestatic minipigs - (Peer Reviewed Journal)
Yun, C., Yin, T., Shatzer, K., Burrin, D.G., Cui, L., Tu, Y., Hu, M. 2016. Determination of 7alpha-OH cholesterol by LC-MS/MS: Application in assessing the activity of CYP7A1 in cholestatic minipigs. Journal of Chromatography B. 1025:76-82.

Insulin modulates energy and substrate sensing and protein catabolism induced by chronic peritonitis in skeletal muscle of neonatal pigs - (Peer Reviewed Journal)
Manjarin, R., Suryawan, A., Koo, S.J., Wilson, F.A., Nguyen, H.V., Davis, T.A., Orellana, R.A. 2016. Insulin modulates energy and substrate sensing and protein catabolism induced by chronic peritonitis in skeletal muscle of neonatal pigs. Pediatric Research. 80(5):744-752.

Microbial and metabolic signatures of necrotizing enterocolitis in formula-fed piglets - (Abstract Only)
Call, L., Stoll, B., Olutoye, O., Ajami, N., Petrosino, J., Wittke, A., Waworuntu, R., Berg, B., Burrin, D. 2016. Microbial and metabolic signatures of necrotizing enterocolitis in formula-fed piglets [abstract]. The Pediatric Academic Society Annual Conference, Session: Platform: Pediatric Nutrition, E-PAS2016:3140.2. April 30–May 3, 2016, Baltimore, Maryland. Available: https://www.pas-meeting.org/

Pulsatile delivery of a leucine supplement during long-term continuous enteral feeding enhances lean growth in term neonatal pigs - (Peer Reviewed Journal)
Boutry, C., El-Kadi, S.W., Suryawan, A., Steinhoff-Wagner, J., Stoll, B., Orellana, R.A., Nguyen, H.V., Kimball, S.R., Fiorotto, M.L., Davis, T.A. 2016. Pulsatile delivery of a leucine supplement during long-term continuous enteral feeding enhances lean growth in term neonatal pigs. American Journal of Physiology - Endocrinology and Metabolism. 310(8):699-713.

Expression of apical Na(+)-L-glutamine co-transport activity, B(0)-system neutral amino acid co-transporter (B(0)AT1) and angiotensin-converting enzyme 2 along the jejunal crypt-villus axis in young pigs fed a liquid formula - (Peer Reviewed Journal)
Yang, C., Yang, X., Lackeyram, D., Rideout, T.C., Wang, Z., Stoll, B., Yin, Y., Burrin, D.G., Fan, M.Z. 2016. Expression of apical Na(+)-L-glutamine co-transport activity, B(0)-system neutral amino acid co-transporter (B(0)AT1) and angiotensin-converting enzyme 2 along the jejunal crypt-villus axis in young pigs fed a liquid formula. Amino Acids. 48(6):1491-1508.

Tumor microenvironment derived exosomes pleiotropically modulate cancer cell metabolism - (Peer Reviewed Journal)
Zhao, H., Yang, L., Baddour, J., Achreja, A., Bernard, V., Moss, T., Marini, J.C., Tudawe, T., Seviour, E.G., San Lucas, F., Alvarez, H., Gupta, S., Maiti, S.N., Cooper, L., Peehl, D., Ram, P.T., Maitra, A., Nagrath, D. 2016. Tumor microenvironment derived exosomes pleiotropically modulate cancer cell metabolism. eLife. 5:e10250.

Trophic factors and regulation of gastrointestinal tract and liver development - (Book / Chapter)
Burrin, D.G. 2016. Trophic factors and regulation of gastrointestinal tract and liver development. In: Polin, R.A., Abman, S.H., and Fox, W.W. editors. Fetal and Neonatal Physiology, Section XIV Physiology of Gastrointestinal Tract in the Fetus and Neonate, 5th edition. Philadelphia PA: Elsevier Publishers. p. 853-858.

Amino acids, independent of insulin, attenuate skeletal muscle autophagy in neonatal pigs during endotoxemia - (Peer Reviewed Journal)
Hernandez-Garcia, A., Manjarin, R., Suryawan, A., Nguyen, H.V., Davis, T.A., Orellana, R.A. 2016. Amino acids, independent of insulin, attenuate skeletal muscle autophagy in neonatal pigs during endotoxemia. Pediatric Research. 80:448–451. doi:10.1038/pr.2016.83.

Working group reports: Evaluation of the evidence to support practice guidelines for nutritional care of preterm infants-the Pre-B Project - (Review Article)
Raiten, D.J., Steiber, A.L., Carlson, S.E., Griffin, I., Anderson, D., Hay, Jr., W.W., Robins, S., Neu, J., Georgieff, M.K., Groh-Wargo, S., Fenton, T.R., Pre-B Consultative, W., Burrin, D.G. 2016. Working group reports: Evaluation of the evidence to support practice guidelines for nutritional care of preterm infants-the Pre-B Project. American Journal of Clinical Nutrition. 103(2):648S-78S. doi:10.3945/ajcn.115.117309.

Interrelationships between glutamine and citrulline metabolism - (Review Article)
Marini, J.C. 2016. Interrelationships between glutamine and citrulline metabolism. Current Opinion in Clinical Nutrition and Metabolic Care. 19(1):62-66.

The ERa-PI3K cascade in proopiomelanocortin progenitor neurons regulates feeding and glucose balance in female mice - (Peer Reviewed Journal)
Zhu, L., Xu, P., Cao, X., Yang, Y., Hinton, A., Xia, Y., Saito, K., Yan, X., Zou, F., Ding, H., Wang, C., Yan, C., Pradip, S., Khan, S.A., Zhao, J., Fukuda, M., Tong, Q., Clegg, D.J., Chan, L., Xu, Y. 2015. The ERa-PI3K cascade in proopiomelanocortin progenitor neurons regulates feeding and glucose balance in female mice. Endocrinology. 156(12):4474-4491.

Impact of prolonged leucine supplementation on protein synthesis and lean growth in neonatal pigs - (Peer Reviewed Journal)
Columbus, D.A., Steinhoff-Wagner, J., Suryawan, A., Nguyen, H.V., Hernandez-Garcia, A., Fiorotto, M.L., Davis, T.A. 2015. Impact of prolonged leucine supplementation on protein synthesis and lean growth in neonatal pigs. American Journal of Physiology - Endocrinology and Metabolism. 309(6):601-610.

Leucine supplementation of a chronically restricted protein and energy diet enhances mTOR pathway activation but not muscle protein synthesis in neonatal pigs - (Peer Reviewed Journal)
Marjarin, R., Columbus, D.A., Suryawan, A., Hernandez-Garcia, A.D., Hoang, N., Fiorotto, M.L., Davis, T.A. 2015. Leucine supplementation of a chronically restricted protein and energy diet enhances mTOR pathway activation but not muscle protein synthesis in neonatal pigs. Amino Acids. 48(1):257-267.

Liver receptor homolog-1 is a critical determinant of methyl-pool metabolism - (Peer Reviewed Journal)
Wagner, M., Choi, S., Panzitt, K., Mamrosh, J.L., Lee, J.M., Zaufel, A., Xiao, R., Wooton-Kee, R., Stahlman, M., Newgard, C.B., Boren, J., Moore, D.D. 2016. Liver receptor homolog-1 is a critical determinant of methyl-pool metabolism. Hepatology. 63(1):95-106. https://doi.org/10.1002/hep.28124.

FABP4-Cre mediated expression of constitutively active ChREBP protects against obesity - (Peer Reviewed Journal)
Nuotio-Antar, A.M., Poungvarin, N., Li, M., Schupp, M., Mohammad, M., Gerard, S., Zou, F., Chan, L. 2015. FABP4-Cre mediated expression of constitutively active ChREBP protects against obesity. Endocrinology. 11:4020-4032.

Enteral obeticholic acid prevents hepatic cholestasis in total parenteral nutrition-fed neonatal pigs - (Abstract Only)
Burrin, D.G., Jiang, Y., Fang, Z., Stoll, B., Guthrie, G.J., Wang, H., Ipharraguerre, I.R., Pastor, J.J. 2015. Enteral obeticholic acid prevents hepatic cholestasis in total parenteral nutrition-fed neonatal pigs [abstract]. Hepatology. Paper No. 194, 62(1)Suppl:307A.

Enteral obeticholic acid promotes intestinal growth in total parenteral nutrition fed neonatal pigs - (Abstract Only)
Jiang, Y., Fang, Z., Stoll, B., Guthrie, G.J., Holst, J., Hartmann, B., Burrin, D.G. 2015. Enteral obeticholic acid promotes intestinal growth in total parenteral nutrition fed neonatal pigs [abstract]. Hepatology. Paper No. 1689. 62(1)Suppl:1032A.

The glucose sensor ChREBP links de-novo lipogenesis to PPARgamma activity and adipocyte differentiation - (Peer Reviewed Journal)
Witte, N., Muenzner, M., Rietscher, J., Knauer, M., Heidenreich, S., Nuotio-Antar, A.M., Graef, F.A., Fedders, R., Tokachov, A., Goehring, I., Schupp, M. 2015. The glucose sensor ChREBP links de-novo lipogenesis to PPARgamma activity and adipocyte differentiation. Endocrinology. http://dx.doi.org/10.1210/EN.2015-1209.

Early gradual feeding with bovine colostrum improves gut function and NEC resistance relative to infant formula in preterm pigs - (Peer Reviewed Journal)
Shen, R.L., Thymann, T., Ostergaard, M.V., Stoy, A.C., Krych, L., Nielsen, D.S., Lauridsen, C., Hartmann, B., Holst, J.J., Burrin, D.G., Sanglid, P.T. 2015. Early gradual feeding with bovine colostrum improves gut function and NEC resistance relative to infant formula in preterm pigs. American Journal of Physiology - Gastrointestinal and Liver Physiology. 309(5):G310-G323.

Circadian dysfunction induces leptin resistance in mice - (Peer Reviewed Journal)
Kettner, N.M., Mayo, S.A., Hua, J., Choogon, L., Moore, D.L., Fu, L. 2015. Circadian dysfunction induces leptin resistance in mice. Cell Metabolism. 22:1-12.

Proinsulin-producing, hyperglycemia-induced adipose tissue macrophages underlie insulin resistance in high fat-fed diabetic mice - (Peer Reviewed Journal)
Buras, E., Yang, L., Saha, P., Kim, J., Mehta, P., Yang, Y., Hilsenbeck, S., Kojima, H., Chen, W., Smith, C.W., Chan, L. 2015. Proinsulin-producing, hyperglycemia-induced adipose tissue macrophages underlie insulin resistance in high fat-fed diabetic mice. Federation of American Societies for Experimental Biology Conference. 29:3537-3548.

Loss of n-6 fatty acid induced pediatric obesity protects against acute murine colitis - (Peer Reviewed Journal)
Nagy-Szakal, D., Mir, S., Harris, R., Dowd, S., Yamada, T., Lacorazza, H., Tatevian, N., Smith, C., De Zoeten, E., Klein, J., Kellermayer, R. 2015. Loss of n-6 fatty acid induced pediatric obesity protects against acute murine colitis. Journal of Federation of American Societies for Experimental Biology. 29:3151-3159.

Formula carbohydrate content differentially shapes the microbial community patterns and NEC incidence in premature pigs - (Abstract Only)
Burrin, D.G., Call, L., Stoll, B., Akinkuotu, A., Olutoye, O., Ajami, N., Petrosino, J., Wittke, A. 2015. Formula carbohydrate content differentially shapes the microbial community patterns and NEC incidence in premature pigs [abstract]. Proceedings of the 48th Annual Meeting of the European Society for Paediatric Gastroenterology, Hepatology and Nutrition, May 6-9, 2015, Amsterdam, The Netherlands, 60(Suppl. 1):748-749.

Enteral obeticholic acid prevents PNALD and promotes intestinal growth in TPN fed neonatal piglets - (Abstract Only)
Stoll, B., Jiang, Y., Fang, Z., Wang, H., Guthrie, G., Burrin, D.G. 2015. Enteral obeticholic acid prevents PNALD and promotes intestinal growth in TPN fed neonatal piglets [abstract]. Proceedings of the 48th Annual Meeting of the European Society for Paediatric Gastroenterology, Hepatology and Nutrition, May 6-9, 2015, Amsterdam, The Netherlands, 60(Suppl. 1):64.

Importance of Animals in Agricultural Sustainability and Food Security - (Other)
Reynolds, L.P., Wulster-Radcliffe, M.C., Aaron, D.K., Davis, T.A. 2015. Importance of Animals in Agricultural Sustainability and Food Security. Journal of Nutrition. 145(7):1377-1379.

Glutamine supplementation, citrulline production, and de novo arginine synthesis: Is there a relation? - (Other)
Ligthart-Melis, G.C., Marini, J.C., Engelen, M.P., Deutz, N.E. 2015. Glutamine supplementation, citrulline production, and de novo arginine synthesis: Is there a relation? [Letter to the Editor]. American Journal of Clinical Nutrition. 101(4):890-892.

Low abdominal NIRS values and elevated plasma intestinal fatty acid-binding protein in a premature piglet model of necrotizing enterocolitis - (Peer Reviewed Journal)
Zamora, I.J., Stoll, B., Ethun, C.G., Sheikh, F., Yu, L., Burrin, D.G., Brandt, M.L., Olutoye, O.O. 2015. Low abdominal NIRS values and elevated plasma intestinal fatty acid-binding protein in a premature piglet model of necrotizing enterocolitis. PLoS One. 10(6):e0125437. doi:10.1371/journal.pone.0125437.

Dietary arginine requirements for growth are dependent on the rate of citrulline production in mice - (Peer Reviewed Journal)
Marini, J.C., Agarwal, U., Didelija, I. 2015. Dietary arginine requirements for growth are dependent on the rate of citrulline production in mice. Journal of Nutrition. 145(6):1227-1231.

Defining meal requirements for protein to optimize metabolic roles of amino acids - (Peer Reviewed Journal)
Layman, D.K., Anthony, T.G., Rasmussen, B.B., Adams, S.H., Lynch, C.J., Brinkworth, G.D., Davis, T.A. 2015. Defining meal requirements for protein to optimize metabolic roles of amino acids. American Journal of Clinical Nutrition. 101(Suppl):1330S-1338S.

Arginine depletion by arginine deiminase does not affect whole protein metabolism or muscle fractional protein synthesis rate in mice - (Peer Reviewed Journal)
Marini, J.C., Didelija, I. 2015. Arginine depletion by arginine deiminase does not affect whole protein metabolism or muscle fractional protein synthesis rate in mice. PLoS One. 10(3):e0119801. doi:10.1371/journal.pone.0119801.

Platelet recruitment promotes keratocyte repopulation following corneal epithelial abrasion in the mouse - (Peer Reviewed Journal)
Lam, F.W., Phillips, J., Landry, P., Magadi, S., Smith, C., Rumbaut, R.E., Burns, A.R. 2015. Platelet recruitment promotes keratocyte repopulation following corneal epithelial abrasion in the mouse. PLoS One. 29:3151-3159.

Validating hyperbilirubinemia and gut mucosal atrophy with a novel ultramobile ambulatory total parenteral nutrition piglet model - (Peer Reviewed Journal)
Jain, A.K., Wen, J.X., Arora, S., Blomenkamp, K.S., Rodrigues, J., Blaufuss, T.A., Liou, V., Burrin, D.G., Long, J.P., Teckman, J.H. 2014. Validating hyperbilirubinemia and gut mucosal atrophy with a novel ultramobile ambulatory total parenteral nutrition piglet model. Nutrition Research. 35(2):169-174.

Vitamin E in new-generation lipid emulsions protects against parenteral nutrition-associated liver disease in parenteral nutrition-fed preterm pigs - (Peer Reviewed Journal)
Ng, K., Stoll, B., Chacko, S., Saenz De Pipaon, M., Lauridsen, C., Gray, M., Squires, E., Marini, J.C., Zamora, I.J., Olutoye, O.O., Burrin, D.G. 2015. Vitamin E in new-generation lipid emulsions protects against parenteral nutrition-associated liver disease in parenteral nutrition-fed preterm pigs. Journal of Parenteral and Enteral Nutrition. DOI: 10.1177/0148607114567900.

Neuroanatomy and transgenic technologies - (Other)
Jackson, A.C., Liu, C., Fukuda, M., Gautron, L. 2015. Neuroanatomy and transgenic technologies. Frontiers in Neuroanatomy. 8:157.

Bolus vs. continuous feeding to optimize anabolism in neonates - (Peer Reviewed Journal)
Davis, T.A., Fiorotto, M.L., Suryawan, A. 2015. Bolus vs. continuous feeding to optimize anabolism in neonates. Current Opinion in Clinical Nutrition and Metabolic Care. 18(1):102-108.

Mechanisms of nutrient sensing - (Book / Chapter)
Burrin, D.G., Davis, T.A. 2014. Mechanisms of nutrient sensing. In: Ross, A.C., Caballero, B., Cousins, R.J., Tucker, K.L., Ziegler T.R., editors. Modern Nutrition in Health and Disease. 11th edition. Baltimore, MD: Lippincott Williams & Wilkens. p. 626-632.

Animal models of gastrointestinal and liver diseases. Animal models of infant short bowel syndrome: Translational relevance and challenges - (Review Article)
Sanglid, P., Ney, D.M., Sigalet, D.L., Vegge, A., Burrin, D.G. 2014. Animal models of gastrointestinal and liver diseases. Animal models of infant short bowel syndrome: Translational relevance and challenges. American Journal of Physiology - Gastrointestinal and Liver Physiology. 307(12):G1147-G1168.

Protein requirements: Are we ready for new recommendations - (Other)
Marini, J.C. 2014. Protein requirements: Are we ready for new recommendations [Commentary]. Journal of Nutrition. 145(4):5-6.

Enteral leucine and protein synthesis in skeletal and cardiac muscle - (Book / Chapter)
Suryawan, A., Davis, T.A. 2015. Enteral leucine and protein synthesis in skeletal and cardiac muscle. In: Rajendram, R., Preedy, V.R, Patel, V.B., editors. Branched Chain Amino Acids in Clinical Nutrition. 1st edition. New York, NY: Springer. p. 197-210.

Gamma delta T cells promote inflammation and insulin resistance during high fat diet-induced obesity in mice - (Peer Reviewed Journal)
Mehta, P., Nuotio-Antar, A.M., Smith, C. 2015. Gamma delta T cells promote inflammation and insulin resistance during high fat diet-induced obesity in mice. Journal of Leukocyte Biology. 97:121-134.

Delayed initiation but not gradual advancement of enteral formula feeding reduces the incidence of necrotizing enterocolitis (NEC) in preterm pigs - (Peer Reviewed Journal)
Ghoneim, N., Bauchart-Thevret, C., Oosterloo, B., Stoll, B., Kulkarni, M., Saenz De Pipaon, M., Zamora, I.J., Olutoye, O.O., Berg, B., Wittke, A., Burrin, D.G. 2014. Delayed initiation but not gradual advancement of enteral formula feeding reduces the incidence of necrotizing enterocolitis (NEC) in preterm pigs. PLoS One. 9(9):e106888. doi: 10.1371/journal.pone.0106888.

New generation lipid emulsion protects against LPS-induced brain inflammation in pemature piglets - (Abstract Only)
Guthrie, G., Hodges, B., Martin, C.R., Stoll, B., Olutoye, O.O., Freedman, S.D., Burrin, D.G. 2014. New generation lipid emulsion protects against LPS-induced brain inflammation in pemature piglets. Archives of Disease in Childhood. 99(Suppl 2):PS-341a, A235.

Metabolomic determinants of necrotizing enterocolitis in preterm piglets - (Abstract Only)
Call, L., Stoll, B., Garcia, S., Bauchart-Thevret, C., Donnelly, J., Sheikh, F., Akinkuotu, A., Olutoye, O.O., Wittke, A., Burrin, D.G. 2014. Metabolomic determinants of necrotizing enterocolitis in preterm piglets. Archives of Disease in Childhood. 99(Suppl 2):PO-0607b, A451.

Extrarenal citrulline disposal in mice with impaired renal function - (Peer Reviewed Journal)
Marini, J.C., Didelija, I.C., Fiorotto, M.L. 2014. Extrarenal citrulline disposal in mice with impaired renal function. American Journal of Physiology - Renal Physiology. 307(6):F660-F665.

Abdominal near-infrared spectroscopy measurements are lower in preterm infants at risk for necrotizing enterocolitis - (Peer Reviewed Journal)
Patel, A.K., Lazar, D.A., Burrin, D.G., Smith, E., Magliaro, T.J., Stark, A.R., Brandt, M.L., Zamora, I.J., Sheikh, F., Akinkuotu, A.C., Olutoye, O.O. 2014. Abdominal near-infrared spectroscopy measurements are lower in preterm infants at risk for necrotizing enterocolitis. Pediatric Critical Care Medicine. 15(8):735-741.

Xbp1s in Pomc neurons connects ER stress with energy balance and glucose homeostasis - (Peer Reviewed Journal)
Williams, K.W., Liu, T., Kong, X., Fukuda, M., Deng, Y., Berglund, E.D., Deng, Z., Gao, Y., Liu, T., Sohn, J., Jia, L., Fujikawa, T., Kohno, D., Scott, M.M., Lee, S., Lee, C.E., Sun, K., Chang, Y., Scherer, P.E., Elmquist, J.K. 2014. Xbp1s in Pomc neurons connects ER stress with energy balance and glucose homeostasis. Cell Metabolism. 20(3):471-482.

Hepatocyte Toll-like receptor 4 regulates obesity-induced inflammation and insulin resistance - (Peer Reviewed Journal)
Jia, L., Vianna, C.R., Fukuda, M., Berglund, E.D., Liu, C., Tao, C., Sun, K., Liu, T., Harper, M.J., Lee, C.E., Lee, S., Scherer, P.E., Elmquist, J.K. 2014. Hepatocyte Toll-like receptor 4 regulates obesity-induced inflammation and insulin resistance. Nature Communications. 5:3878.

Circadian gene variants in cancer - (Review Article)
Kettner, N.M., Katchy, C.A., Fu, L. 2014. Circadian gene variants in cancer. Annals of Medicine. 46:208-220.

Nuclear receptor LRH-1/NR5A2 is required and targetable for liver endoplasmic reticulum stress resolution - (Peer Reviewed Journal)
Mamrosh, J.L., Lee, J., Wagner, M., Stambrook, P.J., Whitby, R.J., Sifers, R.N., Wu, S., Tsai, M., Demayo, F.J., Moore, D.D. 2014. Nuclear receptor LRH-1/NR5A2 is required and targetable for liver endoplasmic reticulum stress resolution. eLife. 3:e01694.

Elevated resistin levels induce central leptin resistance and increased atherosclerotic progression in mice - (Peer Reviewed Journal)
Asterholm, I.W., Rutkowski, J.M., Fujikawa, T., Cho, Y.R., Fukuda, M., Tao, C., Wang, Z.V., Gupta, R.K., Elmquist, J.K., Scherer, P.E. 2014. Elevated resistin levels induce central leptin resistance and increased atherosclerotic progression in mice. Diabetologia. 57(6):1209-1218.

AKI after conditional and kidney-specific knockdown of Stanniocalcin-1 - (Peer Reviewed Journal)
Huang, L., Belousova, T., Szu-Chin Pan, J., Du, J., Ju, H., Lu, L., Zhang, P., Truong, L.D., Nuotio-Antar, A., Sheikh-Hamad, D. 2014. AKI after conditional and kidney-specific knockdown of Stanniocalcin-1. Journal of the American Society of Nephrology. 2(10):2303-2315.

Intergrin-dependent neutrophil migration in the injured mouse cornea - (Peer Reviewed Journal)
Hanlon, S., Smith, C., Sauter, M., Burns, A. 2014. Intergrin-dependent neutrophil migration in the injured mouse cornea. Experimental Eye Research. 120:61-70.

Protein synthesis in skeletal muscle of neonatal pigs is enhanced by administration of beta-hydroxy-beta-methylbutyrate - (Peer Reviewed Journal)
Wheatley, S.M., El-Kadi, S.W., Suryawan, A., Boutry, C., Orellana, R.A., Nguyen, H.V., Davis, S.R., Davis, T.A. 2014. Protein synthesis in skeletal muscle of neonates is enhanced by administration of beta-hydroxy-beta-methylbutyrate. American Journal of Physiology - Endocrinology and Metabolism. 306:E91-E99.

Protein synthesis in skeletal muscle of neonatal pigs is enhanced by administration of Beta-hydroxy-Beta-methylbutyrate - (Peer Reviewed Journal)
Wheatley, S.M., El-Kadi, S.W., Suryawan, A., Boutry, C., Orellana, R.A., Nguyen, H.V., Davis, S.R., Davis, T.A. 2014. Protein synthesis in skeletal muscle of neonatal pigs is enhanced by administration of Beta-hydroxy-Beta-methylbutyrate. American Journal of Physiology - Endocrinology and Metabolism. 306(1):E91-99.