Location: Immunity and Disease Prevention Research
Project Number: 2032-51530-017-13-T
Project Type: Trust Fund Cooperative Agreement
Start Date: Sep 22, 2011
End Date: Sep 30, 2013
The overall goal of the proposed studies is to determine whether high fat meal-induced postprandial lipemia (a single meal experimental protocol) causes monocyte activation, cerebral inflammation and alteration in patterns of brain activity associated with performing memory tasks, and whether concomitant blueberry intake alleviates such pathophysiological consequences of ingesting a high fat meal in healthy human subjects.
Our experimental approaches are: first, to determine whether single high fat meal induces monocyte activation in healthy subjects, and whether the monocyte activation leads to microglial cell activation and alteration of neural activity as assessed by fMRI of brain, and then whether blueberry supplementation suppresses monocyte and microglial cell activation, and restores the alteration of neural activity.