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ARS Home » Pacific West Area » Davis, California » Western Human Nutrition Research Center » Immunity and Disease Prevention Research » Research » Research Project #421626

Research Project: Does Blueberry Intake Alleviate Postprandial Lipemia-induced Inflammation and Consequent Alteration in Neural Activity

Location: Immunity and Disease Prevention Research

Project Number: 2032-51530-017-13-T
Project Type: Trust Fund Cooperative Agreement

Start Date: Sep 22, 2011
End Date: Sep 30, 2013

Objective:
The overall goal of the proposed studies is to determine whether high fat meal-induced postprandial lipemia (a single meal experimental protocol) causes monocyte activation, cerebral inflammation and alteration in patterns of brain activity associated with performing memory tasks, and whether concomitant blueberry intake alleviates such pathophysiological consequences of ingesting a high fat meal in healthy human subjects.

Approach:
Our experimental approaches are: first, to determine whether single high fat meal induces monocyte activation in healthy subjects, and whether the monocyte activation leads to microglial cell activation and alteration of neural activity as assessed by fMRI of brain, and then whether blueberry supplementation suppresses monocyte and microglial cell activation, and restores the alteration of neural activity.