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United States Department of Agriculture

Agricultural Research Service

Daniel Hwang
Research Molecular Biologist


Publications (Clicking on the reprint icon Reprint Icon will take you to the publication reprint.)
What causes high fat diet-induced postprandial inflammation: endotoxin or free fatty acids? -
Toll-like receptor 4-induced endoplasmic reticulum stress contributes to endothelial dysfunction -
Kim, J., Jang, H., Hwang, D.H. 2015. Toll-like receptor 4-induced endoplasmic reticulum stress contributes to endothelial dysfunction. American Journal of Physiology. doi: 10.1152/ajpendo.00369.2015.
Docosahexaenoic acid and palmitic acid reciprocally modulate monocyte activation in part through endoplasmic reticulum stress -
Snodgrass, R.G., Huang, S., Namgaladze, D., Jandali, O., Shao, T., Sama, S., Brune, B., Hwang, D.H. 2016. Docosahexaenoic acid and palmitic acid reciprocally modulate monocyte activation in part through endoplasmic reticulum stress. Journal of Lipid Research. doi: 10.1016/j.jnutbio.2016.01.010.
Acylcarnitines: potential implications for skeletal muscle insulin resistance -
Aguer, C., Mccoin, C.S., Knotts, T.A., Mcpherson, R., Dent, R., Hwang, D.H., Adams, S.H., Harper, M. 2014. Acylcarnitines: potential implications for skeletal muscle insulin resistance. Journal of Federation of American Societies for Experimental Biology. 29(1):336-345. doi: 10.1096/fj.14-255901.
Acylcarnitines activate pro-inflammatory signaling pathways -
Rutkowsky, J.M., Knotts, T.A., Ono-Moore, K.D., Mc Coin, C.S., Huang, S., Schneider, D.A., Singh, S., Adams, S.H., Hwang, D.H. 2014. Acylcarnitines activate pro-inflammatory signaling pathways. American Journal of Physiology - Endocrinology and Metabolism. DOI: 10.1152/ajpendo.00656.2013.
Influence of reactive oxygen species on the sterilization of microbes -
Uhm, H.S., Choi, E.H., Cho, G.S., Hwang, D.H. 2013. Influence of reactive oxygen species on the sterilization of microbes. Current Applied Physics. 13:S30-S35.
Toll-like receptor 2 mediates high-fat diet-induced impairment of vasodilator actions of insulin -
Jang, H., Ridgeway, S.D., Vashista, P., Hwang, D.H., Quon, M.J., Kim, J. 2013. Toll-like receptor 2 mediates high-fat diet-induced impairment of vasodilator actions of insulin. American Journal of Physiology - Endocrinology and Metabolism. 304(10):E1077-E1088. First e-published 03/26/2013. DOI:10.1152/ajpendo.00578.2012.
Dietary strawberries increase proliferative response of CD3/CD28-activated CD8+ T cells and production of TNF-alpha in lipopolysaccharide-stimulated monocytes from obese human subjects -
Zunino, S.J., Storms, D.H., Freytag, T.L., Mackey, B.E., Zhao, L., Gouffon, J.S., Hwang, D.H. 2013. Dietary strawberries increase proliferative response of CD3/CD28-activated CD8+ T cells and production of TNF-alpha in lipopolysaccharide-stimulated monocytes from obese human subjects. British Journal of Nutrition. 110:2011-2019. DOI: 10.1017/S0007114513000937. Epub ahead of print.
Saturated fatty acids activate TLR-mediated pro-inflammatory signaling pathways -
Huang, S., Rutkowsky, J.M., Snodgrass, R.G., Ono-Moore, K., Schneider, D.A., Newman, J.W., Adams, S.H., Hwang, D.H. 2012. Saturated fatty acids activate TLR-mediated pro-inflammatory signaling pathways. Journal of Lipid Research. Epublished. DOI: 10.1194/jlr.D029546.
NOD1 activation induces proinflammatory gene expression and insulin resistance in 3T3-L1 adipocytes Reprint Icon -
Zhao, L., Hu, P., Zhou, Y., Purohit, J., Hwang, D.H. 2011. NOD1 activation induces proinflammatory gene expression and insulin resistance in 3T3-L1 adipocytes. American Journal of Physiology. Available: http://ajpendo.physiology.org/content/early/2011/06/15/ajpendo.00709.2010.reprint
Dietary modulation of inflammation -
Inhibition of pattern recognition receptor-mediated inflammation by bioactive phytochemicals Reprint Icon -
Ling, Z., Lee, J., Hwang, D.H. 2011. Inhibition of pattern recognition receptor-mediated inflammation by bioactive phytochemicals. Nutrition Reviews. 69:6(310-320).
Modulation of blood cell gene expression by DHA supplementation in hypertriglyceridemic men Reprint Icon -
Dawson, K., Zhao, L., Adkins, Y.C., Rodriguez, R.L., Kelley, D.S., Hwang, D.H. 2011. Modulation of blood cell gene expression by DHA supplementation in hypertriglyceridemic men. Journal of Nutritional Biochemistry. Available: http://www.sciencedirect.com/science/article/pii/S0955286311000933
Inhibition of pattern recognition receptor-mediated inflammation by bioactive phytochemicals -
Zhao, L., Lee, J.Y., Hwang, D.H. 2011. Inhibition of pattern recognition receptor-mediated inflammation by bioactive phytochemicals. Nutrition Reviews. 69(6):310-320, DOI: 10.1111/j.1753-4887.2011.00394.x.
FATTY ACIDS MODULATE TOLL-LIKE RECEPTOR 4 ACTIVATION THROUGH REGULATION OF RECEPTOR DIMERIZATION AND RECRUITMENT INTO LIPID RAFTS -
Toll-like receptors in the pathogenesis of inflammatory diseases Reprint Icon -
Lee, J.K., Hwang, D.H., Lee, J.Y. 2009. Toll-like receptors in the pathogenesis of inflammatory diseases. Journal of Organ Dysfuntion. 5:2,119-128, 2009.
Plasma Acylcarnitine Profiles Suggest Incomplete Fatty Acid ß-Oxidation and Altered Tricarboxylic Cycle Activity in Type 2 Diabetic African-American Women Reprint Icon -
Adams, S.H., Hoppel, C.L., Lok, K.H., Zhao, L., Wong, S.W., Minkler, P.E., Hwang, D.H., Newman, J.W., Garvey, W.T. 2009. Plasma Acylcarnitine Profiles Suggest Incomplete Fatty Acid ß-Oxidation and Altered Tricarboxylic Cycle Activity in Type 2 Diabetic African-American Women. Journal of Nutrition, 139:1073-1081.
Suppression of the TRIF-dependent signaling pathway of Toll-like receptors by luteolin Reprint Icon -
Lee, J., Kim, S., Kim, Y., Lee, W., Hwang, D.H., Lee, J. 2009. Suppression of the TRIF-dependent signaling pathway of Toll-like receptors by luteolin. Biochemical Pharmacology. Vol.77:1391-1400.
HIGH GLUCOSE INDUCES TOLL-LIKE RECEPTOR EXPRESSION IN HUMAN MONOCYTES: MECHANISM OF ACTIVATION Reprint Icon -
Dasu, M.R., Devaraj, S., Ling, Z., Hwang, D.H., Jialal, I. 2008. HIGH GLUCOSE INDUCES TOLL-LIKE RECEPTOR EXPRESSION IN HUMAN MONOCYTES: MECHANISM OF ACTIVATION. Diabetes 57(11):3090-3098, 2008.
Inhibition of Nod2 signaling and target gene expression by curcumin Reprint Icon -
Huang, S., Zhao, L., Kim, K., Lee, D., Hwang, D.H. 2008. Inhibition of Nod2 signaling and target gene expression by curcumin. Molecular Pharmacology 74(1):274-281, 2008.
The Phosphatidylinositol 3-Kinase/Akt Pathway Negatively Regulates Nod2-Mediated NF-kB Pathway Reprint Icon -
Zhao, L., Lee, J.Y., Hwang, D.H. The Phosphatidylinositol 3-Kinase/Akt Pathway Negatively Regulates Nod2-Mediated NF-kB Pathway. 2008. Biochemical Pharmacology. 75:1515-1525, 2008.
Garlic (Allium sativum) Extracts Inhibits Lipopolysaccharide-Induced Toll-Like Receptor 4 Dimerization Reprint Icon -
Youn, H., Lim, H., Lee, H., Hwang, D.H., Yang, M., Jeon, R., Ryu, J. 2008. Garlic (Allium sativum) Extracts Inhibits Lipopolysaccharide-Induced Toll-Like Receptor 4 Dimerization. Bioscience Biotechnology and Biochemistry 72(2):368-375, 2008.
Acrolein with an alpha, beta-unsaturated Carbonyl Group Inhibits LPS-induced Homodimerization of Toll-like Receptor 4 -
Lee, J., Lee, J., Lee, M., Hwang, D.H., Youn, H. 2007. Acrolein with an alpha, beta-unsaturated Carbonyl Group Inhibits LPS-induced Homodimerization of Toll-like Receptor 4. Molecules and Cells. Vol.25, No2, 253-257.
Cinnamaldehyde suppresses Toll-like receptor 4 activation mediated through the inhibition of receptor oligomerization Reprint Icon -
Youn, H.S., Lee, J.K., Choi, Y.J., Saitoh, S.I., Miyake, K., Hwang, D.H., Lee, J.Y. 2008. Cinnamaldehyde suppresses Toll-like receptor 4 activation mediated through the inhibition of receptor oligomerization. 2007. Biochemical Pharmacology. Vol.75(2), p.494-502, 2008.
THE MODULATION OF INFLAMMATORY GENE EXPRESSION BY LIPIDS: MEDIATION THROUGH TOLL-LIKE RECEPTORS -
Lee, J., Hwang, D.H. The modulation of inflammatory gene expression by lipids: mediation through toll-like receptors. Review Article. 2006. Molecules and Cells, Vol.21,No.2,pp.174-185.
Differential Modulation of Nods Signaling Pathways by Fatty Acids in Human Colonic Epithelial HCT116 cells -
Zhao, L., Kwon, M., Lee, J.Y., Fukase, K., Inohara, N., Hwang, D.H. 2007. Differential Modulation of Nods Signaling Pathways by Fatty Acids in Human Colonic Epithelial HCT116 cells. Journal of Biological Chemistry. Vol.282, No.16,pp.11618-11628.
AURANOFIN, AS AN ANTI-RHEUMATIC GOLD COMPOUND SUPPRESSES LPS-INDUCED HOMODIMERIZATION OF TLR4 -
Youn, H.S., Lee, J.Y., Saitoh, S.I., Miyake, K., Hwang, D.H. 2006. AURANOFIN, AS AN ANTI-RHEUMATIC GOLD COMPOUND SUPPRESSES LPS-INDUCED HOMODIMERIZATION OF TLR4. Biochemistry and Biophysics Research Communication. 350 (2006) 866-871.
SUPPRESSION OF MYD88- AND TRIF-DEPENDENT SIGNALING PATHWAYS OF TOLL-LIKE RECEPTOR BY (-)-EPIGALLOCATECHIN-3-GALLATE, A POLYPHENOL COMPONENT OF GREEN TEA -
Youn, H.S., Lee, J.Y., Saotoh, S.I., Miyake, K., Kang, K.W., Choi, Y., Hwang, D.H. 2006. Suppression of myd88- and trif-dependent signaling pathways of toll-like receptor by (-)-epigallocatechin-3-gallate, a polyphenol component of green tea. Biochemical Pharmacology; Elsevier 72 (2006) 850-859.
GENOME-WIDE IDENTIFICATION OF PEROXISOME PROLIFERATOR RESPONSE ELEMENTS USING INTEGRATED COMPUTATIONAL GENOMICS -
Lemay, D.G., Hwang, D.H. Genome-wide identification of peroxisome proliferator response elements using integrated computational genomics. Journal of Lipid Research. 47:1583-1587, 2006.
INHIBITION OF HOMODIMERIZATION OF TOLL-LIKE RECEPTOR 4 BY CURCUMIN -
Youn, H.S., Saitoh, S.I., Miyake, K., Hwang, D.H. 2006. INHIBITION OF HOMODIMERIZATION OF TOLL-LIKE RECEPTOR 4 BY CURCUMIN. Biochemical Pharmacology. 72(2006):62-69.
OVEREXPRESSION OF THE PROSTAGLANDIN E2 RECEPTOR EP2 RESULTS IN ENHANCED SKIN TUMOR DEVELOPMENT -
Sung, Y., He, G., Hwang, D.H., Fishcher, S.M. Overexpression of the prostaglandin e2 receptor ep2 results in enhanced skin tumor development. Oncogene (2006) 25, 5507-5516.
THE REGULATION OF THE EXPRESSION OF INDUCIBLE NITRIC OXIDE SYNTHASE BY SRC-FAMILY TYROSINE KINASE MEDIATED THROUGH MYD88-INDEPENDENT SIGNALING PAYWAYS OF TOLL-LIKE RECEPTOR 4 -
Lee, J.Y., Lowell, C.A., Lemay, D.G., Youn, H.S., Rhee, S.H., Sohn, K.H., Jang, B., Ye, J., Chung, J.H., Hwang, D.H. 2005. THE REGULATION OF THE EXPRESSION OF INDUCIBLE NITRIC OXIDE SYNTHASE BY SRC-FAMILY TYROSINE KINASE MEDIATED THROUGH MYD88-INDEPENDENT SIGNALING PAYWAYS OF TOLL-LIKE RECEPTOR 4. Biochemical Pharmacology, 70:1231-1240.
SPECIFIC INHIBITION OF MYD88-INDEPENDENT SIGNALING PATHWAYS OF TOLL-LIKE RECEPTOR 3 AND 4 BY RESVERATROL: MOLECULAR TARGETS ARE TBK1 IN TRIF COMPLEX* -
Youn, H.S., Lee, J.Y., Fitzgerald, K.A., Young, H., Akira, S., Hwang, D.H. 2005. SPECIFIC INHIBITION OF MYD88-INDEPENDENT SIGNALING PATHWAYS OF TOLL-LIKE RECEPTOR 3 AND 4 BY RESVERATROL: MOLECULAR TARGETS ARE TBK1 IN TRIF COMPLEX. Journal of Immunology. 175:3339-3346, 2005.
SRC-FAMILY TYROSINE KINASE INHIBITOR (PP1) SUPPRESSES LPS-INDUCED EXPRESSION OF INDUCIBLE NITRIC OXIDE SYNTHASE MEDIATED THROUGH THE INHIBITION OF INTERFERON B EXPRESSION IN MACROPHAGES -
Lee, J., Youn, H.S., Lemay, D., Lowell, C.A., Hwang, D.H. Src-family tyrosine kinase inhibitor (pp1) suppresses lps-induced expression of inducible nitric oxide synthase mediated through the inhibition of interferon b expression in macrophages. Experimental Biology. Abstract 829.7 (pge A1453)
SATURATED AND POLYUNSATURATED FATTY ACIDS RECIPROCALLY MODULATE DENDRITIC CELL FUNCTIONS MEDIATED THROUGH TLR4 -
Weatherill, A., Lee, J., Zhao, L., Lemay, D., Youn, H.S., Hwang, D.H. Saturated and polyunsaturated fatty acids reciprocally modulate dendritic cell functions mediated through tlr4. Journal of Immunology. 174:5390-5397, 2005.
INHIBITION OF INSULIN SENSITIVITY BY FREE FATTY ACIDS REQUIRES ACTIVATION OF MULTIPLE SERINE KINASES IN 3T3-L1 ADIPOCYTES -
Gao, Z., Zhang, X., Zuberi, A., Hwang, D.H., Quon, M.J., Lefevre, M., Ye, J. Inhibition of insulin sensitivity by free fatty acids requires activation of multiple serine kinases in 3t3-l1 adipocytes. Molecular Endocrinology 18:2024-2034, (2004).
SATURATED FATTY ACID ACTIVATES BUT POLYUNSATURATED FATTY ACID INHIBITS TOLL-LIKE RECEPTOR 2 DIMERIZED WITH TOLL-LIKE RECEPTOR 6 OR 1 -
Lee, J.Y., Zhao, L., Young, H., Weatherill, A., Tapping, R., Feng, L., Lee, W.H., Fitzgerald, K., Hwang, D.H. Saturated fatty acid activates but polyunsaturated fatty acid inhibits toll-like receptor 2 dimerized with toll-like receptor 6 or 1. Journal of Biological Chemistry 279(17) 16971-16979, 2004.
RECIPROCAL MODULATION OF TOLL-LIKE RECEPTOR-4 SIGNALING PATHWAYS INVOLVING MYD88 AND PHOSPHATIDYLINOSITOL 3-KINASE/AKT BY SATURATED AND POLYUNSATURATED FATTY ACIDS -
Lee, J., Ye, J., Gao, Z., Youn, H., Lee, W., Zhao, L., Sizemore, N., Hwang, D.H. 2003. RECIPROCAL MODULATION OF TOLL-LIKE RECEPTOR-4 SIGNALING PATHWAYS INVOLVING MYD88 AND PHOSPHATIDYLINOSITOL 3-KINASE/AKT BY SATURATED AND POLYUNSATURATED FATTY ACIDS. Journal of Biological Chemistry 278 (39) 37041-37051, 2003.
Last Modified: 8/26/2016
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