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ARS Home » Midwest Area » Ames, Iowa » National Animal Disease Center » Virus and Prion Research » People & Locations » Laura Miller

Laura Miller
Virus and Prion Research
Research Microbiologist

Phone: (515) 337-6794
Fax: (515) 337-7149

P.O. BOX 70
1920 DAYTON AVE
AMES, IA 50010
Projects
Intervention Strategies to Control Endemic and New and Emerging Viral Diseases of Swine
In-House Appropriated (D)
  Accession Number: 432022
Role of the Viral Ovarian Domain Protease in PRRSV Pathogenesis
Reimbursable Cooperative Agreement (R)
  Accession Number: 429853

Publications (Clicking on the reprint icon Reprint Icon will take you to the publication reprint.)
Integrate structural analysis, Isoform diversity, and interferon-inductive propensity of ACE2 to refine SARS-CoV2 susceptibility prediction in vertebrates Reprint Icon - (Peer Reviewed Journal)
Sang, E.R., Tian, Y., Gong, Y., Miller, L.C., Sang, Y. 2020. Integrate structural analysis, Isoform diversity, and interferon-inductive propensity of ACE2 to refine SARS-CoV2 susceptibility prediction in vertebrates. Heliyon. e04818. https://doi.org/10.1016/j.heliyon.2020.e04818.
Too much of a good thing: Antiviral response and tissue damage during respiratory infections in the porcine lung - (Abstract Only)
Integrate structural analysis, Isoform diversity, and interferon-inductive propensity of ACE2 to refine SARS-CoV2 susceptibility prediction in vertebrates - (Abstract Only)
Validation of a PRRSV live-virus potentiated by replication-competent expression of porcine interferons - (Proceedings)
Comparison of the transcriptome response within the swine tracheobronchial lymphnode following infection with PRRSV, PCV-2 or IAV-S Reprint Icon - (Peer Reviewed Journal)
Miller, L.C., Fleming, D.S., Lager, K.M. 2020. Comparison of the transcriptome response within the swine tracheobronchial lymphnode following infection with PRRSV, PCV-2 or IAV-S. Pathogens. 9(2):99. https://doi.org/10.3390/pathogens9020099.
(w)HOL(e)ISTIC gene ontology and pathway analysis of data using open source web tools Reprint Icon - (Peer Reviewed Journal)
Fleming, D.S., Miller, L.C. 2020. (w)HOL(e)ISTIC gene ontology and pathway analysis of data using open source web tools. Genomics Data. https://doi.org/10.21203/rs.2.20371/v1.
Transcriptomic analysis among sub-clinically ill cattle following bovine respiratory disease vaccine protocol and challenge with bovine viral diarrhea virus Reprint Icon - (Peer Reviewed Journal)
Fleming, D.S., Herring, A.D., Miller, L.C., Gill, C.A. 2019. Transcriptomic analysis among sub-clinically ill cattle following bovine respiratory disease vaccine protocol and challenge with bovine viral diarrhea virus. BioMed Central (BMC) Immunology. https://doi.org/10.21203/rs.2.16902/v1.
An overview of research at the National Animal Disease Center on endemic and emerging viral diseases of swine - (Abstract Only)
Anderson, T.K., Buckley, A.C., Miller, L.C., Fleming, D.S., Inderski, B., Lager, K.M., Faaberg, K.S. 2019. An overview of research at the National Animal Disease Center on endemic and emerging viral diseases of swine. Meeting Abstract. p. 80.
Persistent atypical porcine pestivirus (APPV) infection in gilts - (Abstract Only)
Buckley, A.C., Arruda, B., Falkenberg, S.M., Miller, L.C., Lager, K.M. 2019. Persistent atypical porcine pestivirus (APPV) infection in gilts. Meeting Abstract. p. 35.
Differentially expressed miRNAs and tRNA genes effect host homeostasis during highly pathogenic porcine reproductive and respiratory syndrome virus infections in young pigs Reprint Icon - (Peer Reviewed Journal)
Fleming, D.S., Miller, L.C. 2019. Differentially expressed miRNAs and tRNA genes effect host homeostasis during highly pathogenic porcine reproductive and respiratory syndrome virus infections in young pigs. Frontiers in Genetics. 10:691. https://doi.org/10.3389/fgene.2019.00691.
Cross-species genome-wide analysis reveals molecular and functional diversity of the unconventional interferon-omega subtype Reprint Icon - (Peer Reviewed Journal)
Shields, L.E., Liu, Q., Lee, Ma, W., Blecha, F., Miller, L.C., Sang, Y. 2019. Cross-species genome-wide analysis reveals molecular and functional diversity of the unconventional interferon-omega subtype. Frontiers in Immunology. https://doi.org/10.3389/fimmu.2019.01431.
e-PIG-enetics: porcine sncRNA response to highly pathogenic PRRSV - (Abstract Only)
Identification of coding and non-coding RNA classes expressed in swine whole blood Reprint Icon - (Peer Reviewed Journal)
Fleming, D.S., Anderson, S.J., Miller, L.C. 2018. Identification of coding and non-coding RNA classes expressed in swine whole blood. Journal of Visualized Experiments. (141):e58689. https://doi.org/10.3791/58689.
Porcine mRNA and sncRNA expression intersections during viral infection - (Abstract Only)
Fleming, D.S., Miller, L.C. 2018. Porcine mRNA and sncRNA expression intersections during viral infection. International Animal Biotechnology Symposium, Cheongju, South Korea. Abstract. p. 3.
e-PIG-enetics: porcine miRNA and tRNA expression during highly pathogenic PRRSV infections - (Abstract Only)
Fleming, D.S., Miller, L.C. 2018. e-PIG-enetics: porcine miRNA and tRNA expression during highly pathogenic PRRSV infections. PAG-ASIA 2018. Abstract No. W060.
Comparison of the transcriptome response within the porcine tracheobronchial lymph node following viral infection - (Peer Reviewed Journal)
Miller, L., Fleming, D., Harhay, G., Kehrli, M., Lager, K. 2018. Comparison of the transcriptome response within the porcine tracheobronchial lymph node following viral infection. Proceedings of the World Congress on Genetics Applied to Livestock Production, Volume Biology - Disease Resistance 2: 672.
Small non-coding RNA expression status in animals faced with highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) - (Peer Reviewed Journal)
Fleming, D.S., Miller, L. 2018. Small non-coding RNA expression status in animals faced with highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV). 2018. Proceedings of the World Congress on Genetics Applied to Livestock Production, Volume Species - Porcine 2:595.
Live virus Immunization (LVI) with a recent 1-7-4 PRRSV isolate elicits broad protection against PRRSV challenge in finishing age swine - (Abstract Only)
Van Geelen, A.G., Buckley, A., Kulshreshtha, V., Brockmeier, S., Miller, L.C., Fleming, D., Loving, C.L., Faaberg, K.S., Lager, K.M. 2018. Live virus Immunization (LVI) with a recent 1-7-4 PRRSV isolate elicits broad protection against PRRSV challenge in finishing age swine. American Association of Swine Veterinarians 49th Annual Meeting, March 3-6, 2018, San Diego, California. Paper No. 69.
Transcriptome responses to respiratory virus infection of pigs within the tracheobronchial lymphnode following infection with PRRSV, PCV2 or IAV - (Abstract Only)
Miller, L.C., Fleming, D.S., Harhay, G.P., Kehrli, Jr., M.E., Lager, K.M. 2018. Transcriptome responses to respiratory virus infection of pigs within the tracheobronchial lymphnode following infection with PRRSV, PCV2 or IAV. The Journal of Immunology. Vol. 200(1 Supplement):59.14.
Identification of small non-coding RNA classes expressed in swine whole blood during HP-PRRSV infection Reprint Icon - (Peer Reviewed Journal)
Fleming, D.S., Miller, L.C. 2018. Identification of small non-coding RNA classes expressed in swine whole blood during HP-PRRSV infection. Virology. 517:56-61. https://doi.org/10.1016/j.virol.2018.01.027.
Transcriptome responses to respiratory virus infection of pigs within the tracheobronchial lymphnode following infection with PRRSV, PCV2 or IAV - (Abstract Only)
Miller, L.C., Fleming, D.S., Harhay, G.P., Kehrli, Jr., M.E., Lager, K.M. 2018. Transcriptome responses to respiratory virus infection of pigs within the tracheobronchial lymphnode following infection with PRRSV, PCV2 or IAV. Plant & Animal Genome Conference XXVI, January 13-17, 2018, San Diego, California. Paper No. P1222.
Effect of miRNA and tRNA gene expression on the homeostatic status of pigs infected with highly pathogenic PRRSV - (Abstract Only)
Comparative analysis of signature genes in PRRSV-infected porcine monocyte-derived cells to different stimuli - (Abstract Only)
Porcine reproductive and respiratory disease virus: evolution and recombination yields distinct ORF5 RFLP 1-7-4 viruses with individual pathogenicity - (Peer Reviewed Journal)
van Geelen, A.G.M., Anderson, T.K., Lager, K.M., Das, P.B., Otis, N.J., Montiel, N.A., Miller, L.C., Kulshreshtha, V., Buckley, A.C., Brockmeier, S.L., Zhang, J., Gauger, P.C., Harmon, K.M., Faaberg, K.S. 2018. Porcine reproductive and respiratory disease virus: evolution and recombination yields distinct ORF5 RFLP 1-7-4 viruses with individual pathogenicity. Virology. 513:168-179.
Comparative analysis of signature genes in PRRSV-infected porcine monocyte-derived cells to different stimuli - (Abstract Only)
Miller, L.C., Fleming, D., Li, X., Bayles, D., Blecha, F., Sang, Y. 2017. Comparative analysis of signature genes in PRRSV-infected porcine monocyte-derived cells to different stimuli. 98th Conference of Research Workers in Animal Diseases. Abstract No. 237, p. 131.
Comparison of the transcriptome response within the tracheobronchial lymphnode following infection with PRRSV, PCV2 or SIV - (Abstract Only)
Miller, L.C., Fleming, D., Harhay, G., Bayles, D., Kehrli, M., Lager, K. 2017. Comparison of the transcriptome response within the tracheobronchial lymphnode following infection with PRRSV, PCV2, or SIV. 98th Conference of Research Workers in Animal Diseases. Abstract No. 190, p. 107.
Effect of miRNA and tRNA gene expression on the homeostatic status of pigs infected with highly pathogenic PRRSV - (Abstract Only)
Fleming, D., Miller, L.C. 2017. Effect of miRNA and tRNA gene expression on the homeostatic status of pigs infected with highly pathogenic PRRSV. 98th Annual Conference of Research Workers in Animal Diseases, December 3-5, 2017, Chicago, Illinois. Abstract No. 189, p. 107.
Live virus immunization (LVI) with a recent 1-7-4 PRRSV isolate elicits broad protection against PRRSV challenge in finishing age swine - (Abstract Only)
Comparative analysis of signature genes in PRRSV-infected porcine monocyte-derived cells at differential activation statuses Reprint Icon - (Peer Reviewed Journal)
Miller, L.C., Fleming, D.S., Li, X., Bayles, D.O., Blecha, F., Sang, Y. 2017. Comparative analysis of signature genes in PRRSV-infected porcine monocyte-derived cells to different stimuli. PLoS One. 12(7):e0181256. https://doi.org/10.1371/journal.pone.0181256.
Reduction of infection by inhibiting mTOR pathway is associated with reversing repression of type I IFN by PRRSV - (Peer Reviewed Journal)
Liu, Q., Miller, L.C., Blecha, F., Sang, Y. 2017. Reduction of infection by inhibiting mTOR pathway is associated with reversed repression of type I interferon by porcine reproductive and respiratory syndrome virus. Journal of General Virology. 98(6):1316-1328. doi:10.1099/jgv.0.000802.
Transcriptomic analysis reveals the potential of highly pathogenic PRRS virus to modulate immune system activation related to host-pathogen and damage associated signaling in infected porcine monocytes - (Abstract Only)
Small non-coding RNAs (sncRNA) regulate gene silencing and modify homeostatic status in animals faced with porcine reproductive and respiratory syndrome virus (PRRSV) - (Abstract Only)
Transcriptomic analysis reveals the potential of highly pathogenic PRRS virus to modulate immune system activation related to host-pathogen and damage associated signaling in infected porcine monocytes - (Abstract Only)
Cross-species comparison reveals molecular and functional novelty of porcine interferon-omega subtype - (Abstract Only)
Sang, Y., Liu, Q., Lee, J., Miller, L.C., Ma, W., Blecha, F. 2017. Cross-species comparison reveals molecular and functional novelty of porcine interferon-omega subtype. Journal of Immunology 198(1):226.6.
Leading edge analysis of transcriptomic changes during pseudorabies virus infection - (Peer Reviewed Journal)
Fleming, D.S., Miller, L.C. 2016. Leading edge analysis of transcriptomic changes during pseudorabies virus infection. Genomics Data. 10:104-106.
Comparative pathogenesis and characterization of contemporary 1-7-4 PRRSV isolates in weanling age piglets - (Abstract Only)
Comparative pathogenesis and characterization of contemporary 1-7-4 PRRSV isolates in weanling age piglets - (Abstract Only)
Status of vaccines for porcine epidemic diarrhea virus in the United States and Canada - (Peer Reviewed Journal)
Crawford, K., Kulshreshtha, V., Lager, K.M., Miller, L.C., Faaberg, K.S. 2016. Status of vaccines for porcine epidemic diarrhea virus in the United States and Canada. Virus Research. 226:108-116.
Enhancement of innate immunity with granulocyte colony-stimulating factor did not mitigate disease in pigs infected with a highly pathogenic Chinese PRRSV strain - (Peer Reviewed Journal)
Schlink, S.N., Lager, K.M., Brockmeier, S.L., Loving, C.L., Miller, L.C., Vorwald, A.C., Yang, H., Kehrli, Jr., M.E., Faaberg, K.S. 2016. Enhancement of innate immunity with granulocyte colony-stimulating factor did not mitigate disease in pigs infected with a highly pathogenic Chinese PRRSV strain. Veterinary Immunology and Immunopathology. 179:70-76.
Comparative analysis of signature genes in porcine reproductive and respiratory syndrome virus (PRRSV)-infected porcine monocyte-derived dendritic cells at differential activation statuses - (Abstract Only)
Susceptibility of swine to H5 and H7 low pathogenic avian influenza viruses Reprint Icon - (Peer Reviewed Journal)
Balzli, C., Lager, K., Vincent, A., Gauger, P., Brockmeier, S., Miller, L., Richt, J.A., Ma, W., Suarez, D., Swayne, D.E. 2016. Susceptibility of swine to H5 and H7 low pathogenic avian influenza viruses. Influenza and Other Respiratory Viruses. 10(4):346-352.
Effects of pseudorabies virus infection on the tracheobronchial lymph node transcriptome - (Peer Reviewed Journal)
Miller, L.C., Bayles, D.O., Zanella, E.L., Lager, K.M., 2016. Effects of pseudorabies virus infection on the tracheobronchial lymph node transcriptome. Bioinformatics and Biology Insights. 9(Suppl 2):25-36.
Comparative analysis of signature genes in PRRSV-infected porcine monocyte-derived dendritic cells at differential activation statuses - (Abstract Only)
Evaluation of two real-time polymerase chain reaction assays for porcine epidemic diarrhea virus (PEDV) to assess PEDV transmission in growing pigs - (Peer Reviewed Journal)
Miller, L.C., Crawford, K.K., Lager, K.M., Kellner, S.G., Brockmeier, S. 2016. Evaluation of two real-time polymerase chain reaction assays for porcine epidemic diarrhea virus (PEDV) to assess PEDV transmission in growing pigs. Journal of Veterinary Diagnostic Investigation. 28(1):20-29.
Evaluation of porcine epidemic diarrhea virus transmission and the immune response in growing pigs - (Peer Reviewed Journal)
Crawford, K., Lager, K., Miller, L., Opriessnig, T., Gerber, P., Hesse, R. 2015. Evaluation of porcine epidemic diarrhea virus transmission and the immune response in growing pigs. Veterinary Research. 46(1):49.
Macrophage polarization in virus-host interactions - (Peer Reviewed Journal)
Sang, Y., Miller, L.C., Blecha, F. 2015. Macrophage polarization in virus-host interactions. Journal of Clinical & Cellular Immunology. 6:2.
Performance assessment of a real-time polymerase chain reaction assay for porcine epidemic diarrhea virus to assess PEDV transmission in growing pigs - (Abstract Only)
Efficacy of type 2 PRRSV vaccine against Chinese and Vietnamese HP-PRRSV challenge in pigs - (Peer Reviewed Journal)
Lager, K.M., Schlink, S.N., Brockmeier, S.L., Miller, L.C., Henningson, J.N., Kappes, M.A., Kehrli, M.E., Loving, C.L., Guo, B., Swenson, S.L., Yang, H., Faaberg, K.S. 2014. Efficacy of type 2 PRRSV vaccine against Chinese and Vietnamese HP-PRRSV challenge in pigs. Vaccine. 32(48):6457–6462.
Evolutionary characterization of pig interferon-inducible transmembrane gene family and member expression dynamics in tracheobronchial lymph nodes of pigs infected with swine respiratory disease viruses - (Peer Reviewed Journal)
Miller, L.C., Jiang, Z., Sang, Y., Harhay, G.P., Lager, K.M. 2014. Evolutionary characterization of pig interferon-inducible transmembrane gene family and member expression dynamics in tracheobronchial lymph nodes of pigs infected with swine respiratory disease viruses. Veterinary Immunology and Immunopathology. 159(3-4):180-191.
Evolutionary characterization of pig interferon-inducible transmembrane gene family and member expression dynamics in tracheobronchial lymph nodes of pigs infected with swine respiratory disease viruses - (Abstract Only)
Miller, L.C., Jiang, Z., Sang, Y., Harhay, G.P., Lager, K.M. 2014.Evolutionary characterization of pig interferon-inducible transmembrane gene family and member expression dynamics in tracheobronchial lymph nodes of pigs infected with swine respiratory disease viruses. International Plant & Animal Genome XXII. P595.
Evolutionary characterization of pig interferon-inducible transmembrane gene family and member expression dynamics in tracheobronchial lymph nodes of pigs infected with swine respiratory disease viruses - (Abstract Only)
Chinese and Vietnamese strains of HP-PRRSV cause different pathogenic outcomes in United States high health swine Reprint Icon - (Peer Reviewed Journal)
Guo, B., Lager, K.M., Schlink, S.N., Kehrli, Jr., M.E., Brockmeier, S.L., Miller, L.C., Swensen, S.L., Faaberg, K.S. 2013. Chinese and Vietnamese strains of HP-PRRSV cause different pathogenic outcomes in United States high health swine. Virology. 446(1-2):238-250.
Evolutionary characterization of pig interferon-inducible transmembrane gene family and member expression dynamics in tracheobronchial lymph nodes of pigs infected with influenza A virus - (Abstract Only)
Miller, L.C., Jiang, Z., Sang, Y., Harhay, G.P., Lager, K.M. 2013. Evolutionary characterization of pig interferon-inducible transmembrane gene family and member expression dynamics in tracheobronchial lymph nodes of pigs infected with influenza A virus. Second Annual Great Plains Emerging Infectious Diseases Conference. p. 23.
Evolutionary characterization of pig interferon-inducible transmembrane gene family and member expression dynamics in tracheobronchial lymph nodes of pigs infected with swine respiratory disease viruses - (Abstract Only)
Development and characterization of two porcine monocyte-derived macrophage cell lines - (Peer Reviewed Journal)
Chitko McKown, C.G., Chapes, S.K., Miller, L.C., Riggs, P.K., Ortega, M.T., Green, B.T., McKown, R.D. 2013. Development and characterization of two porcine monocyte-derived macrophage cell lines. Results in Immunology. 3:26-31.
Two Asian highly pathogenic strains of Type 2 PRRSV in United States swine - (Abstract Only)
Faaberg, K., Lager, K., Brockmeier, S., Guo, B., Swenson, S., Yang, H., Kehrli, M., Nicholson, T., Miller, L., Henningson, J., Schlink, S., Kappes, M. 2013. Two Asian highly pathogenic strains of Type 2 PRRSV in United States swine. Positive Strand RNA Viruses, Keystone Symposia on Molecular and Cellular Biology. Paper No. 1063.
Reactomes of porcine alveolar macrophages infected with porcine reproductive and respiratory syndrome virus Reprint Icon - (Peer Reviewed Journal)
Jiang, Z., Zhou, X., Michal, J.J., Wu, X.-L., Zhang, L., Zhang, M., Ding, B., Liu, B., Manoranjan, V.S., Neill, J.D., Harhay, G.P., Kehrli, Jr., M.E., Miller, L.C. 2013. Reactomes of porcine alveolar macrophages infected with porcine reproductive and respiratory syndrome virus. PLoS One. 8(3):e59229.
Comparative transcriptome response in swine tracheobronchial lymph nodes to viral infection - (Abstract Only)
Miller, L.C., Harhay, G.P., Kehrli, Jr., M.E., Lager, K.M. 2013. Comparative transcriptome response in swine tracheobronchial lymph nodes to viral infection [abstract]. International Plant & Animal Genome XXI, January 12-16, 2013, San Diego, California. Paper No. W756.
Pathogenesis of HP-PRRSV in gnotobiotic pigs - (Abstract Only)
Lager, K.M., Faaberg, K.S., Brockmeier, S.L., Miller, L.C., Kappes, M.A., Spear, A., Kehrli, Jr., M.E. 2012. Pathogenesis of HP-PRRSV in gnotobiotic pigs. 2012 International PRRS Symposium. p. 92.
Swine tracheobronchial lymph node mRNA responses in swine infected with a highly pathogenic strain of porcine reproductive and respiratory syndrome virus - (Abstract Only)
Miller, L.C., Fleming, D., Arbogast, A., Bayles, D.O., Guo, B., Lager, K.M., Henningson, J.N., Schlink, S.N., Yang, H., Faaberg, K.S., Kehrli, Jr., M.E. 2012. Swine tracheobronchial lymph node mRNA responses in swine infected with a highly pathogenic strain of porcine reproductive and respiratory syndrome virus. 2012 International PRRS Symposium. p. 96.
Infection of United States swine with a Chinese highly pathogenic strain of porcine reproductive and respiratory syndrome virus - (Peer Reviewed Journal)
Guo, B., Lager, K.M., Henningson, J.N., Miller, L.C., Schlink, S.N., Kappes, M.A., Kehrli, Jr., M.E., Brockmeier, S.L., Nicholson, T.L., Yang, H., Faaberg, K.S. 2013. Experimental infection of United States swine with a Chinese highly pathogenic strain of porcine reproductive and respiratory syndrome virus. Virology. 435(2):372-384.
Analysis of the swine tracheobronchial lymphnode transcriptomic response to infection with a Chinese highly pathogenic strain of porcine reproductive and respiratory syndrome virus - (Peer Reviewed Journal)
Miller, L.C., Fleming, D., Arbogast, A., Bayles, D.O., Guo, B., Lager, K.M., Henningson, J.N., Schlink, S.N., Yang, H.-C., Faaberg, K.S., Kehrli, Jr., M.E. 2012. Analysis of the swine tracheobronchial lymph node transcriptomic response to infection with a Chinese highly pathogenic strain of porcine reproductive and respiratory syndrome virus. BioMed Central (BMC) Veterinary Research. 8(1):208. Available: http://www.biomedcentral.com/1746-6148/8/208.
Analysis of the swine tracheobronchial lymphnode transcriptomic response to infection with a Chinese highly pathogenic strain of porcine reproductive and respiratory syndrome virus - (Abstract Only)
Genomic sequence and virulence comparison of four type 2 porcine reproductive and respiratory syndrome virus strains - (Peer Reviewed Journal)
Brockmeier, S.L., Loving, C.L., Vorwald, A.C., Kehrli, Jr., M.E., Baker, R.B., Nicholson, T.L., Lager, K.M., Miller, L.C., Faaberg, K.S. 2012. Genomic sequence and virulence comparison of four Type 2 porcine reproductive and respiratory syndrome virus strains. Virus Research. 169(1):212-221.
Development of antinuclear antibodies and a genetic linkage in pigs infected with porcine circovirus type 2 - (Abstract Only)
Cheung, A.K., Kehrli, Jr., M.E., Lager, K.M., Gauger, P.C., Rohrer, G.A., Michael, D.D., Miller, L.C., Vincent, A.L., Braucher, D.R. 2012. Development of antinuclear antibodies and a genetic linkage in pigs infected with porcine circovirus type 2 [abstract]. IXth International Congress of Veterinary Virology. p. 189-190.
Evaluation of a real-time PCR assay for pseudorabies virus surveillance purposes - (Peer Reviewed Journal)
Zanella, E.L., Miller, L.C., Lager, K.M., Bigelow, T.T. 2012. Evaluation of a real-time polymerase chain reaction assay for pseudorabies virus surveillance purposes. Journal of Veterinary Diagnostic Investigation. 24(4):739-745.
The presence of alpha interferon at the time of infection alters the innate and adaptive immune responses to porcine reproductive and respiratory syndrome virus - (Peer Reviewed Journal)
Brockmeier, S.L., Loving, C.L., Nelson, E.A., Miller, L.C., Nicholson, T.L., Register, K.B., Grubman, M.J., Brough, D.E., Kehrli, Jr., M.E. 2012. The presence of alpha interferon at the time of infection alters the innate and adaptive immune responses to porcine reproductive and respiratory syndrome virus. Clinical and Vaccine Immunology. 19(4):508-514.
Effects of interferon-alpha on the immune response to porcine reproductive and respiratory syndrome virus - (Peer Reviewed Journal)
Validation of a real-time PCR assay for pseudorabies virus surveillance purposes - (Abstract Only)
Miller, L.C., Zanella, E.L., Lager, K.M., Bigelow, T.T. 2011. Evaluation of a real-time PCR assay for pseudorabies virus surveillance purposes. Conference of Research Workers in Diseases [abstract]. Paper No. 062P.
Comparison of immune transcriptome response following infection with PRRSV, PCV2 and SIV - (Abstract Only)
Miller, L.C., Harhay, G., Kehrli, M., Lager, K. 2011. Comparison of immune transcriptome response following infection with PRRSV, PCV2 and SIV [abstract]. 2011 International PRRS Symposium. Paper No. 51. p. 68.
Enhancement of innate immunity with granulocyte colony-stimulating factor did not prevent disease in pigs infected with a highly pathogenic Chinese PRRSV strain - (Abstract Only)
Schlink, S.N., Lager, K.M., Brockmeier, S.L., Loving, C.L., Henningson, J.N., Faaberg, K.S., Guo, B., Miller, L.C., Vorwald, A.C., Kehrli, Jr., M.E. 2011. Enhancement of innate immunity with granulocyte colony-stimulating factor did not prevent disease in pigs infected with a highly pathogenic Chinese PRRSV strain. 2011 International PRRS Symposium. Paper No. 59. page 76.
Sequence and virulence comparison of four North American isolates of porcine reproductive and respiratory syndrome virus - (Abstract Only)
Brockmeier, S.L., Loving, C.L., Miller, L.C., Vorwald, A.C., Kehrli, Jr., M.E., Baker, R.B., Nicholson, T.L., Lager, K.M., Faaberg, K.S. 2011. Sequence and virulence comparison of four North American isolates of porcine reproductive and respiratory syndrome virus. Conference of Research Workers in Diseases. Paper No. 174. p. 171.
Fulminant sepsis is a cardinal sign of HP-PRRSV in pigs - (Abstract Only)
Lager, K.M., Faaberg, K.S., Guo, B., Brockmeier, S.L., Henningson, J.N., Schlink, S.N., Miller, L.C., Kappes, M.A., Kehrli, Jr., M.E., Nicholson, T.L., Yang, H.-C. 2011. Fulminant sepsis is a cardinal sign of HP-PRRSV in pigs [abstract]. 2011 International PRRS Symposium. Paper No. 60. page 77.
Comparison of the pathogenicity of Chinese and low virulent US porcine reproductive and respiratory syndrome viruses - (Abstract Only)
Henningson, J.N., Faaberg, K.S., Guo, B., Schlink, S.N., Miller, L.C., Kappes, M.A., Kehrli, Jr., M.E., Brockmeier, S.L., Nicholson, T.L., Vorwald, A.C., Lager, K.M. 2011. Comparison of the pathogenicity of Chinese and low virulent US porcine reproductive and respiratory syndrome viruses [abstract]. American College of Veterinary Pathologists. Paper No. 164. Veterinary Pathology. 48(6):E30.
Immune transcriptome response to PRRSV infection - (Abstract Only)
Miller, L.C., Harhay, G.P., Lager, K.M., Kehrli, Jr., M.E. 2011. Immune transcriptome response to PRRSV infection [abstract]. XIIth International Nidovirus Symposium. p. 79.
Highly pathogenic porcine reproductive and respiratory syndrome virus JXwn06 causes high mortality in vivo - (Abstract Only)
Kappes, M.A., Guo, B., Lager, K.M., Henningson, J.N., Schlink, S.N., Miller, L.C., Brockmeier, S., Kehrli, Jr., M.E., Yang, H., Faaberg, K.S. 2011. Highly pathogenic porcine reproductive and respiratory syndrome virus JXwn06 causes high mortality in vivo [abstract]. XIIth International Nidovirus Symposium. p. 80.
Highly pathogenic Chinese porcine reproductive and respiratory syndrome virus strain JXwn06 in US swine - (Abstract Only)
Kappes, M.A., Guo, B., Lager, K.M., Henningson, J.N., Schlink, S.N., Miller, L.C., Brockmeier, S., Kehrli, Jr., M.E., Yang, H., Faaberg, K.S. 2011. Highly pathogenic Chinese porcine reproductive and respiratory syndrome virus strain JXwn06 in US swine [abstract]. 30th Annual Meeting of the American Society for Virology. p. 211.
HP-PRRSV challenge of 4 and 10-week-old pigs - (Proceedings)
Lager, K.M., Faaberg, K.S., Guo, B., Brockmeier, S., Henningson, J.N., Schlink, S.N., Miller, L.C., Kappes, M.A., Kehrli, Jr., M.E., Loving, C.L., Nicholson, T.L., Yang, H.C. 2011. HP-PRRSV challenge of 4 and 10-week-old pigs. In: Proceedings of the 5th Asian PRRSpective Symposium, May 10, 2011, Bangkok, Thailand. 6 pages.
Utility of a Panviral Microarray for Detection of Swine Respiratory Viruses in Clinical Samples - (Peer Reviewed Journal)
Nicholson, T.L., Kukielka, D., Vincent, A.L., Brockmeier, S.L., Miller, L.C., Faaberg, K.S. 2011. Utility of a panviral microarray for detection of swine respiratory viruses in clinical samples. Journal of Clinical Microbiology. 49(4):1542-1548.
Pathogenesis and Transmission of Feral Swine Pseudorabies Virus Isolates in Domestic Pigs - (Peer Reviewed Journal)
Analysis of Chinese PRRSV Type 2 strain in U.S. swine - (Abstract Only)
Faaberg, K.S., Guo, B., Lager, K.M., Brockmeier, S.L., Henningson, J.N., Schlink, S.N., Miller, L.C., Yang, H. 2011. Analysis of Chinese porcine reproductive and respiratory syndrome virus type 2 strain in United States swine [abstract]. ASM Conference on Viral Genome Replication. Poster No. 55A. p. 69.
In depth global analysis of transcript abundance levels in porcine alveolar macrophages following infection with porcine reproductive and respiratory syndrome virus - (Peer Reviewed Journal)
Miller, L.C., Neill, J.D., Harhay, G.P., Lager, K.M., Laegreid, W.W., Kehrli, Jr., M.E. 2010. In-depth global analysis of transcript abundance levels in porcine alveolar macrophages following infection with porcine reproductive and respiratory syndrome virus. Advances in Virology. 2010:Article 864181. Available: http://downloads.hindawi.com/journals/av/2010/864181.pdf.
Analysis of Asian PRRSV Type 2 Strains - (Abstract Only)
Guo, B., Lager, K.M., Henningson, J.N., Schlink, S.N., Miller, L.C., Brockmeier, S., Yang, H.C., Faaberg, K.S. 2010. Analysis of Asian PRRSV type 2 strains [abstract]. 45th US-Japan Cooperative Program in Natural Resources Panel of Animal and Avian Health Meeting. p. 8.
Transcript Expression Analysis in Tracheobronchial Lymph Nodes of Pseudorabies Virus Infected Pigs - (Abstract Only)
Miller, L.C., Harhay, G.P., Bayles, D.O., Zanella, E.L., Lager, K.M. 2010. Transcript expression analysis in tracheobronchial lymph nodes of pseudorabies virus infected pigs [abstract]. 45th Meeting of the United States-Japan Cooperative Program in Natural Resources Panel of Animal and Avian Health. p. 11.
Transcript Expression Analysis in Tracheobronchial Lymph Nodes of Pseudorabies Virus Infected Pigs - (Abstract Only)
Miller, L.C., Harhay, G.P., Bayles, D.O., Zanella, E.L., Lager, K.M. 2010. Transcript expression analysis in tracheobronchial lymph nodes of pseudorabies virus infected pigs [abstract]. Conference of Research Workers in Animal Diseases. Paper No. 115P.
Pathogenesis Studies of the 2009 Pandemic Influenza Virus and Pseudorabies Virus From Wild Pigs In Swine - (Proceedings)
Lager, K.M., Vincent, A.L., Ciacci-Zanella, J.R., Zanella, E.L., Miller, L.C., Kehrli, Jr., M.E. 2010. Pathogenesis studies of the 2009 pandemic influenza virus and pseudorabies virus from wild pigs in swine. In: Proceedings of the Brazilian Society for Virology XXI Meeting, October 18-20, 2010, Gramado, Rio Grande do Sul, Brazil. p. 33-34.
Transcript Expression Analysis in Tracheobronchial Lymph Nodes of Pseudorabies Virus Infected Pigs - (Abstract Only)
Miller, L.C., Harhay, G.P., Bayles, D.O., Zanella, E.L., Lager, K.M. 2010. Transcript Expression Analysis in Tracheobronchial Lymph Nodes of Pseudorabies Virus Infected Pigs [abstract]. 32nd Conference for the International Society for Animal Genetics. Paper No. P105.
Susceptibility of Swine to Low Pathogenic H5 and H7 Avian Influenza Viruses - (Proceedings)
Lager, K.M., Vincent, A.L., Gauger, P.C., Senne, D.A., Swayne, D.E., Miller, L.C., Richt, J., Ma, W., Suarez, D.L., Kehrli Jr, M.E. 2010. Susceptibility of Swine to Low Pathogenic H5 and H7 Avian Influenza Viruses. In: Proceedings of the International Pig Veterinary Society Congress, July 18-21, 2010, Vancouver, Canada. p. 79.
Pathogenesis and Transmission of Feral Swine Pseudorabies Virus Isolates - (Proceedings)
Zanella, E.L., Lager, K.M., Miller, L.C., Swenson, S.L., Bigelow, T.T., Kehrli, Jr., M.E. 2010. Pathogenesis and Transmission of Feral Swine Pseudorabies Virus Isolates. In: Proceedings of the International Pig Veterinary Society Congress, July 18-21, 2010, Vancouver, Canada. p. 875.
In Depth Global Analysis of Transcript Abundance Levels Following Infection with Porcine Reproductive and Respiratory Syndrome Virus - (Abstract Only)
Miller, L.C., Harhay, G.P., Lager, K.M., Neill, J.D., Kehrli, Jr., M.E. 2010. In-Depth Global Analysis of Transcript Abundance Levels Following Infection with Porcine Reproductive and Respiratory Syndrome Virus [abstract]. In: Proceedings of the 9th International Positive Strand RNA Virus Symposium, May 17-21, 2010, Atlanta, Georgia. p. 54.
Cytokine Protein Expression Levels in Tracheobronchial Lymph Node Homogenates of Pigs Infected with Pseudorabies Virus - (Peer Reviewed Journal)
Miller, L.C., Zanella, E.L., Waters, W.R., Lager, K.M. 2010. Cytokine Protein Expression Levels in Tracheobronchial Lymph Node Homogenates of Pigs Infected with Pseudorabies Virus. Clinical and Vaccine Immunology. 17(5):728-734.
Cytokine Expression in the Tracheobronchial Lymph Nodes of Pigs Infected with Pseudorabies Virus - (Abstract Only)
Miller, L.C., Zanella, E.L., Waters, W.R., Lager, K.M. 2010. Cytokine protein expression levels in tracheobronchial lymph node homogenates of pigs infected with pseudorabies virus [abstract]. Conference of Research Workers in Animal Diseases. Paper No. 71P.
Effect of porcine reproductive and respiratory syndrome virus infection of porcine alveolar macrophages on Toll-like receptors elicitation of type I interferon responses - (Peer Reviewed Journal)
Miller, L.C., Lager, K.M., Kehrli, Jr., M.E. 2009. Role of Toll-Like Receptors in Activation of Porcine Alveolar Macrophages by Porcine Reproductive and Respiratory Syndrome Virus. Clinical and Vaccine Immunology. 16(3):360-365.
Differential roles of Toll-like receptors in the elicitation of type I interferon responses by alveolar macrophages - (Abstract Only)
Miller, L.C., Chitko-Mckown, C.G., Lager, K.M., Kehrli, Jr., M.E. 2008. Differential Roles of Toll-Like Receptors in the Elicitation of Type I Interferon Responses by Alveolar Macrophages [abstract]. International PRRS Symposium. p. 58.
Effects of PRRSV infection on TLR-dependent induction of NOS - (Abstract Only)
Chitko McKown, C.G., Miller, L.C., Lager, K.M., Kehrli Jr, M.E. 2008. Effects of PRRSV infection on TLR-dependent induction of NOS (abstract). Proceedings of the 89th Conference of Research Workers in Animal Health. Poster No. 104P. p. 122.
Characterization of the porcine monocyte-derived cell lines Cdelta2- and Cdelta2+ - (Abstract Only)
Chitko Mckown, C.G., Chapes, S.K., Miller, L.C., Green, B.T. 2008. Characterization of the porcine monocyte-derived cell lines Cdelta2+ and Cdelta2+ [abstract]. Society for Leukocyte Biology. Poster No. 45.
In depth global analysis of gene expression levels in porcine alveolar macrophages following infection with porcine reproductive and respiratory syndrome virus - (Abstract Only)
Miller, L., Harhay, G., Lager, K., Kehrli Jr., M., Laegreid, W., Neill, J. 2008. In depth global analysis of gene expression levels in porcine alveolar macrophages following infection with porcine reproductive and respiratory syndrome virus [abstract]. ARK-Genomics Conference 2008: 3rd International Symposium on Animal Functional Genomics. Paper No. ISAFG-P22. p. 38.
Effect of porcine reproductive and respiratory syndrome virus on porcine alveolar macrophage function as determined using serial analysis of gene expression (SAGE) - (Peer Reviewed Journal)
Miller, L.C., Harhay, G.P., Lager, K.M., Smith, T.P., Neill, J.D. 2008. Effect of porcine reproductive and respiratory syndrome virus on porcine alveolar macrophage function as determined using serial analysis of gene expression (SAGE). Developments in Biologicals. 132:169-174.
Development of cell lines from the sheep used to construct the CHORI-243 ovine BAC library - (Peer Reviewed Journal)
Chitko Mckown, C.G., Leonard, J.C., Moscatello, D., Miller, L.C., Freking, B.A. 2008. Development of cell lines from the sheep used to construct the CHORI-243 ovine BAC library. Animal Biotechnology. 19(2):84-88.
Gene Expression Profiling of Porcine Reproductive and Respiratory Syndrome Virus Infected Porcine Alveolar Macrophages - (Abstract Only)
Miller, L.C., Harhay, G.P., Lager, K.M., Smith, T.P., Neill, J.D. 2007. Gene expression profiling of PRRSV-infected porcine alveolar macrophages [abstract]. Porcine Reproductive and Respiratory Syndrome International Symposium. Paper No. 47.
Determination of the cytokine expression profile after infection of (PK-15) Porcine cells with classical swine fever virus - (Abstract Only)
Lange, A., Greiser-Wilke, I., Bendfeldt, S., Miller, L.C., Neill, J.D. 2007. Determination of the cytokine expression profile after infection of PK-15 Porcine cells with classical swine fever virus [abstract]. Conference of Research Workers in Animal Diseases Annual Meeting. Paper No. 137P. p. 118.
Effect of porcine reproductive and respiratory syndrome virus on porcine alveolar macrophage function as determined using serial analysis of gene expression (SAGE) - (Abstract Only)
Neill, J.D., Miller, L.C., Harhay, G.P., Lager, K.M. 2007. Effect of porcine reproductive and respiratory syndrome virus on porcine alveolar macrophage function as determined using serial analysis of gene expression (SAGE) [abstract]. International Symposium on Animal Genomics for Animal Health. Paper No. PA-070. p. 58.
TYPE I INTERFERON RESPONSES TO PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS INFECTION - (Abstract Only)
Miller, L.C., Chitko McKown, C.G., Laegreid, W.W. 2005. Type I interferon responses to porcine reproductive and respiratory syndrome virus infection [abstract]. International PRRS Symposium. Poster No. 45.
Structure of Foot-and-mouth Disease virus serotype A1061 alone and complexed with oligosaccharide receptor: receptor conservation in the face of antigenic variation - (Peer Reviewed Journal)
Fry, E.E., Newman, J.W.I., Curry, S., Najjam, S., Jackson, T., Blakemore, W., Lea, S.M., Miller, L., Burman, A., King, A.M.Q., Stuart, D.I. 2005. Structure of Foot-and-mouth Disease virus serotype A1061 alone and complexed with oligosaccharide receptor: receptor conservation in the face of antigenic variation. Journal of General Virology. 86:1909-1920.
DISCRIMINTION OF ESCHERICHIA COLI O157:H7 ISOLATES BY GENOTYPING SINGLE NUCLEOTIDE POLYMORPHISMS - (Abstract Only)
Bono, J.L., Keen, J.E., Clawson, M.L., Heaton, M.P., Chitko Mckown, C.G., Miller, L.C., Laegreid, W.W. 2005. Discrimintion of Escherichia coli O157:H7 isolates by genotyping single nucleotide polymorphisms. [abstract] American Society of Microbiologists. p. 318.
DEVELOPMENT AND CHARACTERIZATION OF THREE PORCINE MONOCYTE-DERIVED CELL LINES - (Abstract Only)
Chitko Mckown, C.G., Green, B.T., Miller, L.C., Mckown, R.D., Laegreid, W.W. 2004. Development and characterization of three porcine monocyte-derived cell lines [abstract]. Research Workers in Animal Diseases Conference. p. 96.
APOPTOSIS AND PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS - (Abstract Only)
Miller, L.C., Fox, J.M., Chitko Mckown, C.G., Laegreid, W.W. 2004. Apoptosis and porcine reproductive and respiratory syndrome virus [abstract]. Research Workers in Animal Diseases Conference. p. 101.
APOPTOSIS AND PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS - (Peer Reviewed Journal)
Miller, L.C., Fox, J.M. 2004. Apoptosis and porcine reproductive and respiratory syndrome virus. Veterinary Immunology and Immunopathology 102(3):131-142.
INTERFERON TYPE I RESPONSE IN PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS-INFECTED MARC-145 CELLS - (Peer Reviewed Journal)
Miller, L.C., Laegreid, W.W., Bono, J.L., Chitko McKown, C.G., Fox, J.M. 2004. Interferon type I response in porcine reproductive and respiratory syndrome virus-infected MARC-145 cells. Archives of Virology. 149(12):2453-2463.
EARLY INNATE IMMUNE RESPONSE IN PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS-INFECTED MARC-145 CELLS - (Abstract Only)
Miller, L.C., Fox, J.M., Bono, J.L., Chitko Mckown, C.G., Laegreid, W.W. 2004. Early innate immune response in porcine reproductive and respiratory syndrome virus-infected marc-145 cells [abstract]. 7th Int. Symp. Positive Strand RNA Viruses. Paper No. P2-G1.
EVALUATION OF A REAL-TIME PCR KIT FOR DETECTING ESCHERICHIA COLI O157 IN BOVINE FECAL SAMPLES - (Peer Reviewed Journal)
BONO, J.L., KEEN, J.E., MILLER, L.C., FOX, J.M., CHITKO MCKOWN, C.G., HEATON, M.P., LAEGREID, W.W. EVALUATION OF A REAL-TIME PCR KIT FOR DETECTING ESCHERICHIA COLI O157 IN BOVINE FECAL SAMPLES. APPLIED AND ENVIRONMENTAL MICROBIOLOGY. 2004. V. 70. P. 1855-1857.
GENE EXPRESSION PROFILING OF BOVINE MACROPHAGES IN RESPONSE TO ESCHERICHIA COLI O157:H7 LIPOPOLYSACCHARIDE - (Abstract Only)
CHITKO MCKOWN, C.G., FOX, J.M., MILLER, L.C., HEATON, M.P., BONO, J.L., KEEN, J.E., GROSSE, W.M., LAEGREID, W.W. GENE EXPRESSION PROFILING OF BOVINE MACROPHAGES IN RESPONSE TO ESCHERICHIA COLI O157:H7 LIPOPOLYSACCHARIDE. IMMUNOLOGY RESEARCH WORKSHOP. 2003. ABSTRACT NO. 23.
GENE EXPRESSION PROFILING OF BOVINE MACROPHAGES IN RESPONSE TO ESCHERICHIA COLI O157:H7 LIPOPOLYSACCHARIDE - (Peer Reviewed Journal)
CHITKO MCKOWN, C.G., FOX, J.M., MILLER, L.C., HEATON, M.P., BONO, J.L., KEEN, J.E., GROSSE, W.M., LAEGREID, W.W. GENE EXPRESSION PROFILING OF BOVINE MACROPHAGES IN RESPONSE TO ESCHERICHIA COLI O157:H7 LIPOPOLYSACCHARIDE. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY. 2004. V. 28. P. 635-645.
IDENTIFICATION OF RESPONSIVE GENES IN PRRSV-INFECTED PULMONARY MACROPHAGES USING SEMI-QUANTITATIVE REAL-TIME REVERSE TRANSCRIPTION PCR (RT-PCR) - (Abstract Only)
MILLER, L.C., CHITKO MCKOWN, C.G., BONO, J.L., LAEGREID, W.W., FOX, J.M. IDENTIFICATION OF RESPONSIVE GENES IN PRRSV-INFECTED PULMONARY MACROPHAGES USING SEMI-QUANTITATIVE REAL-TIME REVERSE TRANSCRIPTION PCR (RT-PCR). RESEARCH WORKERS IN ANIMAL DISEASES CONFERENCE PROCEEDINGS. 2003. ABSTRACT NO. 155.
ASSOCIATION OF NOS2A HAPLOTYPES AND BACTERICIDAL ACTIVITY OF BOVINE MONOCYTE-DERIVED MACROPHAGES - (Abstract Only)
CHITKO MCKOWN, C.G., HEATON, M.P., GROSSE, W.M., KEEN, J.E., BONO, J.L., CLAWSON, M.L., FOX, J.M., MILLER, L.C., LAEGREID, W.W. ASSOCIATION OF NOS2A HAPLOTYPES AND BACTERICIDAL ACTIVITY OF BOVINE MONOCYTE-DERIVED MACROPHAGES. AMERICAN ASSOCIATION OF IMMUNOLOGISTS PROCEEDINGS. 2003. Abstract No. 150.1.
DYNAMICS OF GENE EXPRESSION IN PORCINE ARTERIVIRUS INFECTED MARC-145 CELLS - (Abstract Only)
MILLER, L.C., FOX, J.M. DYNAMICS OF GENE EXPRESSION IN PORCINE ARTERIVIRUS INFECTED MARC-145 CELLS. RESEARCH WORKERS IN ANIMAL DISEASES CONFERENCE PROCEEDINGS. 2002. Abstract No. 101P.