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ARS Home » Northeast Area » Orient Point, New York » Plum Island Animal Disease Center » Foreign Animal Disease Research » People & Locations » Teresa De Los Santos
Teresa De Los Santos
Foreign Animal Disease Research
Microbiologist

Phone: (631) 323-3020
Fax: (631) 323-3006

40550 ROUTE 25
ORIENT POINT, NY 11957

(Employee information on this page comes from the REE Directory. Please contact your front office staff to update the REE Directory.)

Projects
Intervention Strategies to Respond, Control, and Eradicate Foot-and-Mouth Disease Virus (FMDV)
In-House Appropriated (D)
  Accession Number: 441364
Research Supporting Workforce Development for the National Bio-Agro Defense Facility: Development of Novel Foot-and-Mouth Disease Virus...Candidates
Non-Assistance Cooperative Agreement (S)
  Accession Number: 435052
Increasing the Efficacy of the Ad5-FMD Vaccine Using a Multi-Gene Delivery System
Non-Assistance Cooperative Agreement (S)
  Accession Number: 436872

Publications (Clicking on the reprint icon Reprint Icon will take you to the publication reprint.)
Foot-and-Mouth Disease virus interserotypic recombination in superinfected carrier cattle Reprint Icon - (Peer Reviewed Journal)
Fish, I., Bertram, M.R., Stenfeldt, C., Smoliga, G.R., Hartwig, E.J., Holinka-Patterson, L.G., De Los Santos, T.B., Spinard III, E.J., Medina, G.N., Arzt, J., Azzinaro, P.A. 2022. Foot-and-Mouth Disease virus interserotypic recombination in superinfected carrier cattle. Pathogens. https://doi.org/10.3390/pathogens11060644.
An Adventitious agent free clonal cell line that is highly susceptible to foot and mouth disease virus Reprint Icon - (Peer Reviewed Journal)
Larocco, M., Krug, P., Ahmed, Z., Rodriguez-Calzada1, M., Azzinaro, P.A., Rodriguez, L.L., De Los Santos, T.B., Medina, G.N. 2021. An Adventitious agent free clonal cell line that is highly susceptible to foot and mouth disease virus. Journal of Clinical Microbiology. https://doi.org/10.1016/j.biologicals.2021.05.003.
Use of Protein Pegylation to prolong the antiviral effect of IFN against FMDV Reprint Icon - (Peer Reviewed Journal)
Diaz San Segundo, F.C., Medina, G.N., Mogulothu, A., Azzinaro, P.A., Attreed, S.E., Gutkoska, J.R., Lombardi, K.R., Shields, J., Hudock, T.A., De Los Santos, T.B. 2021. Use of Protein Pegylation to prolong the antiviral effect of IFN against FMDV. Frontiers in Microbiology. https://doi.org/10.3389/fmicb.2021.668890.
Use of synonymous deoptimization for the development of modified live attenuated strains of foot and mouth disease virus Reprint Icon - (Peer Reviewed Journal)
Diaz San Segundo, F.C., Medina, G., Spinard, E., Kloc, A., Ramirez-Medina, E., Azzinaro, P.A., Mueller, S., Rieder, A.E., De Los Santos, T.B. 2021. Use of synonymous deoptimization for the development of modified live attenuated strains of foot and mouth disease virus. Frontiers in Microbiology. https://doi.org/10.3389/fmicb.2020.610286.
Use of IFN-based biotherapeutics to harness the host against foot-and-mouth disease Reprint Icon - (Peer Reviewed Journal)
Medina, G., De Los Santos, T.B., Diaz San Segundo, F.C. 2020. Use of IFN-based biotherapeutics to harness the host against foot-and-mouth disease. Frontiers in Microbiology. https://doi.org/https://doi.org/10.3389/fvets.2020.00465.
Impairment of the deISGylation activity of foot-and-mouth disease Lpro causes viral attenuation without affecting interferon expression during viral infection. Reprint Icon - (Peer Reviewed Journal)
Medina, G., Azzinaro, P.A., Ramirez-Medina, E., Gutkoska, J.R., Fang, De Los Santos, T.B. 2020. Impairment of the deISGylation activity of foot-and-mouth disease Lpro causes viral attenuation without affecting interferon expression during viral infection. Virology. https://doi.org/10.1128/JVI.00341-20.
The VP1 G-H loop hypervariable epitope contributes to protective immunity against foot and mouth disease virus in swine Reprint Icon - (Peer Reviewed Journal)
Fernandez-Sainz, I., Gavitt, T.D., Koster, M., Ramirez-Medina, E., Rodriguez, Y.Y., Wu, P., Silbart, L.K., De Los Santos, T.B., Szczepanek, S.M. 2019. The VP1 G-H loop hypervariable epitope contributes to protective immunity against foot and mouth disease virus in swine. Vaccine. https://doi.org/10.1016/j.vaccine.2019.05.019.
Mek1 coordinates meiotic progression with DNA break repair by directly phosphorylating and inhibiting the yeast pachytene exit regulator Ndt80 Reprint Icon - (Peer Reviewed Journal)
Chen, X., Gaglione, R., Leong, T., Bednor, L., De los Santos, T.B., Luk, E., Airola, M., Hollingsworth, N.M. 2018. Mek1 coordinates meiotic progression with DNA break repair by directly phosphorylating and inhibiting the yeast pachytene exit regulator Ndt80. PLoS Genetics. https://doi.org/10.1371/journal.pgen.1007832.
FMDV leader protease cleaves G3BP1 and G3BP2 and inhibits stress granule formation Reprint Icon - (Peer Reviewed Journal)
Visser, L.J., Medina, G.N., Rabouw, H.H., De Groot, R.J., Langereis, M.A., De los Santos, T.B., Van Kuppeveld, F.J. 2018. FMDV leader protease cleaves G3BP1 and G3BP2 and inhibits stress granule formation. Journal of Virology. https://doi.org/10.1128/JVI.00922-18.
The different tactics of foot-and-mouth disease virus to evade innate immunity Reprint Icon - (Peer Reviewed Journal)
Medina, G.N., Diaz San-Segundo, F., Stenfeldt, C., Arzt, J., De los Santos, T.B. 2018. The different tactics of foot-and-mouth disease virus to evade innate immunity. Frontiers in Microbiology. https://doi.org/10.3389/fmicb.2018.02644.
The need for improved vaccines against foot-and-mouth disease Reprint Icon - (Peer Reviewed Journal)
De Los Santos, T.B., Diaz-San Segundo, F., Rodriguez, L.L. 2018. The need for improved vaccines against foot-and-mouth disease. Current Opinion in Virology. 29:16-25. https://doi.org/10.1016/j.coviro.2018.02.005.
Foot-and-mouth disease virus 5’-terminal S fragment is required for replication and modulation of the innate immune response in host cells - (Peer Reviewed Journal)
Kloc, A., Diaz-San Segundo, F., Schafer, E.A., Rai, D.K., Kenney, M.A., De Los Santos, T.B., Rieder, A.E. 2017. Foot-and-mouth disease virus 5’-terminal S fragment is required for replication and modulation of the innate immune response in host cells. Virology. 512:132-143.
Attenuation of foot-and-mouth disease virus by engineered viral polymerase fidelity - (Peer Reviewed Journal)
Rai, D.K., Diaz-San Segundo, F., Campagnola, G., Schafer, E.A., Kloc, A., Keith, A., De Los Santos, T.B., Peersen, O., Rieder, A.E. 2017. Attenuation of foot-and-mouth disease virus by engineered viral polymerase fidelity. Journal of Virology. doi: 10.1128/JVI.00081-17.
Recombinant human adenovirus-5 expressing capsid proteins of Indian vaccine strains of foot-and-mouth disease virus elicits effective antibody response in cattle - (Peer Reviewed Journal)
Sreenivasa, B.P., Mohapatra, J.K., Pauszek, S.J., Koster, M.J., Dhanya, V.C., Tamil Selvan, R.P., Hosamani, M., Saravanan, P., Basagoudanavar, S.H., De Los Santos, T.B., Venkataramanan, R., Rodriguez, L.L., Grubman, M.J. 2017. Recombinant human adenovirus-5 expressing capsid proteins of Indian vaccine strains of foot-and-mouth disease virus elicits effective antibody response in cattle. Veterinary Microbiology. 203:196-201. doi: 10.1016/j.vetmic.2017.03.019.
Interaction between FMDV Lpro and transcription factor ADNP is required for viral replication - (Peer Reviewed Journal)
Medina, G.N., Knudsen, G.M., Greninger, A.L., Kloc, A., Diaz-San Segundo, F., Rieder, A.E., Grubman, M., Derisi, J.L., De Los Santos, T.B. 2017. Interaction between FMDV Lpro and transcription factor ADNP is required for viral replication. Virology. 505:12-22. doi: 10.1016/j.virol.2017.02.010.
Host microRNA-203a is antagonistic to the progression of foot-and-mouth disease virus infection - (Peer Reviewed Journal)
Gutkoska, J., Larocco, M.A., Ramirez-Medina, E., De Los Santos, T.B., Lawrence, P.J. 2017. Host microRNA-203a is antagonistic to the progression of foot-and-mouth disease virus infection. Virology. doi: 10.1016/j.virol.2017.01.019.
Adenovirus-vectored foot-and-mouth disease vaccine confers early and full protection against FMDV O1 Manisa in swine - (Peer Reviewed Journal)
Foot-and-mouth disease vaccines - (Peer Reviewed Journal)
Diaz-San Segundo, F., Medina, G., Stenfeldt, C., Arzt, J., De Los Santos, T.B. 2016. Foot-and-mouth disease vaccines. Veterinary Microbiology. doi: 10.1016/j.vetmic.2016.12.018.
Combination of Adt-O1MANISA AND Ad5-boIFN induces early protective immunity against foot-and-mouth diseases in cattle - (Peer Reviewed Journal)
Diaz-San Segundo, F., Montiel, N.A., Sturza, D.F., Perez-Martin, E., Hickman, D.M., Ramirez-Medina, E., Grubman, M.J., De Los Santos, T.B. 2016. Combination of Adt-O1MANISA AND Ad5-boIFN induces early protective immunity against foot-and-mouth diseases in cattle. Journal of Virology. 499:340-349.
Constitutively active IRF7/IRF3 fusion protein completely protects swine against Foot-and-Mouth Disease - (Peer Reviewed Journal)
Ramirez-Carvajal, L., Diaz-San Segundo, F., Ramirez-Medina, E., Rodriguez, L.L., De Los Santos, T.B. 2016. Constitutively active IRF7/IRF3 fusion protein completely protects swine against Foot-and-Mouth Disease. Journal of Virology. 90:8809-8821. doi: 10.1128/JVI.00800-16.
Control of foot-and-mouth disease by using replication-defective human adenoviruses to deliver vaccines and biotherapeutics - (Book / Chapter)
The pathogenesis of Foot-and-Mouth Disease in pigs - (Peer Reviewed Journal)
Stenfeldt, C., Diaz-San Segundo, F., De Los Santos, T.B., Rodriguez, L.L., Arzt, J. 2016. The pathogenesis of Foot-and-Mouth Disease in pigs. Frontiers in Veterinary Science. 3:41. doi: 10.3389/fvets.2016.00041.
Novel 6xHis tagged foot-and-mouth disease virus vaccine bound to nanolipoprotein adjuvant via metal ions provides antigenic distinction and effective protective immunity - (Peer Reviewed Journal)
Rai, D., Daiz-San Segundo, F., Schafer, E.A., Burrage, T., Rodriguez, L.L., De Los Santos, T.B., Hoeprich, P.D., Rieder, A.E. 2016. Novel 6xHis tagged Foot-and-Mouth Disease Virus vaccine bound to nanolipoprotein adjuvant via metal ions provides antigenic distinction and effective protective immunity. Virology. 495:136-147. doi: 10.1016/j.virol.2016.04.027.
Depletion of elongation initiation factor 4E binding proteins by CRISPR/Cas9 genome editing enhances antiviral response in porcine cells - (Peer Reviewed Journal)
Ramirez-Carvajal, L., Singh, N., De Los Santos, T.B., Rodriguez, L.L., Zhu, J.J., Long, C.R. 2015. Depletion of elongation initiation factor 4E binding proteins by CRISPR/Cas9 genome editing enhances antiviral response in porcine cells. Antiviral Research. 125:8-13. doi: 10.1016/j.antiviral.2015.11.002.
Evaluation of fiber-modified adenovirus vector-vaccine against foot-and-mouth diseaes in cattle - (Peer Reviewed Journal)
Montiel, N., Medina, G.N., Sturza, D., Diaz-San Segundo, F., Ramirez-Medina, E., Grubman, M.J., De Los Santos, T.B. 2016. Evaluation of fiber-modified adenovirus vector-vaccine against foot-and-mouth diseaes in cattle. Clinical and Vaccine Immunology. 23:125-136. doi: 10.1128/CVI.00426-15.
Synonymous deoptimization of the foot-and-mouth disease virus P1 coding region causes attenuation in vivo while inducing a strong neutralizing antibody response - (Peer Reviewed Journal)
Diaz-San Segundo, F., Koster, M.J., Ramirez-Medina, E., Medina, G.N., Velazquez-Salinas, L., Grubman, M.J., De Los Santos, T.B. 2015. Synonymous deoptimization of the foot-and-mouth disease virus P1 coding region causes attenuation in vivo while inducing a strong neutralizing antibody response. Journal of Virology. 90:1298-1310. doi:10.1128/JVI.02167-15.
Inhibition of EHMT2 induces a robust antiviral response against Foot-and-Mouth Disease and Vesicular Stomatitis Virus infections in bovine cells - (Peer Reviewed Journal)
Singh, N., Ramirez-Carvajal, L., De Los Santos, T.B., Golding, M.C., Long, C.R. 2015. Inhibition of EHMT2 induces a robust antiviral response against Foot-and-Mouth Disease and Vesicular Stomatitis Virus infections in bovine cells. Journal of Interferon and Cytokine Research. 36(1):37-47. doi: 10.1089/jir.2015.0006.
Treatment with interferon-alpha delays disease in swine infected with a highly virulent CSFV strain Reprint Icon - (Peer Reviewed Journal)
Fernandez-Sainz, I., Zhu, J.J., O'Donnell, V., Diaz San Segundo, F.C., Velazquez, L., De Los Santos, T.B., Borca, M.V. 2015. Treatment with interferon-alpha delays disease in swine infected with a highly virulent CSFV strain. Virology. 483:284-290. DOI: 10.1016/j.virol.2015.04.024.
Poly ICLC increases the potency of a replication-defective human adenovirus vectored foot-and-mouth disease vaccine - (Peer Reviewed Journal)
Diaz San Segundo, F.C., Dias, C.C., Moraes, M.P., Weiss, M., Perez-Martin, E., Salazar, A.M., Grubman, M.J., De Los Santos, T.B. 2014. Poly ICLC increases the potency of a replication-defective human adenovirus vectored foot-and-mouth disease vaccine. Virology. 468-470C:283-292.
Expression of porcine fusion protein IRF7/3(5D) efficiently controls foot-and-mouth disease virus replication - (Peer Reviewed Journal)
Ramirez-Carvajal, L., Long, C.R., Zhu, J.J., Diaz San Segundo, F.C., Rodriguez, L.L., De Los Santos, T.B. 2014. Expression of porcine fusion protein IRF7/3(5D) efficiently controls foot-and-mouth disease virus replication. Journal of Virology. 88(19):11140-11153.
Type III interferon protects swine against foot-and-mouth disease - (Peer Reviewed Journal)
Perez-Martin, E., Diaz San Segundo, F.C., Weiss, M., Sturza, D., Dias, C.C., Ramirez, E., Grubman, M.J., De Los Santos, T.B. 2014. Type III interferon protects swine against foot-and-mouth disease. Journal of Interferon and Cytokine Research. 345(10):810-812 DOI:10.1089/jir.2013.0112.
Foot and mouth disease virus virulence in cattle is co-determined by viral replication dynamics and route of infection Reprint Icon - (Peer Reviewed Journal)
Arzt, J., Pacheco Tobin, J., Tucker, M.T., Smoliga, G.R., Bishop, E.A., Pauszek, S.J., Hartwig, E.J., De Los Santos, T.B., Rodriguez, L.L. 2014. Foot and mouth disease virus virulence in cattle is co-determined by viral replication dynamics and route of infection. Virology. 452-453:12-22.
Animal health: foot-and-mouth disease - (Book / Chapter)
Diaz San Segundo, F.C., Medina, G.N., Grubman, M.J., De Los Santos, T.B. 2014. Animal health: Foot-and-Mouth Disease. In: Van Alfen, N.K., editor. Encyclopedia of Agriculture and Food Systems. 2nd edition. United States of America: Elsevier/Academic Press. p. 327-345.
Understanding the mechanism of interferon-induced protection against foot-and-mouth disease - (Book / Chapter)
Diaz San Segundo, F.C., Montiel, N., De Los Santos, T.B., Grubman, M.J. 2014. Understanding the mechanism of interferon-induced protection against foot-and-mouth disease. In: IConcept Press, Ltd. Virology II Advanced Issues. 1st edition. United States of America: IConcept Press Ltd. p. 51-72.
Venezuelan Equine Encephalitis Virus replicon particles can induce rapid protection against Foot-and-Mouth Disease Virus - (Peer Reviewed Journal)
Diaz San Segundo, F.C., Dias, C.C., Moraes, M.P., Weiss, M., Perez-Martin, E., Owens, G., Custer, M., Kamrud, K., De Los Santos, T.B., Grubman, M.J. 2013. Venezuelan Equine Encephalitis Virus replicon particles can induce rapid protection against Foot-and-Mouth Disease Virus. Journal of Virology. 87(10):5447-5460. DOI: 10.1128/JVI.03462-12.
Foot-and-mouth disease virus L peptidase - (Book / Chapter)
Grubman, M.J., De Los Santos, T.B. 2013. Foot-and-mouth disease virus L peptidase. In: Neil D. Rawlings and Guy S. Salvesen, editors. Handbook of Proteolytic Enzymes. 3rd Edition. Oxford,UK:Academic Press. p.2183-2186.
Use of replication-defective adenoviruses to develop vaccines and biotherapeutics against foot-and-mouth disease - (Peer Reviewed Journal)
Grubman, M.J., Diaz San Segundo, F.C., Dias, C.C., Moraes, M.P., Perez-Martin, E., De Los Santos, T.B. 2012. Use of replication-defective adenoviruses to develop vaccines and biotherapeutics against foot-and-mouth disease. Future Virology. 7(8):767-778.
Novel antiviral therapeutics to control foot-and-mouth disease - (Peer Reviewed Journal)
Dias, C.C., Moraes, M.P., Weiss, M., Diaz San Segundo, F.C., Perez-Martin, E., Salazar, A.M., De Los Santos, T.B., Grubman, M.J. 2012. Novel antiviral therapeutics to control foot-and-mouth disease. Journal of Interferon and Cytokine Research. 32(10):462-473.
Bovine type III interferon significantly delays and reduces the severity of foot-and-mouth disease in cattle - (Peer Reviewed Journal)
Perez-Martin, E., Weiss, M., Diaz San Segundo, F.C., Pacheco Tobin, J., Arzt, J., Grubman, M.J., De Los Santos, T.B. 2012. Bovine type III interferon significantly delays and reduces the severity of foot-and-mouth disease in cattle. Journal of Virology. 86(8):4477-4487.
Inoculation of swine with foot-and-mouth disease SAP-mutant virus induces early protection against disease - (Peer Reviewed Journal)
Diaz San Segundo, F.C., Weiss, M., Perez-Martin, E., Dias, C.C., Grubman, M.J., De Los Santos, T.B. 2012. Inoculation of swine with foot-and-mouth disease SAP-mutant virus induces early protection against disease. Journal of Virology. 86(3):1316-1327.
Antiviral activity of bovine type III interferon against foot-and-mouth disease virus - (Peer Reviewed Journal)
Diaz-San Segundo, F., Weiss, M., Perez-Martin, E., Koster, M.J., Zhu, J.J., Grubman, M.J., De Los Santos, T.B. 2011. Antiviral activity of bovine type III interferon against foot-and-mouth disease virus. Virology. 413(2):283-292.
Evidence of activation and suppression during the early immune response to foot-and-mouth disease virus - (Review Article)
Golde, W.T., De Los Santos, T.B., Robinson, L., Grubman, M.J., Sevilla, N., Summerfield, A. 2011. Evidence of activation and suppression during the early immune response to foot-and-mouth disease virus. Transboundary and Emerging Diseases. 58(4):283-290.
Introduction of tag epitopes in the inter-AUG region of foot and mouth disease virus: effect on the L protein - (Peer Reviewed Journal)
Piccone, M.E., Diaz-San Segundo, F., Kramer, E., Rodriguez, L.L., De Los Santos, T.B. 2011. Introduction of tag epitopes in the inter-AUG region of foot and mouth disease virus: effect on the L protein. Virus Research. 155(1):91-97.
Springer index of viruses, 2nd edition chapter - Aphthovirus, Picornaviridae - (Book / Chapter)
Grubman, M.J., De Los Santos, T.B. 2011. Aphthovirus. In: Tidona, Christian, Darai, Gholamreza, editors. The Springer Index of Viruses. 2nd edition. New York, NY: Springer. p. 1281-1286.
Porcine type I interferon rapidly protects swine against challenge with multiple serotypes of foot-and-mouth disease virus - (Peer Reviewed Journal)
Dias, C.C., Moraes, M.P., Diaz-San Segundo, F., De Los Santos, T.B., Grubman, M.J. 2011. Porcine type I interferon rapidly protects swine against challenge with multiple serotypes of foot-and-mouth disease virus. Journal of Interferon and Cytokine Research. 31(2):227-236.
Differential gene expression in bovine cells infected with wild type and leaderless foot-and-mouth disease virus - (Peer Reviewed Journal)
Zhu, J.J., Weiss, M., Grubman, M.J., De Los Santos, T.B. 2010. Differential gene expression in bovine cells infected with wild type and leaderless foot-and-mouth disease virus. Virology. 404(1):32-40.
Interferon induced protection against foot-and-mouth disease virus correlates with enhanced tissue specific innate immune cell infiltration and interferon stimulated gene expression - (Peer Reviewed Journal)
Diaz-San Segundo, F., Moraes, M.P., De Los Santos, T.B., Dias, C., Grubman, M.J. 2010. Interferon induced protection against foot-and-mouth disease virus correlates with enhanced tissue specific innate immune cell infiltration and interferon stimulated gene expression. Journal of Virology. 84:2063-2077.
Foot-and-mouth disease - (Book / Chapter)
Grubman, M.J., Rodriguez, L.L., De Los Santos, T.B. 2010. Foot-and-mouth disease. In: Ehrenfeld, E., Domingo, E., Roos, R.P., editors. The Picornaviruses. Washington, DC: ASM Press. p. 397-410.
Functional genomics approach to understand the role of Lpro in FMDV virulence - (Abstract Only)
De Los Santos, T.B., Grubman, M.J., Zhu, J.J. 2009. Functional genomics approach to understand the role of Lpro in FMDV virulence. American Society for Virology Meeting. Paper No. 9-21: P.262.
Examing the mechanisms of interferon-induced protection against foot-and-mouth disease virus in swine - (Abstract Only)
Diaz-San Segundo, F., Moraes, M.P., De Los Santos, T.B., Koster, M.J., Dias, C., Grubman, M.J. 2009. Examing the mechanisms of interferon-induced protection against foot-and-mouth disease virus in swine. American Society for Virology Meeting. Paper No. W21-5: p. 133.
Exploring the role of the lab protein of Foot-and-Mouth Disease Virus (FMDV) during viral infection - (Abstract Only)
De Los Santos, T.B., Piccone, M.E., Diaz-San Segundo, F., Pauszek, S.J., Kramer, E.V., Rodriguez, L.L. 2009. Exploring the role of the lab protein of Foot-and-Mouth Disease Virus (FMDV) during viral Infection. American Society for Virology Meeting. Paper No. 32-7: p. 337.
A Conserved Domain in the Leader Proteinase of Foot-and-Mouth Disease Virus is Required for Proper Sub-Cellular Localization and Function - (Peer Reviewed Journal)
De Los Santos, T.B., Diaz-San Segundo, F., Zhu, J.J., Koster, M.J., Dias, C., Grubman, M.J. 2008. A Conserved Domain in the Leader Proteinase of Foot-and-Mouth Disease Virus is Required for Proper Sub-Cellular Localization and Function. Journal of Virology. 83(4):1800-1810.
Role of IL-10 during Foot-and-Mouth Disease Virus (FMDV) Infection and Its Potential Use as Immunomodulator - (Abstract Only)
Type I and II Interferons Activate the Innate Immune System to Promote Early Protection of Swine Against Foot-and-Mouth Disease Virus - (Abstract Only)
Diaz-San Segundo, F., Moraes, M., De Los Santos, T., Pacheco Tobin, J., Koster, M.J., Dawson, H., Golde, W.T., Grubman, M.J. 2008. Type I and II Interferons Activate the Innate Immune System to Promote Early Protection of Swine Against Foot-and-Mouth Disease Virus. European Study Group on the Molecular Biology of Picornaviruses. P 149
A Conserved Domain in the Leader Proteinase of Foot-and-Mouth Disease Virus is Required for Proper Subcellular Localization and Function - (Abstract Only)
De Los Santos, T., San Segundo-Diaz, F., Zhu, J., Koster, M.J., Grubman, M.J. 2008. A conserved domain in the leader proteinase of foot-and-mouth disease virus is required for proper subcellular localization and function. European Study Group on the Molecular Biology of Picornaviruses. P 86
Evading the Host Immune Response: How Foot-and-Mouth Disease Virus Has Become an Effective Pathogen - (Peer Reviewed Journal)
Grubman, M.J., Moraes, M., Diaz-San Segundo, F., Pena, L., De Los Santos, T. 2008. Evading the Host Immune Response: How Foot-and-Mouth Disease Virus Has Become an Effective Pathogen. Federation of European Microbiological Societies Microbiology Letters. 53:8-17.
Degradation of Nuclear Factor Kappa B During Foot-and-Mouth Disease Virus Infection - (Peer Reviewed Journal)
De Los Santos, T., Diaz-San Segundo, F., Grubman, M.J. 2007. Degradation of Nuclear Factor Kappa B During Foot-and-Mouth Disease Virus Infection. Journal of Virology. 81(23):12803-12815.
Enhanced Antiviral Activity against Foot-and-Mouth Disease Virus by a Combination of Type 1 and 2 Porcine Interfereons - (Peer Reviewed Journal)
Moraes, M., De Los Santos, T., Koster, M.J., Turecek, T.E., Wang, H., Andreyev, V.G., Grubman, M.J. 2007. Enhanced Antiviral Activity against Foot-and-Mouth Disease Virus by a Combination of Type 1 and 2 Porcine Interfereons. Journal of Virology. Vol 81. No.13: P7124-7135
Porcine Interferon Gamma Promotes a Protective Innate Immune Response Against Foot-and-Mouth Disease in Swine - (Abstract Only)
Diaz-San Segundo, F., Moraes, M., De Los Santos, T., Pacheco Tobin, J., Koster, M.J., Turecek, T.E., Dawson, H., Golde, W.T., Grubman, M.J. 2007 Porcine Interferon Gamma Promotes a Protective Innate Immune Response Against Foot-and-Mouth Disease in Swine. American Society for Virology Meeting. W20-3, P. 30
Degradation of Nuclear Factor Kappa B During Foot-and-Mouth Disease Virus Infection - (Abstract Only)
De Los Santos, T., Diaz San-Segundo, F., Grubman, M.J., 2007, Degradation of Nuclear Factor Kappa B During Foot-and-Mouth Disease Virus Infection. American Society for Virology Meeting. W1-3, p.71
THE LEADER PROTEINASE OF FOOT-AND-MOUTH DISEASE VIRUS REDUCES THE EXPRESSION OF INTERFERON BY SUPPRESSING THE ACTIVITY OF THE NUCLEAR FACTOR KAPPA B - (Abstract Only)
De Los Santos, T., Brum, M., Grubman, M.J. 2006. The leader proteinase of foot-and-mouth disease virus reduces the expression of interferon by suppressing the activity of the nuclear factor kappa b. American Society of Virology Annual Meeting. 2006. P. 67.
ENHANCED ANTIVIRAL ACTIVITY AGAINST FOOT-AND-MOUTH DISEASE VIRUS BY A COMBINATION OF TYPE 1 AND 2 PORCINE INTERFERONS - (Abstract Only)
Grubman, M.J., De Los Santos, T., Koster, M.J., Turecek, T.E., Wang, H., Andryev, V., Moraes, M.P. 2006. Enhanced antiviral activity against foot-and-mouth disease virus by a combination of type 1 and 2 porcine interferons. American Society of Virology Annual Meeting. 2006. P. 150.
THE LEADER PROTEINASE OF FOOT-AND-MOUTH DISEASE VIRUS INHIBITS THE INDUCTION OF INTERFERON BETA MRNA AND BLOCKS THE HOST INNATE IMMUNE RESPONSE - (Peer Reviewed Journal)
De Los Santos, T., Botton, S.D., Weiblen, R., Grubman, M.J. 2005. The Leader Proteinase of Foot-and-Mouth Disease Virus Inhibits the Induction of Interferon Beta mRNA and Blocks the Host Innate Immune Response. Journal of Virology.(2006) 80.4.1906-1914
THE LEADER PROTEINASE OF FOOT-AND-MOUTH DISEASE VIRUS INHIBITS THE INDUCTION OF INTERFERON BETA MRNA AND BLOCKS THE HOST INNATE IMMUNE RESPONSE - (Abstract Only)
De Los Santos, T., De Avila Botton, S., Grubman, M.J. 2005. The Leader Proteinase of Foot-and-Mouth Disease Virus Inhibits the Induction of Interferon Beta mRNA and Blocks the Host Innate Immune Response. European Study Grop on the Molecular Biology of Picornaviruses (ERUOPIC)2005. P. G06.
THE LEADER PROTEINASE OF FOOT-AND-MOUTH DISEASE VIRUS INHIBITS THE INDUCTION OF INTERFERON BETA MRNA AND BLOCKS THE HOST INNATE IMMUNE RESPONSE - (Abstract Only)
De Los Santos, T., Botton, S.D., Grubman, M.J. 2005. The Leader Proteinase of Foot-and-Mouth Disease Virus Inhibits the Induction of Interferon Beta mRNA and Blocks the Host Innate Immune Response. American Society for Virology 24th Annual Meeting. P. W3-2.
SHORT HAIRPIN RNA TARGETED TO THE HIGHLY CONSERVED 2B NONSTRUCTURAL PROTEIN CODING REGION INHIBITS REPLICATION OF MULTIPLE SEROTYPES OF FOOT-AND-MOUTH DISEASE VIRUS - (Peer Reviewed Journal)
De Los Santos, T., Wu, Q., Botton, S., Grubman, M.J. 2005. Short Hairpin RNA Targeted to the Highly Conserved 2B Nonstructural Protein Coding Region Inhibits Replication of Multiple Serotypes of Foot-and-Mouth Disease Virus. Virology. 335: P222-231.
RAPID CONTROL OF FOOT-AND-MOUTH DISEASE: IS RNAI A POSSIBLE SOLUTION? - (Review Article)
De Los Santos, T., Grubman, M.J. 2005. Rapid Control of Foot-and-Mouth Disease: Is RNAi a Possible Solution?. Trends in Immunology 26 (2)P 65-68.
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