National Program Leader For:

• Emerging Animal Diseases that Exist Offshore
  
  Accession Number: 408188
  
  
• Develop Alternatives to Antibiotics for Priority Diseases in Animal Agriculture
  
  Accession Number: 426570
  
  
• Genomic and Epidemiological Parameters to Inform Interventions Strategies for Enteric Diseases of Poultry
  
  Accession Number: 439671
  
  
• Intervention Strategies to Prevent and Control Crimean-Congo Hemorrhagic Fever (CCHF)
  
  Accession Number: 439774
  
  
• Chronic Wasting Disease Translational Research
  
  Accession Number: 440165
  
  
• Elucidating the Pathobiology and Transmission of Transmissible Spongiform Encephalopathies
  
  Accession Number: 440677
  
  
• Control Strategies to Prevent and Respond to Diseases Outbreaks Caused by Avian Influenza Viruses
  
  Accession Number: 441119
  
  
• Elucidation of Molecular Determinants of Avian Herpesviruses Virulence and Evolution to Inform the Development of Safe and Effective Vaccines
  
  Accession Number: 441124
  
  
• Intervention Strategies to Prevent and Control Viral Respiratory Pathogens of Ruminants
  
  Accession Number: 441143
  
  
• Intervention Strategies to Control Endemic and New Emerging and Re-Emerging Viral Diseases of Swine
  
  Accession Number: 441144
  
  
• Intervention Strategies to Control Endemic and New and Emerging Influenza A Virus Infections in Swine
  
  Accession Number: 441145
  
  
• Intervention Strategies to Predict, Prevent, and Control Emerging Strains of Virulent Newcastle Disease Viruses
  
  Accession Number: 441214
  
  
• Genetic Approaches and Tools to Prevent, Control, and Eradicate Transmissible Spongiform Encephalopathies
  
  Accession Number: 441236
  
  
• Alternatives to Antibiotics Strategies to Control Enteric Diseases of Poultry
  
  Accession Number: 441270
  
  
• Predicting and Mitigating Vesicular Stomatitis Virus (VSV) Outbreaks in North America
  
  Accession Number: 441288
  
  
• Development of a Vaccine and Improved Diagnostics for Malignant Catarrhal Fever
  
  Accession Number: 441300
  
  
• Intervention Strategies to Control and Eradicate Foreign Animal Diseases of Swine
  
  Accession Number: 441308
  
  
• Intervention Strategies to Respond, Control, and Eradicate Foot-and-Mouth Disease Virus (FMDV)
  
  Accession Number: 441364
  
  
• Predicting and Mitigating Vesicular Stomatitis Virus (VSV) in North America
  
  Accession Number: 441383
  
  
• Ecology of Hemorrhagic Orbiviruses in North America
  
  Accession Number: 441386
  
  
• Rift Valley Fever Pathogenesis and Epidemiology
  
  Accession Number: 441467
  
  
• Japanese Encephalitis Virus Prevention and Mitigation Strategies
  
  Accession Number: 441468
  
  
• Systems Biology Approaches to Develop Medical Countermeasures to Detect, Prevent, and Control Poultry Production Viral Diseases
  
  Accession Number: 441471
  
  
• Immune and Genomic Determinants of Host Responses Associated with Porcine Reproductive and Respiratory Syndrome Virus Infections
  
  Accession Number: 441680
  
  
• Rapid Antemortem Tests for the Early Detection of Transmissible Spongiform Encephalopathies and Other Animal Diseases
  
  Accession Number: 441758
  
  
• Viral Ecology of Henipaviruses in Endemic Settings and Intervention Strategies to Prevent their Spread to Domestic Animals
  
  Accession Number: 442238
  
  
• Research, Development, Testing, and Technical Services to Advance the Technology Transfer of Veterinary Medical Countermeasures at the NBAF
  
  Accession Number: 442270
  
  
• Enhancing Biodefense Through Geospatial and Epidemiological Approaches
  
  Accession Number: 443442
  
  
• National Bio and Agro Defense Facility Operations Project
  
  Accession Number: 444095
  
  

Publications (Clicking on the reprint icon will take you to the publication reprint.)

Novel hyperimmune egg yolk IgY antibodies developed against protective antigens of Eimeria and Clostridium perfringens protect against necrotic enteritis - (Peer Reviewed Journal)

Confirming the absence of parental African swine fever virus as a potential contaminant of recombinant live attenuated ASF vaccines - (Peer Reviewed Journal)

Velazquez Salinas, L., Ramirez Medina, E., Rai, A., Pruitt, S.E., Vuono, E., Espinoza, N.N., Gay, C.G., Witte, S.B., Gladue, D.P., Borca, M.V. 2023. Confirming the absence of parental African swine fever virus as a potential contaminant of recombinant live attenuated ASF vaccines. Biologicals. 3;83:101685. https://doi.org/10.1016/j.biologicals.2023.101685.

Orally delivered bacillus subtilis expressing chicken NK-2 peptide stabilizes gut microbiota and enhances intestinal health and local immunity in coccidiosis-infected broiler chickens - (Peer Reviewed Journal)

Wickramasuriya, S.S., Park, I., Lee, Y., Richer, L.R., Przybyszewski, C., Gay, C.G., Van Oosterwijk, J.G., Lillehoj, H.S. 2023. Orally delivered bacillus subtilis expressing chicken NK-2 peptide stabilizes gut microbiota and enhances intestinal health and local immunity in coccidiosis-infected broiler chickens. Poultry Science. https://doi.org/10.1016/j.psj.2023.102590.

Evaluation of the safety profile of the ASFV vaccine candidate ASFV-G-I177L - (Peer Reviewed Journal)

Xuan, T., Le Thi Thu, P., Nguyen Quang, H., Do Thanh, T., Nguyen Van, D., Pham Hào, Q., Quách Võ, N., Gay, C.G., Gladue, D.P., Borca, M.V. 2022. Evaluation of the safety profile of the ASFV vaccine candidate ASFV-G-I177L. Viruses. https://doi.org/10.3390/v14050896.

African swine fever virus vaccine candidate ASFV-G-¿I177L efficiently protects European and native pig breeds against circulating Vietnamese field strain. - (Peer Reviewed Journal)

Tran, X., Le Thi Thu, P., Nguyen Quang, H., Do Thanh, T., Nguyen Van, D., Gay, C.G., Borca, M.V., Gladue, D.P. 2021. African swine fever virus vaccine candidate ASFV-G-I177L efficiently protects European and native pig breeds against circulating Vietnamese field strain. Transboundary and Emerging Diseases. https://doi.org//10.1111/tbed.14329.

Bacillus subtilis expressing chicken NK-2 peptide protects against Eimeria acervulina challenge infection in broiler chickens - (Peer Reviewed Journal)

Wickramasuriya, S.S., Park, I., Van Oosterwijk, J., Gay, C.G., Przybyszwek, C., Lillehoj, H.S. 2021. Bacillus subtilis expressing chicken NK-2 peptide protects against Eimeria acervulina challenge infection in broiler chickens. Frontiers in Veterinary Science. https://doi.org/10.3389/fvets.2021.684818.

ASFV-G-I177L is an effective oral nasal vaccine against the Eurasia Strain of Africa swine fever - (Peer Reviewed Journal)

Borca, M.V., Ramirez Medina, E., Silva, E., Vuono, E., Rai, A., Pruitt, S.E., Gay, C.G., Espinoza, N.N., Velazquez-Salinas, L., Gladue, D.P. 2021. ASFV-G-I177L is an effective oral nasal vaccine against the Eurasia Strain of Africa swine fever. Viruses. https://doi.org/10.3390/v13050765.

Alternatives to antibiotics: A symposium on the challenges and solutions for animal health and production - (Peer Reviewed Journal)

Callaway, T.R., Lillehoj, H.S., Chuanchuen, R., Gay, C.G. 2021. Alternatives to antibiotics: A symposium on the challenges and solutions for animal health and production. Antibiotics. https://doi.org/10.3390/antibiotics10050471.

Recombinant Bacillus subtilis carrying NK-lysin gene as an effective mucosal delivery strategy to prevent against avian coccidiosis - (Abstract Only)

Novel Foot-and-Mouth Disease vaccine platform:Formulations for safe and DIVA-compatible FMD vaccines with improved potency - (Peer Reviewed Journal)

Hardham, J., Krug, P., Pacheco, J., Thompson, J., Domanowski, P., Gay, C.G., Rodriguez, L.L., Rieder, A.E. 2020. Novel Foot-and-Mouth disease vaccine platform: Formulations for safe and DIVA-compatible FMD vaccines with improved potency. Frontiers in Veterinary Science. https://doi.org/https://doi.org/10.3389/fvets.2020.554305.

Strategic priorities for research on antibiotic alternatives in animal agriculture-Results from an expert workshop - (Peer Reviewed Journal)

Kurt, T., Wong, N., Fowler, N., Gay, C.G., Lillehoj, H.S., Plummer, P., Scott, M., Hoelzer, K. 2019. Strategic priorities for research on antibiotic alternatives in animal agriculture-Results from an expert workshop. Frontiers in Veterinary Science. https://doi.org/10.3389/fvets.2019.00429.

"Novel hyperimmune egg yolk IgY antibodies developed against protective antigens of Eimeria sp and Clostridium perfringens protect against coccidiosis and necrotic enteritis" - (Abstract Only)

Research and development of microbiome-related alternatives to antibiotics - (Abstract Only)

Innovative drugs, chemicals, and enzymes within the animal production chain - (Peer Reviewed Journal)

Hassan, Y., Lahave, L., Gong, M., Peng, J., Gong, J., Liu, S., Gay, C.G., Yang, C. 2018. Innovative drugs, chemicals, and enzymes within the animal production chain. Veterinary Research. https://doi.org/10.1186/s13567-018-0559-1.

Phytochemicals as potential antibiotic alternatives to promote growth and enhance host health: A report from the Second International Symposium on Alternatives to Antibiotics - (Peer Reviewed Journal)

Lillehoj, H.S., Liu, Y., Calsamiglia, S., Fernandez-Miyakawa, M.E., Chi, F., Cravens, R.L., Oh, S., Gay, C.G. 2018. Phytochemicals as potential antibiotic alternatives to promote growth and enhance host health: A report from the Second International Symposium on Alternatives to Antibiotics. Veterinary Research. https://doi.org/10.1186/s13567-018-0562-6.

Microbial-derived products as potential new antimicrobials: A report from the Second Alternatives to Antibiotics Symposium - (Review Article)

Seal, B.S., Drider, D., Oakley, B.B., Brussow, H., Bickard, D., Rich, J.O., Miller, S., Devillard, E., Kwan, J., Bertin, G., Reeves, S., Swift, S.M., Raicek, M., Gay, C.G. 2018. Microbial-derived products as potential new antimicrobials: A report from the Second Alternatives to Antibiotics Symposium. Veterinary Research. 49:66. 10.1186/s13567-018-0563-5.

Microbial-derived products as potential new antimicrobials - (Review Article)

Seale, B., Dryder, D., Oakley, B.B., Brussow, H., Bikard, D., Rich, J.O., Miller, S., Devillard, E., Kwan, J., Bertin, G., Reeves, S., Swift, S.M., Raicek, M., Gay, C.G. 2018. Microbial-derived products as potential new antimicrobials. Veterinary Research. 49:66-78.

Vaccines as alternatives to antibiotics for food producing animals - (Review Article)

Hoelzer, K., Bielke, L., Blake, D., Cox, E., Cutting, S., Devriendt, B., Erlacher-Vindel, E., Goossens, E., Karaca, K., Lemiere, S., Metzner, M., Raicek, M., Surinach, M.C., Wong, N.M., Gay, C.G., Van Immerseel, F. 2018. Vaccines as alternatives to antibiotics for food producing animals. Veterinary Research. https://doi.org/10.1186/s13567-018-0560-8.

Vaccines as alternatives to antibiotics for food producing animals. Part 1: challenges and needs - (Review Article)

Hoelzer, K., Bielke, L., Blake, D.P., Cox, E., Cutting, S.M., Devriendt, B., Erlacher-Vindel, E., Goossens, E., Karaca, K., Lemiere, S., Metzner, M., Raicek, M., Surinach, M.C., Wong, N.M., Gay, C.G., Van Immerseel, F. 2018. Vaccines as alternatives to antibiotics for food producing animals. Part 1: challenges and needs. Veterinary Research. 49:64. https://doi.org/10.1186/s13567-018-0560-8

Vaccines as alternatives to antibiotics for food producing animals. Part 2: new approaches and potential solutions - (Review Article)

Hoelzer, K., Bielke, L., Blake, D.P., Cox, E., Cutting, S.M., Devriendt, B., Erlacher-Vindel, E., Gossens, E., Karaca, K., Lemiere, S., Metzner, M., Raicek, M., Surinach, M.C., Wong, N., Gay, C.G., Van Immerseel, F. 2018. Vaccines as alternatives to antibiotics for food producing animals. Part 2: new approaches and potential solutions. Veterinary Research. https://doi.org/10.1186/s13567-018-0561-7.

Global foot-and-mouth disease research update and gap analysis: 6 - immunology - (Review Article)

Robinson, L., Knight-Jones, T., Charleston, B., Rodriguez, L.L., Gay, C.G., Sumption, K., Vosloo, W. 2016. Global foot-and-mouth disease research update and gap analysis: 6 - immunology. Transboundary and Emerging Diseases. 63:56-62. doi: 10.1111.tbed.12518.

Global foot-and-mouth disease research update and gap analysis: 7 - pathogenesis and molecular biology - (Review Article)

Robinson, L., Knight-Jones, T., Charleston, B., Rodriguez, L.L., Gay, C.G., Sumption, K., Vosloo, W. 2016. Global foot-and-mouth disease research update and gap analysis: 7 - pathogenesis and molecular biology. Transboundary and Emerging Diseases. 63:63-71. doi: 10.1111.tbed.12520.

Global foot-and-mouth disease research update and gap analysis: 5 - biotherapeutics and disinfectants - (Review Article)

Robinson, L., Knight-Jones, T., Charleston, B., Rodriguez, L.L., Gay, C.G., Sumption, K., Vosloo, W. 2016. Global foot-and-mouth disease research update and gap analysis: 5 - biotherapeutics and disinfectants. Transboundary and Emerging Diseases. 63:49-55. doi: 10.1111/tbed.12519.

Viral hemorrhagic fevers of animals caused by DNA viruses - (Book / Chapter)

Borca, M.V., Gay, C.G., Risatti, G.R., O'Toole, D., Li, N., Kuhn, J.H., Lewis, C.E., Loiacono, C.M., White, D. 2016. Viral hemorrhagic fevers of animals caused by DNA viruses. Book Chapter. Borca. 2015. Global Virology I: Identifying and Invetsigating Viral Diseases. Springer Science, NY.

Global foot-and-mouth disease research update and gap analysis: 4 - diagnostics - (Review Article)

Knight-Jones, T., Robinson, L., Charleston, B., Rodriguez, L.L., Gay, C.G., Sumption, K., Vosloo, W. 2016. Global foot-and-mouth disease research update and gap analysis: 4 - diagnostics. Transboundary and Emerging Diseases. 63:42-48. doi: 10.1111/tbed.12523.

Global foot-and-mouth disease research update and gap analysis: 3 - vaccines - (Review Article)

Robinson, L., Knight-Jones, T., Charleston, B., Rodriguez, L.L., Gay, C.G., Sumption, K., Vosloo, W. 2016. Global foot-and-mouth disease research update and gap analysis: 3 - vaccines. Transboundary and Emerging Diseases. 63:30-41. doi: 10.1111/tbed.12521.

Global foot-and-mouth disease research update and gap analysis: 2 - epidemiology, wildlife and economics - (Review Article)

Knight-Jones, T., Robinson, L., Charleston, B., Rodriguez, L.L., Gay, C.G., Sumption, K., Vosloo, W. 2016. Global foot-and-mouth disease reearch update and gap analysis: 2 - epidemiology, wildlife and economics. Transboundary and Emerging Diseases. 63:14-29. doi: 10.1111/tbed.12522.

Global foot-and-mouth disease research update and gap analysis: 1 - overview of global status and research needs - (Review Article)

Knight-Jones, T., Robinson, L., Charleston, B., Rodriguez, L.L., Gay, C.G., Sumption, K., Vosloo, W. 2016. Global foot-and-mouth disease research update and gap analysis: 1 - overview of global status and research needs. Transboundary and Emerging Diseases. 63:3-13. doi: 10.1111/tbed.12528.

Genomics for the identification of novel antimicrobials - (Review Article)

Kim, W., Lillehoj, H.S., Gay, C.G. 2016. Genomics for the identification of novel antimicrobials. Scientific and Technical Review. 35(1):95-103. doi: 10.20506/rst.35.1.2420.

Orbiviruses – A North American Perspective - (Peer Reviewed Journal)

McVey, D.S., Drolet, B.S., Ruder, M.G., Wilson, W.C., Nayduch, D., Pfannenstiel, R.S., Cohnstaedt, L.W., Maclachlan, J.N., Gay, C.G. 2015. Orbiviruses – A North American Perspective. Vector-Borne and Zoonotic Diseases. 15(6):335-338. https://doi.org/10.1089/vbz.2014.1699.

Viral hemorrhagic fevers of animals caused by DNA viruses - (Book / Chapter)

Borca, M.V., Gay, C.G., Risatti, G., O'Toole, G., Li, H., Kuhn, J., Lewis, C., Loiacono, C., White, D.M. 2015. Viral hemorrhagic fevers of animals caused by DNA viruses. In:Shapshak, P., Sinnott, J.T., Somboonwit, C., Kuhn, J., editors. Global Virology-Identifying and Investigating Viral Diseases. New York, NY:Springer. p. 319-343.

Alternatives to Antibiotics: Recent Scientific Development - (Abstract Only)

Alternatives to antibiotics: recent scientific development - (Abstract Only)

The gut immune system: new opportunities for targeting dietary immune modulation to enhance gut health - (Proceedings)

Alternatives to Antibiotics: Recent Scientific Development - (Proceedings)

Report from the second international symposium on animal genomics for animal health: critical needs, challenges and potential solutions - (Proceedings)

Bishop, R.C., Lunney, J.K., Pinard-Vander Laan, Gay, C.G. 2011. Report from the second international symposium on animal genomics for animal health: critical needs, challenges and potential solutions. Biomed Central (BMC) Genomics. 5(4):S1.

Rift Valley Fever Overview and Recent Developments at USDA - (Peer Reviewed Journal)

Linthicum, K., Anyamba, A., Gay, C.G., Britch, S.C., Chretien, J., Witt, C., Small, J., Tucker, C.J., Bennett, K.E., Wilson, W.C., Turell, M.J. 2009. Rift Valley Fever Overview and Recent Developments at USDA. United States Animal Health Association Proceedings. 112:256-265.

Pathobiology and diagnosis of animal transmissible spongiform encephalopathies: current knowledge, research gaps, and opportunities - (Government Publication)

Kehrli, Jr., M.E., O'Rourke, K.I., Hamir, A.N., Richt, J.A., Nicholson, E.M., Silva, C.J., Edelman, D., Gay, C.G. 2007. Pathobiology and diagnosis of animal transmissible spongiform encephalopathies: current knowledge, research gaps, and opportunities [government white paper]. Beltsville, MD: Interagency Working Group on Prion Science, Subcommittee on Pathobiology and Diagnostics. USDA, Agriculture Research Service. 33 p.

Genomics and vaccine development - (Peer Reviewed Journal)

Gay, C.G., Zuerner, R., Bannantine, J.P., Lillehoj, H.S., Zhu, J., Green, R.D., Pastoret, P.P. 2007. Genomics and vaccine development. OIE Rev. Sci Tech. 26:49-67.