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ARS Home » Northeast Area » Wyndmoor, Pennsylvania » Eastern Regional Research Center » Molecular Characterization of Foodborne Pathogens Research » Research » Publications at this Location » Publication #404729

Research Project: Molecular Analysis of Foodborne Pathogen Responses to Stressors

Location: Molecular Characterization of Foodborne Pathogens Research

Title: Complete closed genome sequences of multidrug resistant uropathogenic Escherichia coli

Author
item Guragain, Manita
item Kanrar, Siddhartha
item Bagi, Lori
item Chen, Chinyi

Submitted to: Microbiology Resource Announcements
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 8/21/2023
Publication Date: 9/28/2023
Citation: Guragain, M., Kanrar, S., Bagi, L.K., Chen, C. 2023. Complete closed genome sequences of multidrug resistant uropathogenic Escherichia coli. Microbiology Resource Announcements. 12:10. https://doi.org/10.1128/MRA.00422-23.
DOI: https://doi.org/10.1128/MRA.00422-23

Interpretive Summary: Urinary tract infections (UTIs) affect 150 million people globally every year. The most common bacterial UTIs are associated with Uropathogenic E. coli (UPEC). Increased antibiotic resistance among UPEC leads to recurrent UTIs, treatment failures, and serious complications. Food may act as a source of UPEC that may result in UTIs. This study produced complete genomic data of three multidrug resistant human UPECs. Genomics data generated in this study will be utilized to identify and characterize high risk UPEC in food samples, thereby allowing the identification of food-associated hazards leading to UTIs.

Technical Abstract: Infection by antibiotic resistant extraintestinal pathogenic Escherichia coli may result in treatment failure and thus poses a serious public health threat. Here we report the complete closed genome sequence of three multidrug resistant human uropathogenic E. coli isolates using long-read sequencing technology and de novo assembly.