|Gelineau-van Waes, Janne|
|Voss, Kenneth - Ken|
Submitted to: Toxicological Sciences
Publication Type: Abstract Only
Publication Acceptance Date: 11/1/2005
Publication Date: 3/1/2006
Citation: Burns, T.D., Riley, R.T., Gelineau-Van Waes, J.B., Voss, K.A. 2006. Induction of neural tube defects in cd1 mice by intraperitoneal exposure to fumonisin b1[abstract]. Toxicological Sciences. 90(1):408. Interpretive Summary: Abstract - no summary.
Technical Abstract: Fumonisin mycotoxins are found in corn and corn-based foods. Their human health effects are unclear, however, there is evidence suggesting they are a risk factor for neural tube defects (NTDs) in populations consuming large amounts of fumonisin-contaminated food. Fumonisin B1 (FB1) was not teratogenic when given orally to rats or CD1 mice, whereas intraperitoneal (ip) injection of > 5 mg/kg BW FB1 on gestation days (GD) 7-8 to dams of the inbred LM/Bc mouse strain caused NTDs (exencephaly). All litters and > 50 percent of the fetuses from dams given > 15 mg/kg FB1 ip were affected. To determine if CD1 fetuses are susceptible to NTD induction by fumonisins, pregnant CD1 mice (n=8-10/dose level) were given ip doses of FB1 on GD7 and GD8. NTDs were not found in the vehicle control group but were found (exencephaly) in 11, 0, and 40 percent of the litters from dams given 15, 30 or 45 mg/kg BW FB1, respectively. This result was corroborated in a second experiment in which exencephaly was found in 0, 8, 17, 36 and 55 percent of the litters from dams (n=8-12/dose level) given 0 (vehicle controls), 10, 23, 45 or 100 mg/kg BW FB1. In the affected litters of dams given < 45 ppm FB1, < 33 percent of the fetuses had NTDs. The percent fetuses positive for NTDs in affected litters of dams given 100 mg/kg BW FB1 tended to be higher: 15 to 100 percent exhibiting exencephaly (average mean for the group = 42 percent). Thus, induction of NTDs by FB1 is not unique to the LM/Bc mouse, although this strain appears to be more sensitive than CD1 mice. Comparative investigations using these two strains will be useful for elucidating the physiological and biochemical mechanisms contributing to fumonisin-induced NTD formation in mice.