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ARS Home » Northeast Area » Beltsville, Maryland (BARC) » Beltsville Agricultural Research Center » Animal Genomics and Improvement Laboratory » Research » Research Project #442481

Research Project: Accelerating Genetic Improvement of Ruminants Through Enhanced Genome Assembly, Annotation, and Selection

Location: Animal Genomics and Improvement Laboratory

Publications (Clicking on the reprint icon Reprint Icon will take you to the publication reprint.)

Whole-genome resequencing reveals genetic diversity and wool trait-related genes in Liangshan Semi-fine Wool Sheep Reprint Icon - (Peer Reviewed Journal)
Sun, X., Guo, J., Li, R., Zhang, H., Zhang, Y., Liu, G., Emu, Q., Zhang, H. 2024. Whole-genome resequencing reveals genetic diversity and wool trait-related genes in Liangshan Semi-fine Wool Sheep. Animals. 14(3):444. https://doi.org/10.3390/ani14030444.

Current challenges and future of agricultural genomes to phenomes in the USA Reprint Icon - (Peer Reviewed Journal)
Tuggle, C.K., Clarke, J.L., Murdoch, B.M., Lyons, E., Scott, N.M., Mckay, S., Lipka, A., Fulton, J., Hess, A., Lubberstedt, T., Fragomeni, B., Rowan, T., Mccarthy, F., Guadagno, C., Goddard, E., Das Choudhury, S., Sheehan, M., Kramer, L., Feldman, M.J., Daigle, C., Steibel, J.P., Benes, B., Murray, S., Riggs, P., Thompson, A., Hagen, D., Thornton-Kurth, K., Van Tassell, C.P., Campbell, J.D., Dorea, J., Chung, H., Dekkers, J.C., Ertl, D., Lawrence-Dill, C.A., Schnable, P.S. 2024. Current challenges and future of agricultural genomes to phenomes in the USA. Genome Biology. 25:8. https://doi.org/10.1186/s13059-023-03155-w.

Integrated meta-omics reveals the regulatory landscape involved in lipid metabolism between pig breeds Reprint Icon - (Peer Reviewed Journal)
Sun, J., Xie, F., Wang, J., Luo, J., Chen, T., Jiang, Q., Xi, Q., Liu, G., Zhang, Y. 2024. Integrated meta-omics reveals the regulatory landscape involved in lipid metabolism between pig breeds. Microbiome. 12. Article e33. https://doi.org/10.1186/s40168-023-01743-3.

Participatory investigation of goat farmers’ breeding practices, trait preference, and selection criteria in Burkina Faso Reprint Icon - (Peer Reviewed Journal)
Badjibassa, A., Ouedraogo, D., Burger, P.A., Rosen, B.D., Van Tassell, C.P., Solkner, J., Soudre, A. 2024. Participatory investigation of goat farmers’ breeding practices, trait preference, and selection criteria in Burkina Faso. Tropical Animal Health and Production. 56:35. https://doi.org/10.1007/s11250-023-03869-w.

Unraveling the genetic basis of feed efficiency in cattle through integrated DNA methylation and CattleGTEx analysis Reprint Icon - (Peer Reviewed Journal)
Hu, Z., Boschiero, C., Li, C., Connor, E.E., Baldwin, R.L., Liu, G. 2023. Unraveling the genetic basis of feed efficiency in cattle through integrated DNA methylation and CattleGTEx analysis. Genes. 14(12):2121. https://doi.org/10.3390/genes14122121.

A compendium of genetic regulatory effects across pig tissues Reprint Icon - (Peer Reviewed Journal)
Teng, J., Gao, Y., Yin, H., Bai, Z., Liu, S., Zeng, H., Consortium, T., Bai, L., Cai, Z., Zhao, B., Li, X., Xu, Z., Lin, Q., Pan, Z., Yang, W., Yu, X., Guan, D., Hou, Y., Keel-Mercer, B.N., Rohrer, G.A., Lindholm-Perry, A.K., Oliver, W.T., Ballester, M., Crespo, D., Quintanilla, R., Canela-Xandri, O., Rawlik, K., Xia, C., Yao, Y., Zhao, Q., Yao, W., Yang, L., Li, H., Zhang, H., Liao, W., Chen, T., Karlskov-Mortensen, P., Fredholm, M., Amills Eras, M., Clop, A., Giuffra, E., Wu, J., Cai, X., Diao, S., Pan, X., Wei, C., Li, J., Cheng, H., Wang, S., Su, G., Sahana, G., Lund, M., Dekkers, J., Kramer, L., Tuggle, C.K., Corbett, R., Groenen, M.A., Madsen, O., Godia, M., Rocha, D., Li, C., Pausch, H., Hu, X., Frantz, L., Luo, Y., Lin, L., Zhou, Z., Zhang, Z., Chen, Z., Cui, L., Xiang, R., Shen, X., Li, P., Huang, R., Tang, G., Li, M., Zhao, Y., Yi, G., Tang, Z., Jiang, J., Zhao, F., Yuan, X., Liu, X., Chen, Y., Xu, X., Zhao, S., Zhao, P., Haley, C., Zhou, H., Wang, Q., Pan, Y., Ding, X., Ma, L., Li, J., Navarro, P., Zhang, Q., Li, B., Tenesa, A., Liu, G. 2024. A compendium of genetic regulatory effects across pig tissues. Nature Genetics. 56:112-123. https://doi.org/10.1038/s41588-023-01585-7.

Genome-wide association analysis of heifer livability and early first calving in Holstein cattle Reprint Icon - (Peer Reviewed Journal)
Gao, Y., Marceau, A., Iqbal, V., Torres-Vazquez, J.A., Neupane, M., Jiang, J., Liu, G., Ma, L. 2023. Genome-wide association analysis of heifer livability and early first calving in Holstein cattle. BMC Genomics. 24:628. https://doi.org/10.1186/s12864-023-09736-0.

Investigation of lncRNA in Bos taurus mammary tissue during dry and lactation periods Reprint Icon - (Peer Reviewed Journal)
Marceau, A., Wang, J., Iqbal, V., Jiang, J., Liu, G., Ma, L. 2023. Investigation of lncRNA in Bos taurus mammary tissue during dry and lactation periods. Genes. 14(9):1789. https://doi.org/10.3390/genes14091789.

New insights into transcriptome variation during cattle adipocyte adipogenesis by direct RNA sequencing Reprint Icon - (Peer Reviewed Journal)
Peng, L., Zhang, X., Du, Y., Li, F., Han, J., Liu, O., Dai, S., Zhang, X., Liu, G., Yang, L., Zhou, Y. 2023. New insights into transcriptome variation during cattle adipocyte adipogenesis by direct RNA sequencing. iScience. 26(10):107753. https://doi.org/10.1016/j.isci.2023.107753.

The African Goat Improvement Network: A scientific group empowering smallholder farmers Reprint Icon - (Peer Reviewed Journal)
Van Tassell, C.P., Rosen, B.D., Woodward Greene, M.J., Silverstein, J., Huson, H.J., Solkner, J., Boettcher, P., Rothschild, M.F., Meszaros, G., Nakimbugwe, H., Gondwe, T., Muchadeyi, F.C., Nandolo, W., Mulindwa, H.A., Banda, L.J., Kaumbata, W., Getachew, T., Haile, A., Soudre, A., Ouedraogo, D., Rischkowsky, B.A., Mwai, A.O., Dzomba, E.F., Nash, O., Abegaz, S., Masiga, C.W., Wurzinger, M., Sayre, B.L., Stella, A., Tosser-Klopp, G., Sonstegard, T.S. 2023. The African Goat Improvement Network: A scientific group empowering smallholder farmers. Frontiers in Genetics. 14:1183240. https://doi.org/10.3389/fgene.2023.1183240.

Using the community-based breeding program (CBBP) model as a collaborative platform to develop the African Goat Improvement Network—Image collection protocol (AGIN-ICP) with mobile technology for data collection Reprint Icon - (Peer Reviewed Journal)
Woodward Greene, M.J., Kinser, J.M., Huson, H.J., Sonstegard, T.S., Solkner, J., Vaisman, I.I., Boettcher, P., Masiga, C., Mukasa, C., Abegaz, S., Agaba, M., Ahmed, S.S., Fridolin, M., Getachew, T., Gondowe, T., Haile, A., Hassan, Y., Kihara, A., Kouriba, A., Mruttu, H.A., Mujibi, D., Nandolo, W., Rischkowsky, B., Rosen, B.D., Sayre, B., Van Tassell, C.P. 2023. Using the community-based breeding program (CBBP) model as a collaborative platform to develop the African Goat Improvement Network—Image collection protocol (AGIN-ICP) with mobile technology for data collection and management of livestock phenotypes. Frontiers in Genetics. 14:1200770. https://doi.org/10.3389/fgene.2023.1200770.

A Chinese indicine pan-genome reveals a wealth of novel structural variants introgressed from other Bos species Reprint Icon - (Peer Reviewed Journal)
Dai, X., Bian, P., Hu, D., Luo, F., Huang, Y., Jiao, S., Wang, X., Gong, M., Li, R., Cai, Y., Wen, J., Yang, Q., Deng, W., Nanaei, H.A., Wang, Y., Wang, F., Zhang, Z., Rosen, B.D., Heller, R., Jiang, Y. 2023. A Chinese indicine pan-genome reveals a wealth of novel structural variants introgressed from other Bos species. Genome Research. 33(8):1284–1298. https://doi.org/10.1101/gr.277481.122.

Taming transposable elements in livestock and poultry: a review of their roles and applications Reprint Icon - (Peer Reviewed Journal)
Zhao, P., Peng, C., Fang, L., Wang, Z., Liu, G. 2023. Taming transposable elements in livestock and poultry: a review of their roles and applications. Genetic Selection Evolution. 55:50. https://doi.org/10.1186/s12711-023-00821-2.

The single-cell transcriptome and chromatin accessibility datasets of peripheral blood mononuclear cells in Chinese Holstein cattle Reprint Icon - (Peer Reviewed Journal)
Wang, X., Gao, Y., Li, C., Fang, L., Liu, G., Zhao, X., Zhang, Y., Cai, G., Xue, G., Liu, Y., Wang, L., Zhang, F., Wang, K., Zhang, M., Li, R., Gao, Y., Li, J. 2023. The single-cell transcriptome and chromatin accessibility datasets of peripheral blood mononuclear cells in Chinese Holstein cattle. BMC Genomic Data. 24:39. https://doi.org/10.1186/s12863-023-01139-0.

Morphometric characterization of local goat breeds in two agroecological zones of Burkina Faso, West Africa Reprint Icon - (Peer Reviewed Journal)
Akounda, B., Ouedraogo, D., Soudre, A., Burger, P.A., Rosen, B.D., Van Tassell, C.P., Solkner, J. 2023. Morphometric characterization of local goat breeds in two agroecological zones of Burkina Faso, West Africa. Animals. 13(12):1931. https://doi.org/10.3390/ani13121931.

Harnessing male germline epigenomics for the genetic improvement in cattle Reprint Icon - (Peer Reviewed Journal)
Wang, X., Li, W., Feng, X., Li, J., Liu, G., Fang, L., Yu, Y. 2023. Harnessing male germline epigenomics for the genetic improvement in cattle. Journal of Animal Science and Biotechnology. 14:76. https://doi.org/10.1186/s40104-023-00874-9.

Characterization and localization of within and across breed as indications of inbreeding depression and heterosis - (Abstract Only)

The Australasian dingo archetype: de novo chromosome-length genome assembly, DNA methylome, and cranial morphology Reprint Icon - (Peer Reviewed Journal)
Ballard, J.O., Field, M.A., Edwards, R.J., Wilson, L.A., Koungoulos, L.G., Rosen, B.D., Chernoff, B., Dudchenko, O., Omer, A., Keilwagen, J., Skvortsova, K., Bogdanovic, O., Chan, E.K., Zammit, R.A., Hayes, V., Aiden, E.L. 2023. The Australasian dingo archetype: de novo chromosome-length genome assembly, DNA methylome, and cranial morphology. GigaScience. https://doi.org/10.1093/gigascience/giad018.

A sheep pangenome reveals the spectrum of structural variations and their effects on tail phenotypes Reprint Icon - (Peer Reviewed Journal)
Li, R., Gong, M., Zhang, X., Wang, F., Liu, Z., Zhang, L., Yang, Q., Xu, Y., Xu, M., Zhang, H., Zhang, Y., Dai, X., Zhang, Z., Fang, W., Yang, Y., Fu, W., Cao, C., Yang, P., Ghanatsaman, Z.A., Negari, N.J., Nanaei, H.A., Yue, X., Song, Y., Lan, X., Deng, W., Wang, X., Pan, C., Xiang, R., Ibeagha-Awemu, E.M., Heslop-Harrison, P.J., Rosen, B.D., Lenstra, J.A., Gan, S., Jiang, Y. 2023. A sheep pangenome reveals the spectrum of structural variations and their effects on tail phenotypes. Genome Research. 33:463-477. https://doi.org/10.1101/gr.277372.122.

Cis-eQTL analysis and functional validation of candidate genes for carcass yield traits in beef cattle Reprint Icon - (Peer Reviewed Journal)
Wang, T., Niu, Q., Zhang, T., Zheng, X., Li, H., Gao, X., Chen, Y., Gao, H., Zhang, L., Liu, G., Li, J., Xu, L. 2022. Cis-eQTL analysis and functional validation of candidate genes for carcass yield traits in beef cattle. International Journal of Biological Sciences. 23(23):15055. https://doi.org/10.3390/ijms232315055.

Characterization and localization within and across breed measures of dominance as observed in inbreeding depression and heterosis - (Abstract Only)

The conservation of human functional variants and their effects across livestock species Reprint Icon - (Peer Reviewed Journal)
Zhao, R., Talenti, A., Fang, L., Liu, S., Liu, G., Chue Hong, N.P., Tenesa, A., Hassan, M., Prendergast, J.G. 2022. The conservation of human functional variants and their effects across livestock species. Communications Biology. 5:1003. https://doi.org/10.1038/s42003-022-03961-1.

Favored single nucleotide variants identified using whole genome re-sequencing of Austrian and Chinese cattle breeds Reprint Icon - (Peer Reviewed Journal)
Naji, M.M., Jiang, Y., Utsunomiya, Y.T., Rosen, B.D., Solkner, J., Wang, C., Jiang, L., Zhang, Q., Zhang, Y., Ding, X., Meszaros, G. 2022. Favored single nucleotide variants identified using whole genome re-sequencing of Austrian and Chinese cattle breeds. Frontiers in Genetics. https://doi.org/10.3389/fgene.2022.974787.