|YANG, YISHAN - Collaborator|
|ADENIPKUN, EYITAYO - Olabisi Onabanjo University|
|CERUSO, MARINA - The University Of Naples Federico Ii|
Submitted to: Microbiology Resource Announcements
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 4/1/2020
Publication Date: 4/23/2020
Citation: Yang, Y., Sommers, C.H., Adenipkun, E., Ceruso, M., Jackson, C.R., Woodley, T.A., Barrett, J.B., Hiott, L.M., Liu, Y., Frye, J.G. 2020. Draft genomic sequence of three Escherichia coli Sequence Type 131 isolates (H45, H43ii, and H43iii) from patients in Lagos, Nigeria. Microbiology Resource Announcements. 9:17. https://doi.org/10.1128//mra.asm
Interpretive Summary: Pathogenic bacteria known as extraintestinal pathogenic E. coli (ExPEC) are important causes of infections, including urinary tract infections, bloodstream infections, and meningitis. The complete sequence of the DNA of three ExPEC strains known as E. coli Sequence Type 131 (ST131), strains H45, H43ii, and H43iii, recovered from urine samples of patients in Lagos, Nigeria has been determined. The importance of these three ST131 strains is that this group of pathogens has emerged as a leading cause urinary tract and bloodstream infections in humans that are resistant to many antibiotics. The prevalence of E. coli ST131 is possibly attributed to its increased antibiotic resistance, enhanced virulence (disease causing potential), and greater propensity to transfer genetic materials compared to non-ST131 E. coli. The genomic information from these strains will be useful for understanding the dissemination and pathogenicity of E. coli ST131, as well as for facilitating the development of novel antimicrobial therapies.
Technical Abstract: Escherichia coli Sequence Type 131 (ST131) has recently emerged as a leading multidrug resistant pathogen that causes urinary tract and bloodstream infections in humans. Here, we report the draft genomic sequence of three E. coli ST131 isolates, H45, H43ii, and H43iii, from urine samples of patients in Lagos, Nigeria.