Tangeretin and 3',4',3,5,6,7,8-heptamethoxyflavone decrease insulin resistance, fat accumulation and oxidative stress in mice fed high-fat diet

Authors: Manthey, John; NERY, MARINA - Sao Paulo State University (UNESP); GONCALVES, DANIELLE - Sao Paulo State University (UNESP); SPOLIDORIO, LUIS - Sao Paulo State University (UNESP); CESAR, THAIS - Sao Paulo State University (UNESP)

Submitted to: American Chemical Society Abstracts
Publication Type: Abstract Only
Publication Acceptance Date: 3/19/2018
Publication Date: N/A
Citation: N/A

Interpretive Summary: Two chemical compounds in oranges had protective effects against insulin resistance and oxidative stress caused by high-fat diets in mice, and may prevent the development of metabolic syndrome and type 2 diabetes. These findings help create a use for these compounds and other orange peel byproducts in general.

Technical Abstract: Tangeretin and heptamethoxyflavone were investigated for their ability to repair metabolic damage caused by high-fat diet in C57BL/6J mice. In the first four weeks, induction of obesity was performed and the mice received standard diet (11% kcal from fat) or high-fat diet (45% kcal from fat). After that, in the next four weeks, two groups received supplements (tangeretin or heptamethoxyflavone – dose of 100mg/kg) into the high-fat diet, and the other groups continued to receive their respective diets. Tangeretin and heptamethoxyflavone decreased blood serum levels of glucose, leptin and resistin and the HOMA-IR index. Besides that, blood serum TBARS levels were lower in supplemented groups than in non-supplemented. In addition, tangeretin reduced adipocyte size, and heptamethoxyflavone decreased fat accumulation in the liver. The results show that tangeretin and heptamethoxyflavone have protective effects against insulin resistance and oxidative stress caused by high-fat diet in mice, and may prevent metabolic alterations associated with the development of metabolic syndrome and type 2 diabetes.