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Title: Microbial-derived products as potential new antimicrobials: A report from the Second Alternatives to Antibiotics Symposium

Author
item SEAL, BRUCE - OREGON STATE UNIVERSITY
item DRIDER, DJAMEL - UNIVERSITE DE LILLE
item OAKLEY, BRIAN - WESTERN UNIVERSITY OF HEALTH SCIENCES
item BRUSSOW, HARALD - NESTLE
item BICKARD, DAVID - INSTITUT PASTEUR - FRANCE
item Rich, Joseph
item MILLER, STEFAN - LISANDO GMBH
item DEVILLARD, ESTELLE - ADISSEO FRANCE SAS
item KWAN, JASON - UNIVERSITY OF WISCONSIN
item BERTIN, GERARD - ERAWAN CONSULTING
item REEVES, STUART - EMBRIA HEALTH SCIENCES
item SWIFT, STEVEN
item RAICEK, MARGOT - WORLD ORGANIZATION FOR ANIMAL HEALTH
item GAY, CYRIL

Submitted to: Veterinary Research
Publication Type: Review Article
Publication Acceptance Date: 2/1/2018
Publication Date: 7/31/2018
Citation: Seal, B.S., Drider, D., Oakley, B.B., Brussow, H., Bickard, D., Rich, J.O., Miller, S., Devillard, E., Kwan, J., Bertin, G., Reeves, S., Swift, S.M., Raicek, M., Gay, C.G. 2018. Microbial-derived products as potential new antimicrobials: A report from the Second Alternatives to Antibiotics Symposium. Veterinary Research. 49:66. 10.1186/s13567-018-0563-5.
DOI: https://doi.org/10.1186/s13567-018-0563-5

Interpretive Summary:

Technical Abstract: Due to the continuing global concerns involving antibiotic resistance, there is a need for scientific forums to assess advancements in the development of antimicrobials and their alternatives that might reduce development and spread of antibiotic resistance among bacterial pathogens. The objectives of the Second International Symposium on Alternatives to Antibiotics were to highlight promising research results and novel technologies that can provide alternatives to antibiotics for use in animal health and production, assess challenges associated with their authorization and commercialization for use, and provide actionable strategies to support their development. The session on microbial-derived products was directed at presenting novel technologies that included exploiting CRISPR-Cas nucleases to produce sequence-specific antimicrobials, probiotics development via fecal microbiome transplants among monogastric production animals such as chickens and mining microbial sources such as bacteria or yeast to identify new antimicrobial compounds. Other research has included continuing development of antimicrobial peptides such as newly discovered bacteriocins as alternatives to antibiotics, use of bacteriophages accompanied by development of unique lytic proteins with specific cell-wall binding domains, and novel approaches such as microbial-ecology guided discovery of anti-biofilm compounds discovered in marine environments. The symposium was held at the Headquarters of the World Organisation for Animal Health (OIE) in Paris, France during 12-15 December 2016, and information including presentation materials for the symposium can be accessed at: https://www.ars.usda.gov/alternativestoantibiotics/Symposium2016/index.html.