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ARS Home » Southeast Area » Athens, Georgia » U.S. National Poultry Research Center » Avian Disease and Oncology Research » Research » Publications at this Location » Publication #326192

Research Project: EMPLOYING GENOMICS, EPIGENETICS, AND IMMUNOGENETICS TO CONTROL DISEASES INDUCED BY AVIAN TUMOR VIRUSES

Location: Avian Disease and Oncology Research

Title: The conservation and signatures of lincRNAs in Marek’s disease of chicken

Author
item SONG, JIUZHOU - University Of Maryland
item HE, YANGHUA - University Of Maryland
item Zhang, Huanmin
item YANG, NING - China Agricultural University

Submitted to: Plant and Animal Genome Conference
Publication Type: Abstract Only
Publication Acceptance Date: 12/1/2015
Publication Date: 1/9/2016
Citation: Song, J., He, Y., Zhang, H., Yang, N. 2016. The conservation and signatures of lincRNAs in Marek’s disease of chicken. In Proceedings of: International Conference of Plant and Animal Genome, January 8-13, 2016, San Diego, California. P0664.

Interpretive Summary:

Technical Abstract: Long intergenic non-coding RNAs (lincRNAs) associated with a number of cancers and other diseases have been identified in mammals, but they are still formidable to be comprehensively identified and characterized in chicken. Marek’s disease (MD) is a T cell lymphoma of chickens induced by Marek’s disease virus (MDV). Here, we used a MD chicken model to develop a precise pipeline for identifying lincRNAs and to discover lincRNAs in T cell tumorigenesis. More than 1,000 lincRNA loci were identified in chicken bursa. Computational analyses demonstrated that lincRNAs are conserved among different species such as human, mouse, and chicken. The putative lincRNAs were found to be associated with a wide range of biological functions, including immune responses. Interestingly, we observed distinct lincRNA expression signatures in bursa between MD resistant and susceptible lines. One of the candidate lincRNAs was found to play a crucial role in MD immune response. Thus, our results manifested that lincRNAs may exert considerable influence on MDV-induced T cell tumorigenesis and provide a rich resource for hypothesis-driven functional studies to reveal genetic mechanisms underlying susceptibility to tumorigenesis.