Submitted to: Chemistry and Physics of Lipids
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 11/2/2015
Publication Date: 11/10/2015
Citation: Evans, K.O., Compton, D.L., Laszlo, J.A., Appell, M. 2015. Feruloyl glycerol and 1,3-diferuloyl glycerol antioxidant behavior in phospholipid vesicles. Chemistry and Physics of Lipids. 195:1-11. doi: 10.1016/j.chemphyslip.2015.11.001.
Interpretive Summary: This work highlights the ability to incorporate two natural plant compounds with excellent antioxidant properties useful in skin care industries into a lipid delivery system. Our goal is to develop novel, value-added uses for commodity crops and oils through domestically derived bio-based products. We have demonstrated that the two natural compounds feruloyl glycerol (FG) and diferuloyl glycerol (F2G), made from the combination of ferulic acid and soybean oil, incorporated well into liposomes which are a lipid delivery system frequently used in skin care and cosmetic products. We demonstrated that FG and F2G maintained excellent antioxidant properties without destabilizing the delivery system. These findings provide scientists with a better understanding of how similar molecules can protect against lipid damage due to oxidation and will benefit producers by demonstrating new value-added uses for their commodity crops and oils.
Technical Abstract: Enzymatically synthesized feruloyl¬-sn¬-glycerol (FG) and 1,3-diferuloyl-sn-glycerol (F2G) were both found to partition and incorporate well into 1,2-dioleoylphosphocholine vesicles. Incorporation resulted in vesicles that were as or slightly more stable than the unloaded ones. FG and F2G both demonstrated excellent antioxidant properties and were found well within the lipid bilayer.