Location: Hard Winter Wheat Genetics ResearchTitle: A heterozygous moth genome provides insights into herbivory and detoxification Author
Submitted to: Nature Genetics
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 12/12/2012
Publication Date: 1/13/2013
Publication URL: http://www.nature.com/ng/journal/v45/n2/abs/ng.2524.html
Citation: You, M., Yue, Z., He, W., Yang, X., Yang, G., Xie, M., Zhan, D., Baxter, S.W., Vasseur, L., Gurr, G.M., Douglas, C.J., Bai, J., Wang, P., Cui, K., Huang, S., Li, X., Zhou, Q., Wu, Z., Chen, Q., Liu, C., Wang, B., Li, X., Xu, X., Lu, C., Hu, M., Davey, J.W., Smith, S.M., Chen, M., Xia, X., Tang, W., Ke, F., Zheng, D., Hu, Y., Song, F., You, Y., Ma, X., Peng, L., Zheng, Y., Liang, Y., Chen, Y., Yu, L., Zhang, Y., Liu, Y., Li, G., Fang, L., Li, J., Zhou, X., Lou, Y., Gou, C., Wang, J., Wang, J., Yang, H., Wang, J. 2013. A heterozygous moth genome provides insights into herbivory and detoxification. Nature Genetics. doi:10.1038/ng.2524. Interpretive Summary: The diamondback moth is a serious pest of vegetables worldwide. The insect feeds on plants that produce glucosinolates, which are toxic to other types of insects. The diamondback moth is also highly capable of developing new strains that are resistant to various synthetic chemical pesticides. This study sequenced and analyzed the whole genome of the diamondback moth. The genome is highly heterogeneous and contains 18,071 protein-coding and 1,412 unique genes. Several gene families associated with perception and the detoxification of plant defense compounds are expanded in comparison with those of other insect species. A recent expansion of retrotransposons near detoxification-related genes and a wider system used in the metabolism of plant defense compounds are shown to be involved in the development of insecticide resistance. This work revealed the genetic and molecular bases for an herbivore to adapt to toxic chemicals of host plants.
Technical Abstract: How an insect evolves to become a successful herbivore is of profound biological and practical importance. Herbivores are often adapted to feed on a specific group of evolutionarily and biochemically related host plants, but the genetic and molecular bases for adaptation to plant defense compounds remain poorly understood. We report the first whole-genome sequence of a basal lepidopteran species, Plutella xylostella, which contains 18,071 protein-coding and 1,412 unique genes with an expansion of gene families associated with perception and the detoxification of plant defense compounds. A recent expansion of retrotransposons near detoxification-related genes and a wider system used in the metabolism of plant defense compounds are shown to also be involved in the development of insecticide resistance. This work shows the genetic and molecular bases for the evolutionary success of this worldwide herbivore and offers wider insights into insect adaptation to plant feeding, as well as opening avenues for more sustainable pest management.