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United States Department of Agriculture

Agricultural Research Service

Research Project: GENETIC ENHANCEMENT FOR RESISTANCE TO BIOTIC AND ABIOTIC STRESSES IN HARD WINTER WHEAT

Location: Hard Winter Wheat Genetics Research

Title: A heterozygous moth genome provides insights into herbivory and detoxification)

Author
item You, Minsheng
item Yue, Zhen
item He, Weiyi
item Yang, Xinhua
item Yang, Guang
item Xie, Miao
item Zhan, Dongliang
item Baxter, Simon
item Vasseur, Liette
item Gurr, Geoff
item Douglas, Carl
item Bai, Jianlin
item Wang, Ping
item Cui, Kai
item Huang, Shiguo
item Li, Xianchun
item Zhou, Qing
item Wu, Zhangyan
item Chen, Qilin
item Liu, Chunhui
item Wang, Bo
item Li, Xiaojing
item Xu, Xuifeng
item Lu, Changxin
item Hu, Min
item Davey, John
item Smith, Sandy
item Chen, Ming-shun
item Xia, Xiaofeng
item Tang, Weiqi
item Ke, Fushi
item Zheng, Dandan
item Hu, Yulan
item Song, Fengqin
item You, Yanchun
item Ma, Xiaoli
item Peng, Lu
item Zheng, Yunkai
item Liang, Yong
item Chen, Yaqiong
item Yu, Liying
item Zhang, Younan
item Liu, Yuanyuan
item Li, Guoqing
item Fang, Lin
item Li, Jingxiang
item Zhou, Xin
item Lou, Yadan
item Gou, Caiyun
item Wang, Junyi
item Wang, Jian
item Yang, Huanming
item Wang, Jun

Submitted to: Nature Genetics
Publication Type: Peer reviewed journal
Publication Acceptance Date: 12/12/2012
Publication Date: 1/13/2013
Publication URL: http://www.nature.com/ng/journal/v45/n2/abs/ng.2524.html
Citation: You, M., Yue, Z., He, W., Yang, X., Yang, G., Xie, M., Zhan, D., Baxter, S.W., Vasseur, L., Gurr, G.M., Douglas, C.J., Bai, J., Wang, P., Cui, K., Huang, S., Li, X., Zhou, Q., Wu, Z., Chen, Q., Liu, C., Wang, B., Li, X., Xu, X., Lu, C., Hu, M., Davey, J.W., Smith, S.M., Chen, M., Xia, X., Tang, W., Ke, F., Zheng, D., Hu, Y., Song, F., You, Y., Ma, X., Peng, L., Zheng, Y., Liang, Y., Chen, Y., Yu, L., Zhang, Y., Liu, Y., Li, G., Fang, L., Li, J., Zhou, X., Lou, Y., Gou, C., Wang, J., Wang, J., Yang, H., Wang, J. 2013. A heterozygous moth genome provides insights into herbivory and detoxification. Nature Genetics. doi:10.1038/ng.2524.

Interpretive Summary: The diamondback moth is a serious pest of vegetables worldwide. The insect feeds on plants that produce glucosinolates, which are toxic to other types of insects. The diamondback moth is also highly capable of developing new strains that are resistant to various synthetic chemical pesticides. This study sequenced and analyzed the whole genome of the diamondback moth. The genome is highly heterogeneous and contains 18,071 protein-coding and 1,412 unique genes. Several gene families associated with perception and the detoxification of plant defense compounds are expanded in comparison with those of other insect species. A recent expansion of retrotransposons near detoxification-related genes and a wider system used in the metabolism of plant defense compounds are shown to be involved in the development of insecticide resistance. This work revealed the genetic and molecular bases for an herbivore to adapt to toxic chemicals of host plants.

Technical Abstract: How an insect evolves to become a successful herbivore is of profound biological and practical importance. Herbivores are often adapted to feed on a specific group of evolutionarily and biochemically related host plants, but the genetic and molecular bases for adaptation to plant defense compounds remain poorly understood. We report the first whole-genome sequence of a basal lepidopteran species, Plutella xylostella, which contains 18,071 protein-coding and 1,412 unique genes with an expansion of gene families associated with perception and the detoxification of plant defense compounds. A recent expansion of retrotransposons near detoxification-related genes and a wider system used in the metabolism of plant defense compounds are shown to also be involved in the development of insecticide resistance. This work shows the genetic and molecular bases for the evolutionary success of this worldwide herbivore and offers wider insights into insect adaptation to plant feeding, as well as opening avenues for more sustainable pest management.

Last Modified: 8/24/2016
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