|SHARIFOVA, Z - Tajikistan Academy Of Sciences|
|USMANOVA, C - Tajikistan Academy Of Sciences|
|MUHIDINOV, Z - Tajikistan Academy Of Sciences|
|BOBOKALONOV, J - Tajikistan Academy Of Sciences|
|GORSHKOVA, L - Tajikistan Academy Of Sciences|
Submitted to: Journal of Academy of Sciences of the Republic of Tajikistan
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 11/1/2009
Publication Date: 12/1/2009
Citation: Sharifova, Z.B., Usmanova, C.P., Muhidinov, Z.K., Bobokalonov, J.T., Gorshkova, L.M., Liu, L.S. 2009. Characterization of microparticles prepared by emulsion method from pectin and protein. Journal of Academy of Sciences of the Republic of Tajikistan. 135(2):72-77.
Interpretive Summary: Million tons of pectin are available annually by extraction from the byproducts of agricultural processing, such as apple peel, arrange peel, sugar beet pulp, grape skin, and sunflower heads. Small portion of the byproduct are currently used as fertilizer, animal feeds. Most the byproducts are disposed with additional expense. To use these byproducts in an economically and environmentally effective way has raised attention from academy and industries. In this study, pectin from apple peels was used for drug encapsulation. The resultant hydrogel beads have shown a strong potential as drug delivery systems for colon-specific drug delivery. Fruits growers and juice processers will benefit from this research.
Technical Abstract: In this study, pectin was extracted from apple peel and formulated into microparticles in combination with zein, an edible food protein. The physical, chemical, and structural properties of the resultant pectin structures were evaluated. The resultant microparticles were also examined in vitro for colon-specific drug delivery using media mimicking the physiological conditions from the mouth to the gut. Data obtained was significant and informative for the design of coming in vivo experiments.