Research Project: Personalized Nutrition and Healthy Aging

Location: Jean Mayer Human Nutrition Research Center On Aging

Publications (Clicking on the reprint icon will take you to the publication reprint.)

CC genotype at TCF7L2 diabetes risk locus rs7903146 directs a coordinated fatty acid response to a Mediterranean diet intervention: a randomized controlled trial - (Peer Reviewed Journal)
Parnell, L.D., Lai, C., Holzapfel, C., Christensen, J.J., Ordovas, J.M. 2025. CC genotype at TCF7L2 diabetes risk locus rs7903146 directs a coordinated fatty acid response to a Mediterranean diet intervention: a randomized controlled trial. Lifestyle Genomics. https://doi.org/10.1159/000542468.

Sex-specific differences in intestinal microbiota associated with cardiovascular disease - (Peer Reviewed Journal)
Garcia-Fernandez, H., Arenas-De Larriva, A.P., Lopez-Moreno, J., Gutierrez Mariscal, F., Romero Cabrera, J.L., Molina-Abril, H., Torres Pena, J.D., Rodriguez-Cano, D., Malagon, M.M., Ordovas, J.M., Delgado Lista, J., Perez Martinez, P., Lopez Miranda, J., Camargo, A. 2024. Sex-specific differences in intestinal microbiota associated with cardiovascular disease. Biology of Sex Differences. https://doi.org/10.1186/s13293-024-00582-7.

Dietary antioxidant intake reduces carotid intima-media thickness in coronary heart disease patients: from the CORDIOPREV study - (Peer Reviewed Journal)
Rivas-Garcia, L., Quintana-Navarro, G.M., Torres-Pena, J.D., Arenas-de Larriva, A.P., Alcala-Diaz, J.F., Yubero-Serrano, E.M., Perez-Caballero, A.I., Ortiz-Morales, A.M., Rangel-Zuniga, O., Lopez-Moreno, A., Ordovas, J.M., Perez-Martinez, P., Lopez-Miranda, J., Delgado-Lista, J. 2023. Dietary antioxidant intake reduces carotid intima-media thickness in coronary heart disease patients: From the CORDIOPREV study. Free Radicals in Biology and Medicine. https://doi.org/10.1016/j.freeradbiomed.2023.11.026.

Associations between the new DNA-methylation-based telomere length estimator, the mediterranean diet and genetics in a Spanish population at high cardiovascular risk - (Peer Reviewed Journal)
Coltell, O., Asensio, E.M., Sorli, J.V., Ortega-Azorin, C., Fernandez-Carrion, R., Pascual, E.C., Barragan, R., Gonzalez, J.I., Estruch, R., Alzate, J.F., Perez-Fidalgo, A., Portoles, O., Ordovas, J.M., Corella, D. 2023. Associations between the new DNA-methylation-based telomere length estimator, the mediterranean diet and genetics in a Spanish population at high cardiovascular risk. Antioxidants. https://doi.org/10.3390/antiox12112004.

Associations between the new DNA-methylation-based telo-mere length estimator, the Mediterranean diet, and genetics in a Spanish population at high cardiovascular risk - (Peer Reviewed Journal)
Coltell, O., Asensio, E.M., Sorli, J.V., Ortega-Azorin, C., Fernandez-Carrion, R., Pascual, E.C., Barragan, R., Gonzalez, J.I., Estruch, R., Alzate, J.F., Perez-Fidalgo, A., Portoles, O., Ordovas, J.M. 2023. Associations between the new DNA-methylation-based telo-mere length estimator, the Mediterranean diet, and genetics in a Spanish population at high cardiovascular risk. Antioxidants. https://doi.org/10.3390/antiox12112004.

APOE4 allele-specific associations between diet, multimodal biomarkers, and cognition among Puerto Rican adults in Massachusetts - (Peer Reviewed Journal)
Guan, Y., Cheng, C., Bellomo, L.I., Narain, S., Bigornia, S., Garelnabi, M., Scott, T., Ordovas, J.M., Tucker, K.L., Bhadelia, R., Koo, B. 2023. APOE4 allele-specific associations between diet, multimodal biomarkers, and cognition among Puerto Rican adults in Massachusetts. Frontiers in Aging Neuroscience. https://doi.org/10.3389/fnagi.2023.1285333.

Rate-limiting enzymes in cardiometabolic health and aging in humans - (Peer Reviewed Journal)
Parnell, L.D., McCaffrey, K.S., Brooks, A., Smith, C.E., Lai, C., Christensen, J.J., Wiley, C.D., Ordovas, J.M. 2023. Rate-limiting enzymes in cardiometabolic health and aging in humans. Lifestyle Genomics. 16:124-138. https://doi.org/10.1159/000531350.

A multi-omics approach unveils an association between subclinical atherosclerosis and epigenetic age acceleration mediated by systemic inflammation - (Peer Reviewed Journal)
Sanchez-Cabo, F., Fuster, V., Silla, J., Gonzalez, G., Lorenzo-Vivas, E., Alvarez, R., Callejas, S., Benguria, A., Gil, E., Nunez, E., Oliva, B., Mendiguren, J.M., Cortes-Canteli, M., Bueno, H., Andres, V., Ordovas, J.M., Fernandez-Freira, L., Quesada, A.J., Garcia, J.M., Rossello, X., Vasquez, J., Dopazo, A., Fernandez-Ortiz, A., Ibanez, B., Fuster, J.J., Lara-Pezzi, E. 2023. A multi-omics approach unveils an association between subclinical atherosclerosis and epigenetic age acceleration mediated by systemic inflammation. European Heart Journal. https://doi.org/10.1093/eurheartj/ehad361.

Characterisation of fasting and postprandial NMR metabolites: insights from the ZOE PREDICT 1 study - (Peer Reviewed Journal)
Bermingham, K.M., Mazidi, M., Franks, P.W., Maher, T., Valdes, A.M., Linenberg, I., Wolf, J., Hadjigeorgiou, G., Spector, T.D., Menni, C., Ordovas, J.M., Berry, S.E., Hall, W.L. 2023. Characterisation of fasting and postprandial NMR metabolites: Insights from the ZOE PREDICT 1 study. Nutrients. https://doi.org/10.3390/nu15112638.

The epigenetics of early cardiovascular and metabolic diseases development: from mechanisms to precision medicine - (Review Article)
Baccarelli, A., Ordovas, J.M. 2023. The epigenetics of early cardiovascular and metabolic diseases development: From mechanisms to precision medicine. Circulation Research. 132(12):1648-1662. https://doi.org/10.1161/CIRCRESAHA.123.322135.

Omega-3 fatty acids and individual variability in plasma triglyceride response: a mini-review - (Review Article)
Runblad, A., Sandoval, V., Holven, K., Ordovas, J.M., Ulven, S. 2023. Omega-3 fatty acids and individual variability in plasma triglyceride response: A mini-review. Redox Biology. https://doi.org/10.1016/j.redox.2023.102730.

A multifaceted approach to precision nutrition: the genome, epigenome, and microbiome in the prevention and therapy of cardiovascular diseases - (Book / Chapter)

DNA methylation signatures of tobacco smoking in a high cardiovascular risk population: modulation by the mediterranean diet - (Peer Reviewed Journal)
Fernandez-Carrion, R., Sorli, J.V., Asensio, E.M., Pascual, E.C., Portoles, O., Alvarez Sala, A., Frances, F., Ramirez Sabio, J.B., Perez Fidalgo, A., Villamil, L., Tinahones, F.J., Estruch, R., Ordovas, J.M., Coltell, O., Corella, D. 2023. DNA methylation signatures of tobacco smoking in a high cardiovascular risk population: Modulation by the mediterranean diet. International Journal of Environmental Research and Public Health. https://doi.org/10.3390/ijerph20043635.

The impact of alcoholic drinks and dietary factors on epigenetic markers associated with triglyceride levels - (Peer Reviewed Journal)
Lai, C., Parnell, L.D., Lee, Y., Zeng, H., Smith, C., Mckeowan, N.M., Ordovas, J.M. 2023. The impact of alcoholic drinks and dietary factors on epigenetic markers associated with triglyceride levels. Frontiers in Genetics. https://doi.org/10.3389/fgene.2023.1117778.

Dietary responses of dementia-related genes encoding metabolic enzymes - (Peer Reviewed Journal)
Parnell, L.D., Magadmi, R., Zwanger, S., Shukitt Hale, B., Lai, C., Ordovas, J.M. 2023. Dietary responses of dementia-related genes encoding metabolic enzymes. Nutrients. 15(3):644. https://doi.org/10.3390/nu15030644.

Changes in quantity plant based protein intake on type 2 diabetes remission in coronary heart disease patients: from the CORDIOPREV study - (Peer Reviewed Journal)
Guitierrez Mariscal, F., Alcala Diaz, J., Quintana Navarro, G., de la Cruz, A.S., Torres Pena, J.D., Cardelo, M.P., Arenas Larriva, A.P., Malagon, M.M., Romero Cabrera, J.L., Ordovas, J.M., Perez Martinez, P., Delgado Lista, J., Yubero Serrano, E., Lopez Miranda, J. 2023. Changes in quantity plant based protein intake on type 2 diabetes remission in coronary heart disease patients: From the CORDIOPREV study. European Journal of Nutrition. https://doi.org/10.1007/s00394-022-03080-x.

Metabolomic profiling in dogs with dilated cardiomyopathy eating non-traditional or traditional diets and in healthy controls - (Peer Reviewed Journal)
Smith, C.E., Parnell, L.D., Lai, C., Rush, J.E., Adin, D.B., Ordovas, J.M., Freeman, L.M. 2022. Metabolomic profiling in dogs with dilated cardiomyopathy eating non-traditional or traditional diets and in healthy controls. Scientific Reports. https://doi.org/10.1038/s41598-022-26322-8.

APOE genotypes modulate inflammation independently of their effect on lipid metabolism - (Peer Reviewed Journal)
Civeira-Marin, M., Cenarro, A., Marco-Benedi, V., Bea, A.M., Mateo-Gallego, R., Moreno-Franco, B., Ordovas, J.M., Laclaustra, M., Civeira, F., Lamiquiz-Moneo, I. 2022. APOE genotypes modulate inflammation independently of their effect on lipid metabolism. International Journal of Molecular Sciences. https://doi.org/10.3390/ijms232112947.

TMAO upregulates members of the miR-17/92 cluster and impacts targets associated with atherosclerosis - (Peer Reviewed Journal)
Diez-Ricote, L., Ruiz-Valderrey, P., Mico, V., Blanco, R., Tome-Carneiro, J., Davalos, A., Ordovas, J.M., Daimiel, L. 2022. TMAO upregulates members of the miR-17/92 cluster and impacts targets associated with atherosclerosis. International Journal of Molecular Sciences. https://doi.org/10.3390/ijms232012107.

Research gaps and opportunities in precision nutrition: an NIH workshop report - (Review Article)
Lee, B.Y., Ordovas, J.M., Parks, E.J., Anderson, C.A., Barabasi, A., Clinton, S.K., De La Haye, K., Duffy, V.B., Franks, P.W., Ginexi, E.M., Hammond, K.J., Hanlon, E.C., Hittle, M., Ho, E., Horn, A.L., Isaacson, R.S., Mabry, P.L., Malone, S., Martin, C.K., Mattei, J., Meydani, S.N., Nelson, L.M., Neuhouser, M., Parent, B.J., Pronk, N.P., Roche, H.M., Saira, S., Scheer, F.A., Segal, E., Sevick, M., Spector, T.D., Van Horn, L.B., Varady, K.A., Saroja Voruganti, V., Ferguson, M. 2022. Research gaps and opportunities in precision nutrition: an NIH workshop report. The American Journal of Clinical Nutrition. https://doi.org/10.1093/ajcn/nqac237.

Precision nutrition: maintaining scientific integrity while realizing market potential - (Review Article)
Berciano, S., Figueiredo, J., Brisbois, T.D., Alford, S., Koecher, K., Eckhouse, S., Ciati, R., Kussmann, M., Ordovas, J.M., Stebbins, K., Blumberg, J.B. 2022. Precision nutrition: maintaining scientific integrity while realizing market potential. Frontiers in Nutrition. https://doi.org/10.3389/fnut.2022.979665.

A metabolomic signature of the APOE2 allele - (Peer Reviewed Journal)
Sebastiani, P., Song, Z., Ellis, D., Tian, Q., Schwaiger-Haber, M., Stancliffe, E., Lustgarten, M., Funk, C., Baloni, P., Marron, M.M., Gurinovich, A., Li, M., Leschyk, A., Monti, S., Montasser, M., Feitosa, M.F., Ordovas, J.M., Haigis, M., Milman, S., Barzilai, N., Ferrucci, L., Rappaport, N., Patti, G.J., Perls, T.T. 2022. A metabolomic signature of the APOE2 allele. GeroScience. https://doi.org/10.1007/s11357-022-00646-9.

Genetic biomarkers of metabolic detoxification for personalized lifestyle medicine - (Review Article)
Aronica, L., Ordovas, J.M., Volkov, A., Lamb, J.J., Stone, P., Minich, D.M., Leary, M., Class, M., Metti, D., Larson, I.A., Contractor, N., Eck, B., Bland, J. 2022. Genetic biomarkers of metabolic detoxification for personalized lifestyle medicine. Nutrients. https://doi.org/10.3390/nu14040768.

Validity of continuous glucose monitoring for categorizing glycemic responses to diet: implications for use in personalized nutrition - (Peer Reviewed Journal)
Merino, J., Linenberg, I., Bermingham, K.M., Ganesh, S., Bakker, E., Delahanty, L.M., Chan, A.T., Pujol, J.C., Wolf, J., Al Khatib, H., Franks, P.W., Spector, T.D., Ordovas, J.M., Berry, S.E., Valdes, A.M. 2022. Validity of continuous glucose monitoring for categorizing glycemic responses to diet: implications for use in personalized nutrition. American Journal of Clinical Nutrition. https://doi.org/10.1093/ajcn/nqac026.

Personalized lifestyle intervention and functional evaluation health outcomes survey: presentation of the LIFEHOUSE study using N-of-One Tent-Umbrella-Bucket Design - (Review Article)
Lamb, J.J., Sone, M., D'Adamo, C.R., Volkov, A., Metti, D., Aronica, L., Minich, D., Leary, M., Class, M., Carullo, M., Ryan, J.J., Larson, I.A., Lundquist, E., Contractor, N., Eck, B., Ordovas, J.M., Bland, J.S. 2022. Personalized lifestyle intervention and functional evaluation health outcomes survey: presentation of the LIFEHOUSE study using N-of-One Tent-Umbrella-Bucket Design. Personalized Medicine. https://doi.org/10.3390/jpm12010115.

Long-term consumption of a mediterranean diet or a low-fat diet on kidney function in coronary heart disease patients: The CORDIOPREV randomized controlled trial - (Peer Reviewed Journal)
Podadera-Herreros, A., Alcala-Diaz, J.F., Gutierrez-Mariscal, F.M., Jimenez-Torres, J., Cruz-Ares, S., Arenas-De Larriva, A.P., Cardelo, M.P., Torres-Pena, J.D., Luque, R.M., Ordovas, J.M., Delgado-Lista, J., Lopez-Miranda, J., Yubereo-Serrano, E.M. 2022. Long-term consumption of a mediterranean diet or a low-fat diet on kidney function in coronary heart disease patients: The CORDIOPREV randomized controlled trial. Clinical Nutrition. 41(2):552-559. https://doi.org/10.1016/j.clnu.2021.12.041.

Sweet taste preference: Relationships with other tastes, liking for sugary foods and exploratory genome-wide association analysis in subjects with metabolic syndrome - (Peer Reviewed Journal)
Fernandez-Carrion, R., Sorli, J.V., Coltell, O., Pascual, E.C., Ortega-Azorin, C., Barragan, R., Gimenez-Alba, I., Alvarez-Sala, A., Fito, M., Ordovas, J., Corella, D. 2021. Sweet taste preference: Relationships with other tastes, liking for sugary foods and exploratory genome-wide association analysis in subjects with metabolic syndrome. Biomedicines. https://doi.org/10.3390/biomedicines10010079.

Chronodisruption and cardiovascular disease - (Review Article)
Garcia-Rios, A., Ordovas, J.M. 2022. Chronodisruption and cardiovascular disease. Clinica e Investigacion en Arteriosclerosis. 34:S32-S37. https://doi.org/10.1016/j.arteri.2021.12.004.

Poor self-reported sleep is associated with risk factors for cardiovascular disease: a cross-sectional analysis in half a million adults - (Peer Reviewed Journal)
Valenzuela, P.L., Santos-Lozano, A., Torres Barran, A., Morales, J.S., Castillo-Garcia, A., Ruilope, L.M., Rios-Insua, D., Ordovas, J.M., Lucia, A. 2021. Poor self-reported sleep is associated with risk factors for cardiovascular disease: a cross-sectional analysis in half a million adults. European Journal of Clinical Investigation. e13738. https://doi.org/10.1111/eci.13738.

Using machine learning to predict obesity based on genome-wide, epigenome-wide gene-gene and gene-diet interactions - (Peer Reviewed Journal)
Lee, Y., Christensen, J.J., Parnell, L.D., Smith, C.E., Shao, J.Y., McKeown, N.M., Ordovas, J.M., Lai, C. 2022. Using machine learning to predict obesity based on genome-wide, epigenome-wide gene-gene and gene-diet interactions. Frontiers in Genetics. 12:783845. https://doi.org/10.3389/fgene.2021.783845.

Diabetes remission is modulated by branched chain amino acids according to the diet consumed: From the CORDIOPREV Study - (Peer Reviewed Journal)
Cardelo, M.P., Alcala-Diaz, J.F., Gutierrez-Mariscal, F.M., Lopez-Moreno, J., Villasanta-Gonzalez, A., Arenas-De Larriva, A., De La Cruz-Ares, S., Delgado-Lista, J., Rodriguez-Cantalejo, F., Luque, R.M., Ordovas, J., Perez-Martinez, P., Camargo, A., Lopez-Miranda, J. 2022. Diabetes remission is modulated by branched chain amino acids according to the diet consumed: From the CORDIOPREV Study. Molecular Nutrition and Food Research. https://doi.org/10.1002/mnfr.202100652.

Chronodisruption and diet associated with increased cardiometabolic risk in coronary heart disease patients: the CORDIOPREV study - (Peer Reviewed Journal)
Romero-Cabrera, J., Garaulet, M., Jimenez-Torres, J., Alcala-Diaz, J.F., Quintana-Navarro, G.M., Martin-Piedra, L., Torres-Pena, J.D., Rodriguez-Cantalejo, F., Rangel-Zuniga, O.A., Yubero-Serrano, E.M., Luque, R.M., Ordovas, J.M., Lopez-Miranda, J., Perez-Martinez, P., Garcia-Rios, A. 2021. Chronodisruption and diet associated with increased cardiometabolic risk in coronary heart disease patients: the CORDIOPREV study. Translational Research. https://doi.org/10.1016/j.trsl.2021.11.001.

Integrative development of a short screening questionnaire of highly processed food consumption (sQ-HPF) - (Peer Reviewed Journal)
Martinez-Perez, C., Daimiel, L., Climent-Mainar, C., Martinez-Gonzalez, M.A., Salas-Salvado, J., Corella, D., Schroder, H., Martinez, J., Alonso-Gomez, A.M., Warnberg, J., Vioque, J., Romaguera, D., Lopez-Miranda, J., Estruch, R., Tinahones, F.J., Lapetra, J., Serra-Majem, L., Bueno-Cavanillas, A., Tur, J.A., Sanchez, V.M., Pinto, X., Delgado-Rodriguez, M.A., Matia-Martin, P., Vidal, J., Vazquez, C., Ros, E., Basterra, J., Babio, N., Guillem-Saiz, P., Zomeno, M., Abete, I., Vaquero-Luna, J., Baron-Lopez, F.J., Gonzalez-Palacios, S., Konieczna, J., Garcia-Rios, A., Bernal-Lopez, M., Santos-Lozano, J., Bes-Rastrollo, M., Khoury, N., Saiz, C., Perez-Vega, K.A., Zulet, M., Tojal-Sierra, L., Vazquez Ruiz, Z., Martinez, M.A., Malcampo, M., Ordovas, J.M., San-Cristobal, R. 2022. Integrative development of a short screening questionnaire of highly processed food consumption (sQ-HPF). International Journal of Behavioral Nutrition and Physical Activity. 19(1):6. https://doi.org/10.1186/s12966-021-01240-6.

Trimethylamine n-Oxide (TMAO) modulates the expression of cardiovascular disease-related microRNAs and their targets - (Peer Reviewed Journal)
Diez-Ricote, L., Ruiz-Valderrey, P., Mico, V., Blanco-Rojo, R., Tome-Carneiro, J., Davalos, A., Ordovas, J.M., Daimiel, L. 2021. Trimethylamine n-Oxide (TMAO) modulates the expression of cardiovascular disease-related microRNAs and their targets. International Journal of Molecular Sciences. 22(20):11145. https://doi.org/10.3390/ijms222011145.

Dietary saturated fats and health: Are the U.S. guidelines evidence-based? - (Review Article)
Astrup, A., Teicholz, N., Magkos, F., Bier, D., Brenna, J., King, J.C., Mente, A., Ordovas, J.M., Volek, J.S., Yussuf, S., Krauss, R.M. 2021. Dietary saturated fats and health: Are the U.S. guidelines evidence-based? Nutrients. 13(10):3305. https://doi.org/10.3390/nu13103305.

Precision nutrition for gut microbiome and diabetes research: Application of nutritional n-of-1 clinical trials - (Other)
Zheng, J., Ordovas, J.M. 2021. Precision nutrition for gut microbiome and diabetes research: Application of nutritional n-of-1 clinical trials. Journal of Diabetes. https://doi.org/10.1111/1753-0407.13220.

Impact of insufficient sleep on dysregulated blood glucose control under standardised meal conditions - (Peer Reviewed Journal)
Tsereteli, N., Vallat, R., Fernandez-Tajes, J., Delahanty, L.M., Ordovas, J.M., Drew, D.A., Valdes, A.M., Segata, N., Chan, A., Wolf, J., Berry, S.E., Walker, M.P., Spector, T.D., Franks, P.W. 2021. Impact of insufficient sleep on dysregulated blood glucose control under standardised meal conditions. Diabetologia. 65:356-365. https://doi.org/10.1007/s00125-021-05608-y.

Associations of network-derived metabolite clusters with prevalent type 2 diabetes among adults of Puerto Rican descent - (Peer Reviewed Journal)
Haslam, D.E., Liang, L., Wang, D.D., Kelly, R.S., Wittenbecher, C., Perez, C.M., Martinez, M., Lee, C., Clish, C., Wong, D., Parnell, L.D., Lai, C., Ordovas, J.M., Manson, J.E., Hu, F.B., Stampfer, M.J., Tucker, K.L., Joshipura, K., Bhupathiraju, S.N. 2021. Associations of network-derived metabolite clusters with prevalent type 2 diabetes among adults of Puerto Rican descent. BMJ Open Diabetes Research & Care. https://doi.org/10.1136/bmjdrc-2021-002298.

Beta cell functionality and hepatic insulin resistance are major contributors to type 2 diabetes remission and starting pharmacological therapy: from CORDIOPREV randomized controlled trial - (Peer Reviewed Journal)
Roncero-Ramos, I., Gutierrez-Mariscal, F.M., Gomez-Delgado, F., Villasanta-Gonzalez, A., Torres-Pena, J.D., De La Cruz-Ares, S., Rangel-Zuniga, O.A., Luque, R.M., Ordovas, J.M., Delgado-Lista, J., Perez-Martinez, P., Camargo, A., Alcala-Diaz, J.F., Lopez-Miranda, J. 2021. Beta cell functionality and hepatic insulin resistance are major contributors to type 2 diabetes remission and starting pharmacological therapy: from CORDIOPREV randomized controlled trial. Translational Research. https://doi.org/10.1016/j.trsl.2021.07.001.

Use of different food classification systems to assess the association between ultra-processed food consumption and cardiometabolic health in an elderly population with metabolic syndrome (PREDIMED-Plus Cohort) - (Peer Reviewed Journal)
Martinez-Perez, C., San-Cristobal, R., Guallar-Castillon, P., Martinez-Gonzalez, M.A., Salas-Salvado, J., Corella, D., Castaner, O., Martinez, J., Alonso-Gomez, A., Warnberg, J., Vioque, J., Romaguera, D., Lopez-Miranda, J., Estruch, R., Tinahones, F., Lapetra, J., Serra-Majem, L., Bueno-Cavanillas, A., Tur, J.A., Sanchez, V.M., Pinto, X., Gaforio, J., Matia-Martin, P., Vidal, J., Vasquez, C., Ros, E., Bes-Rostrollo, M., Babio, N., Sorli, J.V., Lassale, C., Perez-Sanz, B., Vaquero-Luna, J., Ajejas Bazan, M., Barcelo-Iglesias, M.N., Konieczna, J., Garcia-Rios, A., Bernal-Lopez, M., Santos-Lozano, J., Toledo, E., Becerra-Tomas, N., Portoles, O., Zomeno, M., Abete, I., Moreno-Rodriguez, A., Lecea-Juarez, O., Nishi, S., Munoz-Martinez, J., Ordovas, J.M., Daimiel, L. 2021. Use of different food classification systems to assess the association between ultra-processed food consumption and cardiometabolic health in an elderly population with metabolic syndrome (PREDIMED-Plus Cohort). Nutrients. 13(7):2471. https://doi.org/10.3390/nu13072471.

Investigation of diets associated with dilated cardiomyopathy in dogs using foodomics analysis - (Peer Reviewed Journal)
Smith, C., Parnell, L.D., Lai, C., Rush, J.E., Freeman, L.M. 2021. Investigation of diets associated with dilated cardiomyopathy in dogs using foodomics analysis. Scientific Reports. 11:15881. https://doi.org/10.1038/s41598-021-94464-2.

Anti-COVID-19 measures threaten our healthy body weight: Changes in sleep and external synchronizers of circadian clocks during confinement - (Peer Reviewed Journal)
Baquerizo-Sedano, L., Chaquila, J.A., Aguilar, L., Ordovas, J.M., Gonzalez-Muniesa, P., Garaulet, M. 2021. Anti-COVID-19 measures threaten our healthy body weight: Changes in sleep and external synchronizers of circadian clocks during confinement. Clinical Nutrition. https://doi.org/10.1016/j.clnu.2021.06.019.

Individual postprandial glycemic responses to diet in n-of-1 trials: Westlake N-of-1 trials for macronutrient intake (WE-MACNUTR) - (Peer Reviewed Journal)
Ma, Y., Fu, Y., Tian, Y., Gou, W., Miao, Z., Yang, M., Ordovas, J.M., Zheng, J. 2021. Individual postprandial glycemic responses to diet in n-of-1 trials: Westlake N-of-1 trials for macronutrient intake (WE-MACNUTR). Journal of Nutrition. 151(10):3158-3167. https://doi.org/10.1093/jn/nxab227.

An altered microbiota pattern precedes Type 2 diabetes mellitus development: From the CORDIOPREV study - (Peer Reviewed Journal)
Vals-Delgado, C., Alcala-Diaz, J.F., Molina-Abril, H., Roncero-Ramos, I., Caspers, M.P., Schuren, F.H., Van Den Broek, T.J., Luque, R.M., Perez-Martinez, P., Katsiki, N., Delgado-Lista, J., Ordovas, J., Van Ommen, B., Camargo, A., Lopez-Miranda, J. 2021. An altered microbiota pattern precedes Type 2 diabetes mellitus development: From the CORDIOPREV study. Journal of Advanced Research. https://doi.org/10.1016/j.jare.2021.05.001.

Genetics of sleep and insights into its relationship with obesity - (Review Article)
Dashti, H.S., Ordovas, J.M. 2021. Genetics of sleep and insights into its relationship with obesity. Annual Review of Nutrition. https://doi.org/10.1146/annurev-nutr-082018-124258.

Mediterranean diet reduces atherosclerosis progression in coronary heart disease: An analysis of the CORDIOPREV randomized controlled trial - (Peer Reviewed Journal)
Jimenez-Torres, J., Alcala-Diaz, J.F., Torres-Pena, J.D., Gutierrez-Mariscal, F.M., Leon-Acuna, A., Gomez-Luna, P., Fernandez-Gandara, C., Quintana-Navarro, G., Fernandez-Garcia, J.C., Perez-Martinez, P., Ordovas, J.M., Delgado-Lista, J., Yubero-Serrano, E.M., Lopez-Miranda, J. 2021. Mediterranean diet reduces atherosclerosis progression in coronary heart disease: An analysis of the CORDIOPREV randomized controlled trial. Stroke. 52(11):3440-3449. https://doi.org/10.1161/STROKEAHA.120.033214.

Meal-induced inflammation: postprandial insights from the Personalised REsponses to DIetary Composition Trial (PREDICT) study in 1000 participants - (Peer Reviewed Journal)
Mazidi, M., Valdes, A.M., Ordovas, J.M., Hall, W.L., Pujol, J.C., Wolf, J., Hadjigeorgiou, G., Segata, N., Sattar, N., Koivula, R., Spector, T.D., Franks, P.W., Berry, S.E. 2021. Meal-induced inflammation: postprandial insights from the Personalised REsponses to DIetary Composition Trial (PREDICT) study in 1000 participants. American Journal of Clinical Nutrition. 114(3):1028-1038. https://doi.org/10.1093/ajcn/nqab132.

Work shift, lifestyle factors, and subclinical atherosclerosis in Spanish male workers: A mediation analysis - (Peer Reviewed Journal)
Penalvo, J.L., Mertens, E., Munoz-Cabrejas, A., Leon-Latre, M., Jarauta, E., Laclaustra, M., Ordovas, J.M., Casasnovas, J.A., Uzhova, I., Moreno-Franco, B. 2021. Work shift, lifestyle factors, and subclinical atherosclerosis in Spanish male workers: A mediation analysis. Nutrients. https://doi.org/10.3390/nu13041077.

Association between cholesterol efflux capacity and peripheral artery disease in coronary heart disease patients with and without type 2 diabetes: from the CORDIOPREV study - (Peer Reviewed Journal)
Yubero-Serano, E.M., Alcala-Diaz, J.F., Gutierrez-Mariscal, F., Arrinas De Larriva, A.P., Pena-Orihuela, P.J., Blanco-Rojo, R., Martinez-Botas, J., Torres-Pena, J.D., Perez-Martinez, P., Ordovas, J.M., Delgado-Lista, J., Gomez-Coronado, D., Lopez-Miranda, J. 2021. Association between cholesterol efflux capacity and peripheral artery disease in coronary heart disease patients with and without type 2 diabetes: from the CORDIOPREV study. Cardiovascular Diabetology. 20:72. https://doi.org/10.1186/s12933-021-01260-3.

Association between physical activity and cardiovascular risk factors: Dose and sex matter - (Other)
Santos-Lozano, A., Cervantes, M., Fernandez-Navarro, P., Valenzuela, P.L., Castillo-Garcia, A., Ruilope, L.M., Rios Insua, D., Ordovas, J.M., Ley, V., Alejandro, L. 2021. Association between physical activity and cardiovascular risk factors: Dose and sex matter. Journal of Sport and Health Science. 10(5):604-606. https://doi.org/10.1016/j.jshs.2021.03.002.

A microbiota-based predictive model for type 2 diabetes remission induced by dietary intervention: From the CORDIOPREV study - (Other)
Vals-Delgado, C., Alcala-Diaz, J.F., Roncero-Ramos, I., Leon-Acuna, A., Molina-Abril, H., Gutierrez-Mariscal, F.M., Romero-Cabrera, J.L., De La Cruz-Ares, S., Van Ommen, B., Castano, J., Ordovas, J.M., Perez-Martinez, P., Delgado-Lista, J., Camargo, A., Lopez-Miranda, J. 2021. A microbiota-based predictive model for type 2 diabetes remission induced by dietary intervention: From the CORDIOPREV study. Clinical and Translational Medicine. 11(4):e326. https://doi.org/10.1002/ctm2.326.

Alcoholic and non-alcoholic beer modulate plasma and macrophage microRNAs differently in a pilot intervention in humans with cardiovascular risk - (Peer Reviewed Journal)
Daimiel, L., Mico, V., Diez-Ricote, L., Ruiz-Valderrey, P., Istas, G., Rodriguez-Mateos, A., Ordovas, J. 2020. Alcoholic and non-alcoholic beer modulate plasma and macrophage microRNAs differently in a pilot intervention in humans with cardiovascular risk. Nutrients. 13(1):69. https://doi.org/10.3390/nu13010069.

Microbiome connections with host metabolism and habitual diet from 1,098 deeply phenotyped individuals - (Peer Reviewed Journal)
Asnicar, F., Berry, S.E., Valdes, A.M., Nguyen, L.H., Piccinno, G., Drew, D.A., Leeming, E., Gibson, R., Le Roy, C., Khatib, H.A., Francis, L., Mazidi, M., Mompeo, O., Valles-Colomer, M., Tett, A., Beghini, F., Dubois, L., Bazzani, D., Thomas, A., Mirzayi, C., Khleborodova, A., Oh, S., Hine, R., Bonnett, C., Capdevila, J., Danzanvilliers, S., Giordano, F., Geistlinger, L., Waldron, L., Davies, R., Hadjigeorgiou, G., Wolf, J., Ordovas, J.M., Gardner, C.D., Franks, P.W., Chan, A., Huttenhower, C., Spector, T.D., Segata, N. 2021. Microbiome connections with host metabolism and habitual diet from 1,098 deeply phenotyped individuals. Nature Medicine. 27:321-332. https://doi.org/10.1038/s41591-020-01183-8.

A set of miRNAs predicts T2DM remission in patients with coronary heart disease: from the CORDIOPREV study - (Peer Reviewed Journal)
Rangel-Zuniga, O.A., Vals-Delgado, C., Alcala-Diaz, J.F., Quintana-Navarro, G., Krylova, Y., Leon-Acuna, A., Luque, R.M., Gomez-Delgado, F., Delgado-Lista, J., Ordovas, J.M., Perez-Martinez, P., Camargo, A., Lopez-Miranda, J. 2020. A set of miRNAs predicts T2DM remission in patients with coronary heart disease: from the CORDIOPREV study. Molecular Therapy - Nucleic Acids. 23:255-263. https://doi.org/10.1016/j.omtn.2020.11.001.

Chronological age interacts with the circadian melatonin receptor 1B gene variation, determining fasting glucose concentrations in Mediterranean populations. Additional analyses on type-2 diabetes risk - (Peer Reviewed Journal)
Sorli, J.V., Barragan, R., Coltell, O., Portoles, O., Pascual, E.C., Ortega-Azorin, C., Gonzalez, J.I., Estruch, R., Saiz, C., Perez-Fidalgo, A., Ordovas, J.M., Corella, D. 2020. Chronological age interacts with the circadian melatonin receptor 1B gene variation, determining fasting glucose concentrations in Mediterranean populations. Additional analyses on type-2 diabetes risk. Nutrients. 12(11):3323. https://doi.org/10.3390/nu12113323.

Association between coffee consumption and total dietary caffeine intake with cognitive functioning: cross-sectional assessment in an elderly Mediterranean population - (Peer Reviewed Journal)
Graniel, I.P., Babio, N., Becerra-Tomas, N., Toledo, E., Camacho-Barcia, L., Corella, D., Castaner-Nino, O., Romaguera, D., Vioque, J., Alonso-Gomez, A.M., Warnberg, J., Martinez, J.A., Serra-Majem, L., Estruch, R., Tinahones, F., Fernandez-Aranda, F., Lapertra, J., Pinto, X., Tur, J.A., Garcia-Rios, A., Bueno-Cavanillas, A., Gaforio, J.J., Matia-Martin, P., Daimiel, L., Sanchez, V.M., Prieto-Sanchez, L., Ros, E., Razquin, C., Mestres, C., Sorli, J.V., Cuenca-Royo, A., Rios, A., Torres-Collado, L., Vaquero-Luna, J., Perez-Farinos, N., Zulet, M.A., Sanchez-Villegas, A., Casas, R., Bernal-Lkopez, M., Santos-Lozano, J., Corbella, X., Mateos, D., Buil-Cosiales, P., Jimenez-Murcia, S., Fernandez-Carrion, R., Forcano-Gamazo, L., Lopez, M., Sempere-Pascual, M.A., Moreno-Rodriquez, A., Gea, A., de la Torre-Fornell, R., Salas-Salvado, J., Ordovas, J.M. 2020. Association between coffee consumption and total dietary caffeine intake with cognitive functioning: Cross-sectional assessment in an elderly Mediterranean population. European Journal of Nutrition. https://doi.org/10.1007/s00394-020-02415-w.

A diet-dependent microbiota profile associated with incident type 2 diabetes: From the CORDIOPREV study - (Peer Reviewed Journal)
Camargo, A., Vais-Delgado, C., Alcala-Diaz, J.F., Vallasanta-Gonzalez, A., Gomez-Delgado, F., Haro, C., Leon-Acuna, A., Cardelo, M.P., Torres-Pena, J.D., Guler, I., Malagon, M.M., Ordovas, J.M., Perez-Martinez, P., Delgado-Lista, J., Lopez-Miranda, J. 2020. A diet-dependent microbiota profile associated with incident type 2 diabetes: From the CORDIOPREV study. Molecular Nutrition and Food Research. 64(23):2000730. https://doi.org/10.1002/mnfr.202000730.

Association between body size phenotypes and subclinical atherosclerosis - (Peer Reviewed Journal)
Rossello, X., Fuster, V., Oliva, B., Fernandez-Friera, L., Lopez-Melgar, B., Mendiguren, J.M., Lara-Pezzi, E., Bueno, H., Fernandez-Ortiz, A., Ibanez, B., Ordovas, J.M. 2020. Association between body size phenotypes and subclinical atherosclerosis. Journal of Clinical Endocrinology and Metabolism. 105(12):3734-3744. https://doi.org/10.1210/clinem/dgaa620.

Mediterranean diet and endothelial function in patients with coronary heart disease: an analysis of the CORDIOPREV randomized controlled trial - (Peer Reviewed Journal)
Yubero-Serrano, E., Fernandez-Gandara, C., Garcia-Rios, A., Rangel-Zuniga, O.A., Gutierrez-Mariscal, F.M., Torres-Pena, J.D., Marin, C., Lopez-Moreno, J., Castano, J., Delgado-Lista, J., Ordovas, J.M., Perez-Martinez, P., Lopez-Miranda, J. 2020. Mediterranean diet and endothelial function in patients with coronary heart disease: an analysis of the CORDIOPREV randomized controlled trial. PLoS Medicine. 17(9):e1003282. https://doi.org/10.1371/journal.pmed.1003282.

Personalized nutrition and healthy aging - (Review Article)
Ordovas, J.M., Berciano, S. 2020. Personalized nutrition and healthy aging. Nutrition Reviews. 78(S3):58-65. https://doi.org/10.1093/nutrit/nuaa102.

Machine learning improves cardiovascular risk definition for young, asymptomatic individuals - (Peer Reviewed Journal)
Sanchez-Cabo, F., Rossello, X., Fuster, V., Benito, F., Manzano, J., Silla, J., Fernandez-Alvira, J.M., Oliva, B., Fernandez-Friera, L., Lopez-Melgar, B., Mendiguren, J.M., Sanz, J., Ordovas, J.M., Andres, V., Fernandez-Ortiz, A., Bueno, H., Ibanez, B., Garcia-Ruiz, J., Lara-Pezzi, E. 2020. Machine learning improves cardiovascular risk definition for young, asymptomatic individuals. Journal of the American College of Cardiology. 76(14):1674-1685. https://doi.org/10.1016/j.jacc.2020.08.017.

Gene-diet interactions in colorectal cancer: survey design, instruments, participants and descriptive data of a case-control study in the Basque country - (Peer Reviewed Journal)
Alegria-Lertxundi, I., Aguirre, C., Bujanda, L., Fernandez, F.J., Polo, F., Ordovas, J.M., Etxezarraga, M., Zabalza, I., Larzabal, M., Portillo, I., M. de Pancorbo, M., Palencia-Madrid, L., Garcia-Etxebarria, K., Rocandio, A., Arroyo-Izaga, M. 2020. Gene-diet interactions in colorectal cancer: survey design, instruments, participants and descriptive data of a case-control study in the Basque country. Nutrients. 12(8):2362. https://doi.org/10.3390/nu12082362.

Carbohydrate and fat intake associated with risk of metabolic diseases through epigenetics of CPT1A - (Peer Reviewed Journal)
Lai, C., Parnell, L.D., Smith, C.E., Guo, T., Sayols-Baixeras, S., Aslibekyan, S., Tiwari, H.K., Irvin, M.R., Bender, C., Fei, D., Hidalgo, B., Hopkins, P., Absher, D.M., Province, M., Elosua, R., Arnett, D.K., Ordovas, J.M. 2020. Carbohydrate and fat intake associated with risk of metabolic diseases through epigenetics of CPT1A. American Journal of Clinical Nutrition. 112(5):1200–1211. https://doi.org/10.1093/ajcn/nqaa233.

Food groups, diet quality and colorectal cancer risk in the Basque country - (Peer Reviewed Journal)
Alegria-Lertxundi, I., Aguirre, C., Bujanda, L., Fernandez, F.J., Polo, F., Ordovas, J.M., Etxezarraga, M., Zabalza, I., Larzabal, M., Portillo, I., M de Pancorbo, M., Garcia-Etxebarria, K., Roncandio, A., Arroyo-Izaga, M. 2020. Food groups, diet quality and colorectal cancer risk in the Basque country. World Journal of Gastroenterology. 26(28):4108-4125. https://doi.org/10.3748/wjg.v26.i28.4108.

MiRNAs profile as biomarkers of nutritional therapy for the prevention of type 2 diabetes mellitus: from the CORDIOPREV study - (Peer Reviewed Journal)
Jimenez-Lucena, R., Alcala-Diaz, J.F., Roncero-Ramos, I., Lopez-Moreno, J., Camargo, A., Gomez-Delgado, F., Quintana-Navarro, G., Vals-Delgado, C., Rodriguez-Cantalejo, F., Luque, R.M., Delgado-Lista, J., Ordovas, J.M., Perez-Martinez, P., Rangel-Zuniga, O.A., Lopez-Miranda, J. 2020. MiRNAs profile as biomarkers of nutritional therapy for the prevention of type 2 diabetes mellitus: from the CORDIOPREV study. Clinical Nutrition. https://doi.org/10.1016/j.clnu.2020.06.035.

DNA methylation and incident cardiovascular disease - (Review Article)
Westerman, K.E., Ordovas, J.M. 2020. DNA methylation and incident cardiovascular disease. Current Opinion in Clinical Nutrition and Metabolic Care. 23(4):236-240. https://doi.org/10.1097/MCO.0000000000000659.

Lifestyle interventions for the prevention and treatment of hypertension - (Review Article)
Valenzuela, P.L., Carrera-Bastos, P., Galvez, B.G., Ruiz-Hurtado, G., Ordovas, J.M., Ruilope, L.M., Lucia, A. 2020. Lifestyle interventions for the prevention and treatment of hypertension. Nature Reviews Cardiology. 18(4):251-275. https://doi.org/10.1038/s41569-020-00437-9.

Biological senescence risk score. A practical tool to predict biological senescence status - (Peer Reviewed Journal)
Ortiz-Morales, A.M., Alcala-Diaz, J.F., Rangel-Zuniga, O.A., Corina, A., Quintana-Navarro, G., Cardelo, M.P., Yubero-Serrano, E.M., Malagon, M.M., Delgado-Lista, J., Ordovas, J.M., Lopez-Miranda, J., Perez-Martinez, P. 2020. Biological senescence risk score. A practical tool to predict biological senescence status. European Journal of Clinical Investigation. 50(11):e13305. https://doi.org/10.1111/eci.13305.

Saturated fats and health: A reassessment and proposal for food-based recommendations: JACC State-of-the-Art review - (Review Article)
Astrup, A., Magkos, F., Bier, D.M., Brenna, J.Thomas, de Oliveira Otto, M.C., Hill, J.O., King, J.C., Mente, A., Ordovas, J.M., Volek, J.S., Yusuf, S., Krauss, R.M. 2020. Saturated fats and health: A reassessment and proposal for food-based recommendations: JACC State-of-the-Art review. Journal of the American College of Cardiology. 76(7):844-857. https://doi.org/10.1016/j.jacc.2020.05.077.

Human postprandial responses to food and potential for precision nutrition - (Peer Reviewed Journal)
Berry, S.E., Valdes, A.M., Drew, D.A., Asnicar, F., Mazidi, M., Wolf, J., Capdevila, J., Hadjigeorgiou, G., Davies, R., Al Khatib, H., Bonnett, C., Ganesh, S., Bakker, E., Hart, D., Mangino, M., Merino, J., Linenberg, I., Wyatt, P., Ordovas, J.M., Gardner, C.D., Dalahanty, L.M., Chan, A.T., Segata, N., Franks, P.W., Spector, T.D. 2020. Human postprandial responses to food and potential for precision nutrition. Nature Medicine. 26(6):964-973. https://doi.org/10.1038/s41591-020-0934-0.

Impact of phenol-enriched virgin olive oils on the postprandial levels of circulating microRNAs related to cardiovascular disease - (Peer Reviewed Journal)
Daimiel, L., Mico, V., Valls, R.M., Pedret, A., Motilva, M., Rubio, L., Fito, M., Farras, M., Covas, M., Sola, R., Ordovas, J.M. 2020. Impact of phenol-enriched virgin olive oils on the postprandial levels of circulating microRNAs related to cardiovascular disease. Molecular Nutrition and Food Research. 64(15):e2000049. https://doi.org/10.1002/mnfr.202000049.

Mendelian randomization analysis does not support causal associations of birth weight with hypertension risk and blood pressure in adulthood - (Peer Reviewed Journal)
Zheng, Y., Huang, T., Want, T., Mei, Z., Sun, Z., Zhang, T., Ellervik, C., Chai, J., Sim, X., Van Dam, R.M., Tai, E., Koh, W., Dorajoo, R., Saw, S., Sabanayagam, C., Wong, T., Gupta, P., Rossing, P., Ahluwalia, T.S., Vinding, R.K., Bisgaard, H., Bonnelykke, K., Wang, Y., Graff, M., Voortman, T., Van Rooij, F., Hofman, A., Van Heemst, D., Noordam, R., Estampador, A.C., Varga, T.V., Enzenback, C., Scholz, M., Theiry, J., Burkhardt, R., Orho-Melander, M., Schulz, C.A., Ericson, U., Sonestedt, E., Kubo, M., Akiyama, M., Zhou, A., Kilpelainen, T.O., Hansen, T., Kleber, M.E., Dalgado, G., McCarthy, M., Lemaitre, R., Feliz, J.F., Jaddoe, V.W., Wu, Y., Mohlke, K.L., Lehtimaki, T., Wang, C.A., Pennell, C.E., Schunkert, H., Kessler, T., Zeng, L., Willenborg, C., Peters, A., Lieb, W., Grote, V., Rzehak, P., Koletzko, B., Erdmann, J., Munz, M., Wu, T., He, M., Yu, C., Lecoeur, C., Froguel, P., Corella, D., Moreno, L., Lai, C., Pitkanen, N., Boreham, C.A., Ridker, P.M., Rosendaal, F., de Mutsert, R., Power, C., Paternoster, L., Sorensen, T.I., Tjonneland, A., Overvad, K., Djousse, L., Rivadeneira, F., Lee, N.R., Raitakari, O., Kahonen, M., Viikari, J., Langhendries, J., Escribano, J., Verduci, E., Dedoussis, G., Coltell, O., Ordovas, J.M., Qi, L. 2020. Mendelian randomization analysis does not support causal associations of birth weight with hypertension risk and blood pressure in adulthood. European Journal of Epidemiology. 35:685-697. https://doi.org/10.1007/s10654-020-00638-z.

FADS1 and ELOVL2 polymorphisms reveal associations for differences in lipid metabolism in a cross-sectional population-based survey of Brazilian men and women - (Peer Reviewed Journal)
Mieko de Meneses Fujii, T., Maintinguer Norde, M., Fisberg, R., Lobo Marchioni, D., Ordovas, J.M., Macedo Rogero, M. 2020. FADS1 and ELOVL2 polymorphisms reveal associations for differences in lipid metabolism in a cross-sectional population-based survey of Brazilian men and women. Nutrition Research. 78:42-49. http://doi.org/10.1016/j.nutres.2020.04.003.

Epigenomic assessment of cardiovascular disease risk and interactions with traditional risk metrics - (Peer Reviewed Journal)
Westerman, K., Fernandez-Sanles, A., Patil, P., Sebastiani, P., Jacques, P.F., Starr, J.M., Deary, I.J., Liu, Q., Liu, S., Elosua, R., DeMeo, D.F., Ordovas, J.M. 2020. Epigenomic assessment of cardiovascular disease risk and interactions with traditional risk metrics. Journal of the American Heart Association. 9(8):e015299. https://doi.org/10.1161/JAHA.119.015299.

A gene-diet interaction-based score predicts response to dietary fat in the Women's Health Initiative - (Peer Reviewed Journal)
Westerman, K., Liu, Q., Liu, S., Parnell, L.D., Sebastiani, P., Jacques, P.F., Demeo, D.L., Ordovas, J. 2020. A gene-diet interaction-based score predicts response to dietary fat in the Women's Health Initiative. American Journal of Clinical Nutrition. 111(4):893-902. https://doi.org/10.1093/ajcn/nqaa037.

Epigenome-wide association study reveals a molecular signature of response to phylloquinone (vitaminK1) supplementation - (Peer Reviewed Journal)
Westerman, K., Kelly, J.M., Ordovas, J.M., Booth, S.L., DeMeo, D.F. 2020. Epigenome-wide association study reveals a molecular signature of response to phylloquinone (vitaminK1) supplementation. Epigenetics. 15(8):859-870. https://doi.org/10.1080/15592294.2020.1734714.

Physical fitness and physical activity association with cognitive function and quality of life: baseline cross-sectional analysis of the PREDIMED-Plus trial - (Peer Reviewed Journal)
Daimiel, L., Martinez-Gonzalez, M.A., Corella, D., Salas-Salvado, J., Schroder, H., Vioque, J., Romaguera, D., Martinez, J.A., Warnberg, J., Lopez-Miranda, J., Estruch, R., Cano-Ibanez, N., Alonso-Gomez, A.M., Tur, J.A., Tinahones, F.J., Serra-Majem, L., Mico-Perez, R.M., Lapetra, J., Galdon, A., Pinto, X., Vidal, J., Mico, V., Colmenarejo, G., Gaforio, J.J., Matia-Martin, P., Ros, E., Buil-Cosiales, P., Vazquez-Ruiz, Z., Sorli, J.V., Graniel, I.P., Cuenca-Royo, A., Gisbert-Selles, C., Galmes-Panades, A.M., Zulet, M., Garcia-Rios, A., Diaz-Lopez, A., De La Torre, R., Galilea-Zabalza, I., Ordovas, J.M. 2020. Physical fitness and physical activity association with cognitive function and quality of life: baseline cross-sectional analysis of the PREDIMED-Plus trial. Scientific Reports. 10(1):3472. https://doi.org/10.1038/s41598-020-59458-6.

Genome-wide association study for serum omega-3 and omega-6 polyunsaturated fatty acids: exploratory analysis of the sex-specific effects and dietary modulation in Mediterranean subjects with metabolic syndrome - (Peer Reviewed Journal)
Coltell, O., Sorli, J.V., Asensio, E.M., Barragan, R., Gonzalez, J.I., Gimenez-Alba, I.M., Zanon-Moreno, V.C., Estruch, R., Ramirez-Sabio, J.B., Pascual, E.C., Ortega-Azorin, C., Ordovas, J.M., Corella, D. 2020. Genome-wide association study for serum omega-3 and omega-6 polyunsaturated fatty acids: exploratory analysis of the sex-specific effects and dietary modulation in Mediterranean subjects with metabolic syndrome. Nutrients. 12(2):310. https://doi.org/10.3390/nu12020310.

Postprandial lipemia modulates pancreatic alpha-cell function in the prediction of type 2 diabetes development: the CORDIOPREV study - (Peer Reviewed Journal)
Pozuelo-Sanchez, I., Villasanta-Gonzalez, A., Alcala-Diaz, J.F., Vals-Delgado, C., Leon-Acuna, A., Gonzalez-Requero, A., Yubero-Serrano, E.M., Luque, R.M., Caballero-Villarraso, J., Quesada, I., Ordovas, J.M., Perez-Martinez, P., Roncero-Ramos, I., Lopez-Miranda, J. 2020. Postprandial lipemia modulates pancreatic alpha-cell function in the prediction of type 2 diabetes development: the CORDIOPREV study. Journal of Agricultural and Food Chemistry. 68(5):1266-1275. https://doi.org/10.1021/acs.jafc.9b06801.

Influence of the ACTN3 R577X genotype on the injury epidemiology of marathon runners - (Peer Reviewed Journal)
Moreno, V., Areces, F., Ruiz-Vincente, D., Ordovas, J.M., Del Coso, J. 2020. Influence of the ACTN3 R577X genotype on the injury epidemiology of marathon runners. PLoS ONE. 15(1):e0227548. https://doi.org/10.1371/journal.pone.0227548.

Time course of tolerance to adverse effects associated with the ingestion of a moderate dose of caffeine - (Peer Reviewed Journal)
Ruiz-Moreno, C., Lara, B., Salinero, J.J., Brito De Souxa, D., Ordovas, J.M., Del Coso, J. 2020. Time course of tolerance to adverse effects associated with the ingestion of a moderate dose of caffeine. European Journal of Nutrition. https://doi.org/10.1007/s00394-019-02167-2.

Candidate gene and genome-wide association studies for circulating leptin levels reveal population and sex-specific association in high cardiovascular Mediterranean subjects - (Peer Reviewed Journal)
Ortega-Azorin, C., Coltell, O., Asensio, E.M., Sorli, J.V., Gonzalez, J.I., Portoles, O., Saiz, C., Estruch, R., Ramirez-Sabio, J.B., Perez-Fidalgo, A., Ordovas, J.M., Corella, D. 2019. Candidate gene and genome-wide association studies for circulating leptin levels reveal population and sex-specific association in high cardiovascular Mediterranean subjects. Nutrients. 11(11):2751. https://doi.org/10.3390/nu11112751.

Lipidomic profiling identifies signatures of metabolic risk - (Peer Reviewed Journal)
Vin, X., Willinger, C.M., Keefe, J., Liu, J., Fernandez-Ortiz, A., Ibanez, B., Penalvo, J., Adourian, A., Chen, G., Corella, D., Pamplona, R., Portero-Otin, M., Jove, P., Courchesne, P., Van Duijn, C.M., Fuster, V., Ordovas, J.M., Demirkan, A., Larson, M.G., Levy, D. 2019. Lipidomic profiling identifies signatures of metabolic risk. EBioMedicine. 51:102520. https://doi.org/10.1016/j.ebiom.2019.10.046.

Lifestyle factors modulate postprandial hypertriglyceridemia: from the CORDIOPREV study - (Peer Reviewed Journal)
Leon-Acuna, A., Torres-Pena, J.D., Alcala-Diaz, J.F., Vals-Delgado, C., Roncero-Ramos, I., Yubero-Serrano, E., Tinahones, F.J., Castro Clerico, M., Delgado-Lista, J., Ordovas, J.M., Lopez-Miranda, J., Perez-Martinez, P. 2019. Lifestyle factors modulate postprandial hypertriglyceridemia: from the CORDIOPREV study. Atherosclerosis. 290:118-124. https://doi.org/10.1016/j.atherosclerosis.2019.09.025.

Toward the definition of personalized nutrition: A proposal by the American Nutrition Association - (Review Article)
Bush, C.L., Blumberg, J.B., El-Sohemy, A., Minich, D.M., Ordovas, J.M., Reed, D.G., Yunez Behm, V.A. 2019. Toward the definition of personalized nutrition: A proposal by the American Nutrition Association. Journal of the American College of Nutrition. https://doi.org/10.1080/07315724.2019.1685332.

Potential interplay between dietary saturated fats and genetic variants of the NLRP3 inflammasome to modulate insulin resistance and diabetes risk: insights from a meta-analysis of 19 005 individuals - (Peer Reviewed Journal)
Murphy, A.M., Smith, C.E., Murphy, L.M., Follis, J.L., Tanaka, T., Richardson, K., Noordam, R., Lemaitre, R.N., Kahonen, M., Dupuis, J., Voortman, T., Marouli, E., Mook-Kanamori, D.O., Raitakari, O.T., Hong, J., Dehghan, A., Dedoussis, G., De Mutsert, R., Lehtimaki, T., Liu, C., Rivadeneira, F., Deloukas, P., Mikkila, V., Meigs, J.B., Uitterlinden, A., Ikram, M.A., Franco, O.H., Hughes, M., O'Gaora, P., Ordovas, J.M., Roche, H.M. 2019. Potential interplay between dietary saturated fats and genetic variants of the NLRP3 inflammasome to modulate insulin resistance and diabetes risk: insights from a meta-analysis of 19 005 individuals. Molecular Nutrition and Food Research. 63(22):1900226. https://doi.org/10.1002/mnfr.201900226.

Cross-sectional association between non-soy legume consumption, serum uric acid and hyperuricemia: the PREDIMED-plus study - (Peer Reviewed Journal)
Becerra-Tomas, N., Mena-Sanchez, G., Diaz-Lopez, A., Martinez-Gonzalez, M.A., Babio, N., Corella, D., Freixer, G., Romaguera, D., Vioque, J., Alonso-Gomez, A.M., Warnberg, J., Martinez, J., Serra-Majem, L., Estruch, R., Fernandez-Garcia, J., Lapetra, J., Pinto, X., Tur, J., Lopez-Miranda, J., Bueno-Cavanillas, A., Gaforio, J.J., Matia-Martin, P., Daimiel, L., Matia-Sanchez, V., Vidal, J., Vazquez, C., Ros, E., Razquin, C., Abellan Cano, I., Sorli, J.V., Torres, L., Morey, M., Navarrete-Muno, E.M., Tojal Sierra, L., Crespo-Oliva, E., Zulet, M., Sanchez-Villegas, A., Casas, R., Bernal-Lopez, M., Santos-Lozano, J., Corbella, E., del Mar Bibiloni, M., Ruiz-Canela, M., Fernandez-Carrion, R., Quifer, M., Prieto, R.M., Fernandez-Brufal, N., Salaverria Lete, I., Cenoz, J., Llimona, R., Salas-Salvado, J., Ordovas, J.M. 2019. Cross-sectional association between non-soy legume consumption, serum uric acid and hyperuricemia: the PREDIMED-plus study. European Journal of Nutrition. https://doi.org/10.1007/s00394-019-02070-W.

NutriGenomeDB: a nutrigenomics exploratory and analytical platform - (Peer Reviewed Journal)
Martin-Hernandez, R., Regiero, G., Ordovas, J.M., Davalos, A. 2019. NutriGenomeDB: a nutrigenomics exploratory and analytical platform. Database: The Journal of Biological Databases and Curation. https://doi.org/10.1093/database/baz097.

Perspective: Dietary biomarkers of intake and exposure-exploration with omics approaches - (Review Article)
Maruvada, P., Lampe, J.W., Wishart, D.S., Barupal, D., Chester, D.N., Dodd, D., Djoumbou-Feunang, Y., Dorrestein, P.C., Dragsted, L.O., Draper, J., Duffy, L.C., Dwyer, J.T., Emenaker, N.J., Fiehn, O., Gerszten, R.E., Hu, F.B., Karp, R.W., Klurfeld, D.M., Laughlin, M.R., Little, R.A., Lynch, C.J., Moore, S.C., Nicastro, H.L., O'Brien, D.M., Ordovas, J.M., Osganian, S.K., Playdon, M., Prentice, R., Raftery, D., Reisdorph, N., Roche, H.M., Ross, S.M., Sang, S., Scalbert, A., Srinivas, P.R., Zeisel, S.M. 2019. Perspective: Dietary biomarkers of intake and exposure-exploration with omics approaches. Advances in Nutrition. 11(2):200-215. https://doi.org/10.1093/advances/nmz075.

Apolipoprotein E genetic variants interact with Mediterranean diet to modulate postprandial hypertriglyceridemia in coronary heart disease patients: CORDIOPREV study - (Peer Reviewed Journal)
Gomez-Delgado, F., Alcala-Diaz, J.F., Leon-Acuna, A., Lopez-Moreno, J., Delgado-Lista, J., Gomez-Marin, B., Roncero-Ramos, I., Yubero-Serrano, E.M., Rangel-Zuniga, O.A., Vals-Delgado, C., Luque, R.M., Ordovas, J.M., Lopez-Miranda, J., Perez-Martinez, P. 2019. Apolipoprotein E genetic variants interact with Mediterranean diet to modulate postprandial hypertriglyceridemia in coronary heart disease patients: CORDIOPREV study. European Journal of Clinical Investigation. https://doi.org/10.1111/eci.13146.

Consumption of ultra-processed foods and mortality: a national prospective cohort in Spain - (Peer Reviewed Journal)
Blanco-Rojo, R., Sandoval-Insausti, H., Lopez-Garcia, E., Graciani, A., Ordovas, J.M., Banegas, J.R., Rodriguez-Artalejo, F., Guallar-Castillon, P. 2019. Consumption of ultra-processed foods and mortality: a national prospective cohort in Spain. Mayo Clinic Proceedings. 94(11):2178-2188. https://doi.org/10.1016/j.mayocp.2019.03.035.