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ARS Home » Northeast Area » Boston, Massachusetts » Jean Mayer Human Nutrition Research Center On Aging » Research » Publications at this Location » Publication #414472
Research Project: Personalized Nutrition and Healthy Aging

Location: Jean Mayer Human Nutrition Research Center On Aging

Title: Association between coffee consumption and total dietary caffeine intake with cognitive functioning: cross-sectional assessment in an elderly Mediterranean population

Author
item GRANIEL, INDIRA - Instituto De Salud Carlos Iii
item BABIO, NANCY - University Rovira I Virgili
item BECERRA-TOMAS, NEREA - University Rovira I Virgili
item TOLEDO, ESTEFANIA - Instituto De Salud Carlos Iii
item CAMACHO-BARCIA, LUCIA - University Rovira I Virgili
item CORELLA, DOLORES - Instituto De Salud Carlos Iii
item CASTANER-NINO, OLGA - Instituto De Salud Carlos Iii
item ROMAGUERA, DORA - Instituto De Salud Carlos Iii
item VIOQUE, JESUS - Instituto De Salud Carlos Iii
item ALONSO-GOMEZ, ANGEL - Instituto De Salud Carlos Iii
item WARNBERG, JULIA - Instituto De Salud Carlos Iii
item MARTINEZ, J - Instituto De Salud Carlos Iii
item SERRA-MAJEM, LUIS - Instituto De Salud Carlos Iii
item ESTRUCH, RAMON - Instituto De Salud Carlos Iii
item TINAHONES, FRANCISCO - Instituto De Salud Carlos Iii
item FERNANDEZ-ARANDA, FERNANDO - Instituto De Salud Carlos Iii
item LAPERTRA, JOSE - Instituto De Salud Carlos Iii
item PINTO, XAVIER - Instituto De Salud Carlos Iii
item TUR, JOSEP - Instituto De Salud Carlos Iii
item GARCIA-RIOS, ANTONIO - Instituto De Salud Carlos Iii
item BUENO-CAVANILLAS, AURORA - University De Granada
item GAFORIO, JOSE - Instituto De Salud Carlos Iii
item MATIA-MARTIN, PILAR - Health Research Institute Of The San Carlos Clinical Hospital
item DAIMIEL, LIDIA - Imdea Food
item SANCHEZ, VICENTE - Instituto De Salud Carlos Iii
item PRIETO-SANCHEZ, LUCIA - Instituto De Salud Carlos Iii
item ROS, EMILIO - Iis-Fundacion Jimenez Diaz
item RAZQUIN, CRISTINA - Instituto De Salud Carlos Iii
item MESTRES, CRISTINA - Joan Xxiii University Hospital
item SORLI, JOSE - Instituto De Salud Carlos Iii
item CUENCA-ROYO, AIDA - Hospital Del Mar Medical Research Institute
item RIOS, ANGEL - Son Espases Hospital
item TORRES-COLLADO, LAURA - Instituto De Salud Carlos Iii
item VAQUERO-LUNA, JESSICA - Instituto De Salud Carlos Iii
item PEREZ-FARINOS, NAPOLEON - Instituto De Salud Carlos Iii
item ZULET, M - Instituto De Salud Carlos Iii
item SANCHEZ-VILLEGAS, ALMUDENA - Instituto De Salud Carlos Iii
item CASAS, ROSA - Instituto De Salud Carlos Iii
item BERNAL-LKOPEZ, MARIA-ROSA - Regional University Hospital Of Malaga
item SANTOS-LOZANO, JOSE MANUEL - Instituto De Salud Carlos Iii
item CORBELLA, XAVIER - Hospital Universitario De Bellvitge
item MATEOS, DAVID - Instituto De Salud Carlos Iii
item BUIL-COSIALES, PILAR - Instituto De Salud Carlos Iii
item JIMENEZ-MURCIA, SUSANA - Instituto De Salud Carlos Iii
item FERNANDEZ-CARRION, REBECA - Instituto De Salud Carlos Iii
item FORCANO-GAMAZO, LAURA - Instituto De Salud Carlos Iii
item LOPEZ, MERITXALL - Son Espases Hospital
item SEMPERE-PASCUAL, MIGUEL - Santa Pola Health Center
item MORENO-RODRIQUEZ, ANAI - Instituto De Salud Carlos Iii
item GEA, ALFREDO - Instituto De Salud Carlos Iii
item DE LA TORRE-FORNELL, RAFAEL - Instituto De Salud Carlos Iii
item SALAS-SALVADO, JORDI - University Rovira I Virgili
item ORDOVAS, JOSE - Jean Mayer Human Nutrition Research Center On Aging At Tufts University

Submitted to: European Journal of Nutrition
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 10/13/2020
Publication Date: 10/30/2020
Citation: Graniel, I.P., Babio, N., Becerra-Tomas, N., Toledo, E., Camacho-Barcia, L., Corella, D., Castaner-Nino, O., Romaguera, D., Vioque, J., Alonso-Gomez, A.M., Warnberg, J., Martinez, J.A., Serra-Majem, L., Estruch, R., Tinahones, F., Fernandez-Aranda, F., Lapertra, J., Pinto, X., Tur, J.A., Garcia-Rios, A., Bueno-Cavanillas, A., Gaforio, J.J., Matia-Martin, P., Daimiel, L., Sanchez, V.M., Prieto-Sanchez, L., Ros, E., Razquin, C., Mestres, C., Sorli, J.V., Cuenca-Royo, A., Rios, A., Torres-Collado, L., Vaquero-Luna, J., Perez-Farinos, N., Zulet, M.A., Sanchez-Villegas, A., Casas, R., Bernal-Lkopez, M., Santos-Lozano, J., Corbella, X., Mateos, D., Buil-Cosiales, P., Jimenez-Murcia, S., Fernandez-Carrion, R., Forcano-Gamazo, L., Lopez, M., Sempere-Pascual, M.A., Moreno-Rodriquez, A., Gea, A., de la Torre-Fornell, R., Salas-Salvado, J., Ordovas, J.M. 2020. Association between coffee consumption and total dietary caffeine intake with cognitive functioning: Cross-sectional assessment in an elderly Mediterranean population. European Journal of Nutrition. https://doi.org/10.1007/s00394-020-02415-w.
DOI: https://doi.org/10.1007/s00394-020-02415-w

Interpretive Summary: Coffee is enriched in compounds that can stimulate brain activity. Therefore, the possible association of coffee consumption with cognition is of considerable health interest. The aim of this work conducted by investigators in Spain, the UK, and at the HNRCA in Boston was to assess the association of coffee consumption and total dietary caffeine intake with the risk of poor cognitive functioning in a population of elderly overweight/obese adults with metabolic syndrome (MetS) participating in the PREDIMED-plus study. The data showed that total coffee consumers and caffeinated coffee consumers had better cognitive functioning than non-consumers. These associations were not observed for decaffeinated coffee consumption. Therefore, coffee consumption and total dietary caffeine intake were associated with better mental functioning in a Mediterranean cohort of elderly individuals with MetS.

Technical Abstract: Coffee is rich in compounds such as polyphenols, caffeine, diterpenes, melanoidins and trigonelline, which can stimulate brain activity. Therefore, the possible association of coffee consumption with cognition is of considerable research interest. In this paper, we assess the association of coffee consumption and total dietary caffeine intake with the risk of poor cognitive functioning in a population of elderly overweight/obese adults with metabolic syndrome (MetS). METHODS: PREDIMED-plus study participants who completed the Mini-Mental State Examination test (MMSE) (n=6427; mean age = 65 +/- 5 years) or a battery of neuropsychological tests were included in this cross-sectional analysis. Coffee consumption and total dietary caffeine intake were assessed at baseline using a food frequency questionnaire. Logistic regression models were fitted to evaluate the association between total, caffeinated and decaffeinated coffee consumption or total dietary caffeine intake and cognitive impairment. RESULTS: Total coffee consumers and caffeinated coffee consumers had better cognitive functioning than non-consumers when measured by the MMSE and after adjusting for potential confounders (OR 0.63; 95% CI 0.44-0.90 and OR 0.56; 95% CI 0.38-0.83, respectively). Results were similar when cognitive performance was measured using the Clock Drawing Test (CDT) and Trail Making Test B (TMT-B). These associations were not observed for decaffeinated coffee consumption. Participants in the highest tertile of total dietary caffeine intake had lower odds of poor cognitive functioning than those in the reference tertile when screened by the MMSE (OR 0.64; 95% CI 0.47-0.87) or other neurophysiological tests evaluating a variety of cognitive domains (i.e., CDT and TMT-A). CONCLUSIONS: Coffee consumption and total dietary caffeine intake were associated with better cognitive functioning as measured by various neuropsychological tests in a Mediterranean cohort of elderly individuals with MetS.