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United States Department of Agriculture

Agricultural Research Service

Related Topics

Laurence D Parnell
Boston, Massachusetts
General Biological Science

Phone: (617) 556-3089
Fax: (617) 556-3299

USDA-ARS-HNRCA
711 WASHINGTON STREET
BOSTON , MA 02111

Projects
GENE EXPRESSION AND SYSTEMS-BASED ANALYSIS TO PREDICT GENE-ENVIRONMENT INTERACTIONS
Cooperative Agreement (A)
  Accession Number: 422634
Genomics, Nutrition, and Health
In-House Appropriated (D)
  Accession Number: 427832
COMBINING GENE EXPRESSION DATA AND SYSTEMS-BASED NETWORK ANALYSIS TO PREDICT GENE-ENVIRONMENT INTERACTIONS
Reimbursable Cooperative Agreement (R)
  Accession Number: 422814
Molecular Mechanisms of Dietary Cocoa Epicatechin Extending Lifespan and Improving Skeletal Muscle Function in Aged Mice
Non-Assistance Cooperative Agreement (S)
  Accession Number: 431374

Publications (Clicking on the reprint icon Reprint Icon will take you to the publication reprint.)
Supplementation with major royal jelly proteins increases lifespan, feeding and fecundity in Drosophila -
Xin, X., Chen, Y., Chen, D., Xiao, F., Parnell, L.D., Zhao, J., Liu, L., Ordovas, J.M., Lai, C., Shen, L. 2016. Supplementation with major royal jelly proteins increases lifespan, feeding and fecundity in Drosophila. Journal of Agricultural and Food Chemistry. 64(29):5803–5812. doi: 10.1021/acs.jafc.6b00514.
Effect of personalized nutrition on health-related behavior change: evidence from the Food4Me randomized controlled trial -
Celis-Morales, C., Livingstone, K.M., O'Donovan, C.B., Woolhead, C., Forster, H., Walsh, M.C., Marsaux, C.F., Macready, A.L., Fallaize, R., Tsirigoti, L., Lambrinou, C.P., Efstathopoulou, E., Moschonis, G., Navas-Carretero, S., Can-Cristobal, R., Kolossa, S., Hallmann, J., Godlewska, M., Surwilla, A., Traczyk, I., Drevon, C.A., Bouwman, J., Grimaldi, K., Parnell, L.D., Manios, Y., Daniel, H., Martinez, J., Lovegrove, J.A., Gibney, E.R., Brennan, L., Saris, W.H., Gibney, M., Mathers, J.C. 2016. Effect of personalized nutrition on health-related behavior change: evidence from the Food4Me randomized controlled trial. International Journal of Epidemiology. doi: 10.1093/ije/dyw186.
Interaction of an S100A9 gene variant with saturated fat and carbohydrates to modulate insulin resistance in 3 populations of different ancestries -
Blanco-Rojo, R., Delgado-Lista, J., Lee, Y., Lai, C., Perez-Martinez, P., Rangel-Zuniga, O., Smith, C.E., Hidalgo, B., Alcala-Diaz, J.F., Gomez-Delgado, F., Parnell, L.D., Arnett, D.K., Tucker, K.L., Lopez-Miranda, J., Ordovas, J.M. 2016. Interaction of an S100A9 gene variant with saturated fat and carbohydrates to modulate insulin resistance in 3 populations of different ancestries. American Journal of Clinical Nutrition. 104:508–17.
Physical activity attenuates the effect of the FTO genotype on obesity-related traits in European adults: Findings from the Food4Me study -
Celis-Morales, C., Marsaux, C.F., Livingstone, K.M., Navas-Carretero, S., San-Cristobal, R., O'Donovan, C.B., Forster, H., Woolhead, C., Fallaize, R., Macready, A.L., Kolossa, S., Hallmann, J., Tsirigoti, L., Lambrinou, C.P., Moschonis, G., Godlewska, M., Surwillo, A., Grimaldi, K., Bouwman, J., Manios, Y., Traczyk, I., Drevon, C.A., Parnell, L.D., Daniel, H., Gibney, E.R., Brennan, L., Walsh, M., Gibney, M., Lovegrove, J.A., Martinez, J., Saris, W.H., Mathers, J.C. 2016. Physical activity attenuates the effect of the FTO genotype on obesity-related traits in European adults: Findings from the Food4Me study. International Journal of Obesity. 24:962-969. doi: 10.1002/oby.21422.
Genetic variant modifies the effect of N3 PUFAs on DNA methylation of IL6 in the Genetics of Lipid Lowering Drugs and Diet Network study -
Ma, Y., Smith, C.E., Lai, C., Invin, R.M., Parnell, L.D., Lee, Y., Pham, L., Aslibekyan, S., Claas, S.A., Tsai, M.Y., Borecki, I.B., Kabagambe, E.K., Ordovas, J.M., Absher, D., Donna, A.K. 2016. Genetic variant modifies the effect of N3 PUFAs on DNA methylation of IL6 in the Genetics of Lipid Lowering Drugs and Diet Network study. Epigenetics. doi: 10.1002/mnfr.201500436.
Genetics and gene-environment interactions on longevity and lifespan -
Lai, C., Ma, Y., Parnell, L.D. 2016. Genetics and gene-environment interactions on longevity and lifespan. Book Chapter. Lai, CQ, Ma, YY, Parnell, LD, 2015. In: Qi, Lu, Editor. Gene-Environment Interactions and Human Diseases. Hauppauge, NY: Nova Science Publishers, Inc. p. 245-264.
Diet- and genetically-induced obesity differentially affect the fecal microbiome and metabolome in Apc1638N mice -
Pfalzer, A.C., Nesbeth, P.C., Parnell, L.D., Iyer, L.K., Liu, Z., Kane, A.V., Chen, C., Tai, A.K., Bowman, T.A., Obin, M.S., Mason, J.B., Greenberg, A., Choi, S., Selhub, J., Paul Pottenplackel, L., Crott, J.W. 2015. Diet- and genetically-induced obesity differentially affect the fecal microbiome and metabolome in Apc1638N mice. PLoS One. 10(8):e0135758. doi:10.1371/journal.pone.0135758.
Genome-wide association study of triglyceride response to a high-fat meal among participants of the NHLBI genetics of lipid lowering drugs and diet network (GOLDN) -
Wojczynski, M.K., Parnell, L.D., Pollin, T.I., Lai, C., Feitosa, M.F., O'Connel, J.R., Frazier-Wood, A.C., Gibson, Q., Aslibkeyan, S., Ryan, K.A., Province, M.A., Tiwari, H.K., Ordovas, J.M., Shuldiner, A.R., Arnett, D.K., Borecki, I.B. 2015. Genome-wide association study of triglyceride response to a high-fat meal among participants of the NHLBI genetics of lipid lowering drugs and diet network (GOLDN). Metabolism. 64:1359-1371.
Validation of internet-based self-reported anthropometric, demographic data and participant identity in the Food4Me study -
Celis-Morales, C., Livingstone, K.M., Woolhead, C., Forster, H., O'Donovan, C.B., Macready, A.L., Fallaize, R., Marsaux, C.F., Tsirigoti, L., Efstathopoulou, E., Moschonis, G., Navas-Carretero, S., San-Cristobal, R., Kolossa, S., Godlewska, M., Surwillo, A., Drevon, C.A., Gjelstad, I.F., Karlsen, A.S., Bouwman, J., Grimaldi, K., Parnell, L.D., Manios, Y., Traczyk, I., Gibney, E.R., Brrennan, L., Hallmann, J., Walsh, M.C., Lovegrove, J.A., Martinez, J., Daniel, H., Saris, W.H., Gibney, M., Mathers, J.C. 2015. Validation of internet-based self-reported anthropometric, demographic data and participant identity in the Food4Me study. International Journal of Obesity. 10:476.
Genetic variants modify the effect of age on APOE methylation in the Genetics of Lipid Lowering Drugs and Diet Network study -
Ma, Y., Smith, C.E., Lai, C., Irvin, M.R., Parnell, L.D., Pham, L., Aslibekyan, S., Claas, S.A., Tsai, M.Y., Borecki, I.B., Kabagambe, E.K., Berciano, S., Ordovas, J.M., Absher, D.M. 2014. Genetic variants modify the effect of age on APOE methylation in the Genetics of Lipid Lowering Drugs and Diet Network study. Aging Cell. 14:49-59.
Genome-wide interaction of genotype by erythrocyte n-3 PUFAs contributes to phenotypic variance of diabetes-related traits -
Ordovas, J., Lai, C., Parnell, L.D., Lee, Y., Shen, J., Smith, C.E., Richardson, K., Li, D., Arnett, D.K., Borecki, I.B., Zheng, J. 2014. Genome-wide interaction of genotype by erythrocyte n-3 PUFAs contributes to phenotypic variance of diabetes-related traits. Biomed Central (BMC) Genomics. BMC Genomics, 15:781. doi: 10.1186/1471-2164-15-781.
Phytochemicals for personalized health -
Zirkler, E., Parnell, L.D., Smith, C.E., Obin, M.S., Ordovas, J.M. 2014. Phytochemicals for personalized health. [Abstract]. 11th NuGO Week: Nutrigenomics of Foods p.142.
S-adenosylmethionine lowers the inflammatory response in macrophages associated with changes in DNA methylation -
Pfalzer, A., Choi, S., Tammen, S.A., Park, L.K., Bottiglieri, T., Parnell, L.D., Lamon-Fava, S. 2014. S adenosylmethionine lowers the inflammatory response in macrophages associated with changes in DNA methylation. Physiological Genomics. DOI: 10.1152/physiolgenomics.00056.2014.
Diminished skeletal muscle microRNA expression with aging is associated with attenuated muscle plasticity and inhibition of IGF-1 signaling -
Rivas, D.A., Lessard, S.J., Rice, N.P., Lustgarten, M.S., So, K., Goodyear, L.J., Parnell, L.D., Fielding, R.A. 2014. Diminished skeletal muscle microRNA expression with aging is associated with attenuated muscle plasticity and inhibition of IGF-1 signaling. Journal of Federation of American Societies for Experimental Biology. DOI: 10.1096/fj.14-254490.
Dietary modulators of statin efficacy in cardiovascular disease and cognition -
Wang, H., Blumberg, J.B., Chen, C., Choi, S., Corcoran, M.P., Harris, S.S., Jacques, P.F., Kristo, A.S., Lai, C., Lamon-Fava, S., Matthan, N.R., Mckay, D.L., Meydani, M., Parnell, L.D., Prokopy, M.P., Scott, T.M., Lichtenstein, A.H. 2014. Dietary modulators of statin efficacy in cardiovascular disease and cognition. Molecular Aspects of Medicine. 38:1-53.
Lipoprotein metabolism indicators improve cardiovascular risk prediction -
Van Schalkwijk, D., De Graaf, A., Tsivtsivadze, E., Parnell, L.D., Van Der Werff-Van De, R., Van Ommen, B., Van Der Greef, J., Ordovas, J.M. 2014. Lipoprotein metabolism indicators improve cardiovascular risk prediction. PLoS One. 9:e92840.
Lipoprotein lipase variants interact with polyunsaturated fatty acids to modulate obesity traits in Puerto Ricans -
Ma, Y., Tucker, K.L., Smith, C.E., Lee, Y., Huang, T., Lai, C., Parnell, L.D., Richardson, K., Ordovas, J.M. 2014. Lipoprotein lipase variants interact with polyunsaturated fatty acids to modulate obesity traits in Puerto Ricans. Journal of Federation of American Societies for Experimental Biology. 28:1037.7.
CRY1 circadian gene variant interacts with carbohydrate intake for insulin resistance in two independent populations: Mediterranean and North American -
Dashti, H.S., Smith, C.E., Lee, Y., Parnell, L.D., Lai, C., Arnett, D.K., Ordovas, J.M., Garaulet, M. 2014. CRY1 circadian gene variant interacts with carbohydrate intake for insulin resistance in two independent populations: Mediterranean and North American. Chronobiology International. 31(5):660-668. DOI: 10.3109/07420528.2014.886587.
Integrating nutrigenomics data to identify cardiometabolic gene-environment interactions -
Parnell, L.D., Lee, Y., Dashti, H., Ma, Y., Pham, L., Sloan, S., Smith, C.E., Richardson, K., Lai, C., Ordovas, J.M. 2013. Integrating nutrigenomics data to identify cardiometabolic gene-environment interactions. Meeting Abstract. p.1 Abstract #5.
Circulating 25-hydroxyvitamin D, IRS1 variant rs2943641 and insulin resistance: replication of a gene-nutrient interaction in four populations of different ancestries -
Apolipoprotein A2 polymorphism interacts with intakes of dairy foods to influence body weight in 2 U.S. populations -
Smith, C.E., Tucker, K.L., Arnett, D.K., Noel, S.E., Corella, D., Borecki, I.B., Feitosa, M.F., Aslibekyan, S., Parnell, L.D., Lai, C., Lee, Y., Ordovas, J.M. 2013. Apolipoprotein A2 polymorphism interacts with intakes of dairy foods to influence body weight in 2 U.S. populations. Journal of Nutrition. 143(12):1865-1871.
The emerging relevance of the gut microbiome in cardiometabolic health -
Obin, M., Parnell, L.D., Ordovas, J.M. 2013. The emerging relevance of the gut microbiome in cardiometabolic health. Current Cardiovascular Risk Reports. DOI 10.1007/s12170-013-0357-2.
REV-ERB-ALPHA circadian gene variant associates with obesity in two independent populations: Mediterranean and North American -
Garaulet, M., Smith, C.E., Gomez-Abellan, P., Ordova S-Montanes, M., Lee, Y., Parnell, L.D., Arnett, D.K., Ordovas, J.M. 2014. REV-ERB-ALPHA circadian gene variant associates with obesity in two independent populations: Mediterranean and North American. Molecular Nutrition and Food Research. 58(4):821-829.
Curcumin and aging -
Shen, L., Parnell, L.D., Ordovas, J., Lai, C. 2013. Curcumin and aging. Biofactors. 39(1):133-140.
Genetic variants at PSMD3 interact with dietary fat and carbohydrate to modulate insulin resistance -
Zheng, J., Arnett, D., Parnell, L.D., Lee, Y., Ma, Y., Smith, C., Richardson, K., Li, D., Ordovas, J., Tucker, K., Lai, C., Borecki, I. 2013. Genetic variants at PSMD3 interact with dietary fat and carbohydrate to modulate insulin resistance. Journal of Nutrition. 143(3):354-361.
Association between BDNF-rs6265 and obesity in the Boston Puerto Rican Health Study -
Ma, X., Qiu, W., Smith, C., Parnell, L.D., Jiang, Z., Ordovas, J., Tucker, K., Lai, C. 2012. Association between BDNF-rs6265 and obesity in the Boston Puerto Rican Health Study. Journal of Obesity. DOI: 10.1155/2012102942.
Gain-of-function Lipoprotein Lipase variant rs13702 modulates lipid traits through disruption of a microRNA-410 seed site -
Richardson, K., Nettleton, J.A., Rotlan, N., Tanaka, T., Smith, C.E., Lai, C., Parnell, L.D., Lee, Y., Lahti, J., Lemaitre, R.N., Manichaikul, A., Keller, M., Mikkila, V., Ngwa, J., Van Rooij, F., Ballentyne, C.M., Borecki, I.B., Cupples, L., Garcia, M., Hofman, A., Ferrucci, L., Mozaffarian, D., Perala, M., Raitakari, O., Tracy, R.P., Arnett, D.K., Bandinelli, S., Boerwinkle, E., Eriksson, J.G., Franco, O.H., Kahonen, M., Nalls, M., Siscovick, D.S., Houston, D.K., Psaty, B.M., Viikari, J., Witteman, J., Goodarzi, M.O., Lehtimaki, T., Liu, Y., Zillikens, M., Chen, Y.I., Uitterlinden, A.G., Rotter, J.I., Fernandez-Hernando, C., Ordovas, J. 2013. Gain-of-function Lipoprotein Lipase variant rs13702 modulates lipid traits through disruption of a microRNA-410 seed site. The American Journal of Human Genetics. 92(1):5-14.
Mechanism of action of recombinant Acc-royalisin from royal jelly of Chinese honeybee against gram-positive bacteria -
Shen, L., Liu, D., Yang, X., Jin, F., Din, M., Parnell, L.D., Lai, C. 2012. Mechanism of action of recombinant Acc-royalisin from royal jelly of Chinese honeybee against gram-positive bacteria. PLoS One. 7(10):e47194 DOI: 10.1371/journal.pone.0047194.
Low density lipoprotein receptor related protein 1 variant interacts with saturated fatty acids in Puerto Ricans -
Smith, C.E., Tucker, K.L., Lee, Y., Lai, C., Parnell, L.D., Ordovas, J.M. 2013. Low density lipoprotein receptor related protein 1 variant interacts with saturated fatty acids in Puerto Ricans. Obesity. 21:602-608.
Status of vitamin B-12 and B-6 but not of folate, homocysteine and the methylenetetrahydrofolate reductase C677T polymorphism are associated with impaired cognition and depression in adults -
Moorthy, D., Inga, P., Scott, T.M., Parnell, L.D., Lai, C., Crott, J.W., Ordovas, J.M., Selhub, J., Griffith, J., Rosenberg, I.H., Tucker, K.L., Troen, A.M. 2012. Status of vitamin B-12 and B-6 but not of folate, homocysteine and the methylenetetrahydrofolate reductase C677T polymorphism are associated with impaired cognition and depression in adults. Journal of Nutrition. 142(8):1554-1560.
Curcumin-supplemented diets increase superoxide dismutase activity and mean lifespan in Drosophila -
Shen, L., Xiao, F., Peng, Y., Chen, Y., Qi-Kang, G., Parnell, L.D., Meydani, M., Ordovas, J.M., Li, D., Lai, C. 2013. Curcumin-supplemented diets increase superoxide dismutase activity and mean lifespan in Drosophila. Journal of the American Aging Association (AGE). 35(4):1133-1142. DOI 10.1007/s11357-012-9438-2.
Aging is a more significant determinant of hepatic DNA methylation patterns than a western style diet -
Park, L.K., Saltzman, E., Schnitzler, G., Yoon, B., Parnell, L.D., Lai, C., Choi, S. 2012. Aging is a more significant determinant of hepatic DNA methylation patterns than a western style diet. Journal of Federation of American Societies for Experimental Biology. 2012(26):243.5.
Genetic predisposition to coronary heart disease and stroke using an additive genetic risk score: a population-based study in Greece -
Yiannakouris, N., Katsoulis, M., Dilis, V., Parnell, L.D., Trichopoulos, D., Ordovas, J., Trichopoulou, A. 2012. Genetic predisposition to coronary heart disease and stroke using an additive genetic risk score: a population-based study in Greece. Atherosclerosis. 222(1):175-179.
SIRT1 and CLOCK 3111T greater than C combined genotype is associated with evening preference and weight loss resistance in a behavioral therapy treatment for obesity -
Garaulet, M., Esteban Tardido, A., Lee, Y., Smith, C., Parnell, L.D., Ordovas, J. 2012. SIRT1 and CLOCK 3111T greater than C combined genotype is associated with evening preference and weight loss resistance in a behavioral therapy treatment for obesity. International Journal of Obesity. DOI: 10.1038/ijo.2011.270.
The effect of CYP7A1 polymorphisms on lipid responses to fenofibrate -
Shen, J., Arnett, D., Parnell, L.D., Lai, C., Straka, R., Hopkins, P., An, P., Feitosa, M., Ordovas, J. 2012. The effect of CYP7A1 polymorphisms on lipid responses to fenofibrate. Journal of Cardiovascular Pharmacology. 59(3):254-259.
A genome-wide survey for SNPs altering microRNA seed sites identifies functional candidates in GWAS -
Richardson, K., Lai, C., Parnell, L.D., Lee, Y., Ordovas, J. 2011. A genome-wide survey for SNPs altering microRNA seed sites identifies functional candidates in GWAS. Biomed Central (BMC) Genomics. 2:504.
A high intake of saturated fatty acids strengthens the association between the fat mass and obesity-associated gene and BMI -
Corella, D., Arnett, D.K., Tucker, K.L., Kabagambe, E.K., Tsai, M.Y., Parnell, L.D., Lai, C., Lee, Y., Warodomwichit, D., Hopkins, P.N., Ordovas, J.M. 2011. A high intake of saturated fatty acids strengthens the association between the fat mass and obesity-associated gene and BMI. Journal of Nutrition. 141(12):2219-2225.
Advances in technologies and study design -
Parnell, L.D. 2012. Advances in technologies and study design. In: Bouchard, C., Ordovas, J.M., editors. Progress in Molecular Biology and Translational Science. New York, NY: Elsevier Inc. 108:17-50.
BioStar: an online question & answer resource for the bioinformatics community -
Parnell, L.D., Lindenbaum, P., Shameer, K., Dall'Olio, G.M., Swan, D.C., Jensen, L.J., Cockell, S.J., Pedersen, B.P., Mangan, M.E., Miller, C., Albert, I. 2011. BioStar: an online question & answer resource for the bioinformatics community. PLoS Computational Biology. 7:e1002216.
The PLIN4 variant rs8887 modulates obesity related phenotypes in humans through creation of a novel miR-522 seed site -
Richardson, K., Louie-Gao, Q., Arnett, D., Parnell, L.D., Lai, C., Davalos, A., Fox, C., Demissie, S., Cupples, L., Fernandez-Hernando, C., Ordovas, J. 2011. The PLIN4 variant rs8887 modulates obesity related phenotypes in humans through creation of a novel miR-522 seed site. PLoS One. 6(4):e17944.
A database of gene-environment interactions pertaining to blood lipid traits, cardiovascular disease and type 2 diabetes -
Lee, Y., Lai, C., Ordovas, J.M., Parnell, L.D. 2011. A database of gene-environment interactions pertaining to blood lipid traits, cardiovascular disease and type 2 diabetes. Journal of Data Mining in Genomics & Proteomics. 2:106. DOI:10.4172/2153-0602.1000106.
Interleukin 1B variant -1473G/C (rs1143623) influences triglyceride and interleukin 6 metabolism -
Delgado-Lista, J., Garcia-Rios, A., Perez-Martinez, P., Solivera, J., Yubero-Serrano, E.M., Fuentes, F., Parnell, L.D., Shen, J., Gomez, P., Jimenez-Gomez, Y., Gomez-Luna, M.J., Marin, C., Belisle, S.E., Rodriguez-Cantalejo, F., Meydani, S.N., Ordovas, J.M., Perez-Jimenez, F., Lopez-Miranda, J. 2011. Interleukin 1B variant -1473G/C (rs1143623) influences triglyceride and interleukin 6 metabolism. Journal of Clinical Endocrinology and Metabolism. 96(5):E816-820.
Interactions between genetic variants of folate metabolism genes and lifestyle affect plasma homocysteine concentrations in the Boston Puerto Rican Population -
Huang, T., Tucker, K., Lee, Y., Crott, J., Parnell, L.D., Shen, J., Smith, C., Ordovas, J., Li, D., Lai, C. 2011. Interactions between genetic variants of methionine metabolism genes and lifestyle affect plasma homocysteine concentrations in the Boston Puerto Rican Population. Molecular Nutrition and Food Research. DOI: 10.1017/S1368980011000140.
Perilipin polymorphism interacts with saturated fat and carbohydrates to modulate insulin resistance -
Smith, C.E., Arnett, D.K., Corella, D., Tsai, M.Y., Lai, C., Parnell, L.D., Lee, Y., Ordovas, J.M. 2012. Perilipin polymorphism interacts with saturated fat and carbohydrates to modulate insulin resistance. Nutrition, Metabolism and Cardiovascular Diseases. 22(5):449-455.
Gene variations of nitric oxide synthase regulate the effects of a saturated fat rich meal on endothelial function -
Delgado-Lista, J., Fuentes, F., Jimenez-Gomez, Y., Perez-Martinez, P., Gomez-Luna, M.J., Parnell, L.D., Marin, C., Lai, C., Perez-Jimenez, F., Ordovas, J.M., Lopez-Miranda, J. 2010. Gene variations of nitric oxide synthase regulate the effects of a saturated fat rich meal on endothelial function. Clinical Nutrition. 30(2):234-238.
Apolipoprotein B genetic variants modify the response to fenofibrate: a GOLDN study -
Wojczynski, M.K., Gao, G., Borecki, I., Hopkins, P.N., Parnell, L.D., Lai, C., Ordovas, J.M., Arnett, D.K. 2010. Apolipoprotein B genetic variants modify the response to fenofibrate: a GOLDN study. Journal of Lipid Research. 51(11):3316-3323.
MAT1A variants modulate the effect of dietary fatty acids on plasma homocysteine concentrations and DNA damage -
Huang, T., Tucker, K., Lee, Y., Crott, J., Parnell, L.D., Shen, J., Smith, C.E., Ordovas, J.M., Li, D., Lai, C. 2010. MAT1A variants modulate the effect of dietary fatty acids on plasma homocysteine concentrations and DNA damage. Nutrition, Metabolism and Cardiovascular Diseases. DOI: 1016/j.numecd.2010.07.015.
Drosophila lacks C20 and C22 polyunsaturated fatty acids -
Shen, L., Lai, C., Feng, X., Parnell, L.D., Wang, J., Li, D., Ordovas, J.M., Kang, J. 2010. Drosophila lacks C20 and C22 polyunsaturated fatty acids. Journal of Lipid Research. 51(10)2985-2992.
Apolipoprotein E polymorphisms and postprandial triglyceridemia before and after fenofibrate treatment in the Genetics of Lipid Lowering and Diet Network (GOLDN) Study -
Irvin, M.R., Kabagambe, E.K., Tiwari, H.K., Parnell, L.D., Straka, R.J., Tsai, M., Ordovas, J.M., Arnett, D.K. 2010. Apolipoprotein E polymorphisms and postprandial triglyceridemia before and after fenofibrate treatment in the Genetics of Lipid Lowering and Diet Network (GOLDN) Study. Circulation: Cardiovascular Genetics. 3(5):462-467.
Gene expression changes in peripheral blood mononuclear cells from patients with metabolic syndrome after acute intake of phenol-rich virgin olive oil -
Camargo, A., Ruano, J., Fernandez, J.M., Parnell, L.D., Jimenez, A., Santos-Gonzalez, M., Marin, C., Perez-Martinez, P., Uceda, M., Lopez-Miranda, J., Perez-Jimenez, F. 2010. Gene expression changes in peripheral blood mononuclear cells from patients with metabolic syndrome after acute intake of phenol-rich virgin olive oil. Biomed Central (BMC) Genomics. 11:253-267.
ABCA1 gene variants regulate posprandial lipid metabolism in healthy men -
Delgado-Lista, J., Perez-Martinez, P., Perez-Jiminez, F., Garcia-Rios, A., Fuentes, F., Marin, C., Gomez-Luna, P., Camargo, A., Parnell, L.D., Ordovas, J.M., Lopez-Miranda, J. 2010. ABCA1 gene variants regulate posprandial lipid metabolism in healthy men. Arteriosclerosis Thrombosis and Vascular Biology. 30(5):1051-1057.
MAT1A variants are associated with hypertension, stroke, and DNA damage and are modulated by vlasma vitamin B6 and folate concentration -
Lai, C., Tucker, K., Parnell, L.D., Shen, J., Caouette, H., Warodomwichit, D., Lee, Y., Crott, J., Ordovas, J.M. 2010. MAT1A variants are associated with hypertension, stroke, and DNA damage and are modulated by plasma vitamin B6 and folate concentration. American Journal of Clinical Nutrition. 91(5):1377-1386.
Expression of recombinant AccMRJP1 protein from royal jelly of Chinese honeybee in Pichia pastoris and its proliferation activity in an insect cell line -
Shen, L., Zhang, W., Jin, F., Zhang, L., Chen, Z., Liu, L., Parnell, L.D., Lai, C., Li, D. 2010. Expression of recombinant AccMRJP1 protein from royal jelly of Chinese honeybee in Pichia pastoris and its proliferation activity in an insect cell line. Journal of Agricultural and Food Chemistry. 58(4):2266-2273.
Adaptive genetic variation and heart disease risk -
Parnell, L.D., Lee, Y., Lai, C. 2010. Adaptive genetic variation and heart disease risk. Current Opinion in Lipidology. 21(2):116-122.
PER2 variants are associated with abdominal obesity, psycho-behavioral factors and attrition in the dietary treatment of obesity -
Garaulet, M., Corbalan-Tutau, D., Madrid, J.A., Baraza, J.C., Parnell, L.D., Lee, Y., Ordovas, J.M. 2010. PER2 variants are associated with abdominal obesity, psycho-behavioral factors and attrition in the dietary treatment of obesity. Journal of American Dietetic Association. 110(6):917-921.
Gene-environment interactions and the impact on obesity and lipid profile phenotypes -
Parnell, L.D. 2009. Gene-environment interactions and the impact on obesity and lipid profile phenotypes. Clinical Lipidology. 4:104-107.
CLOCK genetic variation and metabolic syndrome risk: modulation by monounsaturated fatty acids -
Garaulet, M., Lee, Y., Shen, J., Parnell, L.D., Arnett, D.K., Tsai, M.Y., Lai, C., Ordovas, J.M. 2009. CLOCK genetic variation and metabolic syndrome risk: modulation by monounsaturated fatty acids. American Journal of Clinical Nutrition. 90(6):1466-1475.
Genetic variants in human CLOCK associate with total energy intake and cytokine sleep factors -
Garaulet, M., Lee, Y., Shen, J., Parnell, L.D., Arnett, D.K., Tsai, M.Y., Lai, C., Ordovas, J.M. 2009. Genetic variants in human CLOCK associate with total energy intake and cytokine sleep factors. Human Molecular Genetics. 18(3):364-369.
Disparities in allele frequencies and population differentiation for 101 disease-associated single nucleotide polymorphisms between Puerto Ricans and non-Hispanic whites -
Mattei, J., Parnell, L.D., Lai, C., Garcia-Bailo, B., Adiconis, X., Shen, J., Arnett, D., Demissie, S., Tucker, K., Ordovas, J.M. 2009. Disparities in allele frequencies and population differentiation for 101 disease-associated single nucleotide polymorphisms between Puerto Ricans and non-Hispanic whites. BioMed Central (BMC) Genetics. 10:45.
APOA2, dietary fat and body mass index: replication of a gene-diet interaction in three independent populations -
Corella, D., Peloso, G., Arnett, D.K., Demissie, S., Cupples, L., Tucker, K., Lai, C., Parnell, L.D., Coltell, O., Lee, Y., Ordovas, J.M. 2009. APOA2, dietary fat and body mass index: replication of a gene-diet interaction in three independent populations. Archives of Internal Medicine. 169:1897-1906.
Effects of variations in the APOA1/C3/A4/A5 gene cluster on different parameters of postprandial lipid metabolism in healthy young men -
Delgado-Lista, J., Perez-Jimenez, F., Ruano, J., Perez-Martinez, P., Fuentes, F., Criado-Garcia, J., Parnell, L.D., Ordovas, J.M., Lopez-Miranda, J. 2009. Effects of variations in the APOA1/C3/A4/A5 gene cluster on different parameters of postprandial lipid metabolism in healthy young men. Journal of Lipid Research. 51:63-73.
ADAM17_i33780A>G polymorphism interacts with dietary n-6 polyunsaturated fatty acids to modulate obesity risk in the genetics of lipid lowering drugs and diet network study -
Junyent, M., Arnett, D.A., Tsai, M.Y., Kabagambe, E.K., Straka, R.J., Province, M., An, P., Smith, C., Borecki, I., Parnell, L.D., Lai, C., Lee, Y., Ordovas, J.M. 2010. ADAM17_i33780A>G polymorphism interacts with dietary n-6 polyunsaturated fatty acids to modulate obesity risk in the genetics of lipid lowering drugs and diet network study. Nutrition Metabolism and Cardiovascular Disease. 20(101):698-705.
Novel variants at KCTD10 and MVK/MMAB genes interact with dietary carbohydrates to modulate HDL-C concentrations in the genetics of lipid lowering drugs and diet network study -
Junyent, M., Arnett, D.A., Tsai, M.Y., Kabagambe, E.K., Straka, R.J., Province, M., An, P., Smith, C., Borecki, I., Parnell, L.D., Lai, C., Lee, Y., Ordovas, J.M. 2009. Novel variants at KCTD10 and MVK/MMAB genes interact with dietary carbohydrates to modulate HDL-C concentrations in the genetics of lipid lowering drugs and diet network study. American Journal of Clinical Nutrition. 90(3):686-694.
Apolipoprotein A5 and lipoprotein lipase interact to modulate anthropometric measures in Hispanics of Caribbean origin -
Smith, C.E., Tucker, K.L., Parnell, L.D., Lai, C., Lee, Y., Ordovas, J.M. 2010. Apolipoprotein A5 and lipoprotein lipase interact to modulate anthropometric measures in Hispanics of Caribbean origin. Obesity. 18(2):327-332.
The effect of ABCG5/G8 polymorphisms on plasma HDL cholesterol levels depends on the ABCA1 gene variation in the Boston Puerto Rican Health Study -
Junyent, M., Tucker, K.L., Lane, J.M., Mattei, J., Smith, C., Parnell, L.D., Lai, C., Ordovas, J.M. 2009. The effect of ABCG5/G8 polymorphisms on plasma HDL cholesterol levels depends on the ABCA1 gene variation in the Boston Puerto Rican Health Study. Nutrition Metabolism and Cardiovascular Disease. 18:64-69.
The effects of ABCG5/G8 polymorphisms on HDL-cholesterol concentrations depend on ABCA1 genetic variants in the Boston Puerto Rican health study -
Junyent, M., Tucker, K., Smith, C., Lane, J., Mattei, J., Lai, C., Parnell, L.D., Ordovas, J. 2010. The effects of ABCG5/G8 polymorphisms on HDL-cholesterol concentrations depend on ABCA1 genetic variants in the Boston Puerto Rican health study. Nutrition Metabolism and Cardiovascular Disease. 20(8):558-566.
Apolipoprotein C3 polymorphism is associated with cognitive function in Caribbean Hispanics -
Smith, C.E., Tucker, K.L., Scott, T.M., Van Rompay, M., Parnell, L.D., Lai, C., Mattei, J., Junyent, M., Lee, Y., Garcia-Bailo, B., Ordovas, J.M. 2009. Apolipoprotein C3 polymorphism is associated with cognitive function in Caribbean Hispanics. PLoS One. 4(5):e5465.
Polymorphisms in uracil-processing genes, but not one-carbon nutrients, are associated with altered DNA uracil concentrations in an urban Puerto Rican population -
Chanson, A., Parnell, L.D., Ciappio, E.D., Liu, Z., Crott, J.W., Tucker, K., Mason, J.B. 2009. Polymorphisms in uracil-processing genes, but not one-carbon nutrients, are associated with altered DNA uracil concentrations in an urban Puerto Rican population. American Journal of Clinical Nutrition. 89:1927-1936.
A composite scoring of genotypes discriminates coronary heart disease risk beyond conventional risk factors in the Boston Puerto Rican Health Study -
Junyent, M., Parnell, L.D., Lai, C., Ordovas, J.M., Tucker, K.L., Shen, J., Mattei, J., Smith, C., Lee, Y. 2009. A composite scoring of genotypes discriminates coronary heart disease risk beyond conventional risk factors in the Boston Puerto Rican Health Study. Nutrition Metabolism and Cardiovascular Disease.20(3):157-167.
A composite scoring of genotypes discriminates coronary heart disesase risk beyond conventional risk factors in the Boston Puerto Rican Health Study -
Junyent, M., Tucker, K., Shen, J., Lee, Y., Smith, C., Mattei, J., Lai, C., Parnell, L.D., Ordovas, J. 2010. A composite scoring of genotypes discriminates coronary heart disesase risk beyond conventional risk factors in the Boston Puerto Rican Health Study. Nutrition Metabolism and Cardiovascular Disease. 20(3):157-164.
Physical inactivity interacts with an endothelial lipase polymorphism to modulate high density lipoprotein cholesterol in the GOLDN study -
Smith, C.E., Arnett, D.K., Tsai, M.Y., Lai, C., Parnell, L.D., Shen, J., Laclaustra, M., Junyent, M., Ordovas, J.M. 2009. Physical inactivity interacts with an endothelial lipase polymorphism to modulate high density lipoprotein cholesterol in the GOLDN study. Atherosclerosis.206:500-504.
The effect of a novel intergenic polymorphism (rs11774572) on HDL cholesterol concentrations depends on the TaqIB polymorphism in the cholesterol ester transfer protein gene -
Junyent, M., Arnett, D.A., Tsai, M.Y., Kabagambe, E.K., Straka, R.J., Province, M., An, P., Smith, C., Shen, J., Borecki, I., Parnell, L.D., Lai, C., Lee, Y., Ordovas, J.M. 2009. The effect of a novel intergenic polymorphism (rs11774572) on HDL cholesterol concentrations depends on the TaqIB polymorphism in the cholesterol ester transfer protein gene. Nutrition Metabolism and Cardiovascular Disease.20:34-40.
Genetic Variants at the PDZ-Interacting Domain of the Scavenger Receptor Class B Type I Interact with Diet to Influence the Risk of Metabolic Syndrome in Obese Men and Women -
Junyent, M., Arnett, D.A., Tsai, M.Y., Kabagambe, E.K., Straka, R.J., Province, M., An, P., Shen, J., Borecki, I., Parnell, L.D., Lai, C., Lee, Y., Ordovas, J.M. 2009. Genetic Variants at the PDZ-Interacting Domain of the Scavenger Receptor Class B Type I Interact with Diet to Influence the Risk of Metabolic Syndrome in Obese Men and Women. Journal of Nutrition. 139(6):842-848.
The effects of ABCG5/G8 polymorphisms on plasma HDL cholesterol concentrations depend on smoking habit in the Boston Puerto Rican Health Study -
Junyent, M., Tucker, K., Smith, C., Garcia-Rios, A., Mattei, J., Lai, C., Parnell, L.D., Ordovas, J.M. 2008. The effects of ABCG5/G8 polymorphisms on plasma HDL cholesterol concentrations depend on smoking habit in the Boston Puerto Rican Health Study. Journal of Lipid Research. 50:565-573.
WDTC1, an ortholog of Drosphilia adipose gene, associates with human obesity -
Lai, C., Parnell, L.D., Garcia-Bailo, B., Tucker, K., Ordovas, J.M. 2008. WDTC1, an ortholog of Drosphilia adipose gene, associates with human obesity. Obesity. 17(3):593-600.
Association between glucokinase regulatory protein (GCKR) and apolipoprotein A5 (APOA5) gene polymorphisms and triacylglycerol concentrations in fasting, postprandial, and fenofibrate-treated states -
Perez-Martinez, P., Corella, D., Shen, J., Arnett, D.K., Yiannakouris, N., Tai, E., Orho-Melander, M., Tucker, K.L., Tsai, M., Straka, R.J., Province, M., Kai, C., Perez-Jimenez, F., Lai, C., Lopez-Miranda, J., Guillen, M., Parnell, L.D., Borecki, I., Kathiresan, S., Ordovas, J.M. 2009. Association between glucokinase regulatory protein (GCKR) and apolipoprotein A5 (APOA5) gene polymorphisms and triacylglycerol concentrations in fasting, postprandial, and fenofibrate-treated states. American Journal of Clinical Nutrition. 89:391-399.
ADIPOQ Polymorphisms, Monounsaturated Fatty Acids, and Obesity Risk: The GOLDN Study -
Warodomwichit, D., Shen, J., Arnett, D., Tsai, M., Kabagambe, E., Peacock, J., Hixson, J., Straka, R., Province, M., An, P., Lai, C., Parnell, L.D., Borecki, I., Ordovas, J.M. 2009. ADIPOQ Polymorphisms, Monounsaturated Fatty Acids, and Obesity Risk: The GOLDN Study. Obesity. 17:510-517.
Perilipin polymorphism interacts with dietary carbohydrates to modulate anthropometric traits in Hispanics of Caribbean origin -
Smith, C., Tucker, K., Yiannakouris, N., Garcia-Bailo, B., Mattei, J., Lai, C., Parnell, L.D., Ordovas, J.M. 2008. Perilipin Polymorphism Interacts with Dietary Carbohydrates to Modulate Anthropometric Traits in Hispanics of Caribbean Origin. Journal of Nutrition. 138(10):1852-1858.
A Common Missense Variant in the Glucokinase Regulatory Protein Gene (GCKR) Is Associated with Increased Plasma Triglyceride and C-Reactive Protein but Lower Fasting Glucose Concentrations -
Orho-Melander, M., Melander, O., Guiducci, C., Perez-Martinez, P., Corella, D., Roos, C., Tewhey, R., Rieder, M.J., Hall, J., Abecasis, G., Tai, E., Welch, C., Arnett, D.K., Lyssenko, V., Lindholm, E., Saxena, R., De Bakker, P., Burtt, N., Voight, B.F., Hirschhorn, J.N., Tucker, K., Hedner, T., Tuomi, T., Isomaa, B., Eriksson, K., Taskinen, M., Wahlstrand, B., Hughes, T.E., Parnell, L.D., Lai, C., Berglund, G., Peltonen, L., Vartiainen, E., Jousilahti, P., Havulinna, A.S., Salomaa, V., Nilsson, P., Groop, L., Altshuler, D., Ordovas, J.M., Kathiresan, S. 2008. A Common Missense Variant in the Glucokinase Regulatory Protein Gene (GCKR) Is Associated with Increased Plasma Triglyceride and C-Reactive Protein but Lower Fasting Glucose Concentrations. Diabetes. 57:3112-3121.
Associations between single nucleotide polymorphisms in folate uptake and metabolizing genes with blood folate, homocysteine and DNA uracil concentrations -
Devos, L., Chanson, A., Liu, Z., Ciappo, E., Parnell, L.D., Mason, J.B., Tucker, K., Crott, J.W. 2008. Associations between single nucleotide polymorphisms in folate uptake and metabolizing genes with blood folate, homocysteine and DNA uracil concentrations. American Journal of Clinical Nutrition. 88(4):1149-1158.
The effect of IL6-174C/G polymorphisms on postprandial triglycerides metabolism in the GOLDN study -
Shen, J., Arnett, D.K., Perez-Martinez, P., Parnell, L.D., Peacock, J.M., Hixson, J.E., Tsai, M.Y., Lai, C., Straka, R.J., Hopkins, P.N., Ordovas, J.M. 2008. The effect of IL6-174C/G polymorphisms on postprandial triglycerides metabolism in the GOLDN study. Journal of Lipid Research. 49:1839-1845.
Association of common C-protein (CRP) gene polymorphism with baseline plasma CRP levels and fenofibrate response: The GOLDN Study -
Shen, J., Arnett, D.K., Parnell, L.D., Peacock, J.M., Lai, C., Hixson, J.E., Tsai, M.Y., Province, M., Straka, R.J., Ordovas, J.M. 2008. Association of common C-protein (CRP) gene polymorphism with baseline plasma CRP levels and fenofibrate response: The GOLDN Study. Diabetes Care. 31(5):910-915.
Genetic variants in uracil processing enzymes are associated with abnormal DNA uracil content -
Chanson, A., Parnell, L.D., Crott, J., Choi, S., Han, H., Mason, J.B. 2008. Genetic variants in uracil processing enzymes are associated with abnormal DNA uracil content. American Association for Cancer Research (AACR) 2008 Annual Meeting, April 12-16, 2008. Paper No. 1891.
PPARGC1A Variations Associated with DNA Damage, Diabetes, and Cardiovascular Diseases: The Boston Puerto Rican Study -
Lai, C., Tucker, K., Parnell, L.D., Adiconis, X., Garcia-Bailo, B., Griffith, J., Meydani, M., Ordovas, J.M. 2008. PPARGC1A Variations Associated with DNA Damage, Diabetes, and Cardiovascular Diseases: The Boston Puerto Rican Study. Diabetes. 57:809-816.
Speed-Mapping Quantitative Trait Loci Using Microarrays -
Lai, C., Leips, J., Zou, W., Roberts, J.F., Wollenberg, K.R., Parnell, L.D., Zeng, Z., Ordovas, J.M., Mckay, T.F. 2007. Speed-Mapping Quantitative Trait Loci Using Microarrays. Nature Methods. 4(10):839-841.
An apolipoprotein A-II polymorphism (-265T/C, rs5082), regulates postprandial response to a saturated fat overload in healthy men -
Delgado-Lista, J., Perez-Jimenez, F., Tanaka, T., Perez-Martinez, P., Jiminez-Gomez, Y., Marin, C., Ruano, J., Parnell, L.D., Ordovas, J.M., Lopez-Miranda, J. 2007. An apolipoprotein A-II polymorphism (-265T/C, rs5082), regulates postprandial response to a saturated fat overload in healthy men. Journal of Nutrition. 137:2024-2028.
Interleukin 1B genetic polymorphisms interact with polyunsaturated fatty acids to affect risk of the metabolic syndrome in the GOLDN Study -
Shen, J., Arnett, D.K., Peacock, J.M., Parnell, L.D., Aldi, K., Hixson, J.E., Tsai, M.Y., Kabagambe, E.K., Lai, C., Stratka, R.J., Ordovas, J.M. 2007. Interleukin 1B genetic polymorphisms interact with polyunsaturated fatty acids to affect risk of the metabolic syndrome in the GOLDN Study. Journal of Nutrition. 137(8):1846-1851.
The -256T>C Polymorphism in the Apolipoprotein A-II Gene Promoter Is Associated with Body Mass Index and Food Intake in the Genetics of Lipid Lowering Drugs and Diet Network Study -
Corella, D., Arnett, D.K., Tsai, M.Y., Kabagambe, E.K., Peacock, J.M., Hixson, J.E., Straka, R.J., Province, M., Lai, C., Parnell, L.D., Borecki, I., Ordovas, J.M. 2007. The -256T>C Polymorphism in the Apolipoprotein A-II Gene Promoter Is Associated with Body Mass Index and Food Intake in the Genetics of Lipid Lowering Drugs and Diet Network Study. Clinical Chemistry.53:1144-1152.
Fenofibrate Effect on Triglyceride and Postprandial Response of Apolipoprotein A5 Variants: The GOLDN Study -
Lai, C., Arnett, D.K., Straka, R.J., Tsai, M.Y., Peacock, J.M., Adiconis, X., Parnell, L.D., Hixson, J.E., Province, M.A., Ordovas, J.M. 2007. Fenofibrate Effect on Triglyceride and Postprandial Response of Apolipoprotein A5 Variants: The GOLDN Study. Arteriosclerosis Thrombo Vasc Biol. 27:1417-1425.
Candidate genes affecting Drosophila life span identified by integrating microarray gene expression analysis and QTL mapping -
Lai, C., Parnell, L.D., Lyman, R.F., Ordovas, J.M., Mackay, T.F. 2006. Candidate genes affecting Drosophila life span identified by integrating microarray gene expression analysis and QTL mapping. Mechanisms of Aging and Development 128:237-249.
Lifespan modification by glucose and methionine in Drosophila melanogaster fed a chemically defined diet -
Troen, A.M., French, E.E., Roberts, J.F., Selhub, J., Ordovas, J.M., Parnell, L.D., Lai, C. 2006. Lifespan modification by glucose and methionine in Drosophila melanogaster fed a chemically defined diet. Age.29:29-39.
INTERLEUKIN 6-174C>G POLYMORPHISM IS ASSOCIATED WITH LOW BONE MINERAL DENSITY IN OLDER SUBJECTS CONSUMING LOW CALCIUM -
Shen, J., Crosier, M.D., Parnell, L.D., Shea, K., Dawson-Hughes, B., Ordovas, J.M., Booth, S.L. 2006. Interleukin 6-174c>g polymorphism is associated with low bone mineral density in older subjects consuming low calcium. Experimental Biology 2006 Annual Meeting. April 1- 5, 2006. San Francisco, CA. Abstract no. 398.1.
GENOME-WIDE LINKAGE ANALYSES AND CANDIDATE GENE FINE MAPPING FOR HDL3 CHOLESTEROL: THE FRAMINGHAM STUDY -
Yang, Q., Lai, C., Parnell, L.D., Cupples, L., Adiconis, X., Zhu, Y., Wilson, P.W., Housman, D.E., Sherman, A.M., D'Agostino, R.B., Ordovas, J.M. 2005. Genome-wide linkage analyses and candidate gene fine mapping for HDL3 cholesterol: the Framingham Study. Journal of Lipid Research. 46(7):1416-1425.
THE APOA1/C3/A4/A5 GENE CLUSTER, LIPID METABOLISM AND CARDIOVASCULAR DISEASE RISK -
Lai, C., Parnell, L.D., Ordovas, J.M. 2005. The apoa1/c3/a4/a5 gene cluster, lipid metabolism and cardiovascular disease risk. Current Opinion in Lipidology 2005, 16:153-166.
INFLUENCE OF THE APOLIPOPROTEIN A5 LOCUS ON PLASMA TRIGLYCERIDE, REMNANT-LIKE PARTICLES, AND LIPOPROTEIN SUBFRACTION CONCENTRATIONS -IMPLICATION FOR CARDIOVASCULAR RISK IN THE FRAMINGHAM HEART STUDY -
Lai, C., Demissie, S., Cupples, A., Zhu, Y., Adiconis, X., Parnell, L.D., Corella, D., Ordovas, J.M. 2004. Influence of the apolipoprotein a5 locus on plasma triglyceride, remnant-like particles, and lipoprotein subfraction concentrations -implication for cardiovascular risk in the framingham heart study. Arteriosclerosis Thrombosis and Vascular Biology. 2004; 45: 2096-2105
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Last Modified: 5/2/2016
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