Location: Poultry Microbiological Safety and Processing Research Unit
2018 Annual Report
Accomplishments
1. Preliminary test of Salmonella recombinant proteins as vaccines in broiler chickens. ARS researchers at Athens, Georgia, evaluated seven recombinant proteins for use as vaccines to immunize broilers chickens agains Salmonella. Salmonella was orally administered to broilers that had been immunized with the test proteins and to broilers that had not been immunized. Samples from the broilers were later examined for the presence of Salmonella. Results showed that three out of four of the unimmunized chickens carried Salmonella, but none of immunized chickens carried Salmonella. These findings indicated that these proteins can be used as vaccines to reduce Salmonella colonization of live poultry. Other experiments are being planned to validate these studies.
Review Publications
Yeh, H., Line, J.E., Hinton Jr, A. 2018. Molecular analysis, biochemical characterization, antimicrobial activity and immunological analysis of Proteus mirabilis isolated from broilers. Journal of Food Science. 83(3):770-779. https://doi.org/10.1111/1750-3841.14056.
Yeh, H., Kojima, K., Mobley, J.A. 2018. Epitope mapping of salmonella flagellar hook-associated protein, FlgK, with mass spectrometry-based immuno-capture proteomics using chicken (gallus gallus domesticus] sera. Veterinary Immunology and Immunopathology. 201:20-25. https://doi.org/10.1016/j.vetimm.2018.05.006.
