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ARS Home » Northeast Area » Wyndmoor, Pennsylvania » Eastern Regional Research Center » Dairy and Functional Foods Research » People & Locations » Jenni Firrman

Jenni Ann Firrman
Dairy and Functional Foods Research
Research Molecular Biologist

Phone: (215) 836-6908 ext. 6908
Fax:

USDA,REE,ARS,NAA,ERRC
600 E MERMAID LANE
WYNDMOOR, PA 190388598
Projects
In vitro Human Gut System: Interactions Between Diet, Food Processing, and Microbiota
In-House Appropriated (D)
  Accession Number: 439225
Single Molecule Sequencing Gut Microbiota
Non-Assistance Cooperative Agreement (S)
  Accession Number: 436175
Effects of Chlorine on Gut Microbiota in the Mouse Models
Non-Assistance Cooperative Agreement (S)
  Accession Number: 438810
Recovery from Triclosan-Induced Colonic Inflammation Using a Mouse Model
Non-Assistance Cooperative Agreement (S)
  Accession Number: 438812
Developing an in Vitro Model of the Human Small Intestinal Microbiota
Non-Assistance Cooperative Agreement (S)
  Accession Number: 438902

Publications (Clicking on the reprint icon Reprint Icon will take you to the publication reprint.)
Probiotic characteristics of lactobacillus plantarum E680 and its effect on Hypercholesterolemic mice Reprint Icon - (Peer Reviewed Journal)
Zhen, Z., Wang, W., Yu, J., Chen, C., Chen, B., Liu, J., Firrman, J., Renye Jr, J.A., Ren, D. 2020. Probiotic characteristics of lactobacillus plantarum E680 and its effect on hypercholesterolemic mice. BMC Microbiology. 20:239 Pages 1-9. https://doi.org/10.1186/s12866-020-01922-4.
Effects of thermally induced configuration changes on rAAV genome’s enzymatic accessibility Reprint Icon - (Peer Reviewed Journal)
Xu, Y., Guo, P., Chrzanowski, M., Chew, H., Firrman, J., Sang, N., Diao, Y., Xiao, W., Zhang, J. 2020. Effects of thermally induced configuration changes on rAAV genome’s enzymatic accessibility. Molecular Therapy. 18: 328-334. https://doi.org/10.1016/j.omtm.2020.06.005.
Triclosan has a robust, yet reversible impact on human gut microbial composition in vitro. Reprint Icon - (Peer Reviewed Journal)
Mahalak, K.K., Firrman, J., Lee, J., Bittinger, K., Nunez, A., Bobokalonov, J., Arango-Argoty, G., Zhang, L., Zhang, G., Liu, L.S. 2020. Triclosan has a robust, yet reversible impact on human gut microbial composition in vitro. PLoS One. 15(6): 1-22. https://doi.org/10.1371/journal.pone.0234046.
Impact of steviol glycosides and erythritol on the human and Cebus apella gut microbiome Reprint Icon - (Peer Reviewed Journal)
Mahalak, K.K., Firrman, J., Tomasula, M.M., Nunez, A., Lee, J., Bittinger, K., Rinaldi, W., Liu, L.S. 2019. Impact of steviol glycosides and erythritol on the human and Cebus apella gut microbiome. Journal of Agricultural and Food Chemistry. Pages A-I. https://doi.org/10.1021/acs.jafc.9b06181.
Metabolic analysis of the regionally distinct gut microbial communities using an in vitro platform Reprint Icon - (Peer Reviewed Journal)
Firrman, J., Liu, L.S., Tanes, C., Friedman, E., Bittinger, K., Daniel, S., Van Den Abbeele, P., Evans, B. 2019. Metabolic analysis of the regionally distinct gut microbial communities using an in vitro platform. Journal of Agriculture and Food Sciences. Pages A-L. https://doi.org/10.1021/acs.jafc.9b05202.
Metagenomic assessment of the Cebus Apella gut microbiota Reprint Icon - (Peer Reviewed Journal)
Firrman, J., Tanes, C., Bittinger, K., Mahalak, K.K., Rinaldi, W., Liu, L.S. 2019. Metagenomic assessment of the Cebus Apella gut microbiota. American Journal of Primatology. https://doi.org/10.1002/ajp.23023.
Rapid AAV neutralizing antibody determination with a cell-binding assay Reprint Icon - (Peer Reviewed Journal)
Guo, P., Zhang, J., Huang, J., Chew, H., Firrman, J., Sang, N., Diao, Y., Xiao, W. 2018. Rapid AAV neutralizing antibody determination with a cell-binding assay. Molecular Therapy. 13:40-46. https://doi.org/10.1016/j.omtm.2018.11.007.
Applying in vitro culturing technology to establish and evaluate the human gut microbiota Reprint Icon - (Peer Reviewed Journal)
Firrman, J., Liu, L.S., Van Den Abbeele, P., Tanes, C., Bittinger, K., Tomasula, P.M. 2019. Applying in vitro culturing technology to establish and evaluate the human gut microbiota. Journal of Visualized Experiments. 144:1-12. https://doi.org/10.3791/59054.
A deficiency in cathelicidin reduces lung tumor growth in NNK/NTHi-induced A/J mice - (Peer Reviewed Journal)
Yao, Y., Wu, J., Zhou, H., Firrman, J., Xiao, W., Sun, Z., Li, D. 2018. A deficiency in cathelicidin reduces lung tumor growth in NNK/NTHi-induced A/J mice. American Journal of Cancer Research. 8(7):1190-1199.
Establishing a mucosal gut microbial community in vitro using an an artificial simulator Reprint Icon - (Peer Reviewed Journal)
Liu, L.S., Firrman, J., Tanes, C., Bittinger, K., Thomas-Gahring, A.E., Wu, G.D., Van Den Abbeel, P., Tomasula, P.M. 2018. Establishing a mucosal gut microbial community in vitro using an an artificial simulator. PLoS One. 13(7):1-20. https://doi.org/10.1371/journal.pone.0197692.
Analysis of temporal changes in growth and gene expression for commensal gut microbes in response to the polyphenol naringenin Reprint Icon - (Peer Reviewed Journal)
Firrman, J., Liu, L.S., Arango Argoty, G., Zhang, L., Tomasula, P.M., Wang, M., Pontious, S., Kobori, M., Xiao, W. 2018. Analysis of temporal changes in growth and gene expression for commensal gut microbes in response to the polyphenol naringenin. Microbial Insights. 11:1-12. https://doi.org/10.1177/1178636118775100.
A robust system for production of superabundant VP1 recombinant AAV vectors Reprint Icon - (Peer Reviewed Journal)
Wang, Q., Wu, Z., Zhang, J., Firrman, J., Wei, H., Zhuang, Z., Liu, L.S., Miao, L., Hu, Y., Diao, Y., Xiao, W. 2017. A robust system for production of superabundant VP1 recombinant AAV vectors. Molecular Therapy. 7:146-156. https://doi.org/10.1016/j.omtm.2017.11.002.
Apigenin impacts growth of the gut microbiota and alters gene expression of Enterococcus - (Peer Reviewed Journal)
Wang, M., Firrman, J., Zhang, L., Arango-Argoty, G., Tomasula, P.M., Liu, L.S., Xiao, W., Yam, K. 2017. Apigenin impacts growth of the gut microbiota and alters gene expression of Enterococcus. Molecules. 22(8):1292.
Syngeneic AAV pseudo-particles potentiate gene transduction of AAV vectors - (Peer Reviewed Journal)
Wang, Q., Dong, B., Pokiniewski, K.A., Firrman, J., Wu, Z., Chin, M.P., Chen, X., Liu, L.S., Xu, R., Diao, Y., Xiao, W. 2017. Syngeneic AAV pseudo-particles potentiate gene transduction of AAV vectors. Molecular Therapy. doi: 10.1016/j.omtm.2016.12.004. PMCID: PMC5363323.
The effect of quercetin on genetic expression of the commensal gut microbes bifidobacterium catenulatum, enterococcus caccae and ruminococcus gauvreauii - (Peer Reviewed Journal)
Firrman, J., Liu, L.S., Zhang, L., Argoty, G., Wang, M., Tomasula, P.M., Kobori, M., Pontious, S., Xiao, W. 2016. The effect of quercetin on genetic expression of the commensal gut microbes bifidobacterium catenulatum, enterococcus caccae and ruminococcus gauvreauii. Anaerobe. 42:130-141. doi: 10.1016/j.anaerobe.2016.10.004. PMID:27742572.
High density recombinant AAV particles are competent vectors for in vivo transduction - (Peer Reviewed Journal)
Wang, Q., Firrman, J., Wu, Z., Pokiniewski, K.A., Valencia, C.A., Wang, H., Wei, H., Zhuang, Z., Liu, L.S., Wunder, S.L., Chin, M.S., Xu, R., Diao, Y., Dong, B., Xiao, W. 2016. High density recombinant AAV particles are competent vectors for in vivo transduction. Human Gene Therapy. doi: 10.1089/hum.2016.055. PMID: 27550145.
The effect of naringenin on the genetic expression of commensal gut bacteria - (Abstract Only)
Firrman, J., Liu, L.S., Tomasula, P.M., Xiao, W. 2016. The effect of naringenin on the genetic expression of commensal gut bacteria. ASM Conference. 16(9):11.
Evaluation of the biological differences of canine and human factor VIII in gene delivery: Implications in human hemophilia treatment - (Peer Reviewed Journal)
Wang, Q., Firrman, J., Moore, A., Liu, L.S., Kost, J., Xiao, W. 2016. Evaluation of the biological differences of canine and human factor VIII in gene delivery: Implications in human hemophilia treatment. Gene Therapy. 23(7):597-605. doi: 10.1038/gt.2016.34.
Genetic expression profile analysis of the temporal inhibition of quercetin and naringenin on Lactobacillus rhamnosus GG - (Peer Reviewed Journal)
Liu, L.S., Firrman, J., Argoty, G.A., Tomasula, P.M., Kobori, M., Zhang, L., Xiao, W. 2016. Genetic expression profile analysis of the temporal inhibition of quercetin and naringenin on Lactobacillus rhamnosus GG. Journal of Probiotics & Health. 4:139. doi: 10.4172/2329-8901.1000139.
Syngeneic AAV pseudo-vectors potentiates full vector transduction - (Abstract Only)
Wang, Q., Dong, B., Pokiniewski, K., Firrman, J., Wu, Z., Chin, M., Chen, X., Liu, L.S., Xu, R., Diao, Y., Xiao, W. 2016. Syngeneic AAV pseudo-vectors potentiates full vector transduction. Meeting Abstract. 19(5):11.