Mei Wang
Natural Products Utilization Research
Research Chemist
Phone: (662) 915-1046
Fax:
(Employee information on this page comes from the REE Directory. Please contact your front office staff to update the REE Directory.)
Publications
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Chemical mimicry in the corpse flower: Floral odor and phytochemical
profiles of Amorphophallus titanum (Becc.) Becc.
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Raman, V., Wang, M., Avula, B., Khan, I. 2024. Floral scent analysis and phytochemical profiling of titan arum (Amorphophallus titanum) by headspace-solid phase microextraction gas chromatography/liquid chromatography coupled with quadrupole-time of flight mass spectromet. Biochemical Systematics and Ecology. 118:1-12. https://doi.org/10.1016/j.bse.2024.104.
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Insecticidal and repellent activity of Piper crassinervium essential oil and its pure compounds against imported fire ants (Hymenoptera: Formicidae).
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Shah, F., Wang, M., Zhao, J., Lee, J., Farago, P., Manfron, J., Khan, I.A., Ali, A. 2024. Insecticidal and repellent activity of Piper crassinervium essential oil and its pure compounds against imported fire ants (Hymenoptera: Formicidae).. Molecules. 29:1-12. https://doi.org/10.3390/molecules29225430.
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Phytochemical profiling of soybean genotypes using GC-MS and UHPLC-DAD/MS
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Li, S., Wang, M., Lee, J. 2024. Phytochemical profiling of soybean genotypes using GC-MS and UHPLC-DAD/MS. PLOS ONE. 19(8):e0308489. https://doi.org/10.1371/journal.pone.0308489.
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Bioprospecting and Repurposing of Leaf Biomass to Support
Sustainable Biopharmacy: Evaluation of Seasonal Chemical Variations
and Biological Activities of Six Eucalyptus Essential Oils
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Migacz IP, Wang M., Faoro JAM, dos Santos E, Formagio ASN, Kassuya CAL, Rheman JU, Perera W, Gonçalves VC. Chaves DSA, Raman V, Farago PV, Khan IK, Manfron J. Bioprospecting and repurposing of leaf biomass to support sustainable biopharmacy: Evaluation of seasonal chemical variations and biological activities of six eucalyptus essential oils. Int J Environ Res 18, 74, 2024. https://doi.org/10.1007/s41742-024-00628-z (407785)
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Rapid preparation and proton NMR fingerprinting of polysaccharides from Radix Astragali
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Cao, L., Zhao, J., Wang, M., Khan, I. A., & Li, X.-C. (2024). Rapid preparation and proton NMR fingerprinting of polysaccharides from Radix Astragali. Carbohydrate Research, 536, 109053. doi:10.1016/j.carres.2024.109053
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Identification and functional characterization of oxidosqualene cyclases from medicinal plant Hoodia gordonii
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Parveen, I., Wang, M., Zhao, J., Zhu, Y., Chittiboyina, A.G., Khan, I.A., Pan, Z. 2024. Identification and functional characterization of oxidosqualene cyclases from medicinal plant Hoodia gordonii. Plants. 13(2):231. https://doi.org/10.3390/plants13020231.
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Comprehensive quality assessment of peppermint oils and commercial products: An integrated approach involving conventional and chiral GC/MS coupled with chemometrics
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Wang, M., Lee, J., Zhao, J., Lee, J., Chatterjee, S., Chittiboyina, A.G., Ali, Z., Khan, I.A. 2023. Comprehensive quality assessment of peppermint oils and commercial products: An integrated approach involving conventional and chiral GC/MS coupled with chemometrics. Journal of Chromatography B. 1232:123953. https://doi.org/10.1016/j.jchromb.2023.123953.
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Investigation of morpho-anatomical, molecular, GC/QToF, and LC/QToF characterization of Salvia mellifera (black sage), Saliva apiana (white sage) and their varieties
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Adams, S.J., Lee, J., Avula, B., Katragunta, K., Wang, M., Parveen, I., Techen, N., Chittiboyina, A., Khab, I. 2023. Investigation of morpho-anatomical, molecular, GC/QToF, and LC/QToF characterization of Salvia mellifera (black sage), Saliva apiana (white sage) and their varieties. South African Journal of Botany. 164:77-90. https://doi.org/10.1016/j.sajb.2023.11.038.
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The Cardiorenal Effects of Piper amalago Are Mediated by the Nitric Oxide/Cyclic Guanosine Monophosphate Pathway and the Voltage-Dependent Potassium Channels Ethnopharmacological investigation of Piper amalago L
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Monteiro, L.M., Klider, L.M., Marques, A.A., Farago, P.V., Emiliano, J., Souza, R.I., Dos Santos, A.C., Dos Santos, V.L., Wang, M., Cassemiro, N.S., Silva, D.B., Khan, I.A., Gasparotto,Jr, A., Manfron, J. 2023. The Cardiorenal Effects of Piper amalago Are Mediated by the Nitric Oxide/Cyclic Guanosine Monophosphate Pathway and the Voltage-Dependent Potassium Channels Ethnopharmacological investigation of Piper amalago L. Pharmaceuticals. 16:1-24. https://doi.org/10.3390/ph16111630.
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Proximate composition and nutritional analysis of selected bananas cultivated in Hainan, China
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Tan, L., He, Y., Li, S., Deng, J., Avula, B., Zhang, J., Nirmal, P.D., Solis-Sainz, J., Wang, M. 2023. Proximate composition and nutritional analysis of selected bananas cultivated in Hainan, China. Journal of Food Composition and Analysis. https://doi.org/10.1016/j.jfca.2023.105798.
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Chemical profile and cytotoxic activity of essential oils from six species of Baccharis subgenus Coridifoliae (Asteraceae)
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De Almeida, V.P., Tolouei, S.E., Minteguiaga, M., Heiden, G., Khan, S.I., Wang, M., Dellacasa, E., Raman, V., Farago, P.V., Khan, I.A., Junior, A.G., Manfron, J. 2023. Chemical profile and cytotoxic activity of essential oils from six species of Baccharis subgenus Coridifoliae (Asteraceae). Chemistry and Biodiversity. 20:1-13. https://doi.org/10.1002/cbdv.202300862.
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Physiological and Biochemical Responses of Turmeric (Curcuma longa L.) Under Drought Stress
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Bharadwaj, B., Sanathanam, S., Pham, T., Cantrell, C.L., Wang, M., Mentreddy, S., Basu, C. 2024. Physiological and Biochemical Responses of Turmeric (Curcuma longa L.) Under Drought Stress. Journal of Medicinally Active Plants. 13:40-55. https://doi.org/10.7275/jmap.2315.
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6-Oxofurostane and (iso)spirostane type of saponins in Smilax sieboldii: UHPLC-QToF-MS/MS and GNPS-molecular networking approach for the rapid dereplication and biodistribution of specialized metabolites
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Avula, B., Bae, J., Ahn, J., Wang, Y., Wang, M., Kwon, Y., Chittiboyina, A.G., Khan, I.A. 2023. 6-Oxofurostane and (iso)spirostane type of saponins in Smilax sieboldii: UHPLC-QToF-MS/MS and GNPS-molecular networking approach for the rapid dereplication and biodistribution of specialized metabolites. International Journal of Molecular Sciences. https://doi.org/10.3390/ijms241411487.
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Chemical characterization and quantitative determination of flavonoids and phenolic acids in yerba santa (Eriodictyon spp.) using UHPLC/DAD/Q-ToF
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Wang, M., Zhao, J., Avula, B., Lee, J., Upton, R., Khan, I. 2023. Chemical characterization and quantitative determination of flavonoids and phenolic acids in yerba santa (Eriodictyon spp.) using UHPLC/DAD/Q-ToF. Journal of Pharmaceutical and Biomedical Analysis. https://doi.org/10.1016/j.jpba.2023.115570.
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Cannabinoid receptor type II ligands from sandalwood oil and synthetic alpha-santalol derivatives
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Paudel, P., Pandey, P., Paris, J.J., Ashpole, N.M., Mahdi, F., Tian, J., Lee, J., Wang, M., Xu, M., Chittiboyina, A.G., Khan, I.A., Ross, S.A., Li, X. 2023. Cannabinoid receptor type II ligands from sandalwood oil and synthetic alpha-santalol derivatives. Journal of Natural Products. https://doi.org/10.1021/acs.jnatprod.3c00282.
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Chemical characterization and quality assessment of copaiba oil-resin using GS/MS and SFC/MS
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Lee, J., Wang, M., Zhao, J., Ali, Z., Hawwal, M., Khan, I. 2023. Chemical characterization and quality assessment of copaiba oil-resin using GS/MS and SFC/MS. Plants. https://doi.org/10.3390/plants12081619.
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Yerba santa leaves and tops eriodictyon californicum and related species-standards of identity, purity, analysis, and quality control
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Wang, M. 2023. Yerba santa leaves and tops eriodictyon californicum and related species-standards of identity, purity, analysis, and quality control. American Herbal Pharmacopoeia and Therapeutic Compendium. 1.
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Antiplasmodial and antimicrobial activities of ent-abietane diterpenoids from the roots of Suregada zanzibariensis
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Matundura, J.O., Midiwo, J.O., Yenesew, A., Omosa, L., Kumarihamy, M., Zhao, J., Wang, M., Tripathi, S., Khan, S., Masila, V.M., Nchiozem-Ngnitedem, V., Muhammad, I. 2022. Antiplasmodial and antimicrobial activities of ent-abietane diterpenoids from the roots of Suregada zanzibariensis. Natural Product Research. https://doi.org/10.1080/14786419.2022.2158463.
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Development of a GC/Q-ToF method coupled with headspace solid-phase microextraction to evaluate the in vitro metabolism of ß-Caryophyllene
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Lee, J., Wang, M., Mondal, G., Khan, I.A., Yates, C.R. 2022. Development of a GC/Q-ToF method coupled with headspace solid-phase microextraction to evaluate the in vitro metabolism of ß-Caryophyllene. Molecules. https://doi.org/10.3390/molecules27217441.
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Synthesis and inhibitory activity of machaeridiol- based novel anti-MRSA and anti-VRE compounds and their profiling for cancer- related signaling pathways
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Kumarihamy, M., Tripathi, S., Balachandran, P., Avula, B., Zhao, J., Wang, M., Bennett, M., Carr, M.A., Micheal, L., Ocean, W.I., Marquart, M.E., Nanayakkara, D., Muhammad, I. 2022. Synthesis and inhibitory activity of machaeridiol- based novel anti-MRSA and anti-VRE compounds and their profiling for cancer- related signaling pathways. Molecules. https://doi.org/10.3390/molecules27196604.
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Comparative analysis of chemical profiles of Radix Astragali between ultrafine granular powder and traditional sliced mate-rials
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Cao, L., Wang, M., Zhao, J., Peng, L., Cheng, J., Qiu, S., Khan, I., Li, X. 2022. Comparative analysis of chemical profiles of Radix Astragali between ultrafine granular powder and traditional sliced mate-rials. Medicinal Plant Biology. https://doi.org/10.48130/MPB-2022-0004.
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Utility of fatty acid profile and in vitro immune cell activation for chemical and biological standardization of Arthrospira/Limnospira
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Huh, J., Zhang, J., Hauerová, R., Lee, J., Haider, S., Wang, M., Hauer, T., Khan, I., Chittiboyina, A., Pugh, N. 2022. Utility of fatty acid profile and in vitro immune cell activation for chemical and biological standardization of Arthrospira/Limnospira. Scientific Reports. https://doi.org/10.1038/s41598-022-19590-x.
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Phytochemical investigation of Egyptian Spinach leaves, a potential
source for antileukemic metabolites: in vitro and in silico study
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Abdelgawad, S.M., Hetta, M.H., Ibrahim, M.A., Balachandran, P., Zhang, J., Wang, M., Fawzy, G.A., El-Askary, H.I., Ross, S.A. 2022. Phytochemical investigation of Egyptian Spinach leaves, a potential source for antileukemic metabolites: in vitro and in silico study. Revista Brasileira de Farmacognosia. https://doi.org/10.1007/s43450-022-00307-0.
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Metabolite variation and discrimination of five licorice (Glycyrrhiza) species: HPTLC and NMR explorations
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Zhao, J., Wang, M., Sabastian, J.A., Lee, J., Chittiboyina, A.G., Avula, B., Ali, Z., Li, J., Wu, C., Khan, I. 2022. Metabolite variation and discrimination of five licorice (Glycyrrhiza) species: HPTLC and NMR explorations. Journal of Pharmaceutical and Biomedical Analysis. https://doi.org/10.1016/j.jpba.2022.115012.
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Chemical authentication and speciation of Salvia botanicals: an investigation utilizing GC/Q-ToF and chemometrics
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Lee, J., Wang, M., Jianping, Z., Avula, B., Chittiboyinaa, A.G., Khan, I.A. 2022. Chemical authentication and speciation of Salvia botanicals: an investigation utilizing GC/Q-ToF and chemometrics. Foods. https://doi.org/10.3390/foods11142132.
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Phytochemical investigation of Egyptian riverhemp: a potential
source of antileukemic metabolites
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Abdelgawad, S.M., Hett, M.H., Ibrahima, M.A., Balachandran, P., Zhang, J., Wang, M., Fawzy, G.A., El-Askary, H.I., Ross, S.A. 2022. Phytochemical investigation of Egyptian riverhemp: a potential source of antileukemic metabolites. Journal of Natural Medicine. https://doi.org/10.1155/2022/8766625.
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Chemometric analysis and chemical characterization for the botanical identification of Glycyrrhiza species (G. glabra, G. uralensis, G. inflata, G. echinata and G. lepidota) using liquid chromatography-quadrupole time of flig
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Avula, B., Bae, J., Chittiboyina, A.G., Wang, Y., Wang, M., Zhao, J., Zulfiqar, A., Li, J., Wu, C., Khan, I.A. 2022. Chemometric analysis and chemical characterization for the botanical identification of Glycyrrhiza species (G. glabra, G. uralensis, G. inflata, G. echinata and G. lepidota) using liquid chromatography-quadrupole time of flig. Journal of Agricultural and Food Chemistry. https://doi.org/10.1016/j.jfca.2022.104679.
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Agronomy, chemical analysis, and antidiabetic activity of basil (Ocimum species)
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Wang, M., Cantrell, C.L., Matthews, S.T., Paudel, P., Lee, J., Mentreddy, S.R. 2022. Agronomy, chemical analysis, and antidiabetic activity of basil (Ocimum species). Journal of Agricultural and Food Chemistry. https://doi.org/10.1021/acsfoodscitech.2c00100?urlappend=%3Fref%3DPDF&jav=VoR&rel=cite-as.
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A new gnidiflavanone-flavonol dimer and other constituents from Gnidia apiculata
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Kamau, R.W., Midiwo, J.O., Mgani, Q.A., Masila, V.M., Kumarihamy, M., Wang, M., Zhao, J., Muhamma, I. 2022. A new gnidiflavanone-flavonol dimer and other constituents from Gnidia apiculata. Natural Product Research. https://doi.org/10.1080/14786419.2022.2062349.
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Comparative analysis of five salvia species using LC-DAD-QToF
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Avula, B., Bae, J., Chittiboyinaa, A.A., Wang, Y., Wang, M., Srivedavyasasri, R., Ali, Z., Li, J., Wu, C., Khan, I.A. 2021. Comparative analysis of five salvia species using LC-DAD-QToF. Journal of Pharmaceutical and Biomedical Analysis. https://doi.org/10.1016/j.jpba.2021.114520.
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Are atranols the only skin sensitizers in oakmoss, a systematic investigation using non-animal methods
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Avonto, C., Chittiboyina, A.G., Khan, S.I., Dale, O.R., Parcher, J.F., Wang, M., Khan, I.A. 2020. Are atranols the only skin sensitizers in oakmoss, a systematic investigation using non-animal methods. Toxicology In Vitro. 70. Article e105053. https://doi.org/10.1016/j.tiv.2020.105053.
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NMR technique and methodology in botanical health product analysis and quality control
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Zhao, J., Wang, M., Saroja, S.G., Khan, I.A. 2021. NMR technique and methodology in botanical health product analysis and quality control. Journal of Pharmaceutical and Biomedical Analysis. https://doi.org/10.1016/j.jpba.2021.114376.
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Analysis of docosanol using GC/MS: Method development, validation, and application to ex vivo human skin permeation studies
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Shankara, V., Wang, M., Ajjarapua, S., Kolimi, P., Avula, B., Murthy, R., Khan, I., Naraisimha, M. 2021. Analysis of docosanol using GC/MS: Method development, validation, and application to ex vivo human skin permeation studies. Journal of Pharmaceutical and Biomedical Analysis. https://doi.org/10.1016/j.jpha.2021.08.004.
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Chemical constituents and anti-gastric ulcer activity of essential oils of Alpinia officinarum (Zingiberaceae), Cyperus rotundus (Cyperaceae), and their herbal pair
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Huijuan, Q., Lin, K., Li, X., Ou, H., Tan, Y., Wang, M., Wei, N. 2021. Chemical constituents and anti-gastric ulcer activity of essential oils of Alpinia officinarum (Zingiberaceae), Cyperus rotundus (Cyperaceae), and their herbal pair. Chemistry and Biodiversity. https://doi.org/10.1002/cbdv.202100214.
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Synthesis and antifungal activity evaluation of phloeodictine analogues
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Ravu, R., Jacob, M.R., Khan, S.I., Wang, M., Cao, L., Agarwal, A.K., Clark, A.M., Li, X. 2021. Synthesis and antifungal activity evaluation of phloeodictine analogues. Journal of Natural Products. 84,2129-2137. https://doi.org/10.1021/acs.jnatprod.1c00116.
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(E)-2,6,10-Trimethyldodec-8-en-2-ol: An undescribed sesquiterpenoid from copaiba oil
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Hawwal, M.F., Ali, Z., Wang, M., Zhao, J., Lee, J., Fantoukh, O.I., Khan, I.A. 2021. (E)-2,6,10-Trimethyldodec-8-en-2-ol: An undescribed sesquiterpenoid from copaiba oil. Molecules. 2021, 26, 4456. https://doi.org/10.3390/molecules26154456.
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Chemical profiling and characterization of anthraquinones from two Bulbine species and dietary supplements using liquid chromatography-high resolution mass spectrometry
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Avula, B., Bae, J., Wang, Y., Wang, M., Ali, Z., Khan, I.A. 2021. Chemical profiling and characterization of anthraquinones from two Bulbine species and dietary supplements using liquid chromatography-high resolution mass spectrometry. Nature Product Communications. https://doi.org/10.1093/jaoacint/qsab075.
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A novel approach for lavender essential oil authentication and quality assessment
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Wang, M., Zhao, J., Ali, Z., Avonto, C., Khan, I. 2021. A novel approach for lavender essential oil authentication and quality assessment. Journal of Pharmaceutical and Biomedical Analysis. 199. Article e114050. https://doi.org/10.1016/j.jpba.2021.114050.
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Quantitative determination and characterization of polyphenols from Cissus quadrangularis L. and dietary supplements using UHPLC-PDA-MS, LC-QToF and HPTLC
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Avula, B., Bae, J., Zhao, J., Wang, Y., Wang, M., Zhang, Z., Ali, Z., Khan, I. 2021. Quantitative determination and characterization of polyphenols from Cissus quadrangularis L. and dietary supplements using UHPLC-PDA-MS, LC-QToF and HPTLC. Journal of Pharmaceutical and Biomedical Analysis. https://doi.org/10.1016/j.jpba.2021.114036.
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Cross talk of cancer signaling pathways by cyclic hexapeptides and anthraquinones from Rubia cordifolia
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Balachandran, P., Ibrahim, M.A., Zhang, J., Wang, M., Pasco, D.S., Muhammad, I. 2021. Cross talk of cancer signaling pathways by cyclic hexapeptides and anthraquinones from Rubia cordifolia. Molecules. 26/735. https://doi.org/10.3390/molecules26030735.
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Antimicrobial constituents from Machaerium Pers.: Inhibitory activities and synergism of machaeriols and machaeridiols against methicillin-resistant Staphylococcus aureus and Vancomycin-resistant Enterococcus faecium and perm
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Muhammad, I., Jacob, M.R., Ibrahim, M.A., Raman, V., Kumarihamy, M., Wang, M., Al-Adhami, T., Hind, C., Clifford, M., Martin, B., Sutton, M., Rahman, M., Zhao, J. 2020. Antimicrobial constituents from Machaerium Pers.: Inhibitory activities and synergism of machaeriols and machaeridiols against methicillin-resistant Staphylococcus aureus and Vancomycin-resistant Enterococcus faecium and perm. Molecules. 25/6000. https://doi.org/10.3390/molecules25246000.
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Phenolic contents, chemical profiling, in silico and in vitro antiinflammatory and anticancer properties of Alnus nitida (Spach) Endl
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Shaukat, U., Ahemad, S., Wang, M., Khan, S.I., Ali, Z., Muhammad I, T.I., Abdallah, H.H., Khan, I.A., Saleem, M., Mahomoodally, M.F. 2021. Phenolic contents, chemical profiling, in silico and in vitro antiinflammatory and anticancer properties of Alnus nitida (Spach) Endl. South African Journal of Botany. 138:148-155. https://doi.org/10.1016/j.sajb.2020.12.010.
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Newly generated Atractylon derivatives in the processed rhizomes of Atractylodes macrocephala Koidz
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Zhai, C., Zhao, J., Chittiboyina, A.G., Meng, Y., Wang, M., Khan, S.I., Khan, I.A. 2020. Newly generated Atractylon derivatives in the processed rhizomes of Atractylodes macrocephala Koidz. Molecules. https://doi.org/10.3390/molecules25245904.
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Comparative study and quality evaluation regarding morphology characters, volatile constituents and triglycerides in seeds of five species used in traditional Chinese medicine
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Wei, N., Wang, M., Adams, S.J., Yu, P., Avula, B., Wang, Y., Pan, K., Wang, Y., Khan, I.A. 2020. Comparative study and quality evaluation regarding morphology characters, volatile constituents and triglycerides in seeds of five species used in traditional Chinese medicine. Journal of Pharmaceutical and Biomedical Analysis. 194. Article e113801. https://doi.org/10.1016/j.jpba.2020.113801.
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Effects of Euphorbia umbellata extracts on complement activation and chemotaxis of neutrophils
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De Oliveira, T.L., Fontana, P.D., Bavia, L., Cruz, L., Crisma, A.R., Sassaki, G.L., Menezes, L.R., Wang, M., Beltrame, F., Messias-Reason, I.J. 2020. Effects of Euphorbia umbellata extracts on complement activation and chemotaxis of neutrophils. Journal of Ethnopharmacology. 265/113348. https://doi.org/10.1016/j.jep.2020.113348.
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Identification of antifungal bisphosphocholines from medicinal Gentiana species
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Ren, S., Deng, K., Qiu, S., Wang, M., Avula, B., Tripathi, S.K., Jacob, M.R., Gong, L., Wang, W., Khan, I.A., Li, X. 2020. Identification of antifungal Bisphosphocholines from medicinal Gentiana species. Journal of Natural Products. 2020, 83, 10, 3207–3211. https://doi.org/10.1021/acs.jnatprod.0c00584.
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A comprehensive workflow for the analysis of Bio-Macromolecular supplements: Case Study of 20 Whey protein products
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Avula, B., Parveen, I., Zhao, J., Wang, M., Techen, N., Wang, Y., Riaz, M., Bae, J., Shami, A.A., Chittiboyina, A.G., Khan, I.A., Sharp, J.S. 2021. A comprehensive workflow for the analysis of Bio-Macromolecular supplements: Case Study of 20 Whey protein products. Journal of Dietary Supplement. https://doi.org/10.1080/19390211.2021.1897724.
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