NMR technique and methodology in botanical health product analysis and quality control

Authors: ZHAO, JIANPING - University Of Mississippi; Wang, Mei; SAROJA, SEETHAPATHY - University Of Mississippi; KHAN, IKHLAS - University Of Mississippi

Submitted to: Journal of Pharmaceutical and Biomedical Analysis
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 9/14/2021
Publication Date: 9/20/2021
Citation: Zhao, J., Wang, M., Saroja, S.G., Khan, I.A. 2021. NMR technique and methodology in botanical health product analysis and quality control. Journal of Pharmaceutical and Biomedical Analysis. https://doi.org/10.1016/j.jpba.2021.114376.
DOI: https://doi.org/10.1016/j.jpba.2021.114376

Interpretive Summary: This review article intends to provide an overview of the potential uses of NMR methodologies in botanical research and development and quality control of botanical health products, so that the NMR techniques discussed may be further recognized by researchers; while the NMR application examples demonstrated in this review may enlighten the updating path of further explorations in this field. The review covers three main topics. Firstly, the NMR techniques and methodologies commonly used in botanical analysis and quality control will be summarized. Those techniques and methodologies are categorized and discussed based on their technical characteristics to improve their recognition. Secondly, the applications of NMR techniques and methodologies in different areas of botanical health product analysis and quality control will be summarized, and selected application examples will be presented for demonstration purposes. Lastly, a brief summary including some perspectives on NMR and its use in botanical health products will be presented. It is expected that this review may be helpful to the developments of NMR techniques and applications in botanical product research and practice.

Technical Abstract: Botanicals have played an important role in maintaining human health and well-being throughout history. During the past few decades in particular, the use of botanical health products has gained more popularity. Whereas, quality, safety and efficacy concerns have continuously been critical issues due to the intrinsic chemical complexity of botanicals. Chemical analytical technologies play an imperative role in addressing these issues. Nuclear magnetic resonance (NMR) spectroscopy has proven to be a powerful and useful tool for the investigation of botanical health products. In this review, NMR techniques and methodologies that have been successfully applied to the research and development of botanical health products in all the stages, from plants to products, are discussed and summarized. Furthermore, NMR methods together with other analytical techniques used for a variety of application domains, such as plant species differentiation, adulteration detection, and bio-activity evaluation, are discussed and illustrated with typical application examples. This article provides an overview of the potential uses of NMR techniques and methodologies in an attempt to further promote their recognition and utilization in the field of botanical health products research and development.