| fixped.f90 | Checks pedigree relationships and discovers additional relatives | ||
| Downloads | Program files and executable | ||
| Input | Mostly the output files from findhap, version 3. Other input files are: |
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| pedigree.file | Contains genotyped animals and their ancestors (same file used in findhap) Provides a more complete file than just known ancestors of genotyped animals |
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| .../pedigrees.txt | Provides a more complete file than just known ancestors of genotyped animals | ||
| clone.keys | Links known identical animals to one member of clone group | ||
For faster processing, input files from findhap can include only new animals and then link to the following full files from findhap that included all prior animals: |
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| pedigree.priors | Same format as pedigree.file but for all prior animals | ||
| hap.listpriors | hap.list from a prior full run | ||
| hap.foundpriors | hap.found from a prior full run | ||
| hap.filledpriors | hap.filled from a prior full run | ||
Steps |
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| Output | bestmatches | Ancestor type: MGS, MGGS | |
Dam/maternal grandam (MGD) source codes: |
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| 0 | Unknown (no identification information) | ||
| G | Genotyped | ||
| I | Imputed | ||
| P | Pedigree dam or MGD of genotyped animal (has identification information but not genotyped) | ||
Match: |
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| 0 | No likely MGS/MGGS found to replace unknown | ||
| 1 | Pedigree MGS/MGGS has most matches | ||
| 2 | Pedigree MGS/MGGS has 2nd most matches | ||
| 3 | Pedigree MGS/MGGS has 3rd most matches | ||
| 4+ | Pedigree MGS/MGGS has 3 or more bulls with more matches | ||
| ADD | Add MGS/MGGS replacing missing | ||
| DEL | Pedigree MGS/MGGS is unlikely, no better candidate found | ||
| FIX | MGS/MGGS found, likely the true ancestor to replace genotyped one | ||
| P | Pedigree MGS/MGGS not genotyped | ||
| SUB | MGS/MGGS found, likely the true ancestor to replace nongenotyped one | ||
bestmatchesEXTRA |
Ancestor type: Dams, sires, full sibs, PGS, clones |
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Relative type: |
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| CLON | Identical genotype | ||
| DAM1 | Check and confirm if dam genotyped or delete if low match | ||
| DAM2 | Output discovered dam if unknown but full sib has a dam | ||
| DAM3 | Output discovered dam among daughters of MGS | ||
| DAM4 | Discover dam and clones if neither sire nor MGS are genotyped | ||
| SIRE | Sire | ||
| FSIB | Full sib | ||
| PGS | Paternal grandsire (top 3 listed may also include MGS) | ||
Match: |
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| OK | Haplotypes confirm pedigree (used with CLON and FSIB) | ||
| SUG | Discovered full sib has pedigree dam, but this full sib does not | ||
| LOW | Reported sire has low number of matches; no better match found | ||
| References | 2020 | Nani, J.P., L.R. Bacheller, J.B. Cole, and P.M. VanRaden. Discovering ancestors and connecting relatives in large genomic databases. J. Dairy Sci. 103:1729–1734. | |
| 2013 | VanRaden, P.M., T.A. Cooper, G.R. Wiggans, J.R. O'Connell, and L.R. Bacheller. Confirmation and discovery of maternal grandsires and great-grandsires in dairy cattle. J. Dairy Sci. 96:1874–1879. | ||
| License | Fortran package fixped is public domain and was developed with U.S. taxpayer funding. Accurate results are not guaranteed. Please report any bugs to juanonani@gmail.com. You may modify, improve, use, and redistribute the code to anyone for any purpose. Or, you can ask Juan to make changes that could benefit U.S. evaluations and other users. | ||
Juan Nani
Paul VanRaden
Animal Genomics and Improvement Laboratory
Agricultural Research Service, USDA