Edmund Norris

Research Entomologist

Telephone: (352) 374 - 5919

Email: edmund.norris@usda.gov

Google Scholar

Education

Research Focus

Our lab is interested in the development of novel repellents and insecticidal formulations that may circumvent insecticide resistance, while primarily focusing on natural products as our inspiration. Our research focuses on better understanding the mechanisms of novel repellent, insecticidal, and synergistic agents using a variety of electrophysiolgical, pharmacological, and biochemical techniques.

Lab Members

Greg Allen
Jedidiah Kline
Shawn Culley

Research Experience

Research and Product Development, Clarke Mosquito Control Products, 2011 - 2012
Research Associate I, Pesticide Toxicology Laboratory, July 2012 - December 2013
Graduate Research Assistant, Pesticide Toxicology Laboratory, Ames, IA, 2014 - 2018
Laboratory Supervisor, Pesticide Toxicology Laboratory, 2015 - 2018
Post-doctoral Research Associate, Bloomquist Toxicology Laboratory, September 2018 - September 2020
USDA Chemist/Entomologist, September 2020 - Current

Membership in Professional Societies

American Mosquito Control Association – AMCA

Entomological Society of America – ESA

American Chemical Society – Agrochemicals Division of ACS

Society of Vector Ecology – SOVE

Patents (Current and Pending)

1. Monoterpenoid/phenylpropanoid-containing compounds and methods of their making and use as seed treatments. Joel R. Coats, James S. Klimavicz, Edmund J. Norris, A. D. Lindsay, Steven. M. Bessette International Application #PCT/US17/48291
2. Monoterpenoid/phenylpropanoid-containing compounds and methods of their making and use as herbicides. Joel R. Coats, James S. Klimavicz, Edmund J. Norris, A. D. Lindsay, Steven. M. Bessette. International Application #PCT/US17/48290
3. Monoterpenoid/phenylpropanoid-containing compounds and methods of their making and use as insecticidal baits. Joel R. Coats, James S. Klimavicz, Edmund J. Norris, A. D. Lindsay, Steven. M. Bessette International Application # PCT/US17/48293
4. Insect repellent compounds and compositions, and methods thereof. Joel R. Coats, Edmund J. Norris, James S. Klimavicz. US Patent Application # 15684770
5. Natural derivatives and methods of using the same. George A. Kraus, Joel R. Coats, Edmund J Norris, Yang Qu. US Patent Application #20200024246A1
6. Methods of Using Pogostone as an Herbicide. George A. Kraus, Joel R. Coats, Edmund J Norris. US Provisional Patent Application #62/797,760
7. Synergistic and Residual Pesticidal Compositions. J. Coats, E. Norris, Bessette, S. O’Connor, G. US Provisional Patent Application #62838484
8. COMPOSITIONS AND METHODS RELATING TO INSECTICIDES. Jeffrey R. Bloomquist, E. J. Norris. US Provisional Patent Application #62823796
9. Synergistic Mixtures for Arthropod Toxicity and Repellency Liu Yang, Gary Richoux Jr., Edmund J. Norris, Jeffrey R. Bloomquist. US Provisional Patent Application #62/880,503
10. COMPOSITIONS AND METHODS RELATING TO INSECTICIDES. Jeffrey R. Bloomquist, E. J. Norris. US Provisional Patent Application # 62890808
11. Synergistic Mixtures Comprising Pyrethrum for Arthropod Toxicity and Repellency. Jeffrey R. Bloomquist, E. J. Norris. US Provisional Patent Application # 63/143,581

Invited Presentations

1. Edmund J Norris, Quentin R. R. Coquerel, Fabien Démares, Werner J. Geldenhuys, Anne-Marie Le Ray, Dimitri Bréard, Pascal Richomme, Christian Legros, Jeffrey R. Bloomquist. Neurophysiological and insecticidal effects of liriodenine, an alkaloid isolated from the Chinese herb Zanthoxylum nitidum. American Chemical Society – AgroChemicals Division. August 2021.
2. Edmund J Norris. Developing Biorational Repellents and Insecticides. W4045 Agrochemical Impacts on Human And Environmental Health: Mechanisms And Mitigation Annual Meeting. Virtual Meeting – August 2021.
3. Edmund J Norris, Jeffrey Bloomquist. DFDT (p-p’-difluoro-DDT) as an antimalarial mosquitocide. March Malaria Madness Meeting – Virtual Symposium. February 2021.
4. Edmund J Norris, Jeffrey Bloomquist. Target-site Mechanism of Action of Resistance Breaking Natural Products. American Chemical Society – AgroChemicals Division. August 2020.
5. Edmund J. Norris, Adam Mullis, Caleb Corona, Balaji Narasimhan, Lyric Bartholomay, Joel R. Coats. Distribution of biodegradable nano- and microparticles in Aedes aegypti tissues. Entomological Society of America. St. Louis, MO. November 2019.
6. Edmund J. Norris, Jeffrey Bloomquist. Plant essential oils enhance public health insecticides through diverse modes of action. American Chemical Society – AgroChemicals Division. August 2019.
7. Edmund J. Norris, Jeffrey Bloomquist. Natural and synthetic compounds display multiple mechanisms of synergism and resistance-breaking properties. American Chemical Society – AgroChemicals Division. August 2019.
8. Edmund Norris, Jeffrey Bloomquist. Fir needle plant essential oil significantly increases knockdown, but not toxicity, of diverse public health insecticides against Aedes aegypti. St. Augustine Mosquito Control Workshop. March 2019.
9. Edmund Norris, Maria Archevald-Cansobre, Aaron D Gross, Lyric Bartholomay, Joel R. Coats. Phytochemical synergists: Plant oils inhibit detoxification enzymes in the yellow fever mosquito. Entomological Society of America. Vancouver, BC. November 2018.
10. Edmund Norris. Panel Member. INSecticide TARgets Symposium Summit. American Chemical Society. Boston, MA. August 2018.
11. Edmund Norris, Aaron D. Gross, Lyric Bartholomay, Joel Coats. Phytochemical synergists for insecticides: Replacement for piperonyl butoxide. Entomological Society of America. Denver, CO. November 2017.
12. Edmund Norris, Maria Archevald-Cansobre, Aaron D Gross, Lyric Bartholomay, Joel R. Coats. Plant oils are capable of enhancing diverse insecticides against susceptible and resistant strains of mosquitoes. American Society of Tropical Medicine and Hygiene. Baltimore, MD. November 2017.
13. Edmund Norris, Maria Archevald-Cansobre, Aaron D. Gross, Lyric C. Bartholomay, Joel R. Coats. Plant oils are capable of enhancing diverse insecticides against susceptible and resistant strains of mosquitoes. Society of Vector Ecology. Mallorca, Spain. September 2017.
14. Edmund Norris, Maria Archevald-Cansobre, Aaron D. Gross, Lyric C. Bartholomay, Joel R. Coats. Phytochemical synergists: Natural plant oils as synergists for diverse pyrethroids. American Chemical Society – AgroChemicals Division. Washington, DC. August 2017.
15. Edmund Norris, Joel R. Coats, James Klimavicz, Lyric Bartholomay. Biorepellents: Natural and Biorational terpenes. International Congress of Entomology. Repellents Symposium. International Congress of Entomology. Orlando, FL. October 2016.

Projects and Publications

• Projects

  Integrated Pest Management of Mosquitoes and Biting Flies In-House Appropriated (D)   Accession Number:436298

  Improved Surveillance and Control of Stable Flies, House Flies, and Other Filth Flies In-House Appropriated (D)   Accession Number:436307

• Publications

  • (Clicking on the reprint icon will take you to the publication reprint.)
  • Topical toxicity and repellency profiles of 17 essential oil components against insecticide-resistant and susceptible strains of house flies (Diptera: Muscidae) -(Peer Reviewed Journal)
    Tian, Y., Hogsette, Jr, J.A., Norris, E.J., Hu, X. 2024. Topical toxicity and repellency profiles of 17 essential oil components against insecticide-resistant and susceptible strains of house flies (Diptera: Muscidae). Insects. 15(6). https://doi.org/10.3390/insects15060384.
    
  • Point protection with transfluthrin against Musca domestica in a semi-field enclosure -(Database / Dataset)
    Aldridge, R.L., Pagac, A.A., Norris, E.J., Geden, C.J., Kline, D.L., Linthicum, K. 2024. Point protection with transfluthrin against Musca domestica in a semi-field enclosure. Ag Data Commons. https://doi.org/10.15482/USDA.ADC/25222424.v1.
    
  • Point protection with transfluthrin against Musca domestica in a semi-field enclosure -(Peer Reviewed Journal)
    Aldridge, R.L., Pagac, A.A., Norris, E.J., Geden, C.J., Kline, D.L., Linthicum, K. 2024. Point protection with transfluthrin against Musca domestica in a semi-field enclosure. Insects. 15(4). https://doi.org/10.3390/insects15040277.
    
  • Repellent activity of natural products to the Lone Star tick, Amblyomma americanum -(Peer Reviewed Journal)
    Le Mauff, A., Norris, E.J., Li, A.Y., Swale, D.R. 2024. Repellent activity of natural products to the Lone Star tick, Amblyomma americanum. ACS Infectious Diseases. 17:202. https://doi.org/10.1186/s13071-024-06246-0.
    
  • Measuring insecticide resistance in a vacuum: exploring next steps to link resistance data with mosquito control efficacy -(Peer Reviewed Journal)
    Lehane, A., Casey, P., Norris, E.J., Sarah, W., Laura, H. 2024. Measuring insecticide resistance in a vacuum: exploring next steps to link resistance data with mosquito control efficacy. Journal of Medical Entomology. 61(3):584-594. https://doi.org/10.1093/jme/tjae029.
    
  • Repellency and toxicity of vapor-active benzaldehydes against Aedes aegypti -(Peer Reviewed Journal)
    Norris, E.J., Kline, J.D., Bloomquist, J.R. 2023. Repellency and toxicity of vapor-active benzaldehydes against Aedes aegypti. ACS Infectious Diseases. 10:120-126. https://doi.org/10.1021/acsinfecdis.3c00294.
    
  • Fir (Abies balsamea) (Pinales: Pinaceae) needle essential oil enhances the the knockdown activity of select insecticides -(Peer Reviewed Journal)
    Norris, E.J., Bloomquist, J.R. 2023. Fir (Abies balsamea) (Pinales: Pinaceae) needle essential oil enhances the the knockdown activity of select insecticides. Journal of Medical Entomology. 60(6):1350-1356. https://doi.org/10.1093/jme/tjad101.
    
  • Resumption of stable fly and house fly research at post-Covid CMAVE-(Abstract Only)
    
    
  • Insecticidal and synergistic potential of three monoterpenoids against the Yellow Fever mosquito, Aedes aegypti (Diptera: Culicidae), and the house fly, Musca domestica (Diptera: Muscidae) -(Peer Reviewed Journal)
    Baker, O.S., Norris, E.J., Burgess, E.R. 2023. Insecticidal and synergistic potential of three monoterpenoids against the Yellow Fever mosquito, Aedes aegypti (Diptera: Culicidae), and the house fly, Musca domestica (Diptera: Muscidae). Molecules. 28:3250. https://doi.org/10.3390/molecules28073250.
    
  • Neurophysiological action of centrally-acting spider toxin polypeptides derived from Hadronyche versuta and Tegenaria agrestis venom -(Peer Reviewed Journal)
    Bloomquist, J.R., Coquerel, Q.R., Hulbert, D., Norris, E.J. 2023. Neurophysiological action of centrally-acting spider toxin polypeptides derived from Hadronyche versuta and Tegenaria agrestis venom. Pesticide Biochemistry and Physiology. 192:105416. https://doi.org/10.1016/j.pestbp.2023.105416.
    
  • Sodium channel-directed alkaloids synergize the mosquitocidal and neurophysiological effects of natural pyrethrins -(Peer Reviewed Journal)
    Norris, E.J., Bloomquist, J.R. 2022. Sodium channel-directed alkaloids synergize the mosquitocidal and neurophysiological effects of natural pyrethrins. Pesticide Biochemistry and Physiology. https://doi.org/10.1016/j.pestbp.2022.105171.
    
  • Mode of action and toxicological effects of the sesquiterpenoid, nootkatone, in insects -(Peer Reviewed Journal)
    Norris, E.J., Chen, R., Li, Z., Geldenhuys, W., Bloomquist, J.R., Swale, D.R. 2022. Mode of action and toxicological effects of the sesquiterpenoid, nootkatone, in insects. Pesticide Biochemistry and Physiology. 183:105085. https://doi.org/10.1016/j.pestbp.2022.105085.
    
  • Fir needle oil enhances diverse insecticides by increasing cuticular penetration-(Abstract Only)
    
    
  • Black and Sichuan pepper constituents significantly enhance the neurophysiological effects of natural pyrethrins in Aedes aegypti-(Abstract Only)
    
    
  • Permethrin synergized by novel plant essential oils on pyrethroid-susceptible and pyrethroid-resistant strains of Aedes aegypti-(Abstract Only)
    
    
  • Vapor phase repellency and insecticidal activity of pyridinyl amides against Anopheline mosquitoes -(Peer Reviewed Journal)
    Cuba, I.H., Richoux, G.R., Norris, E.J., Bernier, U.R., Linthicum, K., Bloomquist, J.R. 2021. Vapor phase repellency and insecticidal activity of pyridinyl amides against Anopheline mosquitoes. Current Research in Parasitology and Vector Borne Diseases. 1:100062. https://doi.org/10.1016/j.crpvbd.2021.100062.
    
  • Assessing insecticide resistance and potency directly on the mosquito central nervous system: a novel method-(Abstract Only)
    
    
  • Highlights in vector control-(Abstract Only)
    
    
  • The AMCA research fund: now and into the future-(Abstract Only)
    
    
  • Nutritional status significantly affects toxicological endpoints in the CDC bottle bioassay -(Peer Reviewed Journal)
    Norris, E.J., Bloomquist, J.R. 2021. Nutritional status significantly affects toxicological endpoints in the CDC bottle bioassay. Pest Management Science. 78:743-748. https://doi.org/10.1002/ps.6687.
    
  • Novel pyrethroid derivatives as effective mosquito repellents and repellent synergists -(Book / Chapter)
    Bloomquist, J., Jiang, S., Norris, E.J., Richoux, G., Yang, L., Linthicum, K. 2021. Novel pyrethroid derivatives as effective mosquito repellents and repellent synergists. In Corona, C., Debboun, M., Coats, J., editors, Advances in Arthropod Repellents. Elsevier Inc. p.19-32. https://doi.org/10.1016/B978-0-323-85411-5.00004-2.
    
  • Recording central neurophysiological output from mosquito larvae for neuropharmacological and insecticide resistance studies -(Peer Reviewed Journal)
    Norris, E.J., Bloomquist, J.R. 2021. Recording central neurophysiological output from mosquito larvae for neuropharmacological and insecticide resistance studies. Journal of Insect Physiology. 135:104319. https://doi.org/10.1016/j.jinsphys.2021.104319.
    
  • Toxicity and mode of action of the aporphine plant alkaloid liriodenine on the insect GABA receptor -(Peer Reviewed Journal)
    Coquerel, Q.R., Demares, F., Geldenhuys, W.J., Le Ray, A., Breard, D., Richomme, P., Legros, C., Norris, E.J., Bloomquist, J.R. 2021. Toxicity and mode of action of the aporphine plant alkaloid liriodenine on the insect GABA receptor. Toxicon. 201:141-147. https://doi.org/10.1016/j.toxicon.2021.08.019.
    
  • Resistance-breaking insecticidal activity of new spatial insecticides against Aedes aegypti -(Peer Reviewed Journal)
    Richoux, G.M., Yang, L., Norris, E.J., Jiang, S., Linthicum, K., Bloomquist, J.R. 2021. Resistance-breaking insecticidal activity of new spatial insecticides against Aedes aegypti. Journal of Agricultural and Food Chemistry. https://doi.org/10.1021/acs.jafc.1c01200.
    
  • Neurophysiological and insecticidal effects of liriodenine, an alkaloid isolated from the Chinese herb Zanthoxylum nitidum-(Abstract Only)
    
    
  • Mechanism of toxicity for the sesquiterpene, nootkatone-(Abstract Only)
    
    
  • Toxicity and mode of action of experimental aryl amide insecticides-(Abstract Only)
    
    
  • Spatial repellent and synergistic activities of pyrethroid acids-(Abstract Only)
    
    
  • Mode of action of nootkatone, a biorational insecticide and repellent-(Abstract Only)
    Norris, E.J., Geldenhuys, W., Bloomquist, J.R. 2021. Mode of action of nootkatone, a biorational insecticide and repellent. Emerging Pathogens Institute Research Day. p.69-70.
    
  • Plant essential oils enhance the vapor toxicity and repellency of spatial repellent pyrethroids-(Abstract Only)
    Norris, E.J., Bloomquist, J.R. 2021. Plant essential oils enhance the vapor toxicity and repellency of spatial repellent pyrethroids. Emerging Pathogens Institute Research Day. p.73.
    
  • Ester moiety structural modification of repellent and insecticidal pyrethroids-(Abstract Only)
    Richoux, G.M., Yang, L., Linthicum, K., Norris, E.J., Bloomquist, J. 2021. Ester moiety structural modification of repellent and insecticidal pyrethroids. Emerging Pathogens Institute Research Day. p.57-58.
    
  • Resistance breaking insecticidal activity of new spatial insecticides against Aedes aegypti-(Abstract Only)
    Richoux, G.M., Yang, L., Jiang, S., Norris, E.J., Linthicum, K., Bloomquist, J. 2021. Resistance breaking insecticidal activity of new spatial insecticides against Aedes aegypti. Emerging Pathogens Institute Research Day. p.74-75.
    
  • Co-toxicity factor analysis reveals numerous plant essential oils are synergists of natural pyrethrins against Aedes aegypti mosquitoes -(Peer Reviewed Journal)
    Norris, E.J., Bloomquist, J.R. 2021. Co-toxicity factor analysis reveals numerous plant essential oils are synergists of natural pyrethrins against Aedes aegypti mosquitoes. Insects. 12(2):154,1-11. https://doi.org/10.3390/insects12020154.
    
  • DFDT (p-p’-difluoro-DDT) as an antimalarial mosquitocide-(Abstract Only)
    
    
  • Select plant alkaloids synergize the toxicity and neural block of natural pyrethrins in Aedes aegypti-(Abstract Only)
    
    
  • Structure-activity relationship analysis of potential new vapor-active insect repellents -(Peer Reviewed Journal)
    Richoux, G.M., Yang, L., Norris, E.J., Tsikolia, M., Jiang, S., Linthicum, K., Bloomquist, J.R. 2020. Structure-activity relationship analysis of potential new vapor-active insect repellents. Journal of Agricultural and Food Chemistry. 68:13960-13969. https://doi.org/10.1021/acs.jafc.0c03333.